Gene: HRNR

388697
FLG3|S100A16|S100a18
hornerin
protein-coding
1q21.3
Ensembl:ENSG00000197915 MIM:616293 Vega:OTTHUMG00000012243 UniprotKB:Q86YZ3
NC_000001.11
PubMed
0   ANCO-SNPs
ND
0   
4.483e-1 (AD)  4.650e-1 (ND)   (Frontal_Cortex)
1.623e-1 (AD)  5.661e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ACCS0.414
GOLGA8H0.397
AUTS20.394
ASB160.392
C2orf27B0.385
ZNF587B0.379
ANKRD360.376
IBA570.37
KIAA07540.364
DOK70.364

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SFN-0.208
SYT8-0.198
CBY3-0.183
C7orf61-0.181
S100A7-0.176
ZNF114-0.174
EIF4EBP1-0.169
HAO1-0.168
VPREB3-0.167
PAGE2-0.167

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB01593ZincSmall Molecule7440-66-6Approved|InvestigationalTarget
ID Drug Name Action PubMed
C075388beta-damascenonebeta-damascenone results in increased expression of HRNR mRNA22982537
D002104CadmiumHRNR protein binds to Cadmium23896426
D003033Coal TarCoal Tar inhibits the reaction [[IL4 protein co-treated with IL13 protein] results in decreased expression of HRNR mRNA]23348739
D003033Coal TarCoal Tar results in increased expression of HRNR mRNA23348739
D003033Coal TarCoal Tar results in increased expression of HRNR protein23348739
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in increased expression of HRNR mRNA27392435
D004791Enzyme Inhibitors[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of HRNR protein23301498
C544151jinfukang[Cisplatin co-treated with jinfukang] results in increased expression of HRNR mRNA27392435
D007854LeadHRNR protein binds to Lead23896426
D009532NickelHRNR protein binds to Nickel23896426
D010100OxygenOxygen deficiency results in decreased expression of HRNR mRNA24205000
D011192Potassium DichromatePotassium Dichromate results in increased expression of HRNR protein23718831
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of HRNR mRNA21835898|2315218
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of HRNR mRNA21570461
D013749Tetrachlorodibenzodioxin[EGF protein results in increased activity of EGFR protein] inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of HRNR mRNA]21835898
D001335Vehicle EmissionsVehicle Emissions affects the methylation of HRNR gene25560391
D015032ZincHRNR protein binds to Zinc23896426

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005509calcium ion binding-IEA-  
GO:0030280structural constituent of epidermis-IBA21873635  
GO:0046914transition metal ion binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0031424keratinization-IEA-  
GO:0043163cell envelope organization-IDA21282207  
GO:0043312neutrophil degranulation-TAS-  
GO:0061436establishment of skin barrier-IBA21873635  
GO:0061436establishment of skin barrier-IEP23403047  
GO ID GO Term Qualifier Evidence PubMed
GO:0001533cornified envelope-IBA21873635  
GO:0001533cornified envelope-IDA21282207  
GO:0005576extracellular region-TAS-  
GO:0005634nucleus-HDA21630459  
GO:0005737cytoplasm-IDA21282207  
GO:0035578azurophil granule lumen-TAS-  
GO:0036457keratohyalin granule-IBA21873635  
GO:0036457keratohyalin granule-IDA21282207  
GO:0048471perinuclear region of cytoplasm-IDA21282207  
GO:0070062extracellular exosome-HDA21362503  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-168249Innate Immune SystemTAS
R-HSA-168256Immune SystemTAS
R-HSA-6798695Neutrophil degranulationTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal