Gene: ARMS2

387715
ARMD8
age-related maculopathy susceptibility 2
protein-coding
10q26.13
Ensembl:ENSG00000254636 MIM:611313 Vega:OTTHUMG00000048232 UniprotKB:P0C7Q2
NG_011725.1
PubMed
ND
78   
NA (AD)  NA (ND)   (Frontal_Cortex)
9.033e-1 (AD)  6.136e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
MYCL0.573
FSCN30.567
SERPINA70.561
ASTL0.549
SPO110.536
CRYBA40.525
DAZL0.522
HIST1H3B0.522
TMEM950.521
PLA2G2E0.518

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SNX22-0.224
SYNGR4-0.223
SPATA3-0.222
VNN3-0.222
GPR17-0.219
LCN9-0.21
CCDC153-0.206
HBD-0.206
KLRC3-0.2
MS4A1-0.2

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D002392Catechin[Catechin co-treated with Grape Seed Proanthocyanidins] results in decreased expression of ARMS2 mRNA24763279
C511402Grape Seed Proanthocyanidins[Catechin co-treated with Grape Seed Proanthocyanidins] results in decreased expression of ARMS2 mRNA24763279

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO ID GO Term Qualifier Evidence PubMed
GO:0001895retina homeostasis-IMP18511946  
GO ID GO Term Qualifier Evidence PubMed
GO:0001917photoreceptor inner segment-IDA18511946  
GO:0005739mitochondrion-IDA18511946  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
22232432Significance of C2/CFB variants in age-related macular degeneration and polypoidal choroidal vasculopathy in a Japanese population. (2012 Feb 16)Nakata IInvest Ophthalmol Vis Sci
22247473Prospective assessment of genetic effects on progression to different stages of age-related macular degeneration using multistate Markov models. (2012 Mar)Yu YInvest Ophthalmol Vis Sci
25838066Incidence, Progression, and Associated Risk Factors of Medium Drusen in Age-Related Macular Degeneration: Findings From the 15-Year Follow-up of an Australian Cohort. (2015 Jun)Joachim NDJAMA Ophthalmol
23481534Dietary omega-3 fatty acids, other fat intake, genetic susceptibility, and progression to incident geographic atrophy. (2013 May)Reynolds ROphthalmology
29801032Association of Single-Nucleotide Polymorphisms in Age-Related Macular Degeneration With Pseudodrusen: Secondary Analysis of Data From the Comparison of AMD Treatments Trials. (2018 May 3)Lin LYJAMA Ophthalmol
21807600Clinical validation of a genetic model to estimate the risk of developing choroidal neovascular age-related macular degeneration. (2011 Jul)Hageman GSHum Genomics
20346514C-reactive protein and CFH, ARMS2/HTRA1 gene variants are independently associated with risk of macular degeneration. (2010 Aug)Seddon JMOphthalmology
27502478Precursors of age-related macular degeneration: associations with vitamin A and interaction with CFHY402H in the Inter99 Eye Study. (2016 Nov)Munch ICActa Ophthalmol
18164066Alleles in the HtrA serine peptidase 1 gene alter the risk of neovascular age-related macular degeneration. (2008 Jul)Deangelis MMOphthalmology
27974306Common eye diseases in older adults of southern Germany: results from the KORA-Age study. (2017 May 1)Reitmeir PAge Ageing
19796758Comprehensive analysis of complement factor H and LOC387715/ARMS2/HTRA1 variants with respect to phenotype in advanced age-related macular degeneration. (2009 Dec)Andreoli MTAm J Ophthalmol
26896123Incidence of Age-Related Macular Degeneration in a Multi-Ethnic United States Population: The Multi-Ethnic Study of Atherosclerosis. (2016 Jun)Fisher DEOphthalmology
20157618Complement component 3: an assessment of association with AMD and analysis of gene-gene and gene-environment interactions in a Northern Irish cohort. (2010 Feb 10)McKay GJMol Vis
24557084Growth of geographic atrophy on fundus autofluorescence and polymorphisms of CFH, CFB, C3, FHR1-3, and ARMS2 in age-related macular degeneration. (2014 May)Caire JJAMA Ophthalmol
20090206The molecular genetic basis of age-related macular degeneration: an overview. (2009 Dec)Katta SJ Genet
26218915Assessment of Proteins Associated With Complement Activation and Inflammation in Maculae of Human Donors Homozygous Risk at Chromosome 1 CFH-to-F13B. (2015 Jul)Keenan TDInvest Ophthalmol Vis Sci
23950155Association between the cholesteryl ester transfer protein gene and polypoidal choroidal vasculopathy. (2013 Sep 9)Nakata IInvest Ophthalmol Vis Sci
24608419Elevated high-density lipoprotein cholesterol and age-related macular degeneration: the Alienor study. (2014)Cougnard-Gregoire APLoS One
28717807Vitamin D Status and Prevalent Early Age-Related Macular Degeneration in African Americans and Caucasians: The Atherosclerosis Risk in Communities (ARIC) Study. (2017)Millen AEJ Nutr Health Aging
25402348Combined effects of genetic and non-genetic risk factors affect response to ranibizumab in exudative age-related macular degeneration. (2015 Sep)Piermarocchi SActa Ophthalmol
28332910Association between Dietary Xanthophyll (Lutein and Zeaxanthin) Intake and Early Age-Related Macular Degeneration: The Atherosclerosis Risk in Communities Study. (2017 Oct)Lin HOphthalmic Epidemiol
19255159Localization of age-related macular degeneration-associated ARMS2 in cytosol, not mitochondria. (2009 Jul)Wang GInvest Ophthalmol Vis Sci
22065928Analysis of candidate genes for age-related macular degeneration subtypes in the Japanese population. (2011)Tanaka KMol Vis
23706948Incidence and progression of geographic atrophy: observations from a population-based cohort. (2013 Oct)Joachim NOphthalmology
25788651Risk Factors for Age-Related Macular Degeneration in an Elderly Japanese Population: The Hatoyama Study. (2015 Apr)Aoki AInvest Ophthalmol Vis Sci
21959373Risk models for progression to advanced age-related macular degeneration using demographic, environmental, genetic, and ocular factors. (2011 Nov)Seddon JMOphthalmology
22155603Systems biology-based analysis implicates a novel role for vitamin D metabolism in the pathogenesis of age-related macular degeneration. (2011 Oct)Morrison MAHum Genomics
26998717Reticular Pseudodrusen in Intermediate Age-Related Macular Degeneration: Prevalence, Detection, Clinical, Environmental, and Genetic Associations. (2016 Mar)Wu ZInvest Ophthalmol Vis Sci
22933840Association analysis of genetic and environmental risk factors in the cuticular drusen subtype of age-related macular degeneration. (2012)van de Ven JPMol Vis
23404120Long-term blood pressure and age-related macular degeneration: the ALIENOR study. (2013 Mar 28)Cougnard-Gregoire AInvest Ophthalmol Vis Sci
28926193Association between CFH, CFB, ARMS2, SERPINF1, VEGFR1 and VEGF polymorphisms and anatomical and functional response to ranibizumab treatment in neovascular age-related macular degeneration. (2018 Mar)Cobos EActa Ophthalmol
24974817No clinically significant association between CFH and ARMS2 genotypes and response to nutritional supplements: AREDS report number 38. (2014 Nov)Chew EYOphthalmology
25205867Overexpression of HtrA1 and exposure to mainstream cigarette smoke leads to choroidal neovascularization and subretinal deposits in aged mice. (2014 Sep 9)Nakayama MInvest Ophthalmol Vis Sci
23605053[Etiology and pathogenesis of age-related macular degeneration]. (2013 Apr)Herrmann POphthalmologe
25695752Association of Smoking and CFH and ARMS2 Risk Variants With Younger Age at Onset of Neovascular Age-Related Macular Degeneration. (2015 May)Lechanteur YTJAMA Ophthalmol
25298412Identification of vinculin as a potential plasma marker for age-related macular degeneration. (2014 Oct 8)Kim HJInvest Ophthalmol Vis Sci
19661236Plasma complement components and activation fragments: associations with age-related macular degeneration genotypes and phenotypes. (2009 Dec)Reynolds RInvest Ophthalmol Vis Sci
25893111Association of OCT derived drusen measurements with AMD associated-genotypic SNPs in Amish population. (2015)Chavali VRJ Clin Med
28095100Association of combined cigarette smoking and ARMS2/LOC387715 A69S polymorphisms with age-related macular degeneration: A meta-analysis. (2017 Jul-Aug)Jabbarpoor Bonyadi MHOphthalmic Genet
21682878Identifying subtypes of patients with neovascular age-related macular degeneration by genotypic and cardiovascular risk characteristics. (2011 Jun 17)Feehan MBMC Med Genet
27716857Thyroid Dysfunction and Ten-Year Incidence of Age-Related Macular Degeneration. (2016 Oct 1)Gopinath BInvest Ophthalmol Vis Sci
27420564No Sex Differences in the Frequencies of Common Single Nucleotide Polymorphisms Associated with Age-Related Macular Degeneration. (2017 Mar)Popp NACurr Eye Res
21203342Elevated C-reactive protein levels and ARMS2/HTRA1 gene variants in subjects without age-related macular degeneration. (2010 Dec 31)Yasuma TRMol Vis
24290803Genetic susceptibility, dietary antioxidants, and long-term incidence of age-related macular degeneration in two populations. (2014 Mar)Wang JJOphthalmology
21169531Dissection of chromosome 16p12 linkage peak suggests a possible role for CACNG3 variants in age-related macular degeneration susceptibility. (2011 Mar)Spencer KLInvest Ophthalmol Vis Sci
24953792Cigarette smoking and the natural history of age-related macular degeneration: the Beaver Dam Eye Study. (2014 Oct)Myers CEOphthalmology
24491417Risk factors associated with reticular pseudodrusen versus large soft drusen. (2014 May)Boddu SAm J Ophthalmol
24576882Genetic and environmental risk factors for age-related macular degeneration in persons 90 years and older. (2014 Mar 25)Ersoy LInvest Ophthalmol Vis Sci
22035603Plasma biomarkers of oxidative stress and genetic variants in age-related macular degeneration. (2012 Mar)Brantley MA JrAm J Ophthalmol
26154559The genetic variant rs4073 A-->T of the Interleukin-8 promoter region is associated with the earlier onset of exudative age-related macular degeneration. (2015 Dec)Hautamaki AActa Ophthalmol
19933179Inverse association of female hormone replacement therapy with age-related macular degeneration and interactions with ARMS2 polymorphisms. (2010 Apr)Edwards DRInvest Ophthalmol Vis Sci
23103884Age-related macular degeneration and coronary heart disease: evaluation of genetic and environmental associations. (2013 Feb)Keilhauer CNEur J Med Genet
26354764Joint Associations of Diet, Lifestyle, and Genes with Age-Related Macular Degeneration. (2015 Nov)Meyers KJOphthalmology
24346170Genetic evidence for role of carotenoids in age-related macular degeneration in the Carotenoids in Age-Related Eye Disease Study (CAREDS). (2014 Jan 29)Meyers KJInvest Ophthalmol Vis Sci
22777494Relationship Among CFH and ARMS2 Genotypes, Macular Pigment Optical Density, and Neuroretinal Function in Persons Without Age-Related Macular Degeneration. (2012 Nov)Feigl BArch Ophthalmol
22487577Genotype-phenotype associations in neovascular age-related macular degeneration. (2012 Oct)Hogg RERetina
24332379Predictors of anti-VEGF treatment response in neovascular age-related macular degeneration. (2014 Jan-Feb)Finger RPSurv Ophthalmol
23406618High concentrations of plasma n3 fatty acids are associated with decreased risk for late age-related macular degeneration. (2013 Apr)Merle BMJ Nutr
26681391Reticular Pseudodrusen and Their Association with Age-Related Macular Degeneration: The Melbourne Collaborative Cohort Study. (2016 Mar)Finger RPOphthalmology
23098369ARMS2 increases the risk of early and late age-related macular degeneration in the European Eye Study. (2013 Feb)Chakravarthy UOphthalmology
25478207Age-related macular degeneration: insights into inflammatory genes. (2014)Cascella RJ Ophthalmol
21197116Genome-wide association analyses of genetic, phenotypic, and environmental risks in the age-related eye disease study. (2010 Dec 17)Ryu EMol Vis
25655794Risk Prediction for Progression of Macular Degeneration: 10 Common and Rare Genetic Variants, Demographic, Environmental, and Macular Covariates. (2015 Apr)Seddon JMInvest Ophthalmol Vis Sci
28912512Assessing individual risk for AMD with genetic counseling, family history, and genetic testing. (2018 Feb)Cascella REye (Lond)
21825180Risk assessment model for development of advanced age-related macular degeneration. (2011 Dec)Klein MLArch Ophthalmol
23577725Genetic factors in nonsmokers with age-related macular degeneration revealed through genome-wide gene-environment interaction analysis. (2013 May)Naj ACAnn Hum Genet
20878164[Genetic and risk factors for exudative AMD]. (2010 Dec)Dietzel MOphthalmologe
19169232Variations in five genes and the severity of age-related macular degeneration: results from the Muenster aging and retina study. (2009 Dec)Farwick AEye (Lond)
22809783Association of ARMS2 genotype with bilateral involvement of exudative age-related macular degeneration. (2012 Sep)Tamura HAm J Ophthalmol
27099955Single-Nucleotide Polymorphisms Associated With Age-Related Macular Degeneration and Lesion Phenotypes in the Comparison of Age-Related Macular Degeneration Treatments Trials. (2016 Jun 1)Maguire MGJAMA Ophthalmol
26171855Analysis of Genetic and Environmental Risk Factors and Their Interactions in Korean Patients with Age-Related Macular Degeneration. (2015)Woo SJPLoS One
19117936Prediction model for prevalence and incidence of advanced age-related macular degeneration based on genetic, demographic, and environmental variables. (2009 May)Seddon JMInvest Ophthalmol Vis Sci
23399375The relationship of atherosclerosis to the 10-year cumulative incidence of age-related macular degeneration: the Beaver Dam studies. (2013 May)Klein ROphthalmology
26383995The Incidence and Progression of Age-Related Macular Degeneration over 15 Years: The Blue Mountains Eye Study. (2015 Dec)Joachim NOphthalmology
29487693Uncovering genetic and non-genetic biomarkers specific for exudative age-related macular degeneration: significant association of twelve variants. (2018 Jan 30)Cascella ROncotarget
24332537Incidence and progression of reticular drusen in age-related macular degeneration: findings from an older Australian cohort. (2014 Apr)Joachim NOphthalmology
26067391Differential DNA methylation identified in the blood and retina of AMD patients. (2015)Oliver VFEpigenetics
21447678Association of variants in the LIPC and ABCA1 genes with intermediate and large drusen and advanced age-related macular degeneration. (2011 Jun 28)Yu YInvest Ophthalmol Vis Sci