Gene: AFF3

3899
LAF4|MLLT2-like
AF4/FMR2 family member 3
protein-coding
2q11.2
Ensembl:ENSG00000144218 MIM:601464 Vega:OTTHUMG00000153011 UniprotKB:P51826
NG_052835.1
SNP Mapped
2   ANCO-SNPs
AD
0   
4.921e-1 (AD)  5.120e-1 (ND)   (Frontal_Cortex)
9.525e-1 (AD)  4.174e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs4851222chr2:99672469 (GRCh38.p7)G>Aalcohol dependenceSNV(Single Nucleotide Variation)
rs11676683chr2:99659463 (GRCh38.p7)A>Calcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SNAP910.926
AAK10.924
THRB0.919
PRKCE0.916
MYT1L0.916
AMPH0.916
PDS5B0.915
SYNJ10.914
PTPRT0.913
NELL20.913

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CSAG1-0.516
COPZ2-0.514
HEY2-0.504
RNF135-0.492
FZD10-0.487
AQP5-0.486
REST-0.484
RAI14-0.482
MYL3-0.477
FLT3LG-0.476

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5321622-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine"[PIK3CA gene mutant form results in increased susceptibility to 2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine] which results in increased expression of AFF3 mRNA"20453058
C5486512-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in increased expression of AFF3 mRNA19933214
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of AFF3 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of AFF3 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of AFF3 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of AFF3 mRNA"27188386
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of AFF3 gene27153756|2845801
C547126AZM551248AZM551248 results in decreased expression of AFF3 mRNA22323515
C006780bisphenol Abisphenol A results in increased expression of AFF3 mRNA29275510
C006780bisphenol Abisphenol A results in decreased expression of AFF3 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of AFF3 gene28505145
D002737ChloropreneChloroprene results in increased expression of AFF3 mRNA23125180
C014347decitabinedecitabine inhibits the reaction [Smoke results in decreased expression of AFF3 mRNA]21095227
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of AFF3 mRNA21266533
D004054DiethylstilbestrolDiethylstilbestrol results in increased expression of AFF3 mRNA19371625
D002117CalcitriolCalcitriol results in decreased expression of AFF3 mRNA16002434
D002117CalcitriolCalcitriol results in increased expression of AFF3 mRNA21592394|2648566
D002117Calcitriol[Testosterone co-treated with Calcitriol] results in increased expression of AFF3 mRNA21592394
C001277geldanamycingeldanamycin results in increased expression of AFF3 mRNA26705709
C010178heliotrineheliotrine results in decreased expression of AFF3 mRNA26100227
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of AFF3 mRNA24796395
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of AFF3 mRNA"25554681
C029938nickel sulfatenickel sulfate results in increased expression of AFF3 mRNA22714537
D010100OxygenOxygen deficiency results in increased expression of AFF3 mRNA26516004
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of AFF3 mRNA"27188386
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of AFF3 mRNA19710929
C027373potassium chromate(VI)potassium chromate(VI) results in increased expression of AFF3 mRNA22714537
D011441PropylthiouracilPropylthiouracil results in decreased expression of AFF3 mRNA24780913
D011763Pyrrolizidine AlkaloidsPyrrolizidine Alkaloids results in decreased expression of AFF3 mRNA26100227
C009237senecioninesenecionine results in decreased expression of AFF3 mRNA26100227
C009238senkirkinesenkirkine results in decreased expression of AFF3 mRNA26100227
D017632Asbestos, Serpentine"Asbestos, Serpentine results in increased expression of AFF3 mRNA"21148743
D012906Smokedecitabine inhibits the reaction [Smoke results in decreased expression of AFF3 mRNA]21095227
D012906SmokeSmoke results in decreased expression of AFF3 mRNA21095227
C017947sodium arsenitesodium arsenite affects the methylation of AFF3 gene28589171
D013739Testosterone[Testosterone co-treated with Calcitriol] results in increased expression of AFF3 mRNA21592394
D013739TestosteroneTestosterone results in increased expression of AFF3 mRNA21592394
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of AFF3 mRNA24058054
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of AFF3 mRNA19933214
D014028Tobacco Smoke PollutionTobacco Smoke Pollution affects the expression of AFF3 mRNA20133372
D014212TretinoinTretinoin results in increased expression of AFF3 mRNA21934132
C012589trichostatin Atrichostatin A results in increased expression of AFF3 mRNA24935251
C015559trimellitic anhydridetrimellitic anhydride results in increased expression of AFF3 mRNA19042947
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of AFF3 mRNA"27188386
D014635Valproic AcidValproic Acid results in increased expression of AFF3 mRNA23179753|2438349
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of AFF3 gene25560391

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003690double-stranded DNA binding-IBA21873635  
GO:0003690double-stranded DNA binding-IDA8555498  
GO:0003700DNA-binding transcription factor activity-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0006351transcription, DNA-templated-IEA-  
GO:0006355regulation of transcription, DNA-templated-IEA-  
GO:0034612response to tumor necrosis factor-IMP20444755  
GO:0035116embryonic hindlimb morphogenesis-IMP18616733  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IBA21873635  
GO:0005634nucleus-IDA8555498  
GO:0005654nucleoplasm-IDA-  
GO:0005829cytosol-IDA-  
GO:0008023transcription elongation factor complex-IBA21873635  
GO:0016604nuclear body-IDA-  
GO:0032783ELL-EAF complex-IBA21873635  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal