Gene: L1CAM

3897
CAML1|CD171|HSAS|HSAS1|MASA|MIC5|N-CAM-L1|N-CAML1|NCAM-L1|S10|SPG1
L1 cell adhesion molecule
protein-coding
Xq28
Ensembl:ENSG00000198910 MIM:308840 Vega:OTTHUMG00000024221 UniprotKB:P32004
NG_009645.3
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
NA (AD)  NA (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SLC12A50.985
ATP2B30.982
B4GALNT10.977
CLSTN30.972
ARHGAP440.971
ACTL6B0.971
TMEM1300.97
TMEM250.967
RUSC10.963
SCN2B0.963

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
TFPI2-0.585
REST-0.58
YES1-0.574
RAI14-0.572
WWTR1-0.553
HEY2-0.545
FZD10-0.545
MYL3-0.544
GNG11-0.542
RNF135-0.539

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00898EthanolSmall Molecule64-17-5ApprovedTarget
ID Drug Name Action PubMed
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in increased expression of L1CAM mRNA"27291303
C0294972,3-bis(3'-hydroxybenzyl)butyrolactone"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in decreased expression of L1CAM mRNA"19167446
C5262093-azibutanol3-azibutanol binds to and results in decreased activity of L1CAM protein18165316
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of L1CAM mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with methylmercuric chloride co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of L1CAM mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of L1CAM mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of L1CAM mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of L1CAM mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of L1CAM mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of L1CAM mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with methylmercuric chloride co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of L1CAM mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of L1CAM mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of L1CAM mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of L1CAM mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of L1CAM mRNA"27188386
D000082AcetaminophenAcetaminophen results in decreased expression of L1CAM mRNA26690555
D000447AldehydesAldehydes results in increased expression of L1CAM mRNA25014914
D000517alpha-Chlorohydrinalpha-Chlorohydrin results in decreased expression of L1CAM mRNA28522335
D001280AtrazineAtrazine results in decreased expression of L1CAM mRNA25929836
D001280AtrazineAtrazine results in increased expression of L1CAM mRNA22378314
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of L1CAM mRNA"20018196
D004958EstradiolEstradiol results in decreased expression of L1CAM mRNA16474171|1916744
C006780bisphenol Abisphenol A results in decreased expression of L1CAM mRNA16474171
C006780bisphenol Abisphenol A results in decreased expression of L1CAM mRNA25594700
C006780bisphenol Abisphenol A results in increased expression of L1CAM mRNA16902998
C006780bisphenol Abisphenol A results in decreased expression of L1CAM mRNA25181051
C018475butyraldehydebutyraldehyde results in increased expression of L1CAM mRNA26079696
C584509C646 compoundC646 compound results in decreased expression of L1CAM mRNA26191083
C459604candoxincandoxin results in decreased expression of L1CAM mRNA16309724
D002220CarbamazepineCarbamazepine affects the expression of L1CAM mRNA25979313
D004390ChlorpyrifosChlorpyrifos results in decreased expression of L1CAM mRNA18668222
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of L1CAM mRNA20938992
D003300Copper[NSC 689534 binds to Copper] which results in increased expression of L1CAM mRNA20971185
D003300Copper[ATP7A gene mutant form results in increased abundance of Copper] which results in decreased expression of L1CAM mRNA15467011
D003375Coumestrol"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in decreased expression of L1CAM mRNA"19167446
D003375Coumestrol[Coumestrol co-treated with resveratrol] results in decreased expression of L1CAM mRNA19167446
D003375CoumestrolCoumestrol results in decreased expression of L1CAM mRNA19167446
D016572CyclosporineCyclosporine results in increased expression of L1CAM mRNA25562108
C425904davunetidedavunetide inhibits the reaction [Ethanol results in decreased activity of L1CAM protein]21931691
C014347decitabinedecitabine inhibits the reaction [Smoke results in decreased expression of L1CAM mRNA]21095227
D013759DronabinolDronabinol results in decreased expression of L1CAM mRNA17320842
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in decreased expression of L1CAM mRNA27392435
D002945CisplatinCisplatin results in decreased expression of L1CAM mRNA27392435
D002945CisplatinL1CAM affects the susceptibility to Cisplatin21097529
D004178DiquatDiquat affects the expression of L1CAM mRNA22814884
C118739entinostatentinostat results in increased expression of L1CAM mRNA26272509
C118739entinostat"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of L1CAM mRNA"27188386
D000431EthanolEthanol binds to and results in decreased activity of L1CAM protein18165316
D000431EthanolEthanol results in decreased activity of L1CAM protein8609170
D000431EthanolOctanols analog inhibits the reaction [Ethanol binds to and results in decreased activity of L1CAM protein]18165316
D000431EthanolEthanol results in decreased expression of L1CAM mRNA29018328
D000431Ethanoldavunetide inhibits the reaction [Ethanol results in decreased activity of L1CAM protein]21931691
D000431EthanolEthanol results in decreased activity of L1CAM protein21931691
D005472FluorouracilFluorouracil results in decreased expression of L1CAM protein15352031
D005472FluorouracilL1CAM protein affects the susceptibility to Fluorouracil15352031
D005473FluoxetineFluoxetine results in increased expression of L1CAM protein16900104
D005473FluoxetineOndansetron inhibits the reaction [Fluoxetine results in increased expression of L1CAM protein]16900104
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of L1CAM mRNA20938992
D019833GenisteinGenistein results in decreased expression of L1CAM mRNA16474171
D017313FenretinideFenretinide results in decreased expression of L1CAM mRNA28973697
C544151jinfukang[Cisplatin co-treated with jinfukang] results in decreased expression of L1CAM mRNA27392435
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of L1CAM mRNA25961927
C031895lead chromatelead chromate results in decreased expression of L1CAM mRNA23584427
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of L1CAM mRNA20938992
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of L1CAM protein25809596
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of L1CAM mRNA26272509
C004925methylmercuric chloride"[NOG protein co-treated with methylmercuric chloride co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of L1CAM mRNA"27188386
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of L1CAM mRNA"20188158
D016685MitomycinL1CAM protein affects the susceptibility to Mitomycin16217747
C558013NSC 689534[NSC 689534 binds to Copper] which results in increased expression of L1CAM mRNA20971185
C558013NSC 689534NSC 689534 results in increased expression of L1CAM mRNA20971185
D000442OctanolsOctanols analog binds to L1CAM protein18165316
D000442OctanolsOctanols analog inhibits the reaction [Ethanol binds to and results in decreased activity of L1CAM protein]18165316
D017294OndansetronOndansetron inhibits the reaction [Fluoxetine results in increased expression of L1CAM protein]16900104
C496932panobinostat"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of L1CAM mRNA"27188386
C496932panobinostatpanobinostat results in increased expression of L1CAM mRNA26272509
C086401pentabromodiphenyl etherpentabromodiphenyl ether results in increased expression of L1CAM mRNA26705709
C046012pentanalpentanal results in increased expression of L1CAM mRNA26079696
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of L1CAM mRNA"27188386
C006253pirinixic acidpirinixic acid results in decreased expression of L1CAM mRNA17426115
D011078Polychlorinated BiphenylsPolychlorinated Biphenyls analog results in decreased expression of L1CAM mRNA16474171
C027373potassium chromate(VI)potassium chromate(VI) results in increased expression of L1CAM mRNA22714537
D011374ProgesteroneProgesterone results in decreased expression of L1CAM mRNA18070364
C005556propionaldehydepropionaldehyde results in increased expression of L1CAM mRNA26079696
D011441PropylthiouracilPropylthiouracil results in increased expression of L1CAM mRNA24780913
C059514resveratrol[Coumestrol co-treated with resveratrol] results in decreased expression of L1CAM mRNA19167446
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of L1CAM mRNA25895662
D020123SirolimusL1CAM affects the susceptibility to Sirolimus21097529
D012906Smokedecitabine inhibits the reaction [Smoke results in decreased expression of L1CAM mRNA]21095227
C017947sodium arsenitesodium arsenite results in decreased expression of and affects the splicing of L1CAM mRNA25879800
C017947sodium arsenitesodium arsenite results in decreased expression of L1CAM mRNA12016162
C009495titanium dioxidetitanium dioxide results in increased expression of L1CAM mRNA29128614
D014212TretinoinTretinoin results in increased expression of L1CAM mRNA20488242
C011559tributyltintributyltin results in decreased expression of L1CAM mRNA27614199
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of L1CAM mRNA"27188386
C012589trichostatin Atrichostatin A results in increased expression of L1CAM mRNA24935251|2627250
D014302Trinitrobenzenesulfonic AcidTrinitrobenzenesulfonic Acid results in increased expression of L1CAM mRNA17982090
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of L1CAM mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of L1CAM mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of L1CAM mRNA23179753|2484967
D014638VanadatesVanadates results in increased expression of L1CAM mRNA22714537
C029297vinylidene chloridevinylidene chloride results in decreased expression of L1CAM mRNA26682919
C111237vorinostatvorinostat results in increased expression of L1CAM mRNA26272509

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI18321067  
GO:0008046axon guidance receptor activity-IBA21873635  
GO:0019904protein domain specific binding-IDA18321067  
GO ID GO Term Qualifier Evidence PubMed
GO:0006935chemotaxis-TAS19909241  
GO:0007155cell adhesion-NAS7920659  
GO:0007156homophilic cell adhesion via plasma membrane adhesion molecules-IBA21873635  
GO:0007160cell-matrix adhesion-IDA22973895  
GO:0007399nervous system development-TAS1769655  
GO:0007411axon guidance-IDA24155914  
GO:0007411axon guidance-TAS-  
GO:0016477cell migration-IDA22973895  
GO:0031175neuron projection development-IDA22973895  
GO:0045773positive regulation of axon extension-ISS-  
GO:0050808synapse organization-IBA21873635  
GO:0050808synapse organization-IDA24155914  
GO:0050900leukocyte migration-TAS-  
GO:0061564axon development-IDA20621658  
GO ID GO Term Qualifier Evidence PubMed
GO:0005886plasma membrane-IBA21873635  
GO:0005886plasma membrane-IDA20621658  
GO:0005886plasma membrane-TAS-  
GO:0005925focal adhesion-HDA21423176  
GO:0009986cell surface-HDA19581412  
GO:0009986cell surface-IDA22973895  
GO:0016021integral component of membrane-IEA-  
GO:0030424axon-IBA21873635  
GO:0030424axon-IDA20621658  
GO:0030425dendrite-IEA-  
GO:0043025neuronal cell body-IBA21873635  
GO:0043025neuronal cell body-IDA20621658  
GO:0044295axonal growth cone-ISS-  
GO:0062023collagen-containing extracellular matrix-HDA27559042  
KEGG ID KEGG Term
hsa04360Axon guidance
hsa04514Cell adhesion molecules (CAMs)
Reactome ID Reactome Term Evidence
R-HSA-109582HemostasisTAS
R-HSA-1266738Developmental BiologyTAS
R-HSA-1266738Developmental BiologyIEA
R-HSA-202733Cell surface interactions at the vascular wallTAS
R-HSA-210991Basigin interactionsTAS
R-HSA-373760L1CAM interactionsTAS
R-HSA-373760L1CAM interactionsIEA
R-HSA-422475Axon guidanceTAS
R-HSA-422475Axon guidanceIEA
R-HSA-437239Recycling pathway of L1TAS
R-HSA-437239Recycling pathway of L1IEA
R-HSA-445095Interaction between L1 and AnkyrinsTAS
R-HSA-445095Interaction between L1 and AnkyrinsIEA
R-HSA-445144Signal transduction by L1TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
21071578A migration signature and plasma biomarker panel for pancreatic adenocarcinoma. (2011 Jan)Balasenthil SCancer Prev Res (Phila)