Gene: RTL1

388015
HUR1|MART1|Mar1|PEG11|SIRH2
retrotransposon Gag like 1
protein-coding
14q32.2
Ensembl:ENSG00000254656 MIM:611896 Vega:OTTHUMG00000167573 UniprotKB:A6NKG5
NG_045001.1
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.517e-1 (AD)  6.219e-1 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg06165706chr14:101347143RTL1Promoter3.729e-4Alcohol use disorders26763658

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ECEL10.544
TH0.524
IL17RE0.512
IAPP0.497
MUC3A0.493
SIX60.492
HMX20.488
OXT0.488
FEZF10.488
HCRT0.482

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CCDC102B-0.236
MKRN3-0.233
ANXA9-0.225
RAPGEF4-0.22
TCEANC2-0.21
PRR11-0.208
ZDHHC20-0.205
C18orf54-0.204
ST6GALNAC3-0.203
ZNF322-0.202

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0005950156,7-dimethoxy-2-(pyrrolidin-1-yl)-N-(5-(pyrrolidin-1-yl)pentyl)quinazolin-4-amine"6,7-dimethoxy-2-(pyrrolidin-1-yl)-N-(5-(pyrrolidin-1-yl)pentyl)quinazolin-4-amine results in decreased expression of RTL1 mRNA"28073004
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of RTL1 mRNA27195522
C006780bisphenol Abisphenol A affects the expression of RTL1 mRNA21636974
C006780bisphenol Abisphenol A affects the expression of RTL1 mRNA alternative form21636974
C006780bisphenol Abisphenol A results in decreased methylation of RTL1 promoter27312807
C006780bisphenol Abisphenol A results in decreased expression of RTL1 mRNA25181051
C026690cerous chloridecerous chloride results in increased expression of RTL1 mRNA23573234
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate affects the expression of RTL1 mRNA21636974
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate affects the expression of RTL1 mRNA alternative form21636974
D015122MercaptopurineMercaptopurine results in decreased expression of RTL1 mRNA23358152
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of RTL1 mRNA"20188158
D010634PhenobarbitalPhenobarbital results in increased expression of RTL1 mRNA23091169
D014635Valproic AcidValproic Acid results in increased methylation of RTL1 gene29154799
D001335Vehicle EmissionsVehicle Emissions affects the methylation of RTL1 gene25560391

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO ID GO Term Qualifier Evidence PubMed
GO:0007275multicellular organism development-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0016021integral component of membrane-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
29435111Impact of DLK1-DIO3 imprinted cluster hypomethylation in smoker patients with lung cancer. (2018 Jan 12)Molina-Pinelo SOncotarget