Gene: LAMB1

3912
CLM|LIS5
laminin subunit beta 1
protein-coding
7q31.1
Ensembl:ENSG00000091136 MIM:150240 Vega:OTTHUMG00000149966 UniprotKB:P07942
NG_023255.1
PubMed
0   ANCO-SNPs
CD
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
4.761e-1 (AD)  6.486e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ARMCX40.851
DRP20.849
TARBP10.837
DEPDC50.837
ICA10.836
DHDDS0.835
CDK200.834
ME30.833
TCERG10.833
SLC29A10.831

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
TGFB3-0.471
YES1-0.46
AKR1C3-0.456
ROM1-0.454
HEY2-0.449
RAI14-0.444
KIF1C-0.434
CCDC102A-0.434
MYL3-0.433
CTNNA3-0.429

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB06245LanoteplaseBiotechDrug171870-23-8InvestigationalTarget
ID Drug Name Action PubMed
C0352082-amino-4,6-dinitrotoluene"2-amino-4,6-dinitrotoluene results in increased expression of LAMB1 protein"26251320
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of LAMB1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of LAMB1 mRNA"27188386
D000082AcetaminophenAcetaminophen results in decreased expression of LAMB1 mRNA21420995|2669055
D019342Acetic AcidAcetic Acid results in decreased expression of LAMB1 protein21296659
D001149Arsenates[Atrazine co-treated with Arsenates] results in increased expression of LAMB1 mRNA18585445
D001151ArsenicArsenic affects the methylation of LAMB1 gene25304211
D001151ArsenicArsenic results in decreased expression of LAMB1 mRNA19654921
D001280AtrazineAtrazine results in decreased expression of LAMB1 mRNA25929836
D001280Atrazine[Atrazine co-treated with Arsenates] results in increased expression of LAMB1 mRNA18585445
C547126AZM551248AZM551248 results in decreased expression of LAMB1 mRNA22323515
C447119bazedoxifenebazedoxifene results in increased expression of LAMB1 mRNA19914376
D001564Benzo(a)pyreneBenzo(a)pyrene metabolite results in decreased expression of LAMB1 mRNA26314263
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of LAMB1 mRNA22300585
D001622BetaineBetaine inhibits the reaction [Copper deficiency affects the expression of LAMB1 protein]25150618
D001663BilirubinBilirubin results in decreased expression of LAMB1 mRNA20196124
C543008bis(4-hydroxyphenyl)sulfonebis(4-hydroxyphenyl)sulfone results in decreased expression of LAMB1 mRNA25912373
C006780bisphenol Abisphenol A results in increased expression of LAMB1 mRNA29275510
C006780bisphenol Abisphenol A results in increased expression of LAMB1 mRNA25594700
C005961bis(tri-n-butyltin)oxidebis(tri-n-butyltin)oxide results in decreased expression of LAMB1 mRNA26314263
C005961bis(tri-n-butyltin)oxidebis(tri-n-butyltin)oxide results in increased expression of LAMB1 mRNA18958704
C099813bromochloroacetic acidbromochloroacetic acid results in decreased expression of LAMB1 protein21296659
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in decreased expression of LAMB1 mRNA15336504
C018475butyraldehydebutyraldehyde results in decreased expression of LAMB1 mRNA26079696
D002220CarbamazepineCarbamazepine affects the expression of LAMB1 mRNA25979313
C100187chloropicrinchloropicrin results in decreased expression of LAMB1 mRNA26352163
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of LAMB1 gene20938992
C074702chromium hexavalent ionchromium hexavalent ion affects the expression of LAMB1 mRNA28472532
C031180chrysenechrysene results in increased expression of LAMB1 mRNA26377693
C018021cobaltous chloridecobaltous chloride results in decreased expression of LAMB1 mRNA26314263
D003042CocaineCocaine results in increased expression of LAMB1 mRNA18000554
D003300CopperBetaine inhibits the reaction [Copper deficiency affects the expression of LAMB1 protein]25150618
D003300CopperCopper deficiency affects the expression of LAMB1 protein25150618
D016572CyclosporineCyclosporine results in decreased expression of LAMB1 mRNA20106945|2798913
D000069439DasatinibDasatinib results in increased expression of LAMB1 mRNA20579391
D003907Dexamethasone[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of LAMB1 mRNA16054899
D002945CisplatinCisplatin results in decreased expression of LAMB1 mRNA27392435
D004026DieldrinDieldrin results in increased expression of LAMB1 mRNA23153324
D004237DiuronDiuron results in increased expression of LAMB1 mRNA21551480
D004656EnalaprilEnalapril inhibits the reaction [Puromycin Aminonucleoside results in increased expression of LAMB1 mRNA]9175058
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of LAMB1 mRNA26379055
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in decreased expression of LAMB1 mRNA23649840
C540355fenamidonefenamidone results in increased expression of LAMB1 mRNA27029645
D005472FluorouracilFluorouracil results in decreased expression of LAMB1 protein21296659
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of LAMB1 gene20938992
C079574FR 139317FR 139317 inhibits the reaction [Puromycin Aminonucleoside results in increased expression of LAMB1 mRNA]9175058
D019833GenisteinGenistein results in decreased expression of LAMB1 mRNA16169203
D005839GentamicinsGentamicins results in increased expression of LAMB1 protein mutant form18809619
D005944GlucosamineTXNIP promotes the reaction [Glucosamine results in increased expression of LAMB1 mRNA]17178593
D005947GlucoseTXNIP promotes the reaction [Glucose results in increased expression of LAMB1 mRNA]17178593
D006118GriseofulvinGriseofulvin results in decreased expression of LAMB1 protein1573853
D017313FenretinideFenretinide results in decreased expression of LAMB1 mRNA28973697
D017313FenretinideFenretinide results in increased expression of LAMB1 mRNA28973697
D006861Hydrogen PeroxideHydrogen Peroxide affects the expression of LAMB1 mRNA21179406
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of LAMB1 mRNA25613284
D0150561-Methyl-3-isobutylxanthine[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of LAMB1 mRNA16054899
D007545IsoproterenolIsoproterenol results in decreased expression of LAMB1 mRNA20003209
C544151jinfukangjinfukang results in increased expression of LAMB1 mRNA27392435
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of LAMB1 mRNA25961927
C410337K 7174K 7174 results in increased expression of LAMB1 mRNA24086573
D007649KetamineKetamine results in decreased expression of LAMB1 mRNA20080153
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in decreased expression of LAMB1 mRNA"24972896
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of LAMB1 gene20938992
C030957methylmercury IImethylmercury II results in decreased expression of LAMB1 mRNA26314263
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of LAMB1 mRNA23649840
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium affects the expression of LAMB1 mRNA12710931
D008775MethylprednisoloneMethylprednisolone inhibits the reaction [Puromycin Aminonucleoside results in increased expression of LAMB1 mRNA]1762292
D008942MitoxantroneLAMB1 protein affects the susceptibility to Mitoxantrone16217747
D009538NicotineNicotine results in increased expression of LAMB1 mRNA16949557
C025589ochratoxin Aochratoxin A metabolite results in decreased expression of LAMB1 mRNA26314263
C025589ochratoxin Aochratoxin A results in decreased expression of LAMB1 mRNA26314263
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in increased expression of LAMB1 mRNA25729387
C030110oxaliplatinoxaliplatin results in increased expression of LAMB1 mRNA25729387
D010303ParomomycinParomomycin results in increased expression of LAMB1 protein mutant form18809619
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in increased expression of LAMB1 protein26178269
D010575PesticidesPesticides results in decreased methylation of LAMB1 gene28396702
D010634PhenobarbitalPhenobarbital affects the expression of LAMB1 mRNA19159669
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of LAMB1 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of LAMB1 mRNA26272509
D010936Plant ExtractsPlant Extracts results in decreased expression of LAMB1 mRNA23557933
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of LAMB1 mRNA22714537
C045362prochlorazprochloraz results in increased expression of LAMB1 mRNA21470553
D011692Puromycin AminonucleosideEnalapril inhibits the reaction [Puromycin Aminonucleoside results in increased expression of LAMB1 mRNA]9175058
D011692Puromycin AminonucleosideFR 139317 inhibits the reaction [Puromycin Aminonucleoside results in increased expression of LAMB1 mRNA]9175058
D011692Puromycin AminonucleosideMethylprednisolone inhibits the reaction [Puromycin Aminonucleoside results in increased expression of LAMB1 mRNA]1762292
D011692Puromycin AminonucleosidePuromycin Aminonucleoside results in increased expression of LAMB1 mRNA1762292|9175058
C089730rosiglitazone[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of LAMB1 mRNA16054899
D012822Silicon DioxideSilicon Dioxide analog affects the secretion of LAMB1 protein25895662
C017947sodium arsenitesodium arsenite results in decreased expression of LAMB1 mRNA10910055
D000952Antigens, Polyomavirus Transforming"Antigens, Polyomavirus Transforming results in decreased expression of LAMB1 mRNA"26680231
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of LAMB1 mRNA18495758
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of LAMB1 mRNA20106945|2129612
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of LAMB1 mRNA21570461|2637764
D013755Tetradecanoylphorbol Acetate[Zinc co-treated with Tetradecanoylphorbol Acetate] affects the expression of LAMB1 mRNA16979875
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of LAMB1 mRNA25613284
D019284ThapsigarginThapsigargin results in increased expression of LAMB1 mRNA22378314
D019284ThapsigarginThapsigargin results in increased expression of LAMB1 protein24648495
D014028Tobacco Smoke PollutionTobacco Smoke Pollution affects the expression of LAMB1 mRNA27865774
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of LAMB1 mRNA28065790
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in increased expression of LAMB1 mRNA25729387
D019772TopotecanTopotecan results in increased expression of LAMB1 mRNA25729387
D014212TretinoinTretinoin results in increased expression of LAMB1 mRNA17138961|2193413
D014212TretinoinTretinoin results in increased expression of LAMB1 mRNA16236135
C012589trichostatin Atrichostatin A results in increased expression of LAMB1 mRNA15901671
D014635Valproic AcidValproic Acid results in increased expression of LAMB1 mRNA15901671
D014635Valproic AcidValproic Acid affects the expression of LAMB1 mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of LAMB1 mRNA29154799
D014635Valproic AcidValproic Acid results in increased expression of LAMB1 mRNA24896083
D014638VanadatesVanadates results in increased expression of LAMB1 mRNA22714537
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of LAMB1 gene25560391
C025643vinclozolinvinclozolin results in increased expression of LAMB1 mRNA23034163
D015032Zinc[Zinc co-treated with Tetradecanoylphorbol Acetate] affects the expression of LAMB1 mRNA16979875
C088658zoledronic acidzoledronic acid results in decreased expression of LAMB1 mRNA24714768

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005198structural molecule activity-NAS10842354  
GO:0005201extracellular matrix structural constituent-IDA16289578  
GO:0005515protein binding-IPI26438063  
GO ID GO Term Qualifier Evidence PubMed
GO:0007155cell adhesion-TAS14557481  
GO:0021812neuronal-glial interaction involved in cerebral cortex radial glia guided migration-IMP23472759  
GO:0030198extracellular matrix organization-TAS-  
GO:0030335positive regulation of cell migration-IDA16289578  
GO:0031175neuron projection development-IDA15894315  
GO:0034446substrate adhesion-dependent cell spreading-IDA16236823  
GO:0035987endodermal cell differentiation-IEP23154389  
GO:0042476odontogenesis-IDA15894315  
GO:0043687post-translational protein modification-TAS-  
GO:0044267cellular protein metabolic process-TAS-  
GO:0050679positive regulation of epithelial cell proliferation-TAS14557481  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-TAS-  
GO:0005604basement membrane-IDA2099832  14557481  
GO:0005604basement membrane-TAS3493487  
GO:0005606laminin-1 complex-IDA16289578  
GO:0005606laminin-1 complex-IPI10964500  
GO:0005606laminin-1 complex-TAS14557481  
GO:0005607laminin-2 complex-IDA16289578  
GO:0005607laminin-2 complex-TAS15894315  
GO:0005615extracellular space-IDA10964500  
GO:0005788endoplasmic reticulum lumen-TAS-  
GO:0031012extracellular matrix-HDA23658023  
GO:0043257laminin-8 complex-IDA16289578  
GO:0043257laminin-8 complex-TAS15894315  
GO:0043259laminin-10 complex-IDA10964500  16289578  
GO:0048471perinuclear region of cytoplasm-ISS-  
GO:0062023collagen-containing extracellular matrix-HDA27068509  27559042  
GO:0062023collagen-containing extracellular matrixcolocalizes_withISS22261194  
GO:0070062extracellular exosome-HDA21362503  
KEGG ID KEGG Term
hsa04510Focal adhesion
hsa04512ECM-receptor interaction
hsa05145Toxoplasmosis
hsa05146Amoebiasis
hsa05200Pathways in cancer
hsa05222Small cell lung cancer
Reactome ID Reactome Term Evidence
R-HSA-1266738Developmental BiologyIEA
R-HSA-1474228Degradation of the extracellular matrixIEA
R-HSA-1474244Extracellular matrix organizationIEA
R-HSA-1474244Extracellular matrix organizationTAS
R-HSA-162582Signal TransductionTAS
R-HSA-3000157Laminin interactionsIEA
R-HSA-3000157Laminin interactionsTAS
R-HSA-3000171Non-integrin membrane-ECM interactionsIEA
R-HSA-3000178ECM proteoglycansIEA
R-HSA-373760L1CAM interactionsIEA
R-HSA-381426Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)TAS
R-HSA-392499Metabolism of proteinsTAS
R-HSA-422475Axon guidanceIEA
R-HSA-597592Post-translational protein modificationTAS
R-HSA-6806834Signaling by METTAS
R-HSA-8874081MET activates PTK2 signalingTAS
R-HSA-8875878MET promotes cell motilityTAS
R-HSA-8957275Post-translational protein phosphorylationTAS
R-HSA-9006934Signaling by Receptor Tyrosine KinasesTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
18000554Gene expression in human hippocampus from cocaine abusers identifies genes which regulate extracellular matrix remodeling. (2007 Nov 14)Mash DCPLoS One