Gene: LAMP1

3916
CD107a|LAMPA|LGP120
lysosomal associated membrane protein 1
protein-coding
13q34
Ensembl:ENSG00000185896 MIM:153330 Vega:OTTHUMG00000017380 UniprotKB:P11279
NC_000013.11
PubMed
0   ANCO-SNPs
ND|AD
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
8.395e-1 (AD)  4.115e-1 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg11451477chr13:113974478LAMP11.600e-8Smoking27651444

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CNDP20.928
NCSTN0.91
RER10.909
RNH10.906
CTSD0.903
SF3B20.902
NELFCD0.901
PSAP0.897
TALDO10.897
ACAA10.896

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.816
OR4F29-0.792
MTRNR2L6-0.21
MTRNR2L9-0.203
KRT73-0.196
HMHB1-0.19
CLEC6A-0.185
LCE2A-0.185
OR4F16-0.178
OR6C74-0.175

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0703791,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester"1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [cadmium acetate affects the localization of [LAMP1 protein co-treated with MAP1LC3B protein]]"28347754
C5321622-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine"2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine results in increased expression of LAMP1 protein"23000516
C5321622-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine"TFEB mutant form inhibits the reaction [2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine results in increased expression of LAMP1 protein]"23000516
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in decreased expression of LAMP1 mRNA"27291303
C4049102,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane"2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane affects the reaction [Cyclic AMP affects the expression of LAMP1 mRNA]"19414516
C4049102,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane"2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane affects the reaction [FSHB protein affects the expression of LAMP1 mRNA]"19414516
C1099862-aminoethoxydiphenyl borate2-aminoethoxydiphenyl borate inhibits the reaction [cadmium acetate affects the localization of [LAMP1 protein co-treated with MAP1LC3B protein]]28347754
C0303702-methoxy-5-(2',3',4'-trimethoxyphenyl)tropone"2-methoxy-5-(2',3',4'-trimethoxyphenyl)tropone results in increased expression of LAMP1 mRNA"20206263
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of LAMP1 mRNA"18648102
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of LAMP1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of LAMP1 mRNA"27188386
D000111AcetylcysteineAcetylcysteine inhibits the reaction [cadmium acetate affects the localization of [LAMP1 protein co-treated with MAP1LC3B protein]]28347754
D000171Acrolein[ferric oxide analog co-treated with Acrolein] results in decreased expression of LAMP1 protein24847785
D000242Cyclic AMP"2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane affects the reaction [Cyclic AMP affects the expression of LAMP1 mRNA]"19414516
C430898AGN 194204AGN 194204 results in increased expression of LAMP1 mRNA16339527
D000643Ammonium ChlorideAmmonium Chloride affects the expression of LAMP1 mRNA16483693
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of LAMP1 mRNA19770486
D004958EstradiolEstradiol results in increased expression of LAMP1 mRNA19167446
C044887beta-methylcholinebeta-methylcholine affects the expression of LAMP1 mRNA21179406
D001710BiotinBiotin results in decreased expression of LAMP1 mRNA15219929
C028031cadmium acetate"1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [cadmium acetate affects the localization of [LAMP1 protein co-treated with MAP1LC3B protein]]"28347754
C028031cadmium acetate2-aminoethoxydiphenyl borate inhibits the reaction [cadmium acetate affects the localization of [LAMP1 protein co-treated with MAP1LC3B protein]]28347754
C028031cadmium acetateAcetylcysteine inhibits the reaction [cadmium acetate affects the localization of [LAMP1 protein co-treated with MAP1LC3B protein]]28347754
C028031cadmium acetatecadmium acetate affects the localization of [LAMP1 protein co-treated with MAP1LC3B protein]28347754
C028031cadmium acetateThapsigargin promotes the reaction [cadmium acetate affects the localization of [LAMP1 protein co-treated with MAP1LC3B protein]]28347754
D002246Carbon DisulfideCarbon Disulfide results in increased expression of LAMP1 protein24887698
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in decreased expression of LAMP1 mRNA23650126
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in increased expression of LAMP1 mRNA25270620
C100187chloropicrinchloropicrin affects the expression of LAMP1 mRNA26352163
D002784CholesterolCholesterol results in increased expression of LAMP1 protein28275691
D002994ClofibrateClofibrate results in increased expression of LAMP1 mRNA25270620
D003300Copper[Thiosemicarbazones binds to Copper] which results in decreased expression of LAMP1 protein20931265
D003300Copper[ATP7A gene mutant form results in increased abundance of Copper] which results in increased expression of LAMP1 mRNA15467011
D003375CoumestrolCoumestrol results in increased expression of LAMP1 mRNA19167446
D003474CurcuminCurcumin affects the expression of LAMP1 mRNA18539377
C010902decabromobiphenyl etherdecabromobiphenyl ether results in decreased expression of LAMP1 mRNA23640034
D003907DexamethasoneDexamethasone results in increased expression of LAMP1 protein28552552
D004026DieldrinDieldrin results in increased expression of LAMP1 mRNA28385952
D004317DoxorubicinDoxorubicin affects the expression of LAMP1 protein29385562
D004791Enzyme Inhibitors[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of LAMP1 protein23301498
D000431EthanolEthanol results in decreased expression of LAMP1 protein25460735
C000499ferric oxide[ferric oxide analog co-treated with Acrolein] results in decreased expression of LAMP1 protein24847785
D005444FlunarizineFlunarizine inhibits the reaction [Tetrachlorodibenzodioxin results in increased secretion of LAMP1 protein]19546254
D005557FormaldehydeFormaldehyde results in increased expression of LAMP1 mRNA23649840
C056933fumonisin B1fumonisin B1 results in increased expression of LAMP1 mRNA16221962
C039281furanfuran results in increased methylation of LAMP1 gene22079235
C040029gabapentin[gabapentin co-treated with Pentylenetetrazole] affects the expression of LAMP1 mRNA21503142
D005947GlucoseGlucose results in increased expression of LAMP1 protein22253932
D015759IonomycinIonomycin results in increased expression of LAMP1 protein23376802
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of LAMP1 mRNA25613284
D007538IsoniazidLAMP1 affects the susceptibility to Isoniazid24848797
D048628KetolidesKetolides analog results in increased expression of LAMP1 mRNA24967691
C017461lead nitratelead nitrate results in increased expression of LAMP1 protein23376802
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of LAMP1 protein23376802
D008070LipopolysaccharidesLipopolysaccharides results in decreased expression of LAMP1 mRNA25613284
D008694MethamphetamineMethamphetamine results in increased expression of LAMP1 protein23933405
D008746Methylazoxymethanol AcetateMethylazoxymethanol Acetate affects the expression of LAMP1 mRNA28349193
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of LAMP1 mRNA23649840
D008777MethyltestosteroneMethyltestosterone results in decreased expression of LAMP1 mRNA29191790
D020748MibefradilMibefradil inhibits the reaction [Tetrachlorodibenzodioxin results in increased secretion of LAMP1 protein]19546254
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of LAMP1 mRNA"25554681
C028007nickel monoxidenickel monoxide results in increased expression of LAMP1 mRNA19167457
D010269ParaquatATG5 protein affects the reaction [Paraquat results in increased expression of LAMP1 protein]22982048
D010269ParaquatParaquat results in increased expression of LAMP1 protein22982048
D010269ParaquatATG5 protein affects the reaction [Paraquat results in increased expression of LAMP1 protein]22982048
D010269ParaquatParaquat results in increased expression of LAMP1 protein22982048
D010433Pentylenetetrazole[gabapentin co-treated with Pentylenetetrazole] affects the expression of LAMP1 mRNA21503142
D010433Pentylenetetrazole[Pentylenetetrazole co-treated with Vigabatrin] affects the expression of LAMP1 mRNA21503142
D010634PhenobarbitalPhenobarbital results in increased expression of LAMP1 mRNA19162173
D010665PhenylpropanolaminePhenylpropanolamine affects the localization of LAMP1 protein27756839
C030090phosphoramide mustardphosphoramide mustard results in increased expression of LAMP1 protein27888070
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in increased expression of LAMP1 mRNA19162173
C059514resveratrolresveratrol results in decreased expression of LAMP1 protein26167810
C089730rosiglitazonerosiglitazone results in increased expression of LAMP1 protein21376716
D012643SeleniumSelenium results in increased expression of LAMP1 mRNA19244175
D012715Sesame OilSesame Oil results in increased expression of LAMP1 mRNA29191790
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of LAMP1 mRNA23806026
C017947sodium arsenitesodium arsenite affects the expression of LAMP1 mRNA20816728
C025462sulindac sulfidesulindac sulfide results in decreased expression of LAMP1 mRNA16184548
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of LAMP1 mRNA21570461
D013749TetrachlorodibenzodioxinFlunarizine inhibits the reaction [Tetrachlorodibenzodioxin results in increased secretion of LAMP1 protein]19546254
D013749TetrachlorodibenzodioxinMibefradil inhibits the reaction [Tetrachlorodibenzodioxin results in increased secretion of LAMP1 protein]19546254
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased secretion of LAMP1 protein19546254
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of LAMP1 mRNA25613284
D019284ThapsigarginThapsigargin affects the localization of [LAMP1 protein co-treated with MAP1LC3B protein]28347754
D019284ThapsigarginThapsigargin promotes the reaction [cadmium acetate affects the localization of [LAMP1 protein co-treated with MAP1LC3B protein]]28347754
D013882Thiosemicarbazones[Thiosemicarbazones binds to Copper] which results in decreased expression of LAMP1 protein20931265
D014212TretinoinTretinoin results in increased expression of LAMP1 mRNA23724009
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of LAMP1 mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of LAMP1 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased methylation of LAMP1 gene29154799
D014635Valproic AcidValproic Acid results in increased expression of LAMP1 mRNA23179753|2519280
D020888Vigabatrin[Pentylenetetrazole co-treated with Vigabatrin] affects the expression of LAMP1 mRNA21503142
D014810Vitamin EVitamin E results in increased expression of LAMP1 mRNA19244175
C022186xanthatinxanthatin results in increased expression of LAMP1 protein29074359
C088658zoledronic acidzoledronic acid results in decreased expression of LAMP1 protein28871336

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0001618virus receptor activity-IEA-  
GO:0005515protein binding-IPI23394946  24970085  
GO:0019899enzyme binding-IPI22641697  
GO:0019904protein domain specific binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0008626granzyme-mediated apoptotic signaling pathway-IMP23632890  
GO:0043312neutrophil degranulation-TAS-  
GO:0043323positive regulation of natural killer cell degranulation-IMP23632890  
GO:0045954positive regulation of natural killer cell mediated cytotoxicity-IMP23632890  
GO:0046718viral entry into host cell-IEA-  
GO:0048102autophagic cell death-IEA-  
GO:0050821protein stabilization-ISS-  
GO:0072594establishment of protein localization to organelle-IMP23632890  
GO:0090160Golgi to lysosome transport-IMP23632890  
GO:1902513regulation of organelle transport along microtubule-IMP23632890  
GO ID GO Term Qualifier Evidence PubMed
GO:0005737cytoplasm-IDA21266579  
GO:0005764lysosome-IDA15052268  15292400  15613468  16542649  22792322  23704327  
GO:0005764lysosomecolocalizes_withIDA15613468  
GO:0005765lysosomal membrane-ISS-  
GO:0005770late endosome-IDA15052268  15292400  15792797  16542649  18388320  18767904  
GO:0005771multivesicular body-IEA-  
GO:0005829cytosol-IEA-  
GO:0005886plasma membrane-IDA20956541  
GO:0005886plasma membrane-TAS-  
GO:0005887integral component of plasma membrane-TAS3174652  
GO:0008021synaptic vesicle-IEA-  
GO:0009897external side of plasma membrane-IEA-  
GO:0010008endosome membrane-ISS-  
GO:0016020membrane-HDA19946888  
GO:0030425dendrite-IEA-  
GO:0035577azurophil granule membrane-TAS-  
GO:0042383sarcolemma-IEA-  
GO:0042470melanosome-IEA-  
GO:0043025neuronal cell body-IEA-  
GO:0044194cytolytic granule-IEA-  
GO:0044754autolysosome-IEA-  
GO:0048471perinuclear region of cytoplasm-IMP18787122  
GO:0061474phagolysosome membrane-IEA-  
GO:0070062extracellular exosome-HDA19056867  23533145  
GO:0097208alveolar lamellar body-IEA-  
GO:0101003ficolin-1-rich granule membrane-TAS-  
KEGG ID KEGG Term
hsa04142Lysosome
hsa04145Phagosome
Reactome ID Reactome Term Evidence
R-HSA-168249Innate Immune SystemTAS
R-HSA-168256Immune SystemTAS
R-HSA-6798695Neutrophil degranulationTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
29274360Disulfiram with or without metformin inhibits oesophageal squamous cell carcinoma in vivo. (2018 Mar 28)Jivan RCancer Lett