Gene: C1orf146

388649
-
chromosome 1 open reading frame 146
protein-coding
1p22.1
Ensembl:ENSG00000203910 Vega:OTTHUMG00000010285 UniprotKB:Q5VVC0
NC_000001.11
SNP Mapped
2   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
4.664e-1 (AD)  3.525e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs3122320chr1:92240081 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)
rs3131824chr1:92224379 (GRCh38.p7)G>Aalcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
GPR1510.622
ATAD50.619
MTBP0.615
BRIP10.594
ANKRD36C0.594
ZBBX0.593
ZNF5960.593
RANBP170.59
NR2C10.589
DPY19L20.588

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CCDC102A-0.39
TBXA2R-0.373
MDFI-0.354
PLAC9-0.352
NKX6-1-0.32
S100A1-0.319
SERTAD1-0.318
TCF15-0.316
PINLYP-0.309
PPP1R14B-0.304

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C006780bisphenol Abisphenol A results in decreased expression of C1ORF146 mRNA29275510
C006780bisphenol Abisphenol A results in decreased expression of C1ORF146 mRNA25181051
D011374ProgesteroneProgesterone results in increased expression of C1ORF146 mRNA19690047

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO ID GO Term Qualifier Evidence PubMed
GO ID GO Term Qualifier Evidence PubMed
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal