Gene info: ID 39

Gene: ACAT2

GENE ID: 39

Synonyms: -

Description: acetyl-CoA acetyltransferase 2

Gene type: protein-coding

Location: 6q25.3

dbXrefs: Ensembl:ENSG00000120437 MIM:100678 Vega:OTTHUMG00000015935 UniprotKB:Q9BWD1

RefSeq: NG_023389.1

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: ND

# Publications: 1

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 9.224e-1 (AD) 3.310e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
FDPS	0.93
HMGCS1	0.908
SQLE	0.902
HMGCR	0.899
SC5D	0.889
ACLY	0.881
DYNC1LI1	0.88
DHCR24	0.869
PRPS1	0.867
TIMM17A	0.863

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
OR4F5	-0.495
OR4F29	-0.46
MTRNR2L6	-0.45
MTRNR2L9	-0.437
MTRNR2L10	-0.431
MTRNR2L8	-0.425
MTRNR2L2	-0.407
P2RY14	-0.383
S100A12	-0.382
EVC2	-0.377

There is no DrugBank record for this gene !

ID	Drug Name	Action	PubMed
C049325	1,2-dithiol-3-thione	"1,2-dithiol-3-thione results in decreased expression of ACAT2 mRNA"	19162173
C018406	1-(3-trifluoromethylphenyl)piperazine	1-(3-trifluoromethylphenyl)piperazine results in increased expression of ACAT2 mRNA	26821219
C119129	18alpha-glycyrrhetinic acid	18alpha-glycyrrhetinic acid affects the reaction [1-Naphthylisothiocyanate affects the expression of ACAT2 mRNA]	28549656
C078092	1-piperonylpiperazine	1-piperonylpiperazine results in increased expression of ACAT2 mRNA	26821219
C492600	(2,3,5,6-tetrafluoro-4-methoxymethylphenyl)methyl-2,2-dimethyl-3-(1-propenyl)cyclopropanecarboxylate	"(2,3,5,6-tetrafluoro-4-methoxymethylphenyl)methyl-2,2-dimethyl-3-(1-propenyl)cyclopropanecarboxylate affects the expression of ACAT2 mRNA"	19176366
C029497	2,3-bis(3'-hydroxybenzyl)butyrolactone	"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of ACAT2 mRNA"	19167446
C014024	2,4,5,2',4',5'-hexachlorobiphenyl	"[Tetrachlorodibenzodioxin co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate co-treated with bisphenol A] results in decreased expression of ACAT2 mRNA"	28433925
C016403	2,4-dinitrotoluene	"2,4-dinitrotoluene affects the expression of ACAT2 mRNA"	21346803
C023514	2,6-dinitrotoluene	"2,6-dinitrotoluene affects the expression of ACAT2 mRNA"	21346803
C511621	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [Particulate Matter results in increased expression of ACAT2 mRNA]	28655636
C511621	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [Vehicle Emissions results in increased expression of ACAT2 mRNA]	28655636
C572491	3-(2-hydroxy-4-(2-methylnonan-2-yl)phenyl)cyclohexan-1-ol	3-(2-hydroxy-4-(2-methylnonan-2-yl)phenyl)cyclohexan-1-ol results in increased expression of ACAT2 protein	26194647
C023035	3,4,5,3',4'-pentachlorobiphenyl	"3,4,5,3',4'-pentachlorobiphenyl results in increased expression of ACAT2 mRNA"	23196670
D000082	Acetaminophen	Acetaminophen results in decreased expression of ACAT2 mRNA	11793227\|2906747
D000082	Acetaminophen	Acetaminophen affects the expression of ACAT2 mRNA	17562736
D020106	Acrylamide	Acrylamide results in decreased expression of ACAT2 mRNA	28959563
D016604	Aflatoxin B1	Aflatoxin B1 results in decreased expression of ACAT2 mRNA	27153756
D016604	Aflatoxin B1	Aflatoxin B1 results in decreased methylation of ACAT2 gene	27153756
D000497	Alloys	Alloys results in decreased expression of ACAT2 mRNA	23499988
C040534	alpha-hexachlorocyclohexane	alpha-hexachlorocyclohexane results in increased expression of ACAT2 mRNA	17785943
D000535	Aluminum	[APP protein modified form binds to Aluminum] which results in increased expression of ACAT2 mRNA	21298039
C519728	archazolid B	archazolid B results in increased expression of ACAT2 mRNA	25218289
C006632	arsenic trioxide	arsenic trioxide results in decreased expression of ACAT2 mRNA	19128835
D001379	Azathioprine	Azathioprine results in decreased expression of ACAT2 mRNA	22623647
D019324	beta-Naphthoflavone	AHR protein affects the reaction [beta-Naphthoflavone results in decreased expression of ACAT2 mRNA]	22234961
D019324	beta-Naphthoflavone	beta-Naphthoflavone results in decreased expression of ACAT2 mRNA	22234961
D019324	beta-Naphthoflavone	[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of ACAT2 mRNA	18164116
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of ACAT2 mRNA	21632981\|2217879
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of ACAT2 mRNA	22228805
C543008	bis(4-hydroxyphenyl)sulfone	bis(4-hydroxyphenyl)sulfone results in increased expression of ACAT2 mRNA	27685785
C006780	bisphenol A	bisphenol A affects the expression of ACAT2 mRNA	21786754
C006780	bisphenol A	bisphenol A results in increased expression of ACAT2 mRNA	25270620
C006780	bisphenol A	"[Tetrachlorodibenzodioxin co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate co-treated with bisphenol A] results in decreased expression of ACAT2 mRNA"	28433925
C006780	bisphenol A	bisphenol A affects the expression of ACAT2 mRNA	25181051
D015124	8-Bromo Cyclic Adenosine Monophosphate	8-Bromo Cyclic Adenosine Monophosphate results in increased expression of ACAT2 mRNA	22079614
C584509	C646 compound	C646 compound results in decreased expression of ACAT2 mRNA	26191083
D019256	Cadmium Chloride	Cadmium Chloride results in increased expression of ACAT2 protein	24527689
D002110	Caffeine	Caffeine results in decreased expression of ACAT2 mRNA	11793227
D002251	Carbon Tetrachloride	Carbon Tetrachloride results in decreased expression of ACAT2 mRNA	27339419
D004390	Chlorpyrifos	Chlorpyrifos results in increased expression of ACAT2 mRNA	21356183
D004390	Chlorpyrifos	[Copper co-treated with Chlorpyrifos] results in increased expression of ACAT2 mRNA	21356183
D003024	Clozapine	Clozapine results in increased expression of ACAT2 mRNA	17052361
D003300	Copper	[Copper co-treated with Chlorpyrifos] results in increased expression of ACAT2 mRNA	21356183
D003300	Copper	Copper results in increased expression of ACAT2 mRNA	21356183
D003300	Copper	[NSC 689534 binds to Copper] which results in decreased expression of ACAT2 mRNA	20971185
D019327	Copper Sulfate	Copper Sulfate results in decreased expression of ACAT2 mRNA	19549813
D003375	Coumestrol	"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of ACAT2 mRNA"	19167446
D003375	Coumestrol	Coumestrol results in increased expression of ACAT2 mRNA	19167446
C029892	cupric chloride	cupric chloride results in increased expression of ACAT2 mRNA	19174923
C057862	cyanoginosin LR	cyanoginosin LR affects the expression of ACAT2 protein	26984711
D016572	Cyclosporine	Cyclosporine results in decreased expression of ACAT2 mRNA	20106945\|2163298
D016572	Cyclosporine	Cyclosporine results in decreased expression of ACAT2 mRNA	23830897
C093628	cyproconazole	[cyproconazole co-treated with epoxiconazole] results in increased expression of ACAT2 mRNA	29038839
C014347	decitabine	decitabine affects the expression of ACAT2 mRNA	23300844
D003907	Dexamethasone	Dexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of ACAT2 mRNA]	27941970
D003907	Dexamethasone	Dexamethasone results in increased expression of ACAT2 mRNA	25047013
D003993	Dibutyl Phthalate	Dibutyl Phthalate results in increased expression of ACAT2 mRNA	21266533
D002945	Cisplatin	Cisplatin affects the expression of ACAT2 mRNA	23300844
D002945	Cisplatin	[Cisplatin co-treated with jinfukang] results in increased expression of ACAT2 mRNA	27392435
D002945	Cisplatin	Cisplatin results in increased expression of ACAT2 mRNA	27392435
C000944	dicrotophos	dicrotophos results in decreased expression of ACAT2 mRNA	28302478
C036042	dicyclohexyl phthalate	dicyclohexyl phthalate affects the expression of ACAT2 mRNA	26924002
D004041	Dietary Fats	Dietary Fats results in decreased expression of ACAT2 mRNA	18042831
D004051	Diethylhexyl Phthalate	Diethylhexyl Phthalate results in increased expression of ACAT2 mRNA	19850644
D004051	Diethylhexyl Phthalate	"[Tetrachlorodibenzodioxin co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate co-treated with bisphenol A] results in decreased expression of ACAT2 mRNA"	28433925
D004052	Diethylnitrosamine	[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of ACAT2 mRNA	18164116
D004052	Diethylnitrosamine	Diethylnitrosamine results in increased expression of ACAT2 mRNA	19638242
C024629	dimethyl phthalate	dimethyl phthalate affects the expression of ACAT2 mRNA	26924002
D004147	Dioxins	Dioxins affects the expression of ACAT2 mRNA	20463971
D004237	Diuron	Diuron results in decreased expression of ACAT2 mRNA	21551480
C118739	entinostat	entinostat results in decreased expression of ACAT2 mRNA	27188386
D004791	Enzyme Inhibitors	[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of ACAT2 protein	23301498
C109476	epoxiconazole	[cyproconazole co-treated with epoxiconazole] results in increased expression of ACAT2 mRNA	29038839
D000431	Ethanol	Ethanol results in increased expression of ACAT2 mRNA	19167417
D004997	Ethinyl Estradiol	Ethinyl Estradiol affects the expression of ACAT2 mRNA	17555576
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in increased expression of ACAT2 mRNA	17942748
D004997	Ethinyl Estradiol	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of ACAT2 mRNA	17942748
D004997	Ethinyl Estradiol	Ethinyl Estradiol affects the expression of ACAT2 mRNA	17351261
C002994	ethylene dimethanesulfonate	ethylene dimethanesulfonate results in decreased expression of ACAT2 mRNA	22711419
D015025	Zearalenone	Zearalenone results in decreased expression of ACAT2 protein	25058043
D005228	Fatty Acids, Essential	"Fatty Acids, Essential deficiency results in increased expression of ACAT2 mRNA"	23333450
C061365	flusilazole	flusilazole results in decreased expression of ACAT2 mRNA	22382673
C061365	flusilazole	flusilazole results in increased expression of ACAT2 mRNA	22382673
D005485	Flutamide	Flutamide results in increased expression of ACAT2 mRNA	21525395
D005485	Flutamide	Flutamide results in increased expression of ACAT2 protein	17311803
D005557	Formaldehyde	Formaldehyde results in decreased expression of ACAT2 mRNA	23649840
D019695	Glycyrrhizic Acid	Glycyrrhizic Acid affects the reaction [1-Naphthylisothiocyanate affects the expression of ACAT2 mRNA]	28549656
C412815	GW 4064	GW 4064 results in increased expression of ACAT2 mRNA	26655953
D006820	Hyaluronic Acid	Hyaluronic Acid analog inhibits the reaction [Hydrogen Peroxide results in decreased expression of ACAT2 protein]	23178681
D006820	Hyaluronic Acid	Hyaluronic Acid analog results in decreased expression of ACAT2 protein	23178681
D006830	Hydralazine	[Hydralazine co-treated with Valproic Acid] results in increased expression of ACAT2 mRNA	17183730
D006861	Hydrogen Peroxide	[isoquercitrin co-treated with Hydrogen Peroxide] results in increased expression of ACAT2 mRNA	18032389
D006861	Hydrogen Peroxide	Hyaluronic Acid analog inhibits the reaction [Hydrogen Peroxide results in decreased expression of ACAT2 protein]	23178681
D006861	Hydrogen Peroxide	Hydrogen Peroxide results in decreased expression of ACAT2 protein	23178681
C492448	ICG 001	ICG 001 results in decreased expression of ACAT2 mRNA	26191083
D015759	Ionomycin	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of ACAT2 mRNA	25613284
C016527	isoquercitrin	[isoquercitrin co-treated with Hydrogen Peroxide] results in increased expression of ACAT2 mRNA	18032389
C544151	jinfukang	[Cisplatin co-treated with jinfukang] results in increased expression of ACAT2 mRNA	27392435
C544151	jinfukang	jinfukang results in increased expression of ACAT2 mRNA	27392435
C410337	K 7174	K 7174 results in decreased expression of ACAT2 mRNA	24086573
D007649	Ketamine	Ketamine results in decreased expression of ACAT2 mRNA	20080153
C008261	lead acetate	lead acetate results in decreased expression of ACAT2 mRNA	21829687
D008345	Manganese	Manganese results in decreased expression of ACAT2 mRNA	23499988
D008627	Mercuric Chloride	Mercuric Chloride affects the expression of ACAT2 mRNA	20353558
C030667	methylazoxymethanol	methylazoxymethanol results in increased expression of ACAT2 mRNA	17107856
C517284	monomethyl phthalate	monomethyl phthalate affects the expression of ACAT2 mRNA	26924002
C523799	MRK 003	MRK 003 results in decreased expression of ACAT2 mRNA	21169257
D037742	Nanotubes, Carbon	"Nanotubes, Carbon analog results in decreased expression of ACAT2 mRNA"	25620056
D037742	Nanotubes, Carbon	"Nanotubes, Carbon analog results in increased expression of ACAT2 mRNA"	25554681
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in decreased expression of ACAT2 mRNA"	25620056
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in increased expression of ACAT2 mRNA"	25554681
D015058	1-Naphthylisothiocyanate	18alpha-glycyrrhetinic acid affects the reaction [1-Naphthylisothiocyanate affects the expression of ACAT2 mRNA]	28549656
D015058	1-Naphthylisothiocyanate	1-Naphthylisothiocyanate affects the expression of ACAT2 mRNA	28549656
D015058	1-Naphthylisothiocyanate	Glycyrrhizic Acid affects the reaction [1-Naphthylisothiocyanate affects the expression of ACAT2 mRNA]	28549656
C461488	N-benzylpiperazine	N-benzylpiperazine results in increased expression of ACAT2 mRNA	26821219
D009532	Nickel	Nickel results in decreased expression of ACAT2 mRNA	24768652
C558013	NSC 689534	[NSC 689534 binds to Copper] which results in decreased expression of ACAT2 mRNA	20971185
D000073878	Palm Oil	Palm Oil results in decreased expression of ACAT2 mRNA	18042831
D052638	Particulate Matter	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [Particulate Matter results in increased expression of ACAT2 mRNA]	28655636
D052638	Particulate Matter	Particulate Matter results in increased expression of ACAT2 mRNA	28655636
C471071	perfluorohexanesulfonic acid	perfluorohexanesulfonic acid results in increased expression of ACAT2 mRNA	21705711
C076994	perfluorooctane sulfonic acid	perfluorooctane sulfonic acid results in increased expression of ACAT2 mRNA	20936131
C023036	perfluorooctanoic acid	perfluorooctanoic acid results in decreased expression of ACAT2 mRNA	23427857
C023036	perfluorooctanoic acid	perfluorooctanoic acid results in increased expression of ACAT2 mRNA	23427857
C023036	perfluorooctanoic acid	perfluorooctanoic acid results in increased expression of ACAT2 mRNA	18467677
C023036	perfluorooctanoic acid	PPARA protein promotes the reaction [perfluorooctanoic acid results in increased expression of ACAT2 mRNA]	18467677
C027579	periodate-oxidized adenosine	periodate-oxidized adenosine affects the expression of ACAT2 mRNA	17097637
C058305	phenethyl isothiocyanate	phenethyl isothiocyanate results in decreased expression of ACAT2 mRNA	26678675
D010634	Phenobarbital	Phenobarbital results in decreased expression of ACAT2 mRNA	19270015
D010634	Phenobarbital	Phenobarbital results in increased expression of ACAT2 mRNA	19162173
D010656	Phenylephrine	Phenylephrine results in increased expression of ACAT2 mRNA	18158353
C006253	pirinixic acid	pirinixic acid results in decreased expression of ACAT2 mRNA	17426115\|1844570
C006253	pirinixic acid	pirinixic acid results in increased expression of ACAT2 mRNA	18467677\|2005976
C006253	pirinixic acid	PPARA protein promotes the reaction [pirinixic acid results in increased expression of ACAT2 mRNA]	18467677\|2005976
D011192	Potassium Dichromate	Potassium Dichromate results in increased expression of ACAT2 protein	23718831
D011285	Pregnenolone Carbonitrile	Pregnenolone Carbonitrile results in decreased expression of ACAT2 mRNA	28903501
D011285	Pregnenolone Carbonitrile	Pregnenolone Carbonitrile results in decreased expression of ACAT2 mRNA	19162173
D011374	Progesterone	Progesterone results in increased expression of ACAT2 mRNA	18070364
D011794	Quercetin	Quercetin results in decreased expression of ACAT2 mRNA	21632981
D015125	Oxyquinoline	Oxyquinoline results in decreased expression of ACAT2 mRNA	21632981
D015474	Isotretinoin	Isotretinoin results in decreased expression of ACAT2 mRNA	20436886
C089730	rosiglitazone	rosiglitazone affects the expression of ACAT2 mRNA	22013433
D012524	Sarin	Sarin results in decreased expression of ACAT2 mRNA	19522546
D012524	Sarin	Sarin results in increased expression of ACAT2 mRNA	19522546
D012822	Silicon Dioxide	Silicon Dioxide analog results in decreased expression of ACAT2 mRNA	23806026
C009277	sodium arsenate	sodium arsenate results in increased expression of ACAT2 mRNA	23922661
C017947	sodium arsenite	sodium arsenite affects the methylation of ACAT2 gene	28589171
C016104	sodium bichromate	sodium bichromate results in decreased expression of ACAT2 mRNA	24612858
D013605	T-2 Toxin	T-2 Toxin affects the expression of ACAT2 protein	26141394
D013629	Tamoxifen	Tamoxifen affects the expression of ACAT2 mRNA	17555576
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of ACAT2 mRNA	21570461
D013749	Tetrachlorodibenzodioxin	"[Tetrachlorodibenzodioxin co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate co-treated with bisphenol A] results in decreased expression of ACAT2 mRNA"	28433925
D013749	Tetrachlorodibenzodioxin	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of ACAT2 mRNA	17942748
D013752	Tetracycline	Tetracycline results in decreased expression of ACAT2 mRNA	24489787
D013752	Tetracycline	Tetracycline results in increased expression of ACAT2 mRNA	16917069
D013755	Tetradecanoylphorbol Acetate	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of ACAT2 mRNA	25613284
D019284	Thapsigargin	Thapsigargin results in decreased expression of ACAT2 mRNA	22378314
D013853	Thioacetamide	Thioacetamide results in decreased expression of ACAT2 mRNA	11793227
D013853	Thioacetamide	Thioacetamide results in increased expression of ACAT2 mRNA	26222700
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution results in decreased expression of ACAT2 mRNA	28065790
C066340	tolcapone	tolcapone results in increased expression of ACAT2 mRNA	24136188
D019772	Topotecan	ACAT2 protein affects the susceptibility to Topotecan	16217747
D014212	Tretinoin	Tretinoin results in decreased expression of ACAT2 mRNA	23724009
D014241	Trichloroethylene	Trichloroethylene results in increased methylation of ACAT2 gene	27618143
C012589	trichostatin A	trichostatin A results in increased expression of ACAT2 mRNA	15901671
C016805	tris(1,3-dichloro-2-propyl)phosphate	"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of ACAT2 mRNA"	26179874
C057693	troglitazone	troglitazone results in increased expression of ACAT2 protein	21315101
D014415	Tunicamycin	Tunicamycin results in decreased expression of ACAT2 mRNA	22378314
D014501	Uranium	Uranium affects the expression of ACAT2 mRNA	15672453
C005460	uranyl acetate	uranyl acetate affects the expression of ACAT2 mRNA	15672453
D014520	Urethane	Urethane results in decreased expression of ACAT2 mRNA	28818685
C406224	valdecoxib	valdecoxib results in increased expression of ACAT2 mRNA	24136188
D014635	Valproic Acid	[Hydralazine co-treated with Valproic Acid] results in increased expression of ACAT2 mRNA	17183730
D014635	Valproic Acid	Valproic Acid affects the expression of ACAT2 mRNA	25979313
D014635	Valproic Acid	Valproic Acid results in decreased expression of ACAT2 mRNA	19101580\|2317975
D014635	Valproic Acid	Valproic Acid affects the expression of ACAT2 mRNA	17292431
D014635	Valproic Acid	Valproic Acid results in increased expression of ACAT2 mRNA	23665938
D014635	Valproic Acid	Valproic Acid results in increased expression of ACAT2 mRNA	15901671
D001335	Vehicle Emissions	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [Vehicle Emissions results in increased expression of ACAT2 mRNA]	28655636
D001335	Vehicle Emissions	Vehicle Emissions results in increased expression of ACAT2 mRNA	28655636
D001335	Vehicle Emissions	Vehicle Emissions results in decreased methylation of ACAT2 gene	25560391
D014747	Vinblastine	ACAT2 protein affects the susceptibility to Vinblastine	16217747
D024483	Vitamin K 3	Vitamin K 3 affects the expression of ACAT2 mRNA	20044591
C088658	zoledronic acid	zoledronic acid results in increased expression of ACAT2 mRNA	24714768

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0003857	3-hydroxyacyl-CoA dehydrogenase activity	-	IBA	21873635
GO:0003985	acetyl-CoA C-acetyltransferase activity	-	IBA	21873635
GO:0003985	acetyl-CoA C-acetyltransferase activity	-	IDA	7911016
GO:0003985	acetyl-CoA C-acetyltransferase activity	-	TAS	-
GO:0003988	acetyl-CoA C-acyltransferase activity	-	IBA	21873635
GO:0004300	enoyl-CoA hydratase activity	-	IBA	21873635
GO:0005515	protein binding	-	IPI	21044950 25416956

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0006629	lipid metabolic process	-	IC	7911016
GO:0006635	fatty acid beta-oxidation	-	IBA	21873635
GO:0006695	cholesterol biosynthetic process	-	TAS	-
GO:0006696	ergosterol biosynthetic process	-	IBA	21873635

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005634	nucleus	-	IDA	-
GO:0005730	nucleolus	-	IDA	-
GO:0005737	cytoplasm	-	IDA	7911016
GO:0005739	mitochondrion	-	IBA	21873635
GO:0005829	cytosol	-	IBA	21873635
GO:0005829	cytosol	-	IDA	-
GO:0005829	cytosol	-	TAS	-
GO:0070062	extracellular exosome	-	HDA	23533145

KEGG ID	KEGG Term
hsa00071	Fatty acid degradation
hsa00072	Synthesis and degradation of ketone bodies
hsa00280	Valine, leucine and isoleucine degradation
hsa00310	Lysine degradation
hsa00380	Tryptophan metabolism
hsa00620	Pyruvate metabolism
hsa00630	Glyoxylate and dicarboxylate metabolism
hsa00640	Propanoate metabolism
hsa00650	Butanoate metabolism
hsa00900	Terpenoid backbone biosynthesis
hsa01100	Metabolic pathways
hsa04975	Fat digestion and absorption

Reactome ID	Reactome Term	Evidence
R-HSA-1430728	Metabolism	TAS
R-HSA-191273	Cholesterol biosynthesis	TAS
R-HSA-556833	Metabolism of lipids	TAS
R-HSA-8957322	Metabolism of steroids	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
18339850	Promoter methylation of genes in and around the candidate lung cancer susceptibility locus 6q23-25. (2008 Mar 15)	Tessema M	Cancer Res