Gene: HES5

388585
bHLHb38
hes family bHLH transcription factor 5
protein-coding
1p36.32
Ensembl:ENSG00000197921 MIM:607348 Vega:OTTHUMG00000000793 UniprotKB:Q5TA89
NC_000001.11
PubMed
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.848e-1 (AD)  9.752e-1 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg13102889chr1:2463136HES5Promoter2.308e-4Alcohol use disorders26763658

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
HPDL0.707
MMD20.7
ARSF0.685
BTBD170.681
SLC13A50.67
PYGM0.661
SFXN50.643
C1orf610.636
EMID10.634
SLC7A100.617

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
TIFA-0.516
FCGR3A-0.483
SERPINA3-0.478
CP-0.474
RASEF-0.472
ELOVL7-0.469
ADAMTS9-0.466
PLXDC2-0.466
MTHFD2-0.463
GABRE-0.462

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C1202272-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluorobenzamide"[2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluorobenzamide co-treated with SU 5402 co-treated with Chir 99021] results in decreased expression of HES5 mRNA"20865013
C0140242,4,5,2',4',5'-hexachlorobiphenyl"2,4,5,2',4',5'-hexachlorobiphenyl results in decreased expression of HES5 mRNA"21908764
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with belinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of HES5 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of HES5 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of HES5 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of HES5 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of HES5 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of HES5 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of HES5 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of HES5 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of HES5 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with belinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of HES5 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of HES5 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of HES5 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of HES5 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of HES5 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of HES5 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of HES5 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of HES5 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of HES5 mRNA"27188386
D000079AcetaldehydeAcetaldehyde affects the expression of HES5 mRNA22634333
D000082AcetaminophenAcetaminophen results in decreased expression of HES5 mRNA22230336
D000082Acetaminophen[Clofibrate co-treated with Acetaminophen] affects the expression of HES5 mRNA17585979
D000082AcetaminophenPPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of HES5 mRNA]17585979
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of HES5 mRNA21641981
D000643Ammonium ChlorideAmmonium Chloride affects the expression of HES5 mRNA16483693
D003913DextroamphetamineDextroamphetamine results in decreased expression of HES5 mRNA12558987
C006632arsenic trioxidearsenic trioxide results in decreased expression of HES5 mRNA24685274
D001280AtrazineAtrazine results in decreased expression of HES5 mRNA25929836
C487081belinostatbelinostat results in decreased expression of HES5 mRNA26272509
C487081belinostat"[NOG protein co-treated with belinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of HES5 mRNA"27188386
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of HES5 mRNA21871943
D001564Benzo(a)pyreneBenzo(a)pyrene promotes the reaction [AHR protein binds to HES5 promoter]19654925
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of HES5 mRNA27195522
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of HES5 mRNA21839799
C006780bisphenol Abisphenol A results in decreased methylation of HES5 promoter27312807
C006780bisphenol Abisphenol A results in decreased expression of HES5 mRNA25181051
D002104CadmiumCadmium results in increased expression of HES5 mRNA21120746
D002220CarbamazepineCarbamazepine affects the expression of HES5 mRNA22634333
C473711Chir 99021"[2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluorobenzamide co-treated with SU 5402 co-treated with Chir 99021] results in decreased expression of HES5 mRNA"20865013
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in increased expression of HES5 mRNA15862623
D020245p-Chloromercuribenzoic Acid"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of HES5 mRNA"27188386
D020245p-Chloromercuribenzoic Acidp-Chloromercuribenzoic Acid results in decreased expression of HES5 mRNA26272509
D002994Clofibrate[Clofibrate co-treated with Acetaminophen] affects the expression of HES5 mRNA17585979
D002994ClofibratePPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of HES5 mRNA]17585979
C000541cyclopaminecyclopamine results in decreased expression of HES5 mRNA21703336
D003561CytarabineCytarabine results in increased expression of HES5 mRNA21198554
D004041Dietary FatsDietary Fats results in increased expression of HES5 mRNA25016146
C024629dimethyl phthalatedimethyl phthalate affects the expression of HES5 mRNA26924002
C118739entinostatentinostat results in decreased expression of HES5 mRNA26272509
C118739entinostat"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of HES5 mRNA"27188386
D005419FlavonoidsFlavonoids results in increased expression of HES5 mRNA18035473
D005473FluoxetineFluoxetine results in increased expression of HES5 mRNA17033635|1980184
D005473FluoxetineFluoxetine results in increased expression of HES5 protein19801843
C069837fullerene C60fullerene C60 affects the expression of HES5 mRNA19167457
C004312glycidolglycidol results in increased expression of HES5 mRNA24915197
D007649KetamineKetamine results in decreased expression of HES5 mRNA20080153
C440499lipopolysaccharide, Escherichia coli O111 B4"lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of HES5 mRNA"21843347
C042720mercuric bromidemercuric bromide results in decreased expression of HES5 mRNA26272509
C042720mercuric bromide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of HES5 mRNA"27188386
D008694Methamphetamine[Methamphetamine co-treated with SCH 23390] results in decreased expression of HES5 mRNA19564919
D008694MethamphetamineMethamphetamine results in decreased expression of HES5 mRNA19564919
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of HES5 mRNA23203475|2800136
C004925methylmercuric chloridemethylmercuric chloride affects the expression of HES5 mRNA21613230
C020771methylmercury hydroxidemethylmercury hydroxide results in increased expression of HES5 mRNA21908764
C517284monomethyl phthalatemonomethyl phthalate affects the expression of HES5 mRNA26924002
C523799MRK 003MRK 003 results in decreased expression of HES526115193
C523799MRK 003MRK 003 results in decreased expression of HES5 mRNA19775282|2116925
D009151Mustard GasMustard Gas results in increased expression of HES5 mRNA25102026
C028007nickel monoxidenickel monoxide results in decreased expression of HES5 mRNA19167457
C025589ochratoxin Aochratoxin A results in decreased expression of HES5 mRNA21703336
C025589ochratoxin ASHH protein modified form inhibits the reaction [ochratoxin A results in decreased expression of HES5 mRNA]21703336
C496932panobinostat"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of HES5 mRNA"27188386
C496932panobinostatpanobinostat results in decreased expression of HES5 mRNA26272509
C410127PCB 180PCB 180 results in decreased expression of HES5 mRNA21908764
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of HES5 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in decreased expression of HES5 mRNA26272509
C006253pirinixic acidpirinixic acid results in decreased expression of HES5 mRNA19162173
D010936Plant ExtractsPlant Extracts results in decreased expression of HES5 mRNA23557933
D020959PolyethylenePolyethylene results in decreased expression of HES5 mRNA23203475
D011374ProgesteroneProgesterone results in decreased expression of HES5 mRNA21540246
D011441Propylthiouracil[Propylthiouracil results in increased abundance of Thyroxine] which results in increased expression of HES5 mRNA15862623
D011441PropylthiouracilPropylthiouracil results in increased expression of HES5 mRNA24780913
C534628SCH 23390[Methamphetamine co-treated with SCH 23390] results in decreased expression of HES5 mRNA19564919
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of HES5 mRNA23806026
D019821SimvastatinSimvastatin results in increased expression of HES5 mRNA19109527
D012999SomanSoman results in decreased expression of HES5 mRNA19281266
C105686SU 5402"[2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluorobenzamide co-treated with SU 5402 co-treated with Chir 99021] results in decreased expression of HES5 mRNA"20865013
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of HES5 mRNA16443690
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of HES5 mRNA22298810
D013974Thyroxine[Propylthiouracil results in increased abundance of Thyroxine] which results in increased expression of HES5 mRNA15862623
D014050TolueneToluene results in decreased expression of HES5 mRNA22967744
D014212TretinoinTretinoin results in decreased expression of HES5 mRNA21934132
C012589trichostatin Atrichostatin A results in decreased expression of HES5 mRNA15901671
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of HES5 mRNA"27188386
C012589trichostatin Atrichostatin A results in decreased expression of HES5 mRNA24935251|2627250
D014635Valproic AcidValproic Acid results in decreased expression of HES5 mRNA15901671
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of HES5 mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of HES5 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of HES5 mRNA23179753|2438349
D014635Valproic AcidValproic Acid results in increased methylation of HES5 gene29154799
C111237vorinostat"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of HES5 mRNA"27188386
C111237vorinostatvorinostat results in decreased expression of HES5 mRNA26272509

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000977RNA polymerase II regulatory region sequence-specific DNA binding-IBA21873635  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISA-  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISM19274049  
GO:0001078transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding-IBA21873635  
GO:0001078transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding-ISS-  
GO:0003682chromatin binding-IEA-  
GO:0003690double-stranded DNA binding-IEA-  
GO:0003714transcription corepressor activity-IBA21873635  
GO:0008134transcription factor binding-IBA21873635  
GO:0008134transcription factor binding-NAS17611704  
GO:0043565sequence-specific DNA binding-IBA21873635  
GO:0046983protein dimerization activity-IEA-  
GO:1990837sequence-specific double-stranded DNA binding-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0000122negative regulation of transcription by RNA polymerase II-ISS-  
GO:0001756somitogenesis-IBA21873635  
GO:0002062chondrocyte differentiationNOTISS-  
GO:0006351transcription, DNA-templated-IEA-  
GO:0007155cell adhesion-ISS-  
GO:0007219Notch signaling pathway-IBA21873635  
GO:0007219Notch signaling pathway-IMP19682396  19855400  
GO:0007219Notch signaling pathway-TAS-  
GO:0007224smoothened signaling pathway-ISS-  
GO:0007420brain development-ISS-  
GO:0008284positive regulation of cell proliferation-IMP17849174  
GO:0014003oligodendrocyte development-ISS-  
GO:0021537telencephalon development-ISS-  
GO:0021781glial cell fate commitment-ISS-  
GO:0021861forebrain radial glial cell differentiation-IEA-  
GO:0021915neural tube development-ISS-  
GO:0022010central nervous system myelination-ISS-  
GO:0030154cell differentiation-IBA21873635  
GO:0030513positive regulation of BMP signaling pathway-ISS-  
GO:0031641regulation of myelination-ISS-  
GO:0042491inner ear auditory receptor cell differentiation-ISS-  
GO:0042531positive regulation of tyrosine phosphorylation of STAT protein-ISS-  
GO:0042668auditory receptor cell fate determination-IEA-  
GO:0043010camera-type eye development-ISS-  
GO:0045595regulation of cell differentiation-ISS-  
GO:0045607regulation of inner ear auditory receptor cell differentiation-IEA-  
GO:0045665negative regulation of neuron differentiation-ISS-  
GO:0045747positive regulation of Notch signaling pathway-IEA-  
GO:0045893positive regulation of transcription, DNA-templated-ISS-  
GO:0045944positive regulation of transcription by RNA polymerase II-IEA-  
GO:0046427positive regulation of JAK-STAT cascade-ISS-  
GO:0048469cell maturation-ISS-  
GO:0048661positive regulation of smooth muscle cell proliferation-IGI19855400  
GO:0048708astrocyte differentiation-ISS-  
GO:0048712negative regulation of astrocyte differentiation-ISS-  
GO:0048715negative regulation of oligodendrocyte differentiation-ISS-  
GO:0050678regulation of epithelial cell proliferation-IEA-  
GO:0050767regulation of neurogenesis-IBA21873635  
GO:0050767regulation of neurogenesis-ISS-  
GO:0051216cartilage development-IDA17093926  
GO:0060122inner ear receptor cell stereocilium organization-IEA-  
GO:0065003protein-containing complex assembly-ISS-  
GO:0072049comma-shaped body morphogenesis-IEA-  
GO:0072050S-shaped body morphogenesis-IEA-  
GO:0072086specification of loop of Henle identity-IEA-  
GO:0072282metanephric nephron tubule morphogenesis-IEA-  
GO:0090162establishment of epithelial cell polarity-IEA-  
GO:0097150neuronal stem cell population maintenance-IEP19682396  
GO:2000737negative regulation of stem cell differentiation-IMP19682396  
GO:2000974negative regulation of pro-B cell differentiation-ISS-  
GO:2000978negative regulation of forebrain neuron differentiation-IEA-  
GO:2000981negative regulation of inner ear receptor cell differentiation-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005575cellular_component-ND-  
GO:0005634nucleus-IBA21873635  
GO:0005654nucleoplasm-TAS-  
KEGG ID KEGG Term
hsa04330Notch signaling pathway
Reactome ID Reactome Term Evidence
R-HSA-157118Signaling by NOTCHTAS
R-HSA-157118Signaling by NOTCHIEA
R-HSA-162582Signal TransductionTAS
R-HSA-162582Signal TransductionIEA
R-HSA-1643685DiseaseTAS
R-HSA-1980143Signaling by NOTCH1TAS
R-HSA-1980145Signaling by NOTCH2IEA
R-HSA-2122947NOTCH1 Intracellular Domain Regulates TranscriptionTAS
R-HSA-2197563NOTCH2 intracellular domain regulates transcriptionIEA
R-HSA-2644602Signaling by NOTCH1 PEST Domain Mutants in CancerTAS
R-HSA-2644603Signaling by NOTCH1 in CancerTAS
R-HSA-2644606Constitutive Signaling by NOTCH1 PEST Domain MutantsTAS
R-HSA-2894858Signaling by NOTCH1 HD+PEST Domain Mutants in CancerTAS
R-HSA-2894862Constitutive Signaling by NOTCH1 HD+PEST Domain MutantsTAS
R-HSA-5663202Diseases of signal transductionTAS
R-HSA-9012852Signaling by NOTCH3IEA
R-HSA-9013508NOTCH3 Intracellular Domain Regulates TranscriptionIEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
19106307Down-regulation of the notch pathway in human airway epithelium in association with smoking and chronic obstructive pulmonary disease. (2009 Mar 15)Tilley AEAm J Respir Crit Care Med