Gene: FAM69A

388650
-
family with sequence similarity 69 member A
protein-coding
1p22.1
Ensembl:ENSG00000154511 MIM:614542 Vega:OTTHUMG00000010894 UniprotKB:Q5T7M9
NG_033051.1
SNP Mapped
10   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
3.238e-1 (AD)  8.006e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs7542608chr1:92935637 (GRCh38.p7)A>Galcohol dependenceSNV(Single Nucleotide Variation)
rs10493863chr1:92934137 (GRCh38.p7)T>Calcohol dependenceSNV(Single Nucleotide Variation)
rs6698233chr1:92931743 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)
rs7515257chr1:92928161 (GRCh38.p7)G>Aalcohol dependenceSNV(Single Nucleotide Variation)
rs2255723chr1:92902752 (GRCh38.p7)G>Talcohol dependenceSNV(Single Nucleotide Variation)
rs2263247chr1:92898510 (GRCh38.p7)T>Calcohol dependenceSNV(Single Nucleotide Variation)
rs2481713chr1:92889332 (GRCh38.p7)G>Talcohol dependenceSNV(Single Nucleotide Variation)
rs2391177chr1:92888386 (GRCh38.p7)G>Aalcohol dependenceSNV(Single Nucleotide Variation)
rs10782946chr1:92887112 (GRCh38.p7)G>Aalcohol dependenceSNV(Single Nucleotide Variation)
rs10874744chr1:92840760 (GRCh38.p7)G>Aalcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CLASP20.95
PRKACB0.948
ZDHHC170.946
DNAJC180.943
CSE1L0.942
TRIM20.939
UBQLN20.936
USP330.936
ATP8A10.935
CD470.935

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.593
OR4F29-0.551
TFPI2-0.456
CSAG1-0.441
AJUBA-0.416
FZD10-0.416
SIX1-0.415
MTRNR2L10-0.391
EVC2-0.39
MTRNR2L6-0.39

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0512461-methylanthracene[1-methylanthracene co-treated with fluoranthene] results in decreased expression of FAM69A mRNA28329830
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether analog results in decreased expression of FAM69A mRNA"19095052
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in increased expression of FAM69A mRNA"19692669
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of FAM69A mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of FAM69A mRNA"27188386
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of FAM69A gene27153756
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of FAM69A mRNA19770486
D000517alpha-Chlorohydrinalpha-Chlorohydrin results in increased expression of FAM69A mRNA28522335
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of FAM69A mRNA24449571
D004958Estradiol[Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of FAM69A mRNA19619570
D004958EstradiolEstradiol results in increased expression of FAM69A mRNA19619570
C006780bisphenol Abisphenol A affects the expression of FAM69A mRNA21786754
D002392Catechin[Catechin co-treated with Grape Seed Proanthocyanidins] results in decreased expression of FAM69A mRNA24763279
D004052DiethylnitrosamineDiethylnitrosamine results in decreased expression of FAM69A mRNA24535843
D004317DoxorubicinFAM69A protein affects the susceptibility to Doxorubicin16217747
C118739entinostatentinostat results in increased expression of FAM69A mRNA27188386
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in decreased expression of FAM69A mRNA23649840
C007738fluoranthene[1-methylanthracene co-treated with fluoranthene] results in decreased expression of FAM69A mRNA28329830
D005485FlutamideFlutamide results in decreased expression of FAM69A mRNA24793618
D005557FormaldehydeFormaldehyde results in decreased expression of FAM69A mRNA23649840
C039281furanfuran results in decreased expression of FAM69A mRNA24183702
C511402Grape Seed Proanthocyanidins[Catechin co-treated with Grape Seed Proanthocyanidins] results in decreased expression of FAM69A mRNA24763279
C492448ICG 001ICG 001 results in decreased expression of FAM69A mRNA26191083
D007649KetamineKetamine results in increased expression of FAM69A mRNA20080153
D007854LeadLead affects the expression of FAM69A mRNA28903495
D008694MethamphetamineMethamphetamine results in decreased expression of FAM69A mRNA19564919
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of FAM69A mRNA28001369
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of FAM69A mRNA23649840
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of FAM69A mRNA"25620056
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of FAM69A mRNA"25620056
C016030pantogabpantogab results in decreased expression of FAM69A mRNA17379144
C086401pentabromodiphenyl etherpentabromodiphenyl ether analog results in decreased expression of FAM69A mRNA19095052
D010416PentachlorophenolPentachlorophenol results in increased expression of FAM69A mRNA23892564
D010634PhenobarbitalPhenobarbital affects the expression of FAM69A mRNA23091169
C009277sodium arsenatesodium arsenate results in increased expression of FAM69A mRNA21795629
D013749Tetrachlorodibenzodioxin[Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of FAM69A mRNA19619570
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of FAM69A mRNA22298810|2257421
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of FAM69A mRNA19619570|1969266
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with TIPARP gene mutant form] results in increased expression of FAM69A mRNA25975270
D013750TetrachloroethyleneTetrachloroethylene results in increased expression of FAM69A mRNA28973375
D014212TretinoinTretinoin results in increased expression of FAM69A mRNA21934132
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of FAM69A mRNA"27188386
C012589trichostatin Atrichostatin A results in decreased expression of FAM69A mRNA26272509
D014635Valproic AcidValproic Acid affects the expression of FAM69A mRNA25979313
D014635Valproic AcidValproic Acid results in decreased methylation of FAM69A gene29154799
D014635Valproic AcidValproic Acid results in increased expression of FAM69A mRNA23179753|2718838
D014747VinblastineFAM69A protein affects the susceptibility to Vinblastine16217747
C111237vorinostatvorinostat results in increased expression of FAM69A mRNA22083351|2718838

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO ID GO Term Qualifier Evidence PubMed
GO ID GO Term Qualifier Evidence PubMed
GO:0005789endoplasmic reticulum membrane-IEA-  
GO:0016021integral component of membrane-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal