Gene: C5orf46

389336
SSSP1
chromosome 5 open reading frame 46
protein-coding
5q32
Ensembl:ENSG00000178776 Vega:OTTHUMG00000163420 UniprotKB:Q6UWT4
NC_000005.10
SNP Mapped
0   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
3.392e-1 (AD)  3.235e-2 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PRAMEF70.471
PRAMEF60.459
OTX20.456
WISP10.434
FCRLA0.429
FGF30.423
OR51A20.394
TFPI20.392
UNCX0.385
CLCNKB0.382

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
DQX1-0.294
EPN3-0.282
SCRT2-0.279
TMEM81-0.277
PLEKHA6-0.273
P2RX6-0.269
USP2-0.267
ATXN7L2-0.267
ZFHX2-0.266
HAPLN4-0.262

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C006780bisphenol Abisphenol A results in decreased expression of C5ORF46 mRNA25181051
D016572CyclosporineCyclosporine results in decreased expression of C5ORF46 mRNA27989131
D002945CisplatinCisplatin results in decreased expression of C5ORF46 mRNA27392435
C544151jinfukangjinfukang results in decreased expression of C5ORF46 mRNA27392435
D009532NickelNickel results in decreased expression of C5ORF46 mRNA24768652|2558310
D010100OxygenOxygen deficiency results in increased expression of C5ORF46 mRNA26516004
D018038Sodium SeleniteSodium Selenite results in decreased expression of C5ORF46 mRNA18175754
C012589trichostatin Atrichostatin A results in increased expression of C5ORF46 mRNA26705709
D014635Valproic AcidValproic Acid results in decreased expression of C5ORF46 mRNA29154799
D014635Valproic AcidValproic Acid results in increased methylation of C5ORF46 gene29154799

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003674molecular_function-ND-  
GO ID GO Term Qualifier Evidence PubMed
GO:0008150biological_process-ND-  
GO ID GO Term Qualifier Evidence PubMed
GO:0070062extracellular exosome-HDA19199708  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

There is no Interaction data for this gene.

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal