Gene: RHOA

387
ARH12|ARHA|RHO12|RHOH12
ras homolog family member A
protein-coding
3p21.31
Ensembl:ENSG00000067560 MIM:165390 Vega:OTTHUMG00000156838 UniprotKB:P61586
NG_051308.1
PubMed
ND
12   
NA (AD)  NA (ND)   (Frontal_Cortex)
5.797e-1 (AD)  3.805e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
EEF1A10.947
DAZAP20.935
LSM14A0.924
CTNNA10.922
RBM170.921
EEF1G0.921
CNBP0.921
WDR45B0.921
RPL100.916
RPL50.915

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F29-0.876
OR4F5-0.852
OPRD1-0.157
HTR6-0.099
C14orf180-0.099
C4orf50-0.099
KLHL34-0.096
ADRA1D-0.096
KCNG2-0.096
SSX5-0.095

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB04315Guanosine-5'-DiphosphateSmall Molecule146-91-8ExperimentalTarget
ID Drug Name Action PubMed
D0140131,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt"1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt inhibits the reaction [Oxygen results in increased activity of RHOA protein]"21439370
D0140131,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt"1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt inhibits the reaction [Oxygen results in increased activity of RHOA protein]"21439370
C0602291-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione"1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [Brimonidine Tartrate promotes the reaction [AGT protein results in increased expression of RHOA protein]]"18250367
C0297902,2',3',4,4',5-hexachlorobiphenyl"2,2',3',4,4',5-hexachlorobiphenyl results in decreased expression of RHOA mRNA"23829299
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in increased expression of RHOA mRNA"20056577
C0495842-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine"2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of RHOA mRNA"15215175
C5343052-methyl-5-(1-methylethenyl)cyclohexanol2-methyl-5-(1-methylethenyl)cyclohexanol results in increased expression of RHOA protein12671036
C5343052-methyl-5-(1-methylethenyl)cyclohexanolMevalonic Acid affects the reaction [2-methyl-5-(1-methylethenyl)cyclohexanol results in increased expression of RHOA protein]12671036
C5612313-(3-(quinolin-2-ylamino)phenyl)acrylic Acid3-(3-(quinolin-2-ylamino)phenyl)acrylic Acid results in decreased activity of RHOA protein21615130
C5612303-(3-(quinoxalin-3-ylamino)phenyl)prop-2-en-1-ol3-(3-(quinoxalin-3-ylamino)phenyl)prop-2-en-1-ol results in decreased activity of RHOA protein21615130
C5240423,5-bis(2-fluorobenzylidene)piperidin-4-one"3,5-bis(2-fluorobenzylidene)piperidin-4-one results in decreased phosphorylation of RHOA protein"25725129
C5240423,5-bis(2-fluorobenzylidene)piperidin-4-one"MIR33B mRNA affects the reaction [3,5-bis(2-fluorobenzylidene)piperidin-4-one results in decreased phosphorylation of RHOA protein]"25725129
C0414773-hydroxyflavone3-hydroxyflavone results in decreased expression of RHOA protein27600294
C1081234-amino-5-(4-methylphenyl)-7-(tert-butyl)pyrazolo(3,4-d)pyrimidine"4-amino-5-(4-methylphenyl)-7-(tert-butyl)pyrazolo(3,4-d)pyrimidine inhibits the reaction [Brimonidine Tartrate promotes the reaction [AGT protein results in increased expression of RHOA protein]]"18250367
C0022024-oxoretinoic acid4-oxoretinoic acid results in decreased expression of RHOA mRNA15982314
C0806695,7-dihydroxy-6-methoxy-2-phenylchromen-4-one"5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one inhibits the reaction [Lipopolysaccharides results in decreased expression of and results in decreased activity of RHOA protein]"26694894
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine inhibits the reaction [resveratrol inhibits the reaction [AGT protein results in increased activity of RHOA protein]]"24965170
C0159298-((4-chlorophenyl)thio)cyclic-3',5'-AMP"8-((4-chlorophenyl)thio)cyclic-3',5'-AMP inhibits the reaction [RHOA protein binds to RTKN protein]"20610540
C0159298-((4-chlorophenyl)thio)cyclic-3',5'-AMP"8-((4-chlorophenyl)thio)cyclic-3',5'-AMP results in decreased activity of RHOA protein"20610540
C0556568-((4-chlorophenyl)thio)cyclic-3',5'-GMP"[8-((4-chlorophenyl)thio)cyclic-3',5'-GMP co-treated with PRKG1 protein] promotes the reaction [ARHGEF17 protein results in increased activity of RHOA protein]"23195829
C0556568-((4-chlorophenyl)thio)cyclic-3',5'-GMP"[8-((4-chlorophenyl)thio)cyclic-3',5'-GMP co-treated with PRKG1 protein] results in increased activity of RHOA protein"23195829
C0556568-((4-chlorophenyl)thio)cyclic-3',5'-GMP"KT 5823 inhibits the reaction [[8-((4-chlorophenyl)thio)cyclic-3',5'-GMP co-treated with PRKG1 protein] results in increased activity of RHOA protein]"23195829
D000082Acetaminophen[Clofibrate co-treated with Acetaminophen] affects the expression of RHOA mRNA17585979
D000082AcetaminophenPPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of RHOA mRNA]17585979
D000109Acetylcholine"[[Antigens, Bacterial co-treated with Allergens] results in increased expression of and results in increased activity of RHOA protein] which results in increased susceptibility to Acetylcholine"18391481
D000109Acetylcholine"Beclomethasone inhibits the reaction [[[Antigens, Bacterial co-treated with Allergens] results in increased expression of and results in increased activity of RHOA protein] which results in increased susceptibility to Acetylcholine]"18391481
D000109Acetylcholine"Prednisolone inhibits the reaction [[[Antigens, Bacterial co-treated with Allergens] results in increased expression of and results in increased activity of RHOA protein] which results in increased susceptibility to Acetylcholine]"18391481
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of RHOA mRNA27153756|2894338
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of RHOA mRNA19770486
C103303alitretinoinalitretinoin results in decreased expression of RHOA mRNA15982314
D000485Allergens"[Antigens, Bacterial co-treated with Allergens] results in increased expression of and results in increased activity of RHOA protein"18391481
D000485Allergens"[[Antigens, Bacterial co-treated with Allergens] results in increased expression of and results in increased activity of RHOA protein] which results in increased susceptibility to Acetylcholine"18391481
D000485Allergens"[Antigens, Bacterial co-treated with Allergens] results in increased expression of RHOA mRNA"18391481
D000485Allergens"Beclomethasone inhibits the reaction [[Antigens, Bacterial co-treated with Allergens] results in increased expression of and results in increased activity of RHOA protein]"18391481
D000485Allergens"Beclomethasone inhibits the reaction [[[Antigens, Bacterial co-treated with Allergens] results in increased expression of and results in increased activity of RHOA protein] which results in increased susceptibility to Acetylcholine]"18391481
D000485Allergens"Beclomethasone inhibits the reaction [[Antigens, Bacterial co-treated with Allergens] results in increased expression of RHOA mRNA]"18391481
D000485Allergens"Prednisolone inhibits the reaction [[Antigens, Bacterial co-treated with Allergens] results in increased expression of and results in increased activity of RHOA protein]"18391481
D000485Allergens"Prednisolone inhibits the reaction [[[Antigens, Bacterial co-treated with Allergens] results in increased expression of and results in increased activity of RHOA protein] which results in increased susceptibility to Acetylcholine]"18391481
D000485Allergens"Prednisolone inhibits the reaction [[Antigens, Bacterial co-treated with Allergens] results in increased expression of RHOA mRNA]"18391481
D000643Ammonium ChlorideAmmonium Chloride affects the expression of RHOA mRNA16483693
D000942Antigens, Bacterial"[Antigens, Bacterial co-treated with Allergens] results in increased expression of and results in increased activity of RHOA protein"18391481
D000942Antigens, Bacterial"[[Antigens, Bacterial co-treated with Allergens] results in increased expression of and results in increased activity of RHOA protein] which results in increased susceptibility to Acetylcholine"18391481
D000942Antigens, Bacterial"[Antigens, Bacterial co-treated with Allergens] results in increased expression of RHOA mRNA"18391481
D000942Antigens, Bacterial"Beclomethasone inhibits the reaction [[Antigens, Bacterial co-treated with Allergens] results in increased expression of and results in increased activity of RHOA protein]"18391481
D000942Antigens, Bacterial"Beclomethasone inhibits the reaction [[[Antigens, Bacterial co-treated with Allergens] results in increased expression of and results in increased activity of RHOA protein] which results in increased susceptibility to Acetylcholine]"18391481
D000942Antigens, Bacterial"Beclomethasone inhibits the reaction [[Antigens, Bacterial co-treated with Allergens] results in increased expression of RHOA mRNA]"18391481
D000942Antigens, Bacterial"Prednisolone inhibits the reaction [[Antigens, Bacterial co-treated with Allergens] results in increased expression of and results in increased activity of RHOA protein]"18391481
D000942Antigens, Bacterial"Prednisolone inhibits the reaction [[[Antigens, Bacterial co-treated with Allergens] results in increased expression of and results in increased activity of RHOA protein] which results in increased susceptibility to Acetylcholine]"18391481
D000942Antigens, Bacterial"Prednisolone inhibits the reaction [[Antigens, Bacterial co-treated with Allergens] results in increased expression of RHOA mRNA]"18391481
C006632arsenic trioxidearsenic trioxide results in increased expression of RHOA mRNA22521957
D017638Asbestos, Crocidolite"Asbestos, Crocidolite inhibits the reaction [RHOA protein binds to Guanosine Triphosphate]"21257924
D017638Asbestos, Crocidolite"Asbestos, Crocidolite results in decreased activity of and results in decreased lipidation of RHOA protein"17322126
D017638Asbestos, Crocidolite"Asbestos, Crocidolite results in decreased prenylation of RHOA protein"21257924
D017638Asbestos, Crocidolite"Mevalonic Acid inhibits the reaction [Asbestos, Crocidolite results in decreased activity of and results in decreased lipidation of RHOA protein]"17322126
D017638Asbestos, Crocidolite"tempol inhibits the reaction [Asbestos, Crocidolite inhibits the reaction [RHOA protein binds to Guanosine Triphosphate]]"21257924
D017638Asbestos, Crocidolite"tempol inhibits the reaction [Asbestos, Crocidolite results in decreased prenylation of RHOA protein]"21257924
D000069059Atorvastatin CalciumAtorvastatin Calcium results in decreased activity of RHOA protein16470222
D000069059Atorvastatin CalciumAtorvastatin Calcium results in decreased localization of RHOA protein18172863
D000069059Atorvastatin CalciumAtorvastatin Calcium results in increased expression of RHOA protein18172863
D000069059Atorvastatin CalciumAtorvastatin Calcium results in increased localization of and results in decreased prenylation of RHOA protein16470222
D000069059Atorvastatin CalciumCelecoxib promotes the reaction [Atorvastatin Calcium results in decreased localization of RHOA protein]18172863
D000069059Atorvastatin CalciumCelecoxib promotes the reaction [Atorvastatin Calcium results in increased expression of RHOA protein]18172863
D000069059Atorvastatin Calciumgeranylgeranyl pyrophosphate inhibits the reaction [Atorvastatin Calcium results in decreased activity of RHOA protein]16470222
D000069059Atorvastatin Calciumgeranylgeranyl pyrophosphate inhibits the reaction [Atorvastatin Calcium results in increased localization of RHOA protein]16470222
D000069059Atorvastatin CalciumMevalonic Acid inhibits the reaction [Atorvastatin Calcium results in decreased activity of RHOA protein]16470222
D000069059Atorvastatin CalciumMevalonic Acid inhibits the reaction [Atorvastatin Calcium results in increased localization of RHOA protein]16470222
D000069059Atorvastatin CalciumRHOA mutant form inhibits the reaction [Atorvastatin Calcium results in decreased expression of BCL2 protein]16470222
D000069059Atorvastatin CalciumRHOA mutant form inhibits the reaction [Atorvastatin Calcium results in decreased phosphorylation of MAPK1 protein]16470222
D000069059Atorvastatin CalciumRHOA mutant form inhibits the reaction [Atorvastatin Calcium results in decreased phosphorylation of MAPK3 protein]16470222
D000069059Atorvastatin CalciumRHOA protein inhibits the reaction [Atorvastatin Calcium results in increased activity of CASP3 protein]16470222
D000069059Atorvastatin CalciumAtorvastatin Calcium inhibits the reaction [Streptozocin results in increased activity of RHOA protein]17589825
D001285AtropineAtropine inhibits the reaction [Parathion results in increased expression of RHOA protein]17390078
D001507Beclomethasone"Beclomethasone inhibits the reaction [[Antigens, Bacterial co-treated with Allergens] results in increased expression of and results in increased activity of RHOA protein]"18391481
D001507Beclomethasone"Beclomethasone inhibits the reaction [[[Antigens, Bacterial co-treated with Allergens] results in increased expression of and results in increased activity of RHOA protein] which results in increased susceptibility to Acetylcholine]"18391481
D001507Beclomethasone"Beclomethasone inhibits the reaction [[Antigens, Bacterial co-treated with Allergens] results in increased expression of RHOA mRNA]"18391481
C020711beryllium sulfateberyllium sulfate results in increased expression of RHOA mRNA16314022
D004958Estradiol[Parathion co-treated with Estradiol] results in increased expression of RHOA protein17622325
D004958Estradiol[Estradiol co-treated with Progesterone] results in increased expression of RHOA mRNA19687787
D004958EstradiolEstradiol results in increased expression of RHOA mRNA19687787
D004958EstradiolEstradiol results in increased expression of RHOA protein22342969
D004958Estradiol[Progesterone co-treated with Estradiol] results in increased expression of RHOA protein22342969
D004958EstradiolDizocilpine Maleate inhibits the reaction [Estradiol results in decreased expression of RHOA protein]24231043
D004958EstradiolEstradiol results in decreased expression of RHOA protein24231043
D004958EstradiolU 0126 inhibits the reaction [Estradiol results in decreased expression of RHOA protein]24231043
C070515bisindolylmaleimide Ibisindolylmaleimide I inhibits the reaction [Brimonidine Tartrate promotes the reaction [AGT protein results in increased expression of RHOA protein]]18250367
C006780bisphenol Abisphenol A results in decreased expression of RHOA protein24231043
C006780bisphenol ADizocilpine Maleate inhibits the reaction [bisphenol A results in decreased expression of RHOA protein]24231043
C006780bisphenol AU 0126 inhibits the reaction [bisphenol A results in decreased expression of RHOA protein]24231043
C000611646bisphenol F[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of RHOA mRNA28628672
C423844BL 11282BL 11282 results in decreased expression of RHOA protein17458497
D000068438Brimonidine Tartrate"1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [Brimonidine Tartrate promotes the reaction [AGT protein results in increased expression of RHOA protein]]"18250367
D000068438Brimonidine Tartrate"4-amino-5-(4-methylphenyl)-7-(tert-butyl)pyrazolo(3,4-d)pyrimidine inhibits the reaction [Brimonidine Tartrate promotes the reaction [AGT protein results in increased expression of RHOA protein]]"18250367
D000068438Brimonidine Tartratebisindolylmaleimide I inhibits the reaction [Brimonidine Tartrate promotes the reaction [AGT protein results in increased expression of RHOA protein]]18250367
D000068438Brimonidine TartrateBrimonidine Tartrate promotes the reaction [AGT protein results in increased activity of RHOA protein]18250367
D000068438Brimonidine Tartratediphenyleneiodonium inhibits the reaction [Brimonidine Tartrate promotes the reaction [AGT protein results in increased expression of RHOA protein]]18250367
D000068438Brimonidine Tartratetempol inhibits the reaction [Brimonidine Tartrate promotes the reaction [AGT protein results in increased expression of RHOA protein]]18250367
C022777bufalinbufalin results in decreased expression of RHOA protein23949904
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in increased expression of RHOA mRNA18804290
D019256Cadmium ChlorideCadmium Chloride promotes the reaction [RHOA protein binds to Guanosine Triphosphate]26220685
D019256Cadmium ChlorideCadmium Chloride results in increased expression of and results in increased activity of RHOA protein26220685
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of RHOA mRNA18804290
D019256Cadmium ChlorideCadmium Chloride results in increased methylation of RHOA promoter22457795
C071482calpeptincalpeptin results in increased activity of RHOA protein25277379
C071482calpeptinLM11A-31 inhibits the reaction [calpeptin results in increased activity of RHOA protein]25277379
C006923carvonecarvone results in increased expression of RHOA protein12671036
C006923carvoneMevalonic Acid affects the reaction [carvone results in increased expression of RHOA protein]12671036
C054133casticincasticin results in decreased expression of RHOA protein28444820
D000068579CelecoxibCelecoxib promotes the reaction [Atorvastatin Calcium results in decreased localization of RHOA protein]18172863
D000068579CelecoxibCelecoxib promotes the reaction [Atorvastatin Calcium results in increased expression of RHOA protein]18172863
C086276cerivastatincerivastatin results in decreased localization of RHOA protein15705602
C086276cerivastatincerivastatin results in increased localization of and results in decreased prenylation of RHOA protein16470222
C086276cerivastatincerivastatin results in decreased localization of RHOA protein11950701
C086276cerivastatingeranylgeranyl pyrophosphate inhibits the reaction [cerivastatin results in decreased localization of RHOA protein]11950701
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in decreased expression of RHOA protein23650126
C100187chloropicrinchloropicrin results in increased expression of RHOA mRNA26352163
D002994Clofibrate[Clofibrate co-treated with Acetaminophen] affects the expression of RHOA mRNA17585979
D002994ClofibratePPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of RHOA mRNA]17585979
C488583Clostridium difficile lethal toxin BClostridium difficile lethal toxin B results in decreased activity of RHOA protein17322126
C488583Clostridium difficile lethal toxin BClostridium difficile lethal toxin B results in decreased activity of RHOA protein11158304
D003471CuprizoneCuprizone results in decreased expression of RHOA mRNA26577399
D003474CurcuminCurcumin analog results in decreased expression of RHOA mRNA26409325
D015638Cytochalasin D[Cytochalasin D results in increased expression of CDH1 protein] which results in decreased activity of RHOA protein25756282
D015638Cytochalasin DRHOA protein mutant form affects the reaction [Cytochalasin D results in increased expression of CDH1 protein]25756282
C060296cytotoxic necrotizing factor type 1cytotoxic necrotizing factor type 1 results in increased activity of and results in decreased expression of RHOA protein23732113
C014347decitabinedecitabine results in decreased expression of RHOA mRNA27915011
C107676deguelindeguelin results in decreased expression of RHOA mRNA25322282
C107676deguelindeguelin results in decreased expression of RHOA protein25322282
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of RHOA mRNA28628672
D003907DexamethasoneDexamethasone results in decreased expression of RHOA mRNA29111458
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of RHOA mRNA21266533
D002945CisplatinCisplatin results in increased activity of RHOA protein25277379
D002945CisplatinLM11A-31 inhibits the reaction [Cisplatin results in increased activity of RHOA protein]25277379
D002945CisplatinCisplatin results in increased oxidation of and results in decreased activity of RHOA protein17128987
D004041Dietary FatsDietary Fats results in increased expression of RHOA mRNA22010203
D004041Dietary FatsTestosterone inhibits the reaction [Dietary Fats results in increased expression of RHOA mRNA]22010203
C007517diphenyleneiodoniumdiphenyleneiodonium inhibits the reaction [AGT protein affects the localization of RHOA protein]16569756
C007517diphenyleneiodoniumdiphenyleneiodonium inhibits the reaction [Brimonidine Tartrate promotes the reaction [AGT protein results in increased expression of RHOA protein]]18250367
D016291Dizocilpine MaleateDizocilpine Maleate inhibits the reaction [bisphenol A results in decreased expression of RHOA protein]24231043
D016291Dizocilpine MaleateDizocilpine Maleate inhibits the reaction [Estradiol results in decreased expression of RHOA protein]24231043
D004298Dopamine[Dopamine co-treated with DRD2 protein alternative form] results in increased activity of RHOA protein27717053
D004317DoxorubicinRHOA protein results in decreased susceptibility to Doxorubicin15448013
D004642EmodinEmodin results in decreased expression of RHOA mRNA16045814
D004967EstrogensEstrogens results in decreased expression of RHOA mRNA20970835
D000431EthanolEthanol results in decreased expression of RHOA protein20133374|2082942
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of RHOA mRNA17942748
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of RHOA mRNA17942748
C063007exoenzyme C3, Clostridium botulinum"exoenzyme C3, Clostridium botulinum inhibits the reaction [ARHGEF17 protein results in increased activity of RHOA protein]"23195829
C063007exoenzyme C3, Clostridium botulinum"exoenzyme C3, Clostridium botulinum inhibits the reaction [lead titanate zirconate results in increased expression of RHOA protein]"24203571
C063007exoenzyme C3, Clostridium botulinum"exoenzyme C3, Clostridium botulinum results in decreased activity of RHOA protein"11839765|1866045
D005204FarnesolFarnesol inhibits the reaction [Lovastatin affects the localization of RHOA protein]9398081
C004808farnesyl pyrophosphatefarnesyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [Lipopolysaccharides results in decreased activity of RHOA protein]]18625914
C004808farnesyl pyrophosphatefarnesyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [TNF affects the localization of RHOA protein]]18310456
C049347fasudilfasudil results in decreased expression of RHOA mRNA26172442
C049347fasudilfasudil results in decreased expression of RHOA protein26172442
D018120FinasterideFinasteride results in increased expression of RHOA mRNA24136188
D005419FlavonoidsFlavonoids results in increased expression of RHOA mRNA18035473
D005472FluorouracilRHOA protein results in decreased susceptibility to Fluorouracil15448013
C065180fluvastatinfluvastatin inhibits the reaction [Puromycin Aminonucleoside results in increased expression of RHOA protein]16452496
C065180fluvastatinfluvastatin inhibits the reaction [Puromycin Aminonucleoside results in increased expression of RHOA protein]16452496
D005707Gallic AcidGallic Acid results in decreased expression of RHOA protein23153558
C017338geranylgeraniolgeranylgeraniol inhibits the reaction [Lovastatin affects the localization of RHOA protein]12933658
C017338geranylgeraniolgeranylgeraniol inhibits the reaction [zoledronic acid results in decreased expression of and affects the localization of RHOA protein]15324309
C017338geranylgeraniolgeranylgeraniol inhibits the reaction [Lovastatin affects the localization of RHOA protein]9398081
C017338geranylgeraniolgeranylgeraniol inhibits the reaction [Simvastatin inhibits the reaction [Phenylephrine results in increased activity of RHOA protein]]24449418
C002963geranylgeranyl pyrophosphategeranylgeranyl pyrophosphate inhibits the reaction [Atorvastatin Calcium results in decreased activity of RHOA protein]16470222
C002963geranylgeranyl pyrophosphategeranylgeranyl pyrophosphate inhibits the reaction [Atorvastatin Calcium results in increased localization of RHOA protein]16470222
C002963geranylgeranyl pyrophosphategeranylgeranyl pyrophosphate inhibits the reaction [Simvastatin affects the localization of and results in decreased activity of RHOA protein]18031796
C002963geranylgeranyl pyrophosphategeranylgeranyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [Lipopolysaccharides results in decreased activity of RHOA protein]]18625914
C002963geranylgeranyl pyrophosphategeranylgeranyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [TNF results in increased activity of RHOA protein]]17075836
C002963geranylgeranyl pyrophosphategeranylgeranyl pyrophosphate inhibits the reaction [Simvastatin results in decreased activity of RHOA protein]16470222
C002963geranylgeranyl pyrophosphategeranylgeranyl pyrophosphate inhibits the reaction [Simvastatin results in increased localization of RHOA protein]16005304|1647022
C002963geranylgeranyl pyrophosphateSimvastatin inhibits the reaction [geranylgeranyl pyrophosphate affects the localization of RHOA protein]18625202
C002963geranylgeranyl pyrophosphategeranylgeranyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [TNF affects the localization of RHOA protein]]18310456
C002963geranylgeranyl pyrophosphategeranylgeranyl pyrophosphate inhibits the reaction [cerivastatin results in decreased localization of RHOA protein]11950701
C102521GGTI 298GGTI 298 affects the localization of RHOA protein16740276
C102521GGTI 298GGTI 298 results in decreased farnesylation of RHOA protein mutant form22028818
C102521GGTI 298GGTI 298 results in decreased geranoylation of RHOA protein22028818
D005947GlucoseGlucose results in increased activity of RHOA protein23376009
D016244Guanosine 5'-O-(3-Thiotriphosphate)Guanosine 5'-O-(3-Thiotriphosphate) affects the localization of RHOA protein12960549
D016244Guanosine 5'-O-(3-Thiotriphosphate)sevoflurane inhibits the reaction [Guanosine 5'-O-(3-Thiotriphosphate) affects the localization of RHOA protein]12960549
D006160Guanosine TriphosphateAGT protein modified form promotes the reaction [Guanosine Triphosphate binds to RHOA protein]21289285
D006160Guanosine Triphosphate"Asbestos, Crocidolite inhibits the reaction [RHOA protein binds to Guanosine Triphosphate]"21257924
D006160Guanosine TriphosphateCadmium Chloride promotes the reaction [RHOA protein binds to Guanosine Triphosphate]26220685
D006160Guanosine TriphosphateRHOA protein binds to Guanosine Triphosphate21257924
D006160Guanosine TriphosphateRisedronate Sodium results in increased abundance of [Guanosine Triphosphate binds to RHOA protein]16734383
D006160Guanosine Triphosphate"tempol inhibits the reaction [Asbestos, Crocidolite inhibits the reaction [RHOA protein binds to Guanosine Triphosphate]]"21257924
D006160Guanosine Triphosphatetempol inhibits the reaction [Vitamin K 3 inhibits the reaction [RHOA protein binds to Guanosine Triphosphate]]21257924
D006160Guanosine TriphosphateVitamin K 3 inhibits the reaction [RHOA protein binds to Guanosine Triphosphate]21257924
D006160Guanosine Triphosphatezoledronic acid results in increased expression of [RHOA protein binds to Guanosine Triphosphate]28871336
D006160Guanosine TriphosphateRisedronate Sodium results in increased abundance of [Guanosine Triphosphate binds to RHOA protein]16734383
D006160Guanosine Triphosphatezoledronic acid results in increased abundance of [Guanosine Triphosphate binds to RHOA protein]16734383
D006160Guanosine TriphosphateRisedronate Sodium results in increased abundance of [Guanosine Triphosphate binds to RHOA protein]16734383
D006220HaloperidolHaloperidol results in decreased expression of RHOA mRNA15860345
D002112CalcifediolCalcifediol deficiency results in decreased expression of RHOA mRNA17293106
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of RHOA mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of RHOA mRNA28628672
D007608Kainic AcidKainic Acid results in increased expression of RHOA mRNA19700661
D007612KanamycinKanamycin inhibits the reaction [DIAPH1 binds to RHOA]16521128
D007612KanamycinKanamycin results in decreased expression of RHOA protein16521128
D007612KanamycinKanamycin results in increased expression of RHOA protein16521128
C073601KT 5823"KT 5823 inhibits the reaction [[8-((4-chlorophenyl)thio)cyclic-3',5'-GMP co-treated with PRKG1 protein] results in increased activity of RHOA protein]"23195829
C065536lead titanate zirconate"exoenzyme C3, Clostridium botulinum inhibits the reaction [lead titanate zirconate results in increased expression of RHOA protein]"24203571
C065536lead titanate zirconatelead titanate zirconate results in increased expression of RHOA protein24203571
C108255levormeloxifenelevormeloxifene results in decreased expression of RHOA mRNA20970835
D008070Lipopolysaccharidesfarnesyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [Lipopolysaccharides results in decreased activity of RHOA protein]]18625914
D008070Lipopolysaccharidesgeranylgeranyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [Lipopolysaccharides results in decreased activity of RHOA protein]]18625914
D008070LipopolysaccharidesLipopolysaccharides results in decreased activity of RHOA protein18625914
D008070LipopolysaccharidesLipopolysaccharides results in increased activity of RHOA22226621
D008070LipopolysaccharidesRHOA mutant form inhibits the reaction [Lipopolysaccharides results in increased expression of ICAM1 protein]22226621
D008070LipopolysaccharidesRHOA mutant form inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK14 protein]22226621
D008070LipopolysaccharidesRHOA mutant form inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK1 protein]22226621
D008070LipopolysaccharidesRHOA mutant form inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK3 protein]22226621
D008070LipopolysaccharidesRHOA mutant form inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of RELA protein]22226621
D008070LipopolysaccharidesSimvastatin inhibits the reaction [Lipopolysaccharides results in decreased activity of RHOA protein]18625914
D008070LipopolysaccharidesTLR4 mutant form inhibits the reaction [Lipopolysaccharides results in increased activity of RHOA]22226621
D008070Lipopolysaccharides"5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one inhibits the reaction [Lipopolysaccharides results in decreased expression of and results in decreased activity of RHOA protein]"26694894
D008070LipopolysaccharidesLipopolysaccharides results in decreased expression of and results in decreased activity of RHOA protein26694894
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of RHOA19024099
D008070LipopolysaccharidesLipopolysaccharides results in increased phosphorylation of RHOA protein21247645
D008070Lipopolysaccharidesrosiglitazone inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of RHOA protein]21247645
D008070LipopolysaccharidesSimvastatin inhibits the reaction [Lipopolysaccharides results in increased expression of RHOA]19024099
C575077LM11A-31LM11A-31 inhibits the reaction [calpeptin results in increased activity of RHOA protein]25277379
C575077LM11A-31LM11A-31 inhibits the reaction [Cisplatin results in increased activity of RHOA protein]25277379
D008148Lovastatingeranylgeraniol inhibits the reaction [Lovastatin affects the localization of RHOA protein]12933658
D008148LovastatinLovastatin affects the localization of RHOA protein12933658
D008148LovastatinLovastatin results in decreased prenylation of RHOA protein16156861
D008148LovastatinMevalonic Acid inhibits the reaction [Lovastatin affects the localization of RHOA protein]12933658
D008148LovastatinLovastatin results in decreased expression of RHOA mRNA20493250
D008148LovastatinFarnesol inhibits the reaction [Lovastatin affects the localization of RHOA protein]9398081
D008148Lovastatingeranylgeraniol inhibits the reaction [Lovastatin affects the localization of RHOA protein]9398081
D008148LovastatinLovastatin affects the localization of RHOA protein20578043|9398081
D008148LovastatinLovastatin results in decreased prenylation of RHOA protein11178870
C032881lysophosphatidic acidlysophosphatidic acid results in increased activity of RHOA protein15081308
D008610MentholMenthol analog results in increased expression of RHOA protein12671036
D008610MentholMevalonic Acid affects the reaction [Menthol analog results in increased expression of RHOA protein]12671036
D008627Mercuric ChlorideMercuric Chloride affects the expression of RHOA protein21458406
D008627Mercuric ChlorideRHOA protein results in decreased susceptibility to Mercuric Chloride22223485
D008727MethotrexateMethotrexate results in increased expression of RHOA mRNA21678067
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of RHOA protein22223485
C004925methylmercuric chlorideRHOA protein results in decreased susceptibility to methylmercuric chloride22223485
D008767Methylmercury CompoundsMethylmercury Compounds results in decreased expression of RHOA protein23220560
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium affects the expression of RHOA mRNA12710931
D008798Mevalonic AcidMevalonic Acid affects the reaction [2-methyl-5-(1-methylethenyl)cyclohexanol results in increased expression of RHOA protein]12671036
D008798Mevalonic AcidMevalonic Acid affects the reaction [carvone results in increased expression of RHOA protein]12671036
D008798Mevalonic AcidMevalonic Acid affects the reaction [Menthol analog results in increased expression of RHOA protein]12671036
D008798Mevalonic AcidMevalonic Acid affects the reaction [myrtenol results in increased expression of RHOA protein]12671036
D008798Mevalonic AcidMevalonic Acid affects the reaction [perillaldehyde results in increased expression of RHOA protein]12671036
D008798Mevalonic AcidMevalonic Acid affects the reaction [perillic acid results in increased expression of RHOA protein]12671036
D008798Mevalonic AcidMevalonic Acid affects the reaction [perillyl alcohol results in increased expression of RHOA protein]12671036
D008798Mevalonic Acid"Mevalonic Acid inhibits the reaction [Asbestos, Crocidolite results in decreased activity of and results in decreased lipidation of RHOA protein]"17322126
D008798Mevalonic AcidMevalonic Acid inhibits the reaction [Atorvastatin Calcium results in decreased activity of RHOA protein]16470222
D008798Mevalonic AcidMevalonic Acid inhibits the reaction [Atorvastatin Calcium results in increased localization of RHOA protein]16470222
D008798Mevalonic AcidMevalonic Acid inhibits the reaction [Lovastatin affects the localization of RHOA protein]12933658
D008798Mevalonic AcidMevalonic Acid inhibits the reaction [mevastatin results in decreased lipidation of RHOA protein]17322126
D008798Mevalonic AcidMevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [TNF results in increased activity of RHOA protein]]17075836
D008798Mevalonic AcidMevalonic Acid inhibits the reaction [Simvastatin results in decreased activity of RHOA protein]16470222
D008798Mevalonic AcidMevalonic Acid inhibits the reaction [Simvastatin results in increased localization of RHOA protein]16005304|1647022
D008798Mevalonic AcidMevalonic Acid inhibits the reaction [Simvastatin results in decreased expression of RHOA protein]16698853
C012258mevastatinMevalonic Acid inhibits the reaction [mevastatin results in decreased lipidation of RHOA protein]17322126
C012258mevastatinmevastatin results in decreased lipidation of RHOA protein17322126
C406082monomethylarsonous acidmonomethylarsonous acid affects the expression of RHOA mRNA20886546
C406082monomethylarsonous acidmonomethylarsonous acid promotes the reaction [Phenylephrine results in increased activity of RHOA protein]21708234
C534317myrtenolMevalonic Acid affects the reaction [myrtenol results in increased expression of RHOA protein]12671036
C534317myrtenolmyrtenol results in increased expression of RHOA protein12671036
C119536nickel acetatenickel acetate affects the expression of RHOA mRNA12915101
D009569Nitric OxideNitric Oxide deficiency affects the localization of and results in increased activity of RHOA protein14732730
C007350nitrofennitrofen results in increased expression of RHOA mRNA25783350
C007350nitrofennitrofen results in increased expression of RHOA protein25783350
D009585Nitrogen DioxideNitrogen Dioxide results in increased oxidation of RHOA protein17128987
C472349oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholineoxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine affects the expression of RHOA mRNA17655762
C472349oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholineoxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine promotes the reaction [Particulate Matter affects the expression of RHOA mRNA]17655762
C472349oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholineoxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine promotes the reaction [Vehicle Emissions affects the expression of RHOA mRNA]17655762
C472349oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholineParticulate Matter promotes the reaction [oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine affects the expression of RHOA mRNA]17655762
C472349oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholineVehicle Emissions promotes the reaction [oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine affects the expression of RHOA mRNA]17655762
C029341oxophenylarsineoxophenylarsine results in decreased activity of RHOA protein17128987
D010100Oxygen"1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt inhibits the reaction [Oxygen results in increased activity of RHOA protein]"21439370
D010100OxygenOxygen results in increased activity of RHOA protein21439370
D010100OxygenRHOA protein affects the reaction [Oxygen results in increased expression of ACTA2 mRNA]23517783
D010100OxygenRHOA protein affects the reaction [Oxygen results in increased expression of ACTA2 protein]23517783
D010100OxygenRHOA protein affects the reaction [Oxygen results in increased expression of COL1A1 mRNA]23517783
D010100OxygenRHOA protein affects the reaction [Oxygen results in increased expression of COL1A2 mRNA]23517783
D010100Oxygen"1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt inhibits the reaction [Oxygen results in increased activity of RHOA protein]"21439370
D010100OxygenOxygen results in increased activity of RHOA protein21439370
C570200P61-E7 compoundRHOA protein affects the reaction [P61-E7 compound affects the localization of VCL protein]22028818
C570200P61-E7 compoundRHOA protein affects the reaction [P61-E7 compound results in increased expression of CDKN1A protein]22028818
C570200P61-E7 compoundRHOA protein affects the reaction [P61-E7 compound results in increased expression of CDKN1B protein]22028818
C570200P61-E7 compoundP61-E7 compound results in decreased activity of and affects the localization of RHOA protein22028818
C019248pamidronatepamidronate results in decreased expression of RHOA protein modified form16298452
D010278ParathionAtropine inhibits the reaction [Parathion results in increased expression of RHOA protein]17390078
D010278Parathion[Parathion co-treated with Estradiol] results in increased expression of RHOA protein17622325
D010278ParathionParathion results in increased expression of RHOA protein17390078|1762232
D052638Particulate Matteroxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine promotes the reaction [Particulate Matter affects the expression of RHOA mRNA]17655762
D052638Particulate MatterParticulate Matter affects the expression of RHOA mRNA17655762
D052638Particulate MatterParticulate Matter promotes the reaction [oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine affects the expression of RHOA mRNA]17655762
D052638Particulate MatterParticulate Matter results in increased expression of and results in increased activity of RHOA protein18599801
C008776pelargonic acidpelargonic acid results in increased expression of RHOA mRNA11379042
D010416PentachlorophenolPentachlorophenol results in decreased expression of RHOA mRNA23892564
C033342perillaldehydeMevalonic Acid affects the reaction [perillaldehyde results in increased expression of RHOA protein]12671036
C033342perillaldehydeperillaldehyde results in increased expression of RHOA protein12671036
C078706perillic acidMevalonic Acid affects the reaction [perillic acid results in increased expression of RHOA protein]12671036
C078706perillic acidperillic acid results in increased expression of RHOA protein12671036
C032208perillyl alcoholMevalonic Acid affects the reaction [perillyl alcohol results in increased expression of RHOA protein]12671036
C032208perillyl alcoholperillyl alcohol results in increased expression of RHOA protein12671036
C032208perillyl alcohol[perillyl alcohol co-treated with Vitamin A] results in increased expression of RHOA mRNA15959631
D010578PetroleumPetroleum results in decreased expression of RHOA mRNA25208076
D010656Phenylephrinegeranylgeraniol inhibits the reaction [Simvastatin inhibits the reaction [Phenylephrine results in increased activity of RHOA protein]]24449418
D010656Phenylephrinemonomethylarsonous acid promotes the reaction [Phenylephrine results in increased activity of RHOA protein]21708234
D010656PhenylephrinePhenylephrine promotes the reaction [RHOA protein results in increased phosphorylation of PPP1R12A protein]24449418
D010656PhenylephrinePhenylephrine promotes the reaction [RHOA protein results in increased phosphorylation of PPP1R14A protein]24449418
D010656PhenylephrinePhenylephrine results in increased activity of RHOA protein15081308|2170823
D010656Phenylephrinepolydatin inhibits the reaction [Phenylephrine results in increased activity of RHOA protein]25449040
D010656PhenylephrineRHOA protein affects the reaction [Phenylephrine results in increased expression of NPPA mRNA]10843871
D010656PhenylephrineSimvastatin inhibits the reaction [Phenylephrine promotes the reaction [RHOA protein results in increased phosphorylation of PPP1R12A protein]]24449418
D010656PhenylephrineSimvastatin inhibits the reaction [Phenylephrine promotes the reaction [RHOA protein results in increased phosphorylation of PPP1R14A protein]]24449418
D010656PhenylephrineSimvastatin inhibits the reaction [Phenylephrine results in increased activity of RHOA protein]24449418
D010672PhenytoinPhenytoin results in decreased expression of RHOA mRNA15136057
D015240Phorbol 12,13-Dibutyrate"Phorbol 12,13-Dibutyrate results in increased expression of RHOA protein modified form"18986333
D015240Phorbol 12,13-Dibutyrate"Ro 31-8220 inhibits the reaction [Phorbol 12,13-Dibutyrate results in increased expression of RHOA protein modified form]"18986333
D010795Phthalic AcidsPhthalic Acids results in increased expression of RHOA mRNA21061450
C006253pirinixic acidpirinixic acid results in increased expression of RHOA mRNA19162173
D010936Plant ExtractsPlant Extracts results in decreased expression of RHOA protein23955962
D028321Plant PreparationsPlant Preparations results in increased expression of RHOA mRNA24973489
C058229polydatinpolydatin inhibits the reaction [Phenylephrine results in increased activity of RHOA protein]25449040
D011239Prednisolone"Prednisolone inhibits the reaction [[Antigens, Bacterial co-treated with Allergens] results in increased expression of and results in increased activity of RHOA protein]"18391481
D011239Prednisolone"Prednisolone inhibits the reaction [[[Antigens, Bacterial co-treated with Allergens] results in increased expression of and results in increased activity of RHOA protein] which results in increased susceptibility to Acetylcholine]"18391481
D011239Prednisolone"Prednisolone inhibits the reaction [[Antigens, Bacterial co-treated with Allergens] results in increased expression of RHOA mRNA]"18391481
D011374Progesterone[Estradiol co-treated with Progesterone] results in increased expression of RHOA mRNA19687787
D011374Progesterone[Progesterone co-treated with Estradiol] results in increased expression of RHOA protein22342969
D011374ProgesteroneProgesterone results in increased expression of RHOA protein22342969
D011374ProgesteroneProgesterone results in increased expression of RHOA mRNA17170212
D011692Puromycin Aminonucleosidefluvastatin inhibits the reaction [Puromycin Aminonucleoside results in increased expression of RHOA protein]16452496
D011692Puromycin AminonucleosidePuromycin Aminonucleoside results in increased expression of RHOA protein16452496
D011692Puromycin Aminonucleosidefluvastatin inhibits the reaction [Puromycin Aminonucleoside results in increased expression of RHOA protein]16452496
D011692Puromycin AminonucleosidePuromycin Aminonucleoside results in increased expression of RHOA protein16452496
D011794QuercetinQuercetin results in increased expression of RHOA protein23645742
D019257Quinpirole[Quinpirole co-treated with DRD2 protein alternative form] results in increased activity of RHOA protein27717053
D020849Raloxifene HydrochlorideRaloxifene Hydrochloride results in decreased expression of RHOA mRNA20970835
C059514resveratrolresveratrol inhibits the reaction [AGT protein results in increased activity of RHOA protein]24965170
C059514resveratrol"(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine inhibits the reaction [resveratrol inhibits the reaction [AGT protein results in increased activity of RHOA protein]]"24965170
C059514resveratrolresveratrol inhibits the reaction [AGT protein results in increased activity of RHOA protein]24965170
C059514resveratrolresveratrol results in increased expression of RHOA protein25505154
D015474IsotretinoinIsotretinoin results in decreased expression of RHOA mRNA15982314
D000068296Risedronate SodiumRisedronate Sodium results in increased abundance of [Guanosine Triphosphate binds to RHOA protein]16734383
D000068296Risedronate SodiumRisedronate Sodium results in increased abundance of [Guanosine Triphosphate binds to RHOA protein]16734383
D000068296Risedronate SodiumRisedronate Sodium results in increased abundance of [Guanosine Triphosphate binds to RHOA protein]16734383
D000068296Risedronate SodiumRisedronate Sodium results in increased localization of RHOA protein19505369
C064758Ro 31-8220"Ro 31-8220 inhibits the reaction [Phorbol 12,13-Dibutyrate results in increased expression of RHOA protein modified form]"18986333
C089730rosiglitazonerosiglitazone inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of RHOA protein]21247645
D012402RotenoneRHOA protein results in decreased susceptibility to Rotenone22223485
C009250sevofluranesevoflurane inhibits the reaction [Guanosine 5'-O-(3-Thiotriphosphate) affects the localization of RHOA protein]12960549
D019821SimvastatinSimvastatin inhibits the reaction [RHOA results in increased expression of EDN1 mRNA]11009568
D019821SimvastatinSimvastatin results in decreased activity of RHOA protein21289285
D019821Simvastatin[Simvastatin results in decreased activity of RHOA protein] inhibits the reaction [AGT protein modified form results in increased expression of ARG1 protein]21289285
D019821Simvastatinfarnesyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [Lipopolysaccharides results in decreased activity of RHOA protein]]18625914
D019821Simvastatingeranylgeranyl pyrophosphate inhibits the reaction [Simvastatin affects the localization of and results in decreased activity of RHOA protein]18031796
D019821Simvastatingeranylgeranyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [Lipopolysaccharides results in decreased activity of RHOA protein]]18625914
D019821Simvastatingeranylgeranyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [TNF results in increased activity of RHOA protein]]17075836
D019821Simvastatingeranylgeranyl pyrophosphate inhibits the reaction [Simvastatin results in decreased activity of RHOA protein]16470222
D019821Simvastatingeranylgeranyl pyrophosphate inhibits the reaction [Simvastatin results in increased localization of RHOA protein]16005304|1647022
D019821SimvastatinMevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [TNF results in increased activity of RHOA protein]]17075836
D019821SimvastatinMevalonic Acid inhibits the reaction [Simvastatin results in decreased activity of RHOA protein]16470222
D019821SimvastatinMevalonic Acid inhibits the reaction [Simvastatin results in increased localization of RHOA protein]16005304|1647022
D019821SimvastatinRHOA inhibits the reaction [Simvastatin results in increased expression of SCARB1]18981156
D019821SimvastatinRHOA protein affects the reaction [Simvastatin results in increased localization of and results in increased activity of NFKB1 protein]18463201
D019821SimvastatinRHOA protein affects the reaction [Simvastatin results in increased localization of and results in increased activity of RELA protein]18463201
D019821SimvastatinSimvastatin affects the localization of and results in decreased activity of RHOA protein18031796
D019821SimvastatinSimvastatin affects the localization of RHOA protein16740276|1862520
D019821SimvastatinSimvastatin inhibits the reaction [geranylgeranyl pyrophosphate affects the localization of RHOA protein]18625202
D019821SimvastatinSimvastatin inhibits the reaction [Lipopolysaccharides results in decreased activity of RHOA protein]18625914
D019821SimvastatinSimvastatin inhibits the reaction [TNF results in increased activity of RHOA protein]17075836
D019821SimvastatinSimvastatin results in decreased localization of and results in decreased activity of RHOA protein17560598
D019821SimvastatinSimvastatin results in decreased prenylation of RHOA protein16005304|2125792
D019821SimvastatinSimvastatin results in increased expression of RHOA mRNA14630613
D019821SimvastatinSimvastatin results in increased localization of and results in decreased prenylation of RHOA protein16470222
D019821SimvastatinSimvastatin results in increased localization of RHOA protein16005304
D019821Simvastatinfarnesyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [TNF affects the localization of RHOA protein]]18310456
D019821Simvastatingeranylgeranyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [TNF affects the localization of RHOA protein]]18310456
D019821SimvastatinSimvastatin inhibits the reaction [TNF affects the localization of RHOA protein]18310456
D019821Simvastatingeranylgeraniol inhibits the reaction [Simvastatin inhibits the reaction [Phenylephrine results in increased activity of RHOA protein]]24449418
D019821SimvastatinMevalonic Acid inhibits the reaction [Simvastatin results in decreased expression of RHOA protein]16698853
D019821SimvastatinSimvastatin inhibits the reaction [Lipopolysaccharides results in increased expression of RHOA]19024099
D019821SimvastatinSimvastatin inhibits the reaction [Phenylephrine promotes the reaction [RHOA protein results in increased phosphorylation of PPP1R12A protein]]24449418
D019821SimvastatinSimvastatin inhibits the reaction [Phenylephrine promotes the reaction [RHOA protein results in increased phosphorylation of PPP1R14A protein]]24449418
D019821SimvastatinSimvastatin inhibits the reaction [Phenylephrine results in increased activity of RHOA protein]24449418
D019821SimvastatinSimvastatin results in decreased activity of RHOA protein21124329
D019821SimvastatinSimvastatin results in decreased expression of RHOA19659652
D019821SimvastatinSimvastatin results in decreased expression of RHOA protein16698853
D019821SimvastatinSimvastatin results in decreased geranoylation of and results in decreased prenylation of RHOA protein15200425
D019821SimvastatinSimvastatin results in increased expression of RHOA protein15200425
D019821SimvastatinSimvastatin results in decreased prenylation of RHOA protein18660453
C009277sodium arsenatesodium arsenate results in decreased expression of RHOA mRNA21795629
C009277sodium arsenatesodium arsenate results in increased expression of RHOA mRNA21795629
D012999SomanSoman results in increased expression of RHOA mRNA19281266
C075117squalestatin 1squalestatin 1 results in increased activity of RHOA protein20578043
D013311StreptozocinAtorvastatin Calcium inhibits the reaction [Streptozocin results in increased activity of RHOA protein]17589825
D013311StreptozocinStreptozocin results in increased activity of RHOA protein17589825|2337600
C452601sulindac derivative IND 12sulindac derivative IND 12 results in decreased activity of RHOA protein11912145
C025462sulindac sulfideRHOA protein promotes the reaction [sulindac sulfide results in increased expression of THBS1 protein]18261746
C025462sulindac sulfide[sulindac sulfide results in increased activity of RHOA protein] which results in increased expression of THBS1 protein18261746
C001803tempol"tempol inhibits the reaction [Asbestos, Crocidolite inhibits the reaction [RHOA protein binds to Guanosine Triphosphate]]"21257924
C001803tempol"tempol inhibits the reaction [Asbestos, Crocidolite results in decreased prenylation of RHOA protein]"21257924
C001803tempoltempol inhibits the reaction [Vitamin K 3 inhibits the reaction [RHOA protein binds to Guanosine Triphosphate]]21257924
C001803tempoltempol inhibits the reaction [Vitamin K 3 results in decreased prenylation of RHOA protein]21257924
C001803tempoltempol inhibits the reaction [Brimonidine Tartrate promotes the reaction [AGT protein results in increased expression of RHOA protein]]18250367
C041359terbinafineterbinafine results in increased localization of RHOA protein17172416
D013739TestosteroneTestosterone inhibits the reaction [Dietary Fats results in increased expression of RHOA mRNA]22010203
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of RHOA mRNA21570461
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of RHOA mRNA17942748
D013792ThalidomideThalidomide affects the expression of RHOA mRNA26006729
C009495titanium dioxidetitanium dioxide results in decreased expression of RHOA mRNA23557971
D014051Toluene 2,4-Diisocyanate"Toluene 2,4-Diisocyanate results in decreased expression of RHOA mRNA"11379042
D014212TretinoinTretinoin metabolite results in decreased expression of RHOA mRNA15982314
C012589trichostatin Atrichostatin A results in decreased expression of RHOA protein12445420
C001899triptolidetriptolide results in decreased expression of RHOA protein26420756
C001899triptolidetriptolide results in decreased expression of RHOA mRNA27554044
C001899triptolidetriptolide results in decreased expression of RHOA protein27554044
C113580U 0126U 0126 results in decreased expression of and results in decreased activity of RHOA protein26828592
C113580U 0126U 0126 inhibits the reaction [bisphenol A results in decreased expression of RHOA protein]24231043
C113580U 0126U 0126 inhibits the reaction [Estradiol results in decreased expression of RHOA protein]24231043
D014501UraniumUranium affects the expression of RHOA mRNA15672453
C005460uranyl acetateuranyl acetate affects the expression of RHOA mRNA15672453
D014580Ursodeoxycholic AcidDLC1 mutant form inhibits the reaction [Ursodeoxycholic Acid results in decreased activity of RHOA protein]21455586
D014580Ursodeoxycholic AcidUrsodeoxycholic Acid results in decreased activity of RHOA protein21455586
D014635Valproic AcidValproic Acid results in decreased methylation of RHOA gene29154799
D014635Valproic AcidValproic Acid results in decreased expression of RHOA mRNA23665938
D001335Vehicle Emissionsoxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine promotes the reaction [Vehicle Emissions affects the expression of RHOA mRNA]17655762
D001335Vehicle EmissionsVehicle Emissions affects the expression of RHOA mRNA17655762
D001335Vehicle EmissionsVehicle Emissions promotes the reaction [oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine affects the expression of RHOA mRNA]17655762
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of RHOA gene25560391
D014801Vitamin A[perillyl alcohol co-treated with Vitamin A] results in increased expression of RHOA mRNA15959631
D014801Vitamin AVitamin A results in increased expression of RHOA mRNA15959631
D024483Vitamin K 3tempol inhibits the reaction [Vitamin K 3 inhibits the reaction [RHOA protein binds to Guanosine Triphosphate]]21257924
D024483Vitamin K 3tempol inhibits the reaction [Vitamin K 3 results in decreased prenylation of RHOA protein]21257924
D024483Vitamin K 3Vitamin K 3 inhibits the reaction [RHOA protein binds to Guanosine Triphosphate]21257924
D024483Vitamin K 3Vitamin K 3 results in decreased prenylation of RHOA protein21257924
C111237vorinostatvorinostat results in increased expression of RHOA protein17593366
D014859WarfarinWarfarin results in decreased expression of RHOA mRNA20493250
D014874Water Pollutants, Chemical"Water Pollutants, Chemical results in decreased expression of RHOA mRNA"25208076
C108830Y 27632Y 27632 results in decreased expression of RHOA protein19896475
C108830Y 27632[Y 27632 results in decreased expression of RHOA protein] which results in decreased expression of MMP2 protein19896475
C108830Y 27632[Y 27632 results in decreased expression of RHOA protein] which results in decreased expression of MMP9 protein19896475
C088658zoledronic acidgeranylgeraniol inhibits the reaction [zoledronic acid results in decreased expression of and affects the localization of RHOA protein]15324309
C088658zoledronic acidzoledronic acid inhibits the reaction [RHOA protein results in decreased expression of IBSP mRNA]15324309
C088658zoledronic acidzoledronic acid results in decreased expression of and affects the localization of RHOA protein15324309
C088658zoledronic acidzoledronic acid results in decreased geranoylation of RHOA protein15324309
C088658zoledronic acid[zoledronic acid results in decreased geranoylation of RHOA protein] which results in increased expression of IBSP mRNA15324309
C088658zoledronic acidzoledronic acid results in increased expression of and affects the localization of RHOA protein28871336
C088658zoledronic acidzoledronic acid results in increased expression of [RHOA protein binds to Guanosine Triphosphate]28871336
C088658zoledronic acidzoledronic acid results in increased abundance of [Guanosine Triphosphate binds to RHOA protein]16734383

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003924GTPase activity-EXP18829532  
GO:0003924GTPase activity-IBA21873635  
GO:0003924GTPase activity-IDA19734146  19787194  26529257  
GO:0003924GTPase activity-TAS10436159  
GO:0005515protein binding-IPI9214622  10051605  10066731  10489445  11067852  11335720  
11889037  11927263  12006984  12879077  14660612  15364580  
15530360  15644318  15670823  16189514  17115030  17353931  
18218625  18256687  19470470  19887681  19944695  20195357  
20300064  20348415  20711218  20974804  21029865  21281639  
21708152  21988832  22404908  22621765  22705156  22740689  
23241886  25150978  25186459  25241761  25416956  25588844  
26529257  27807006  
GO:0005525GTP binding-IBA21873635  
GO:0005525GTP binding-IDA12777804  15601624  
GO:0017022myosin binding-IPI15644318  
GO:0019003GDP binding-IEA-  
GO:0019901protein kinase binding-IBA21873635  
GO:0019904protein domain specific binding-IEA-  
GO:0051022Rho GDP-dissociation inhibitor binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0001666response to hypoxia-IEA-  
GO:0001998angiotensin-mediated vasoconstriction involved in regulation of systemic arterial blood pressure-IEA-  
GO:0002363alpha-beta T cell lineage commitment-IEA-  
GO:0003100regulation of systemic arterial blood pressure by endothelin-IEA-  
GO:0006357regulation of transcription by RNA polymerase II-IEA-  
GO:0007015actin filament organization-IBA21873635  
GO:0007160cell-matrix adhesion-IEA-  
GO:0007163establishment or maintenance of cell polarity-IBA21873635  
GO:0007179transforming growth factor beta receptor signaling pathway-TAS-  
GO:0007186G-protein coupled receptor signaling pathway-TAS-  
GO:0007266Rho protein signal transduction-IBA21873635  
GO:0007266Rho protein signal transduction-IDA26529257  
GO:0007266Rho protein signal transduction-IMP23241886  
GO:0007266Rho protein signal transduction-TAS10436159  
GO:0007519skeletal muscle tissue development-IEA-  
GO:0008360regulation of cell shape-IBA21873635  
GO:0009612response to mechanical stimulus-IEA-  
GO:0009749response to glucose-IEA-  
GO:0010812negative regulation of cell-substrate adhesion-ISS-  
GO:0016032viral process-IEA-  
GO:0016477cell migration-IBA21873635  
GO:0016477cell migration-IDA26529257  
GO:0016477cell migration-IMP19782033  
GO:0016579protein deubiquitination-TAS-  
GO:0021762substantia nigra development-HEP22926577  
GO:0021795cerebral cortex cell migration-IEA-  
GO:0021861forebrain radial glial cell differentiation-IEA-  
GO:0030036actin cytoskeleton organization-TAS10436159  
GO:0030307positive regulation of cell growth-IEA-  
GO:0030334regulation of cell migration-IBA21873635  
GO:0030334regulation of cell migration-IMP19934221  
GO:0030521androgen receptor signaling pathway-IEA-  
GO:0030838positive regulation of actin filament polymerization-IEA-  
GO:0030950establishment or maintenance of actin cytoskeleton polarity-IBA21873635  
GO:0031098stress-activated protein kinase signaling cascade-IEA-  
GO:0031532actin cytoskeleton reorganization-IMP19782033  
GO:0032467positive regulation of cytokinesis-IMP16103226  17115030  
GO:0032956regulation of actin cytoskeleton organization-IBA21873635  
GO:0032956regulation of actin cytoskeleton organization-IDA25911094  
GO:0033144negative regulation of intracellular steroid hormone receptor signaling pathway-IEA-  
GO:0033688regulation of osteoblast proliferation-ISS-  
GO:0034329cell junction assembly-IMP22891260  
GO:0035385Roundabout signaling pathway-IDA26529257  
GO:0036089cleavage furrow formation-IDA16103226  
GO:0038027apolipoprotein A-I-mediated signaling pathway-IMP23726972  
GO:0042476odontogenesis-IEA-  
GO:0043123positive regulation of I-kappaB kinase/NF-kappaB signaling-IEP12761501  
GO:0043124negative regulation of I-kappaB kinase/NF-kappaB signaling-IEA-  
GO:0043149stress fiber assembly-IBA21873635  
GO:0043149stress fiber assembly-IMP19782033  
GO:0043200response to amino acid-IEA-  
GO:0043280positive regulation of cysteine-type endopeptidase activity involved in apoptotic process-IEA-  
GO:0043297apical junction assembly-IMP20974804  
GO:0043312neutrophil degranulation-TAS-  
GO:0043366beta selection-IEA-  
GO:0043524negative regulation of neuron apoptotic process-IEA-  
GO:0043525positive regulation of neuron apoptotic process-IEA-  
GO:0043542endothelial cell migration-IGI20208559  
GO:0043931ossification involved in bone maturation-ISS-  
GO:0044319wound healing, spreading of cells-ISS-  
GO:0045198establishment of epithelial cell apical/basal polarity-IMP22891260  
GO:0045471response to ethanol-IEA-  
GO:0045666positive regulation of neuron differentiation-IMP17488780  
GO:0045727positive regulation of translation-IEA-  
GO:0045792negative regulation of cell size-IMP8625410  
GO:0046039GTP metabolic process-IEA-  
GO:0046638positive regulation of alpha-beta T cell differentiation-IEA-  
GO:0048010vascular endothelial growth factor receptor signaling pathway-TAS-  
GO:0048013ephrin receptor signaling pathway-TAS-  
GO:0048015phosphatidylinositol-mediated signaling-TAS-  
GO:0048812neuron projection morphogenesis-IEA-  
GO:0050771negative regulation of axonogenesis-TAS-  
GO:0050772positive regulation of axonogenesis-TAS-  
GO:0050773regulation of dendrite development-IEA-  
GO:0050919negative chemotaxis-IMP23726972  
GO:0051017actin filament bundle assembly-IBA21873635  
GO:0051056regulation of small GTPase mediated signal transduction-TAS-  
GO:0051384response to glucocorticoid-IEA-  
GO:0051496positive regulation of stress fiber assembly-IDA15467718  
GO:0051496positive regulation of stress fiber assembly-IMP8625410  
GO:0051893regulation of focal adhesion assembly-TAS18981818  
GO:0051924regulation of calcium ion transport-IEA-  
GO:0060071Wnt signaling pathway, planar cell polarity pathway-NAS24431302  
GO:0060071Wnt signaling pathway, planar cell polarity pathway-TAS-  
GO:0060193positive regulation of lipase activity-IDA19887681  
GO:0060193positive regulation of lipase activity-IMP22740689  
GO:0061383trabecula morphogenesis-ISS-  
GO:0070507regulation of microtubule cytoskeleton organization-IEA-  
GO:0071222cellular response to lipopolysaccharide-IDA19734146  
GO:0071277cellular response to calcium ion-HEP21237226  
GO:0071803positive regulation of podosome assembly-IEA-  
GO:0071902positive regulation of protein serine/threonine kinase activity-IDA8617235  
GO:0090051negative regulation of cell migration involved in sprouting angiogenesis-IGI20208559  
GO:0090307mitotic spindle assembly-IMP19635168  
GO:0090324negative regulation of oxidative phosphorylation-IEA-  
GO:0097498endothelial tube lumen extension-IGI20208559  
GO:1901224positive regulation of NIK/NF-kappaB signaling-NAS12761501  
GO:1902766skeletal muscle satellite cell migration-ISS-  
GO:1903427negative regulation of reactive oxygen species biosynthetic process-IEA-  
GO:1903673mitotic cleavage furrow formation-IMP16103226  
GO:1904695positive regulation of vascular smooth muscle contraction-IEA-  
GO:1905244regulation of modification of synaptic structure-IEA-  
GO:1990869cellular response to chemokine-IMP23241886  
GO:2000145regulation of cell motility-TAS-  
GO:2000177regulation of neural precursor cell proliferation-IEA-  
GO:2000406positive regulation of T cell migration-IMP23241886  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IEA-  
GO:0005737cytoplasm-IBA21873635  
GO:0005768endosome-IMP19887681  
GO:0005789endoplasmic reticulum membrane-TAS-  
GO:0005829cytosol-IDA1328215  
GO:0005829cytosol-TAS-  
GO:0005856cytoskeleton-IEA-  
GO:0005886plasma membraneCOLOCALIZES_WITHIBA21873635  
GO:0005886plasma membrane-TAS-  
GO:0005925focal adhesion-HDA21423176  
GO:0005938cell cortex-IBA21873635  
GO:0005938cell cortex-IDA16103226  
GO:0030027lamellipodium-ISS-  
GO:0030054cell junction-TAS-  
GO:0030424axon-IEA-  
GO:0030496midbody-IEA-  
GO:0030667secretory granule membrane-TAS-  
GO:0031234extrinsic component of cytoplasmic side of plasma membrane-IDA1328215  
GO:0031410cytoplasmic vesicle-IBA21873635  
GO:0031982vesicle-IDA19887681  
GO:0032153cell division site-IBA21873635  
GO:0032154cleavage furrowCOLOCALIZES_WITHIBA21873635  
GO:0032154cleavage furrowcolocalizes_withIDA16103226  
GO:0032587ruffle membrane-IEA-  
GO:0043005neuron projection-IBA21873635  
GO:0043197dendritic spine-IBA21873635  
GO:0043197dendritic spine-IDA24352656  
GO:0043231intracellular membrane-bounded organelle-IBA21873635  
GO:0043296apical junction complex-IDA20974804  
GO:0070062extracellular exosome-HDA19056867  20458337  
GO:0071944cell periphery-IMP25911094  
GO:0101003ficolin-1-rich granule membrane-TAS-  
KEGG ID KEGG Term
hsa04062Chemokine signaling pathway
hsa04144Endocytosis
hsa04270Vascular smooth muscle contraction
hsa04310Wnt signaling pathway
hsa04350TGF-beta signaling pathway
hsa04360Axon guidance
hsa04510Focal adhesion
hsa04520Adherens junction
hsa04530Tight junction
hsa04660T cell receptor signaling pathway
hsa04670Leukocyte transendothelial migration
hsa04722Neurotrophin signaling pathway
hsa04810Regulation of actin cytoskeleton
hsa04972Pancreatic secretion
hsa05100Bacterial invasion of epithelial cells
hsa05130Pathogenic Escherichia coli infection
hsa05200Pathways in cancer
hsa05210Colorectal cancer
Reactome ID Reactome Term Evidence
R-HSA-109582HemostasisTAS
R-HSA-114604GPVI-mediated activation cascadeTAS
R-HSA-1227986Signaling by ERBB2TAS
R-HSA-1266738Developmental BiologyTAS
R-HSA-1266738Developmental BiologyIEA
R-HSA-162582Signal TransductionTAS
R-HSA-162582Signal TransductionIEA
R-HSA-166520Signaling by NTRKsTAS
R-HSA-168249Innate Immune SystemTAS
R-HSA-168256Immune SystemTAS
R-HSA-170834Signaling by TGF-beta Receptor ComplexIEA
R-HSA-170834Signaling by TGF-beta Receptor ComplexTAS
R-HSA-187037Signaling by NTRK1 (TRKA)TAS
R-HSA-193634Axonal growth inhibition (RHOA activation)TAS
R-HSA-193697p75NTR regulates axonogenesisTAS
R-HSA-193704p75 NTR receptor-mediated signallingTAS
R-HSA-194138Signaling by VEGFTAS
R-HSA-194315Signaling by Rho GTPasesTAS
R-HSA-194315Signaling by Rho GTPasesIEA
R-HSA-194840Rho GTPase cycleTAS
R-HSA-195258RHO GTPase EffectorsTAS
R-HSA-195258RHO GTPase EffectorsIEA
R-HSA-195721Signaling by WNTTAS
R-HSA-198203PI3K/AKT activationTAS
R-HSA-209563Axonal growth stimulationTAS
R-HSA-2173791TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)IEA
R-HSA-2173791TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)TAS
R-HSA-2682334EPH-Ephrin signalingTAS
R-HSA-2682334EPH-Ephrin signalingIEA
R-HSA-372790Signaling by GPCRTAS
R-HSA-373755Semaphorin interactionsTAS
R-HSA-373755Semaphorin interactionsIEA
R-HSA-376176Signaling by ROBO receptorsTAS
R-HSA-3858494Beta-catenin independent WNT signalingTAS
R-HSA-388396GPCR downstream signallingTAS
R-HSA-392451G beta:gamma signalling through PI3KgammaTAS
R-HSA-392499Metabolism of proteinsTAS
R-HSA-3928662EPHB-mediated forward signalingTAS
R-HSA-3928662EPHB-mediated forward signalingIEA
R-HSA-3928663EPHA-mediated growth cone collapseIEA
R-HSA-3928663EPHA-mediated growth cone collapseTAS
R-HSA-397795G-protein beta:gamma signallingTAS
R-HSA-400685Sema4D in semaphorin signalingTAS
R-HSA-400685Sema4D in semaphorin signalingIEA
R-HSA-4086400PCP/CE pathwayTAS
R-HSA-416482G alpha (12/13) signalling eventsTAS
R-HSA-416550Sema4D mediated inhibition of cell attachment and migrationTAS
R-HSA-416572Sema4D induced cell migration and growth-cone collapseTAS
R-HSA-416572Sema4D induced cell migration and growth-cone collapseIEA
R-HSA-422475Axon guidanceTAS
R-HSA-422475Axon guidanceIEA
R-HSA-4420097VEGFA-VEGFR2 PathwayTAS
R-HSA-5625740RHO GTPases activate PKNsTAS
R-HSA-5625900RHO GTPases activate CITTAS
R-HSA-5625900RHO GTPases activate CITIEA
R-HSA-5625970RHO GTPases activate KTN1TAS
R-HSA-5627117RHO GTPases Activate ROCKsTAS
R-HSA-5627117RHO GTPases Activate ROCKsIEA
R-HSA-5663220RHO GTPases Activate ForminsTAS
R-HSA-5666185RHO GTPases Activate Rhotekin and RhophilinsTAS
R-HSA-5666185RHO GTPases Activate Rhotekin and RhophilinsIEA
R-HSA-5688426DeubiquitinationTAS
R-HSA-5689896Ovarian tumor domain proteasesTAS
R-HSA-597592Post-translational protein modificationTAS
R-HSA-6785631ERBB2 Regulates Cell MotilityTAS
R-HSA-6798695Neutrophil degranulationTAS
R-HSA-73887Death Receptor SignallingTAS
R-HSA-76002Platelet activation, signaling and aggregationTAS
R-HSA-8848021Signaling by PTK6TAS
R-HSA-8849471PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinasesTAS
R-HSA-8985586SLIT2:ROBO1 increases RHOA activityTAS
R-HSA-9006927Signaling by Non-Receptor Tyrosine KinasesTAS
R-HSA-9006934Signaling by Receptor Tyrosine KinasesTAS
R-HSA-9006936Signaling by TGF-beta family membersIEA
R-HSA-9006936Signaling by TGF-beta family membersTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
22688403Differential transcriptomic analysis of spontaneous lung tumors in B6C3F1 mice: comparison to human non-small cell lung cancer. (2012 Dec)Pandiri ARToxicol Pathol
29066090Genetic variants associated with susceptibility to idiopathic pulmonary fibrosis in people of European ancestry: a genome-wide association study. (2017 Nov)Allen RJLancet Respir Med
12853766Erectile physiological and pathophysiological pathways involved in erectile dysfunction. (2003 Aug)Andersson KEJ Urol
18522770Coronary artery spasm--clinical features, diagnosis, pathogenesis, and treatment. (2008 Feb)Yasue HJ Cardiol
17284169RhoA, encoding a Rho GTPase, is associated with smoking initiation. (2007 Nov)Chen XGenes Brain Behav
20049135Recent insights into the mechanisms of vasospastic angina. (2009 Dec)Yoo SYKorean Circ J
28728277[Effects of PI3Kdelta-RhoA pathway on phagocytosis defect of alveolar macrophages in a mouse model of chronic obstructive pulmonary disease]. (2017 Jul 12)Hu STZhonghua Jie He He Hu Xi Za Zhi
21757850Different effects of smoke from heavy and light cigarettes on the induction of bronchial smooth muscle hyperresponsiveness in rats. (2011)Sakai HJ Smooth Muscle Res
29326688Cigarette Smoke Increases Endothelial CXCL16-Leukocyte CXCR6 Adhesion In Vitro and In Vivo. Potential Consequences in Chronic Obstructive Pulmonary Disease. (2017)Marques PFront Immunol
19659652Simvastatin attenuates experimental small airway remodelling in rats. (2009 Jul)Ou XMRespirology
25047806Augmented bronchial smooth muscle contractility induced by aqueous cigarette smoke extract in rats. (2014)Sakai HJ Smooth Muscle Res
16166743Effect of cigarette smoke exposure in vivo on bronchial smooth muscle contractility in vitro in rats. (2005 Dec)Chiba YAm J Respir Cell Mol Biol