Gene: LAD1

3898
LadA
ladinin 1
protein-coding
1q32.1
Ensembl:ENSG00000159166 MIM:602314 Vega:OTTHUMG00000035737 UniprotKB:O00515
NC_000001.11
PubMed
0   ANCO-SNPs
AD
3   
NA (AD)  NA (ND)   (Frontal_Cortex)
6.387e-1 (AD)  2.138e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SERPINB50.779
KLK110.773
TACSTD20.762
IVL0.752
NCCRP10.741
ALDH3B20.741
SPINK50.734
SCEL0.725
DSC30.723
SPRR1B0.716

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PCDHB10-0.247
DCDC1-0.24
DEPDC1-0.24
CCDC13-0.236
ZNF835-0.234
PDZD9-0.234
GNRH2-0.234
STPG1-0.229
SOSTDC1-0.227
CNGA4-0.223

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in decreased expression of LAD1 mRNA"22698814
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in decreased expression of LAD1 mRNA"18648102
D000082AcetaminophenAcetaminophen results in decreased expression of LAD1 mRNA21420995|2223033
D000082AcetaminophenAcetaminophen affects the expression of LAD1 mRNA17562736
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of LAD1 mRNA19770486
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of LAD1 mRNA24449571
D004958EstradiolEstradiol results in increased expression of LAD1 mRNA23019147
C006780bisphenol Abisphenol A results in increased expression of LAD1 mRNA26364221
C006780bisphenol Abisphenol A results in decreased expression of LAD1 mRNA25181051
D002330CarmustineCarmustine results in decreased expression of LAD1 mRNA15980968
D004390ChlorpyrifosChlorpyrifos results in decreased expression of LAD1 mRNA21356183
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of LAD1 gene20938992
D019327Copper SulfateCopper Sulfate results in increased expression of LAD1 mRNA19549813
C030123coumarincoumarin results in increased expression of LAD1 mRNA18480146
D016572CyclosporineCyclosporine results in increased expression of LAD1 mRNA25562108
C014347decitabinedecitabine affects the expression of LAD1 mRNA23300844
C014347decitabinedecitabine inhibits the reaction [Smoke results in decreased expression of LAD1 mRNA]21095227
D003907Dexamethasone[Dexamethasone results in increased phosphorylation of and results in increased activity of NR3C1 protein] which results in increased expression of LAD1 mRNA18483179
D002945CisplatinCisplatin affects the expression of LAD1 mRNA23300844
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of LAD1 mRNA17942748
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of LAD1 gene20938992
C039281furanfuran results in increased expression of LAD1 mRNA27387713
D017313FenretinideFenretinide results in increased expression of LAD1 mRNA28973697
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of LAD1 mRNA25613284
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of LAD1 mRNA25613284
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of LAD1 gene20938992
D008774MethylphenidateMethylphenidate results in decreased expression of LAD1 mRNA22470460
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of LAD1 mRNA"25620056
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of LAD1 mRNA"25620056
D009532NickelNickel results in increased expression of LAD1 mRNA25583101
C029938nickel sulfatenickel sulfate results in increased expression of LAD1 mRNA16780908
D010416PentachlorophenolPentachlorophenol results in increased expression of LAD1 mRNA23892564
D010936Plant ExtractsPlant Extracts results in decreased expression of LAD1 mRNA23557933
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in decreased expression of LAD1 mRNA28903501
C005556propionaldehydepropionaldehyde results in decreased expression of LAD1 mRNA26079696
D011794QuercetinQuercetin results in increased expression of LAD1 mRNA21632981
D012906Smokedecitabine inhibits the reaction [Smoke results in decreased expression of LAD1 mRNA]21095227
D012906SmokeSmoke results in decreased expression of LAD1 mRNA21095227
D013467SulindacSulindac results in increased expression of LAD1 mRNA11507085
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of LAD1 mRNA26377647|2892240
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of LAD1 mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of LAD1 mRNA19770486
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of LAD1 mRNA25613284
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of LAD1 mRNA28065790
D014212TretinoinTretinoin results in decreased expression of LAD1 mRNA23830798
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of LAD1 mRNA"26743178
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of LAD1 mRNA"24407104
D014501UraniumUranium affects the expression of LAD1 mRNA15672453
C005460uranyl acetateuranyl acetate affects the expression of LAD1 mRNA15672453
D014520UrethaneUrethane results in decreased expression of LAD1 mRNA28818685
D014635Valproic AcidValproic Acid results in decreased expression of LAD1 mRNA29154799
D014635Valproic AcidValproic Acid results in increased expression of LAD1 mRNA23527032
C025643vinclozolinvinclozolin affects the expression of LAD1 mRNA23034163
D014810Vitamin EVitamin E results in decreased expression of LAD1 mRNA19244175

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005198structural molecule activity-IEA-  
GO:0045296cadherin binding-HDA25468996  
GO ID GO Term Qualifier Evidence PubMed
GO ID GO Term Qualifier Evidence PubMed
GO:0005604basement membrane-IEA-  
GO:0015629actin cytoskeleton-IDA-  
GO:0070062extracellular exosome-HDA18570454  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
12960747Confirmation of alcohol preference quantitative trait loci in the replicate high alcohol drinking and low alcohol drinking rat lines. (2003 Sep)Foroud TPsychiatr Genet
21521426Behavioral profiling of multiple pairs of rats selectively bred for high and low alcohol intake using the MCSF test. (2012 Jan)Roman EAddict Biol
12405517Phenotypic and genotypic characterization of the Indiana University rat lines selectively bred for high and low alcohol preference. (2002 Sep)Murphy JMBehav Genet