Gene: THEMIS

387357
C6orf190|C6orf207|GASP|SPOT|TSEPA
thymocyte selection associated
protein-coding
6q22.33
Ensembl:ENSG00000172673 MIM:613607 Vega:OTTHUMG00000015534 UniprotKB:Q8N1K5
NG_016226.1
PubMed
0   ANCO-SNPs
AD
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
7.258e-1 (AD)  1.267e-2 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
FOXP20.86
SMYD10.857
RXFP10.846
CHN20.841
DACH10.822
SEMA3E0.82
RSPO30.812
ISLR0.81
HS3ST40.806
NPFFR20.8

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
MSX1-0.467
C4orf19-0.458
RXRG-0.458
NR2F2-0.448
ASB4-0.445
LYPD1-0.441
TFAP2C-0.437
SPRY1-0.435
C1QL2-0.434
NR2E1-0.433

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in decreased expression of THEMIS mRNA"25614096
C0284513,4,3',4'-tetrachlorobiphenyl"3,4,3',4'-tetrachlorobiphenyl inhibits the reaction [Dietary Fats results in increased expression of THEMIS mRNA]"19467301
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of THEMIS gene27153756
D000535Aluminum[APP protein modified form binds to Aluminum] which results in increased expression of THEMIS mRNA21298039
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of THEMIS mRNA24449571
C006632arsenic trioxidearsenic trioxide results in decreased expression of THEMIS mRNA26705709
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased mutagenesis of THEMIS gene25435355
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of THEMIS mRNA19770486
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of THEMIS mRNA21266533
D004041Dietary Fats"3,4,3',4'-tetrachlorobiphenyl inhibits the reaction [Dietary Fats results in increased expression of THEMIS mRNA]"19467301
D004041Dietary FatsDietary Fats results in decreased expression of THEMIS mRNA25016146
D004041Dietary FatsDietary Fats results in increased expression of THEMIS mRNA19467301|2260994
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of THEMIS mRNA25613284
D009532NickelNickel results in increased expression of THEMIS mRNA24768652|2558310
C086401pentabromodiphenyl etherpentabromodiphenyl ether results in decreased expression of THEMIS mRNA26705709
D010426Pentosan Sulfuric PolyesterPentosan Sulfuric Polyester results in decreased expression of THEMIS mRNA28973697
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in increased expression of THEMIS mRNA26300304
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in increased expression of THEMIS protein26300304
D011192Potassium DichromatePotassium Dichromate results in increased expression of THEMIS mRNA23608068
D053260SootSoot analog results in increased expression of THEMIS mRNA25451823
C030141taurine-ursodeoxycholate conjugatetaurine-ursodeoxycholate conjugate inhibits the reaction [LEP gene mutant form results in increased expression of THEMIS mRNA]21079772
D013750TetrachloroethyleneTetrachloroethylene results in increased expression of THEMIS mRNA28973375
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of THEMIS mRNA25613284
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of THEMIS gene25560391
D015032ZincZinc deficiency results in decreased expression of THEMIS mRNA22171008

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI21189249  23455924  25535246  28046066  
GO ID GO Term Qualifier Evidence PubMed
GO:0002250adaptive immune response-IEA-  
GO:0043368positive T cell selection-ISS-  
GO:0043383negative T cell selection-ISS-  
GO:0050852T cell receptor signaling pathway-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-ISS-  
GO:0005737cytoplasm-ISS-  
GO:0005911cell-cell junction-IEA-  
GO:0008180COP9 signalosome-ISS-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
21547531Polymorphisms in ABLIM1 are associated with personality traits and alcohol dependence. (2012 Feb)Wang KSJ Mol Neurosci