Gene: KCTD8

386617
-
potassium channel tetramerization domain containing 8
protein-coding
4p13
Ensembl:ENSG00000183783 Vega:OTTHUMG00000099409 UniprotKB:Q6ZWB6
NC_000004.12
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
4.042e-1 (AD)  5.619e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
MRPS300.934
RGS70.933
NSF0.932
SLC25A140.931
ELMOD10.93
GPRASP20.93
REEP10.928
MAGEE10.928
GPR1580.927
CHGB0.927

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CSAG1-0.556
MYL3-0.5
RNF135-0.493
RAI14-0.485
RUNX3-0.482
MAGEA12-0.482
CNN2-0.479
CARD8-0.478
FZD10-0.477
SYDE1-0.474

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D000082AcetaminophenAcetaminophen results in increased expression of KCTD8 mRNA29067470
D020106AcrylamideAcrylamide results in decreased expression of KCTD8 mRNA28959563
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of KCTD8 gene27153756
D001280AtrazineAtrazine results in increased expression of KCTD8 mRNA22378314
D001507BeclomethasoneBeclomethasone results in decreased expression of KCTD8 mRNA23656298
C006703benzo(b)fluoranthenebenzo(b)fluoranthene results in decreased expression of KCTD8 mRNA26377693
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased methylation of KCTD8 promoter28329817
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of KCTD8 mRNA22316170
C006780bisphenol Abisphenol A results in decreased expression of KCTD8 mRNA25181051
D003471CuprizoneCuprizone results in increased expression of KCTD8 mRNA26577399
D003976DiazinonDiazinon results in decreased methylation of KCTD8 gene22964155
D007213IndomethacinIndomethacin results in increased expression of KCTD8 mRNA28201806
D007854LeadLead affects the expression of KCTD8 mRNA28903495
D011441PropylthiouracilPropylthiouracil results in decreased expression of KCTD8 mRNA24780913
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of KCTD8 mRNA23806026
C009495titanium dioxidetitanium dioxide results in increased expression of KCTD8 mRNA23557971
D014635Valproic AcidValproic Acid affects the expression of KCTD8 mRNA17292431
D001335Vehicle EmissionsVehicle Emissions affects the methylation of KCTD8 gene25560391

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO ID GO Term Qualifier Evidence PubMed
GO:0008277regulation of G-protein coupled receptor protein signaling pathway-IEA-  
GO:0051260protein homooligomerization-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0030054cell junction-IEA-  
GO:0042734presynaptic membrane-IEA-  
GO:0043235receptor complex-IEA-  
GO:0045211postsynaptic membrane-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

There is no Interaction data for this gene.

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
22156575KCTD8 gene and brain growth in adverse intrauterine environment: a genome-wide association study. (2012 Nov)Paus TCereb Cortex