Gene: LAMA5

3911
-
laminin subunit alpha 5
protein-coding
20q13.33
Ensembl:ENSG00000130702 MIM:601033 Vega:OTTHUMG00000032908 UniprotKB:O15230
NG_050626.1
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
5.852e-1 (AD)  4.060e-1 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg08597733chr20:60886158LAMA5Gene body5.136e-4Alcohol use disorders26763658

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
NBEAL20.909
PXN0.837
DOCK60.833
ITPR30.829
SCARF10.827
HDAC70.822
EHBP1L10.801
MYO1C0.792
SLC26A60.79
PODXL0.788

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CRH-0.365
OR4F29-0.345
OR4F5-0.338
NKX2-8-0.305
GSDMC-0.287
SMIM18-0.281
MYCNOS-0.271
ALG1L-0.267
C1orf53-0.262
FAM180B-0.253

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB06245LanoteplaseBiotechDrug171870-23-8InvestigationalTarget
ID Drug Name Action PubMed
C0297902,2',3',4,4',5-hexachlorobiphenyl"2,2',3',4,4',5-hexachlorobiphenyl results in decreased expression of LAMA5 mRNA"23829299
C0094072,5,2',5'-tetrachlorobiphenyl"2,5,2',5'-tetrachlorobiphenyl results in decreased expression of LAMA5 mRNA"23829299
C0065932-anthramine2-anthramine results in increased expression of LAMA5 mRNA23038007
C0194992-nitrofluorene2-nitrofluorene results in increased expression of LAMA5 mRNA22484513
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of LAMA5 mRNA"27188386
C0352074-amino-2,6-dinitrotoluene"4-amino-2,6-dinitrotoluene affects the expression of LAMA5 mRNA"21346803
C0165834-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of LAMA5 mRNA22484513
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of LAMA5 mRNA"27188386
D000082AcetaminophenAcetaminophen affects the expression of LAMA5 mRNA17562736
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of LAMA5 mRNA22484513|2363061
D000452AldrinAldrin results in increased expression of LAMA5 mRNA18579281
D013196DihydrotestosteroneDihydrotestosterone results in increased expression of LAMA5 mRNA17023530
D001151ArsenicArsenic results in increased methylation of LAMA5 gene24525453
D019324beta-Naphthoflavone[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of LAMA5 mRNA18164116
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of LAMA5 mRNA20106945|2163298
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of LAMA5 mRNA27195522
C044887beta-methylcholinebeta-methylcholine affects the expression of LAMA5 mRNA21179406
C006780bisphenol Abisphenol A results in increased expression of LAMA5 mRNA26364221
C006780bisphenol Abisphenol A results in increased expression of LAMA5 mRNA25181051
C000611646bisphenol F[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of LAMA5 mRNA28628672
C032688boric acidboric acid results in increased expression of LAMA5 mRNA27206737
C032688boric acidboric acid results in increased expression of LAMA5 mRNA27206737
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in decreased expression of LAMA5 mRNA15336504
C018475butyraldehydebutyraldehyde results in decreased expression of LAMA5 mRNA26079696
C584509C646 compoundC646 compound results in increased expression of LAMA5 mRNA26191083
D002251Carbon TetrachlorideCarbon Tetrachloride affects the expression of LAMA5 mRNA17484886
C010063carbonyl sulfidecarbonyl sulfide results in increased expression of LAMA5 mRNA19395590
C100187chloropicrinchloropicrin results in increased expression of LAMA5 mRNA26352163
D004390Chlorpyrifos[Copper co-treated with Chlorpyrifos] results in decreased expression of LAMA5 mRNA21356183
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of LAMA5 mRNA20938992
C031180chrysenechrysene results in increased expression of LAMA5 mRNA26377693
C018021cobaltous chloridecobaltous chloride results in decreased secretion of LAMA5 protein22079246
D003300Copper[Copper co-treated with Chlorpyrifos] results in decreased expression of LAMA5 mRNA21356183
D019327Copper SulfateCopper Sulfate results in increased expression of LAMA5 mRNA18579281
D003471CuprizoneCuprizone results in increased expression of LAMA5 mRNA26577399
D016572CyclosporineCyclosporine results in decreased expression of LAMA5 mRNA25562108|2798913
D016047Zalcitabine"[gp120 protein, Human immunodeficiency virus 1 co-treated with Zalcitabine] results in increased expression of LAMA5 mRNA"18606552
C010902decabromobiphenyl etherdecabromobiphenyl ether results in increased expression of LAMA5 mRNA23640034|2391405
C014347decitabinedecitabine affects the expression of LAMA5 mRNA23300844
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of LAMA5 mRNA28628672
D003907DexamethasoneDexamethasone results in decreased expression of LAMA5 mRNA20032058
D003907DexamethasoneTestosterone inhibits the reaction [Dexamethasone results in decreased expression of LAMA5 mRNA]20032058
D002945CisplatinCisplatin affects the expression of LAMA5 mRNA23300844
D002945CisplatinCisplatin results in decreased expression of LAMA5 mRNA27392435
C000944dicrotophosdicrotophos results in increased expression of LAMA5 mRNA28302478
D004026DieldrinDieldrin results in decreased expression of LAMA5 mRNA23041725
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of LAMA5 mRNA18164116
D002117CalcitriolCalcitriol results in increased expression of LAMA5 mRNA26485663
D0198131,2-Dimethylhydrazine"[APC protein affects the susceptibility to 1,2-Dimethylhydrazine] which results in increased expression of LAMA5 mRNA"27840820
D004147DioxinsDioxins affects the expression of LAMA5 mRNA20463971
D004237DiuronDiuron results in decreased expression of LAMA5 mRNA21551480
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of LAMA5 mRNA17942748
C540355fenamidonefenamidone results in increased expression of LAMA5 mRNA27029645
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of LAMA5 mRNA20938992
D006072Gossypol[zoledronic acid co-treated with Gossypol] results in decreased expression of LAMA5 mRNA19825521
C514793gp120 protein, Human immunodeficiency virus 1"[gp120 protein, Human immunodeficiency virus 1 co-treated with Zalcitabine] results in increased expression of LAMA5 mRNA"18606552
D017313FenretinideFenretinide results in increased expression of LAMA5 mRNA28973697
D006861Hydrogen PeroxideHydrogen Peroxide affects the expression of LAMA5 mRNA21179406
C492448ICG 001ICG 001 results in increased expression of LAMA5 mRNA26191083
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of LAMA5 mRNA28628672
D007213IndomethacinIndomethacin results in increased expression of LAMA5 mRNA28201806
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of LAMA5 mRNA28628672
C410337K 7174K 7174 results in decreased expression of LAMA5 mRNA24086573
C008261lead acetatelead acetate results in increased expression of LAMA5 mRNA22609695
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of LAMA5 mRNA20938992
D008748Methylcholanthrene[Methylcholanthrene co-treated with Tetradecanoylphorbol Acetate] results in increased expression of LAMA5 mRNA23519560
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of LAMA5 mRNA26011545
D008777MethyltestosteroneMethyltestosterone results in decreased expression of LAMA5 mRNA29191790
D015735MifepristoneMifepristone results in decreased expression of LAMA5 mRNA25972201
C568376MT19c compoundMT19c compound results in decreased expression of LAMA5 mRNA21781307
D009151Mustard GasMustard Gas results in decreased expression of LAMA5 protein12880345
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of LAMA5 mRNA"24389112
C028007nickel monoxidenickel monoxide results in increased expression of LAMA5 mRNA19167457
C472349oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholineoxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine affects the expression of LAMA5 mRNA17655762
C472349oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholineoxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine promotes the reaction [Particulate Matter affects the expression of LAMA5 mRNA]17655762
C472349oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholineoxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine promotes the reaction [Vehicle Emissions affects the expression of LAMA5 mRNA]17655762
C472349oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholineParticulate Matter promotes the reaction [oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine affects the expression of LAMA5 mRNA]17655762
C472349oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholineVehicle Emissions promotes the reaction [oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine affects the expression of LAMA5 mRNA]17655762
D052638Particulate Matteroxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine promotes the reaction [Particulate Matter affects the expression of LAMA5 mRNA]17655762
D052638Particulate MatterParticulate Matter affects the expression of LAMA5 mRNA17655762
D052638Particulate MatterParticulate Matter promotes the reaction [oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine affects the expression of LAMA5 mRNA]17655762
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of LAMA5 protein26879310
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of LAMA5 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of LAMA5 mRNA26272509
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of LAMA5 mRNA19710929
D010936Plant ExtractsPlant Extracts results in decreased expression of LAMA5 mRNA23557933
D011192Potassium DichromatePotassium Dichromate results in increased expression of LAMA5 mRNA23608068
C513428pyrachlostrobinpyrachlostrobin results in increased expression of LAMA5 mRNA27029645
C009166retinol acetateretinol acetate results in increased expression of LAMA5 mRNA16772331
D012906SmokeSmoke results in decreased expression of LAMA5 mRNA21095227
C538809sodium pentaboratesodium pentaborate analog results in increased expression of LAMA5 mRNA27206737
C538809sodium pentaboratesodium pentaborate analog results in increased expression of LAMA5 mRNA27206737
D013605T-2 ToxinT-2 Toxin results in increased expression of LAMA5 mRNA26141394
D013629TamoxifenTamoxifen affects the expression of LAMA5 mRNA14699072
D013739TestosteroneTestosterone inhibits the reaction [Dexamethasone results in decreased expression of LAMA5 mRNA]20032058
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of LAMA5 mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of LAMA5 mRNA22298810
D013755Tetradecanoylphorbol Acetate[Methylcholanthrene co-treated with Tetradecanoylphorbol Acetate] results in increased expression of LAMA5 mRNA23519560
D013853ThioacetamideThioacetamide results in increased expression of LAMA5 mRNA23411599
C009495titanium dioxide[Vitallium analog binds to titanium dioxide] which results in increased expression of LAMA5 mRNA23825117
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of LAMA5 mRNA27865774|2806579
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of LAMA5 mRNA28111298
D014118Toxins, Biological"Toxins, Biological affects the expression of LAMA5 mRNA"19682533
D014212TretinoinTretinoin results in increased expression of LAMA5 mRNA17138961
D014212TretinoinTretinoin results in increased expression of LAMA5 mRNA24977338
D017973Tungsten CompoundsTungsten Compounds results in decreased expression of LAMA5 mRNA28666766
D014635Valproic AcidValproic Acid results in decreased expression of LAMA5 mRNA29154799
D001335Vehicle Emissionsoxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine promotes the reaction [Vehicle Emissions affects the expression of LAMA5 mRNA]17655762
D001335Vehicle EmissionsVehicle Emissions affects the expression of LAMA5 mRNA17655762
D001335Vehicle EmissionsVehicle Emissions promotes the reaction [oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine affects the expression of LAMA5 mRNA]17655762
C025643vinclozolinvinclozolin results in decreased expression of LAMA5 mRNA23034163
D014800Vitallium[Vitallium analog binds to titanium dioxide] which results in increased expression of LAMA5 mRNA23825117
D014800VitalliumVitallium analog results in increased expression of LAMA5 mRNA23825117
D024483Vitamin K 3Vitamin K 3 affects the expression of LAMA5 mRNA20044591
D015032ZincZinc deficiency results in increased expression of LAMA5 mRNA22171008
C088658zoledronic acid[zoledronic acid co-treated with Gossypol] results in decreased expression of LAMA5 mRNA19825521

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005178integrin binding-IDA11821406  
GO ID GO Term Qualifier Evidence PubMed
GO:0001525angiogenesis-NAS11821406  
GO:0001658branching involved in ureteric bud morphogenesis-IEA-  
GO:0001738morphogenesis of a polarized epithelium-IEA-  
GO:0001755neural crest cell migration-IEA-  
GO:0001942hair follicle development-IEA-  
GO:0007010cytoskeleton organization-NAS11821406  
GO:0007229integrin-mediated signaling pathway-IMP11821406  
GO:0007517muscle organ development-IEA-  
GO:0008037cell recognition-NAS11821406  
GO:0008283cell proliferation-NAS11821406  
GO:0016331morphogenesis of embryonic epithelium-IEA-  
GO:0016477cell migration-IDA11821406  
GO:0019221cytokine-mediated signaling pathway-TAS-  
GO:0030154cell differentiation-NAS11821406  
GO:0030155regulation of cell adhesion-IEA-  
GO:0030198extracellular matrix organization-TAS-  
GO:0030324lung development-IEA-  
GO:0030334regulation of cell migration-IEA-  
GO:0034446substrate adhesion-dependent cell spreading-IDA16236823  
GO:0042127regulation of cell proliferation-IEA-  
GO:0042475odontogenesis of dentin-containing tooth-IEA-  
GO:0045446endothelial cell differentiation-NAS11821406  
GO:0045995regulation of embryonic development-IEA-  
GO:0048041focal adhesion assembly-NAS11821406  
GO:0060271cilium assembly-IEA-  
GO:0060445branching involved in salivary gland morphogenesis-IEA-  
GO:0072659protein localization to plasma membrane-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-TAS-  
GO:0005604basement membrane-IDA14557481  
GO:0005605basal lamina-NAS11821406  
GO:0005610laminin-5 complex-IEA-  
GO:0005615extracellular space-IDA10964500  
GO:0005634nucleus-HDA21630459  
GO:0031012extracellular matrix-HDA23658023  
GO:0043083synaptic cleft-IEA-  
GO:0043259laminin-10 complex-IDA10964500  
GO:0043259laminin-10 complex-TAS16236823  
GO:0043260laminin-11 complex-TAS16236823  
GO:0062023collagen-containing extracellular matrix-HDA27068509  27559042  
GO:0062023collagen-containing extracellular matrixcolocalizes_withHDA20551380  
GO:0070062extracellular exosome-HDA19056867  19199708  23533145  
KEGG ID KEGG Term
hsa04510Focal adhesion
hsa04512ECM-receptor interaction
hsa05145Toxoplasmosis
hsa05146Amoebiasis
hsa05200Pathways in cancer
hsa05222Small cell lung cancer
Reactome ID Reactome Term Evidence
R-HSA-1280215Cytokine Signaling in Immune systemTAS
R-HSA-1474228Degradation of the extracellular matrixIEA
R-HSA-1474244Extracellular matrix organizationIEA
R-HSA-1474244Extracellular matrix organizationTAS
R-HSA-162582Signal TransductionTAS
R-HSA-168256Immune SystemTAS
R-HSA-3000157Laminin interactionsIEA
R-HSA-3000157Laminin interactionsTAS
R-HSA-3000171Non-integrin membrane-ECM interactionsIEA
R-HSA-3000178ECM proteoglycansIEA
R-HSA-449147Signaling by InterleukinsTAS
R-HSA-6785807Interleukin-4 and 13 signalingTAS
R-HSA-6806834Signaling by METTAS
R-HSA-8874081MET activates PTK2 signalingTAS
R-HSA-8875878MET promotes cell motilityTAS
R-HSA-9006934Signaling by Receptor Tyrosine KinasesTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
23755407Effects of maternal nicotine exposure on expression of laminin alpha 5 in lung tissue of newborn. (2012 Dec 15)Mahdi Shariati KPak J Biol Sci