Gene: LAG3

3902
CD223
lymphocyte activating 3
protein-coding
12p13.31
Ensembl:ENSG00000089692 MIM:153337 Vega:OTTHUMG00000169197 UniprotKB:P18627
NC_000012.12
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
9.068e-1 (AD)  2.559e-3 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
IDO10.888
KRTAP20-10.887
ZBP10.867
RUFY40.861
CCL70.859
CYP19A10.845
CCL80.837
IL270.821
LAMP30.811
STAP10.788

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SNX22-0.258
MRO-0.235
ACBD7-0.229
SLC14A1-0.229
MYOM1-0.227
FAT1-0.226
LRTOMT-0.226
FBXL22-0.21
SHISA6-0.207
MYBPC1-0.202

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0264861,2,5,6-dibenzanthracene"1,2,5,6-dibenzanthracene results in decreased expression of LAG3 mRNA"26377693
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of LAG3 mRNA24449571
D001151ArsenicArsenic affects the expression of LAG3 mRNA28793237
C015001arsenitearsenite affects the expression of LAG3 mRNA22959463
D001564Benzo(a)pyreneAHR protein affects the reaction [Benzo(a)pyrene affects the expression of LAG3 mRNA]22228805
C006780bisphenol Abisphenol A results in decreased methylation of LAG3 promoter27312807
C006780bisphenol Abisphenol A affects the expression of LAG3 mRNA25181051
D002994ClofibrateClofibrate results in decreased expression of LAG3 mRNA17585979
D019327Copper SulfateCopper Sulfate results in increased expression of LAG3 mRNA19549813
C014347decitabinedecitabine affects the expression of LAG3 mRNA23300844
D002945CisplatinCisplatin affects the expression of LAG3 mRNA23300844
D002945CisplatinCisplatin results in decreased expression of LAG3 mRNA27392435
C121718dicyclanildicyclanil results in increased expression of LAG3 mRNA15664270
D004041Dietary FatsDietary Fats results in increased expression of LAG3 mRNA25016146
D005557FormaldehydeFormaldehyde results in increased expression of LAG3 mRNA28937961
C546771gardiquimodgardiquimod results in increased expression of LAG3 mRNA28003376
C546771gardiquimodProtein Kinase Inhibitors inhibits the reaction [gardiquimod results in increased expression of LAG3 mRNA]28003376
D017313FenretinideFenretinide results in decreased expression of LAG3 mRNA28973697
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of LAG3 mRNA25613284
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of LAG3 mRNA23086925
D009532NickelNickel results in increased expression of LAG3 mRNA24768652
D009966OrphenadrineOrphenadrine affects the expression of LAG3 mRNA23665939
C101814perfluoro-n-undecanoic acidperfluoro-n-undecanoic acid results in increased expression of LAG3 mRNA23602845
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of LAG3 mRNA19710929
D010936Plant ExtractsPlant Extracts results in decreased expression of LAG3 mRNA23557933
D047428Protein Kinase InhibitorsProtein Kinase Inhibitors inhibits the reaction [gardiquimod results in increased expression of LAG3 mRNA]28003376
D013739TestosteroneTestosterone results in decreased expression of LAG3 mRNA20844152
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of LAG3 mRNA21570461
D013750TetrachloroethyleneTetrachloroethylene results in decreased expression of LAG3 mRNA28973375
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of LAG3 mRNA25613284
D013853ThioacetamideThioacetamide results in decreased expression of LAG3 mRNA23411599
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of LAG3 mRNA28065790
C015559trimellitic anhydridetrimellitic anhydride results in increased expression of LAG3 mRNA19042947
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of LAG3 mRNA"26179874
C013320tris(2-butoxyethyl) phosphatetris(2-butoxyethyl) phosphate affects the expression of LAG3 mRNA29024780
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of LAG3 gene25560391

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003823antigen binding-TAS1692078  
GO:0004888transmembrane signaling receptor activity-IEA-  
GO:0042289MHC class II protein binding-IDA9159144  
GO ID GO Term Qualifier Evidence PubMed
GO:0007166cell surface receptor signaling pathway-IEA-  
GO:0019886antigen processing and presentation of exogenous peptide antigen via MHC class II-TAS-  
GO:0045085negative regulation of interleukin-2 biosynthetic process-IEA-  
GO:0045954positive regulation of natural killer cell mediated cytotoxicity-IEA-  
GO:0050868negative regulation of T cell activation-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005886plasma membrane-TAS-  
GO:0009897external side of plasma membrane-IEA-  
GO:0016021integral component of membrane-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1280218Adaptive Immune SystemTAS
R-HSA-168256Immune SystemTAS
R-HSA-2132295MHC class II antigen presentationTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
29716923Interferon Gamma Messenger RNA Signature in Tumor Biopsies Predicts Outcomes in Patients with Non-Small-Cell Lung Carcinoma or Urothelial Cancer Treated with Durvalumab. (2018 May 1)Higgs BWClin Cancer Res