Gene: LEKR1

389170
-
leucine, glutamate and lysine rich 1
protein-coding
3q25.31
Ensembl:ENSG00000197980 MIM:613536 Vega:OTTHUMG00000160130 UniprotKB:Q6ZMV7
NC_000003.12
PubMed
0   ANCO-SNPs
ND
4   
NA (AD)  NA (ND)   (Frontal_Cortex)
5.135e-1 (AD)  8.857e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
RSPH4A0.591
FAM196A0.567
RBM30.539
TATDN30.531
FAM122C0.529
BMP2K0.518
DIRAS30.518
TMEM1280.517
KLF50.515
DUS4L0.509

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CLDN9-0.305
REP15-0.272
MIA-0.269
SLC7A9-0.256
OR4F5-0.248
C7orf61-0.246
OR7C1-0.243
UPK1A-0.241
CXorf67-0.239
LBX2-0.226

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D020106AcrylamideAcrylamide affects the expression of LEKR1 mRNA28959563
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of LEKR1 gene27153756
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of LEKR1 mRNA24449571
C006780bisphenol Abisphenol A results in decreased expression of LEKR1 mRNA25181051
C039281furanfuran results in increased expression of LEKR1 mRNA25539665
D009966OrphenadrineOrphenadrine affects the expression of LEKR1 mRNA23665939
C005556propionaldehydepropionaldehyde results in increased expression of LEKR1 mRNA26079696
D012969Sodium FluorideSodium Fluoride results in decreased expression of LEKR1 mRNA27862939
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of LEKR1 mRNA26377647
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of LEKR1 mRNA20159946|2188995
D014635Valproic AcidValproic Acid results in decreased methylation of LEKR1 gene29154799
D014635Valproic AcidValproic Acid results in increased expression of LEKR1 mRNA28001369

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO ID GO Term Qualifier Evidence PubMed
GO ID GO Term Qualifier Evidence PubMed
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
23575227The chromosome 3q25 genomic region is associated with measures of adiposity in newborns in a multi-ethnic genome-wide association study. (2013 Sep 1)Urbanek MHum Mol Genet
27591263Genome-wide DNA methylation study in human placenta identifies novel loci associated with maternal smoking during pregnancy. (2016 Oct)Morales EInt J Epidemiol
20372150Variants in ADCY5 and near CCNL1 are associated with fetal growth and birth weight. (2010 May)Freathy RMNat Genet
21885063Replication of a genome-wide association study of birth weight in preterm neonates. (2012 Jan)Ryckman KKJ Pediatr