Gene: LASP1

3927
Lasp-1|MLN50
LIM and SH3 protein 1
protein-coding
17q12
Ensembl:ENSG00000002834 MIM:602920 Vega:OTTHUMG00000133182 UniprotKB:Q14847
NC_000017.11
SNP Mapped
1   ANCO-SNPs
ND
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
5.818e-1 (AD)  8.448e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs82977chr17:38908095 (GRCh38.p7)G>Anicotine dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
USP220.945
TAF60.945
EXOC70.942
VPS26B0.939
IP6K10.938
STIM10.938
PRRC2B0.937
RNF440.937
TNPO20.935
WDTC10.934

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.709
OR4F29-0.653
CTNNA3-0.37
SH2D1A-0.37
TFPI2-0.333
ANXA13-0.333
SNHG18-0.321
SGMS2-0.318
C5orf64-0.313
IL18RAP-0.313

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of LASP1 mRNA"21346803
C5116212-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [Particulate Matter results in increased expression of LASP1 mRNA]28655636
C5116212-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [Vehicle Emissions results in increased expression of LASP1 mRNA]28655636
C0326424-aminophenylarsenoxide4-aminophenylarsenoxide binds to LASP1 protein26598702
C0326424-aminophenylarsenoxidearsenic trioxide inhibits the reaction [4-aminophenylarsenoxide binds to LASP1 protein]26598702
C1217077,3'-dihydroxy-4'-methoxyisoflavone"7,3'-dihydroxy-4'-methoxyisoflavone results in increased expression of LASP1 protein"24455688
D000082AcetaminophenAcetaminophen results in decreased expression of LASP1 mRNA21420995
D000082AcetaminophenAcetaminophen results in increased expression of LASP1 mRNA26690555
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of LASP1 mRNA19770486
D000535Aluminum[APP protein modified form binds to Aluminum] which results in increased expression of LASP1 mRNA21298039
D000643Ammonium ChlorideAmmonium Chloride affects the expression of LASP1 mRNA16483693
C006632arsenic trioxidearsenic trioxide inhibits the reaction [4-aminophenylarsenoxide binds to LASP1 protein]26598702
C547126AZM551248AZM551248 results in decreased expression of LASP1 mRNA22323515
C030935benz(a)anthracene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of LASP1 mRNA27858113
C006703benzo(b)fluoranthene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of LASP1 mRNA27858113
D001564Benzo(a)pyrene[Soot co-treated with Benzo(a)pyrene] results in increased expression of LASP1 protein24464499
D001564Benzo(a)pyrene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of LASP1 mRNA27858113
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of LASP1 mRNA19770486
D004958EstradiolEstradiol affects the expression of LASP1 mRNA22574217
C044887beta-methylcholinebeta-methylcholine affects the expression of LASP1 mRNA21179406
C002791bismuth tripotassium dicitratebismuth tripotassium dicitrate results in increased expression of LASP1 mRNA15912405
C006780bisphenol Abisphenol A affects the expression of LASP1 mRNA21786754
C006780bisphenol Abisphenol A affects the expression of LASP1 mRNA25181051
C000611646bisphenol F[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of LASP1 mRNA28628672
D001761BleomycinBleomycin results in increased expression of LASP1 protein25933445
C013418bromfenacoumbromfenacoum results in decreased expression of LASP1 protein28903499
D002104CadmiumCadmium results in increased expression of LASP1 mRNA23369406|2437683
D002122Calcium ChlorideCalcium Chloride results in increased expression of LASP1 protein25824407
C117342calfactant"[Nanotubes, Carbon co-treated with calfactant] results in decreased expression of LASP1 protein"23026733
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in decreased expression of LASP1 mRNA23650126
C100187chloropicrinchloropicrin affects the expression of LASP1 mRNA26352163
C031180chrysene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of LASP1 mRNA27858113
D019327Copper SulfateCopper Sulfate results in increased expression of LASP1 mRNA19549813
C423222cotylenin Acotylenin A results in increased expression of LASP1 mRNA16129123
C015763cumene[cumene co-treated with KRAS gene mutant form] results in decreased expression of LASP1 mRNA18648096
D003520CyclophosphamideCyclophosphamide results in decreased expression of LASP1 mRNA27281708
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of LASP1 mRNA28628672
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of LASP1 mRNA21266533
D004041Dietary FatsDietary Fats results in decreased expression of LASP1 mRNA25016146
D004317DoxorubicinDoxorubicin affects the expression of LASP1 protein29385562
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of LASP1 mRNA17942748
D005472FluorouracilLASP1 protein affects the susceptibility to Fluorouracil16217747
D005485FlutamideFlutamide results in decreased expression of LASP1 mRNA24793618
C056933fumonisin B1fumonisin B1 results in increased expression of LASP1 mRNA16221962
C039281furanfuran results in increased methylation of LASP1 gene22079235
D005839GentamicinsGentamicins results in increased expression of LASP1 mRNA22061828
D017313FenretinideFenretinide results in decreased expression of LASP1 mRNA28973697
D006830Hydralazine[Hydralazine co-treated with Valproic Acid] results in increased expression of LASP1 mRNA17183730
D006861Hydrogen PeroxideHydrogen Peroxide results in decreased secretion of LASP1 mRNA21179422
C031927hydroquinonehydroquinone affects the expression of LASP1 protein20021034
C475919hydroxytamoxifenhydroxytamoxifen results in increased expression of LASP1 mRNA16849584
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of LASP1 mRNA28628672
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of LASP1 mRNA25613284
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of LASP1 mRNA28628672
D007657Ketone BodiesKetone Bodies results in decreased expression of LASP1 mRNA16807920
D008148LovastatinLovastatin results in decreased expression of LASP1 mRNA20493250
D008746Methylazoxymethanol AcetateMethylazoxymethanol Acetate results in increased expression of LASP1 mRNA28349193
D008774MethylphenidateMethylphenidate results in increased expression of LASP1 mRNA22470460
D052998MicrocystinsMicrocystins results in increased expression of LASP1 protein22430071
D037742Nanotubes, Carbon"[Nanotubes, Carbon co-treated with calfactant] results in decreased expression of LASP1 protein"23026733
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of LASP1 mRNA"25620056
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of LASP1 mRNA"25620056
C031721naphthalenenaphthalene results in decreased expression of LASP1 protein19438287
C028007nickel monoxidenickel monoxide results in increased expression of LASP1 mRNA19167457
D010100OxygenOxygen deficiency results in increased expression of LASP1 protein25937538
C016030pantogabpantogab results in decreased expression of LASP1 mRNA17379144
D052638Particulate Matter2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [Particulate Matter results in increased expression of LASP1 mRNA]28655636
D052638Particulate MatterParticulate Matter results in increased expression of LASP1 mRNA28655636
C086401pentabromodiphenyl etherpentabromodiphenyl ether results in decreased expression of LASP1 protein19954255
D010416PentachlorophenolPentachlorophenol affects the expression of LASP1 mRNA23892564
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid affects the expression of LASP1 mRNA19429403
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of LASP1 protein26879310
C023036perfluorooctanoic acidperfluorooctanoic acid affects the expression of LASP1 mRNA19429403
C121565pifithrinpifithrin results in increased expression of LASP1 mRNA28232485
C006253pirinixic acidpirinixic acid results in decreased expression of LASP1 mRNA18445702
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in decreased expression of LASP1 mRNA28903501
C045950propiconazolepropiconazole results in increased expression of LASP1 mRNA21278054
C089730rosiglitazonerosiglitazone affects the expression of LASP1 protein19556978
D012524SarinSarin results in decreased expression of LASP1 protein28973502
D012645SelenomethionineSelenomethionine affects the expression of LASP1 mRNA17222674
C080703SK&F 83959SK&F 83959 affects the expression of LASP1 protein25852303
D053260Soot[Soot co-treated with Benzo(a)pyrene] results in increased expression of LASP1 protein24464499
D053260SootSoot results in increased expression of LASP1 protein24464499
C061133tamibarotenetamibarotene results in increased expression of LASP1 mRNA15498508
D013739TestosteroneTestosterone results in increased expression of LASP1 mRNA21669218
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of LASP1 mRNA21570461
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin binds to AHR protein] which results in decreased expression of LASP1 mRNA16214954
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of LASP1 mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of LASP1 mRNA18796159|2629044
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of LASP1 mRNA15644576|1879615
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of LASP1 mRNA25613284
C009495titanium dioxidetitanium dioxide results in increased expression of LASP1 mRNA23557971
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of LASP1 mRNA28111298
D014212TretinoinTretinoin results in increased expression of LASP1 mRNA15498508|1612912
D014303TrinitrotolueneTrinitrotoluene affects the expression of LASP1 mRNA21346803
C013320tris(2-butoxyethyl) phosphatetris(2-butoxyethyl) phosphate results in increased expression of LASP1 mRNA25855008
D014635Valproic Acid[Hydralazine co-treated with Valproic Acid] results in increased expression of LASP1 mRNA17183730
D014635Valproic AcidValproic Acid affects the expression of LASP1 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of LASP1 mRNA29154799
D001335Vehicle Emissions2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [Vehicle Emissions results in increased expression of LASP1 mRNA]28655636
D001335Vehicle EmissionsVehicle Emissions results in increased expression of LASP1 mRNA28655636
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of LASP1 gene25560391
C111237vorinostatvorinostat results in decreased expression of LASP1 protein20543569
D014859WarfarinWarfarin results in decreased expression of LASP1 mRNA20493250

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005070SH3/SH2 adaptor activity-TAS7589475  
GO:0005515protein binding-IPI16189514  19060904  21516116  22665060  25416956  25814554  
GO:0015075ion transmembrane transporter activity-ISS-  
GO:0045296cadherin binding-HDA25468996  
GO:0046872metal ion binding-IEA-  
GO:0051015actin filament binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006811ion transport-ISS-  
GO:0009967positive regulation of signal transduction-IEA-  
GO:0034220ion transmembrane transport-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005737cytoplasm-IDA25468996  
GO:0005925focal adhesion-HDA21423176  
GO:0030864cortical actin cytoskeleton-ISS-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal