Gene: NPSR1

387129
ASRT2|GPR154|GPRA|NPSR|PGR14|VRR1
neuropeptide S receptor 1
protein-coding
7p14.3
Ensembl:ENSG00000187258 MIM:608595 Vega:OTTHUMG00000099383 UniprotKB:Q6W5P4
NG_012185.1
PubMed
0   ANCO-SNPs
ND
1   
9.756e-1 (AD)  7.786e-1 (ND)   (Frontal_Cortex)
7.720e-1 (AD)  5.520e-2 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
RPRM0.44
SLC17A80.439
RAB3B0.429
CHRM20.427
CYP26A10.422
ADRA2A0.418
GRIK30.414
GALNT140.412
FABP60.412
CBLN10.411

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
EYA1-0.333
RFX2-0.331
NBPF10-0.328
PHF21B-0.322
ZIC5-0.32
SIX5-0.305
NFATC1-0.302
CDC14A-0.302
CCDC144NL-0.282
SLC16A9-0.28

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB01159HalothaneSmall Molecule151-67-7ApprovedTarget
ID Drug Name Action PubMed
C5294933-oxo-1,1-diphenyltetrahydrooxazolo(3,4-a)pyrazine-7-carboxylic acid 4-fluorobenzylamide"3-oxo-1,1-diphenyltetrahydrooxazolo(3,4-a)pyrazine-7-carboxylic acid 4-fluorobenzylamide binds to and results in decreased activity of NPSR1 protein"21466221
C5294933-oxo-1,1-diphenyltetrahydrooxazolo(3,4-a)pyrazine-7-carboxylic acid 4-fluorobenzylamide"3-oxo-1,1-diphenyltetrahydrooxazolo(3,4-a)pyrazine-7-carboxylic acid 4-fluorobenzylamide binds to and results in decreased activity of NPSR1 protein"21466221
C5294933-oxo-1,1-diphenyltetrahydrooxazolo(3,4-a)pyrazine-7-carboxylic acid 4-fluorobenzylamide"3-oxo-1,1-diphenyltetrahydrooxazolo(3,4-a)pyrazine-7-carboxylic acid 4-fluorobenzylamide binds to and results in decreased activity of NPSR1 protein"20974945
D020106AcrylamideAcrylamide results in increased expression of NPSR1 mRNA28959563
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of NPSR1 gene27153756
D000638AmiodaroneAmiodarone results in increased expression of NPSR1 mRNA19774075
D001280AtrazineAtrazine results in increased expression of NPSR1 mRNA22378314
C006780bisphenol Abisphenol A results in increased expression of NPSR1 mRNA26063408
C006780bisphenol Abisphenol A affects the expression of NPSR1 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of NPSR1 gene28505145
D002104CadmiumCadmium results in decreased expression of NPSR1 mRNA24376830
D003300CopperCopper deficiency results in increased expression of NPSR1 mRNA26033743
C008261lead acetatelead acetate results in increased expression of NPSR1 mRNA22641619
C006253pirinixic acid[pirinixic acid co-treated with PPARA] results in decreased expression of NPSR1 mRNA20813756
C006253pirinixic acidpirinixic acid results in decreased expression of NPSR1 mRNA20813756
D012834SilverSilver affects the expression of NPSR1 mRNA27131904
D013739TestosteroneTestosterone results in increased expression of NPSR1 mRNA20850559
D013739TestosteroneTestosterone results in increased expression of NPSR1 protein20850559
D013739TestosteroneWater deficiency affects the reaction [Testosterone results in increased expression of NPSR1 mRNA]20850559
D013739TestosteroneWater deficiency inhibits the reaction [Testosterone results in increased expression of NPSR1 protein]20850559
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of NPSR1 mRNA21570461
D014635Valproic AcidValproic Acid results in decreased methylation of NPSR1 gene29154799
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of NPSR1 gene25560391
D014867WaterWater deficiency affects the reaction [Testosterone results in increased expression of NPSR1 mRNA]20850559
D014867WaterWater deficiency inhibits the reaction [Testosterone results in increased expression of NPSR1 protein]20850559
D014867WaterWater deficiency results in decreased expression of NPSR1 mRNA20850559
D014867WaterWater deficiency results in decreased expression of NPSR1 protein20850559

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005000vasopressin receptor activity-IEA-  
GO:0008188neuropeptide receptor activity-IDA16790440  
GO ID GO Term Qualifier Evidence PubMed
GO:0007186G-protein coupled receptor signaling pathway-TAS-  
GO:0007218neuropeptide signaling pathway-IEA-  
GO:0051281positive regulation of release of sequestered calcium ion into cytosol-IDA16790440  
GO ID GO Term Qualifier Evidence PubMed
GO:0005737cytoplasm-IEA-  
GO:0005886plasma membrane-TAS-  
GO:0005887integral component of plasma membrane-IDA16790440  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-162582Signal TransductionTAS
R-HSA-372790Signaling by GPCRTAS
R-HSA-373076Class A/1 (Rhodopsin-like receptors)TAS
R-HSA-375276Peptide ligand-binding receptorsTAS
R-HSA-388396GPCR downstream signallingTAS
R-HSA-416476G alpha (q) signalling eventsTAS
R-HSA-418555G alpha (s) signalling eventsTAS
R-HSA-500792GPCR ligand bindingTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
23372674DNA methylation in the Neuropeptide S Receptor 1 (NPSR1) promoter in relation to asthma and environmental factors. (2013)Reinius LEPLoS One