Gene info: ID 3929

Gene: LBP

GENE ID: 3929

Synonyms: BPIFD2

Description: lipopolysaccharide binding protein

Gene type: protein-coding

Location: 20q11.23

dbXrefs: Ensembl:ENSG00000129988 MIM:151990 Vega:OTTHUMG00000032447 UniprotKB:P18428

RefSeq: NG_034239.1

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: OD|ND|AD

# Publications: 28

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 7.585e-1 (AD) 4.686e-2 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
TMEM95	0.696
FAM170B	0.677
KRT33A	0.663
FAM83E	0.633
HELB	0.62
PITX3	0.62
APOH	0.616
KCTD11	0.612
CA6	0.607
SERPINH1	0.589

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
NXPH1	-0.372
C2orf27A	-0.372
RASGEF1C	-0.37
ENPP6	-0.364
ASIC2	-0.349
AK9	-0.349
SORCS3	-0.347
MFSD6	-0.341
ZNF223	-0.34
PLD5	-0.334

There is no DrugBank record for this gene !

ID	Drug Name	Action	PubMed
C026486	1,2,5,6-dibenzanthracene	"[1,2,5,6-dibenzanthracene co-treated with dibenzo(a,l)pyrene] affects the expression of LBP mRNA"	18711122
C026486	1,2,5,6-dibenzanthracene	"[1,2,5,6-dibenzanthracene co-treated with fluoranthene] affects the expression of LBP mRNA"	18711122
C026486	1,2,5,6-dibenzanthracene	"[Benzo(a)pyrene co-treated with 1,2,5,6-dibenzanthracene] affects the expression of LBP mRNA"	18711122
C016403	2,4-dinitrotoluene	"2,4-dinitrotoluene affects the expression of LBP mRNA"	21346803
C023514	2,6-dinitrotoluene	"2,6-dinitrotoluene affects the expression of LBP mRNA"	21346803
C023035	3,4,5,3',4'-pentachlorobiphenyl	"3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of LBP mRNA"	23196670
C023035	3,4,5,3',4'-pentachlorobiphenyl	"3,4,5,3',4'-pentachlorobiphenyl results in increased expression of LBP mRNA"	19692669\|2095900
C009505	4,4'-diaminodiphenylmethane	"4,4'-diaminodiphenylmethane results in increased expression of LBP mRNA"	18648102
C009505	4,4'-diaminodiphenylmethane	"4,4'-diaminodiphenylmethane results in increased expression of LBP mRNA"	25380136
D000082	Acetaminophen	Acetaminophen results in decreased expression of LBP mRNA	29067470
D000082	Acetaminophen	Acetaminophen results in increased expression of LBP mRNA	26690555
D000082	Acetaminophen	Acetaminophen affects the expression of LBP mRNA	17562736
D000082	Acetaminophen	Acetaminophen results in increased expression of LBP mRNA	17585979
D000082	Acetaminophen	LBP protein results in increased susceptibility to Acetaminophen	15619225
D000082	Acetaminophen	Acetaminophen results in increased expression of LBP mRNA	17522070
D016604	Aflatoxin B1	Aflatoxin B1 results in decreased expression of LBP mRNA	19770486
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of LBP mRNA	16483693
D018501	Antirheumatic Agents	Antirheumatic Agents results in decreased expression of LBP mRNA	24449571
D034341	Aristolochic Acids	Aristolochic Acids results in increased expression of LBP mRNA	19717638
C015001	arsenite	arsenite results in decreased expression of LBP mRNA	18929588
C015001	arsenite	TRP53 protein affects the reaction [arsenite results in decreased expression of LBP mRNA]	18929588
D017638	Asbestos, Crocidolite	"Asbestos, Crocidolite results in increased expression of LBP mRNA"	23917077
D001205	Ascorbic Acid	Ascorbic Acid inhibits the reaction [Ethanol results in increased expression of LBP mRNA]	24239723
D019324	beta-Naphthoflavone	[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of LBP mRNA	18164116
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of LBP mRNA	20106945
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of LBP mRNA	19770486
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of LBP mRNA	27195522
D001564	Benzo(a)pyrene	"[Benzo(a)pyrene co-treated with 1,2,5,6-dibenzanthracene] affects the expression of LBP mRNA"	18711122
D001564	Benzo(a)pyrene	"[Benzo(a)pyrene co-treated with dibenzo(a,l)pyrene] affects the expression of LBP mRNA"	18711122
D004958	Estradiol	Estradiol results in decreased expression of LBP mRNA	20106945
C543008	bis(4-hydroxyphenyl)sulfone	bis(4-hydroxyphenyl)sulfone results in increased expression of LBP mRNA	27685785
C543008	bis(4-hydroxyphenyl)sulfone	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in increased expression of LBP mRNA	28628672
C006780	bisphenol A	bisphenol A results in increased expression of LBP mRNA	27685785
C006780	bisphenol A	bisphenol A results in increased expression of LBP mRNA	26063408
C006780	bisphenol A	bisphenol A results in increased methylation of LBP promoter	27312807
C006780	bisphenol A	bisphenol A results in decreased expression of LBP mRNA	25181051
C006780	bisphenol A	bisphenol A results in increased expression of LBP mRNA	17010207
D002065	Buspirone	Buspirone results in increased expression of LBP mRNA	24136188
C018475	butyraldehyde	butyraldehyde results in decreased expression of LBP mRNA	26079696
D002104	Cadmium	LBP protein binds to Cadmium	23896426
D019256	Cadmium Chloride	Cadmium Chloride results in increased expression of LBP mRNA	26352046
D019256	Cadmium Chloride	Cadmium Chloride results in increased expression of LBP mRNA	25993096
D002251	Carbon Tetrachloride	Carbon Tetrachloride results in increased expression of LBP mRNA	16239168\|1752207
D002330	Carmustine	LBP mRNA affects the susceptibility to Carmustine	16365179
D002725	Chloroform	Chloroform results in increased expression of LBP mRNA	17522070
C418118	CI 1044	CI 1044 results in increased expression of LBP mRNA	17569694
D002922	Ciguatoxins	Ciguatoxins affects the expression of LBP mRNA	18353800
C018021	cobaltous chloride	cobaltous chloride results in decreased expression of LBP protein	24386269
D003474	Curcumin	Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of LBP mRNA]	18200517
D016572	Cyclosporine	Cyclosporine results in decreased expression of LBP mRNA	20106945\|2798913
D016572	Cyclosporine	Cyclosporine results in decreased expression of LBP mRNA	19770486
D016572	Cyclosporine	Cyclosporine results in increased expression of LBP mRNA	21865292
D003907	Dexamethasone	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in increased expression of LBP mRNA	28628672
D003907	Dexamethasone	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in increased expression of LBP mRNA	28628672
D003907	Dexamethasone	[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of LBP mRNA	16054899
D003907	Dexamethasone	Dexamethasone results in increased expression of LBP mRNA	22733784
C041517	dibenzo(a,l)pyrene	"[1,2,5,6-dibenzanthracene co-treated with dibenzo(a,l)pyrene] affects the expression of LBP mRNA"	18711122
C041517	dibenzo(a,l)pyrene	"[Benzo(a)pyrene co-treated with dibenzo(a,l)pyrene] affects the expression of LBP mRNA"	18711122
D004008	Diclofenac	Diclofenac affects the expression of LBP mRNA	26934552
D004008	Diclofenac	Diclofenac results in decreased expression of LBP mRNA	26934552
D004008	Diclofenac	Diclofenac results in increased expression of LBP protein	26934552
D004041	Dietary Fats	Dietary Fats affects the expression of LBP mRNA	19680557
D004041	Dietary Fats	Dietary Fats results in decreased expression of LBP mRNA	25016146
D019422	Dietary Sucrose	Dietary Sucrose results in increased expression of LBP mRNA	26033743
D004052	Diethylnitrosamine	[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of LBP mRNA	18164116
D002117	Calcitriol	Calcitriol results in decreased expression of LBP mRNA	26485663
D002117	Calcitriol	Calcitriol results in increased expression of LBP mRNA	26485663
D004128	Dimethylnitrosamine	Dimethylnitrosamine results in increased expression of LBP mRNA	17072980\|2538013
D004317	Doxorubicin	Doxorubicin affects the expression of LBP mRNA	12187937
D004917	Erythromycin	[Penicillin G co-treated with Erythromycin] results in increased expression of LBP mRNA	27503388
D004918	Erythromycin Estolate	Erythromycin Estolate results in increased expression of LBP mRNA	17522070
D000431	Ethanol	Ascorbic Acid inhibits the reaction [Ethanol results in increased expression of LBP mRNA]	24239723
D000431	Ethanol	Ethanol results in increased expression of LBP mRNA	24239723
D000431	Ethanol	Silymarin inhibits the reaction [Ethanol results in increased expression of LBP mRNA]	24239723
D000431	Ethanol	Ethanol results in decreased expression of LBP mRNA	16098508
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in increased expression of LBP mRNA	15834898
C024565	ethylene dichloride	ethylene dichloride results in increased expression of LBP mRNA	28189721
C007738	fluoranthene	"[1,2,5,6-dibenzanthracene co-treated with fluoranthene] affects the expression of LBP mRNA"	18711122
D005485	Flutamide	Flutamide results in decreased expression of LBP mRNA	24136188
C039281	furan	furan results in decreased expression of LBP mRNA	25539665
D019833	Genistein	Genistein results in decreased expression of LBP mRNA	22553218\|2496738
D019833	Genistein	Genistein results in increased expression of LBP mRNA	17010207
D005897	Glafenine	Glafenine results in increased expression of LBP mRNA	24136188
D017313	Fenretinide	Fenretinide results in decreased expression of LBP mRNA	28973697
D017313	Fenretinide	Fenretinide results in increased expression of LBP mRNA	28973697
D007213	Indomethacin	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in increased expression of LBP mRNA	28628672
D007213	Indomethacin	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in increased expression of LBP mRNA	28628672
D015056	1-Methyl-3-isobutylxanthine	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in increased expression of LBP mRNA	28628672
D015056	1-Methyl-3-isobutylxanthine	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in increased expression of LBP mRNA	28628672
D015056	1-Methyl-3-isobutylxanthine	[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of LBP mRNA	16054899
D007545	Isoproterenol	Isoproterenol results in increased expression of LBP mRNA	20003209\|2133504
D007649	Ketamine	Ketamine inhibits the reaction [Lipopolysaccharides binds to LBP protein]	19540866
C008261	lead acetate	lead acetate results in increased expression of LBP mRNA	21829687
C045463	leflunomide	leflunomide results in increased expression of LBP mRNA	24136188
D064704	Levofloxacin	Levofloxacin results in increased expression of LBP mRNA	24136188
C482199	lipopolysaccharide, E coli O55-B5	"[Sulindac co-treated with lipopolysaccharide, E coli O55-B5] affects the expression of LBP mRNA"	20371263
D008070	Lipopolysaccharides	Ketamine inhibits the reaction [Lipopolysaccharides binds to LBP protein]	19540866
D008070	Lipopolysaccharides	LBP polymorphism results in increased susceptibility to Lipopolysaccharides	22167001
D008070	Lipopolysaccharides	Lipopolysaccharides binds to LBP protein	19540866\|2126130
D008070	Lipopolysaccharides	Lipopolysaccharides results in increased expression of LBP protein	20699433
D008070	Lipopolysaccharides	Lipopolysaccharides results in increased expression of LBP mRNA	27339419
D008070	Lipopolysaccharides	Lipopolysaccharides results in increased expression of LBP mRNA	16309824
D008727	Methotrexate	Methotrexate results in increased expression of LBP mRNA	17400583
D008727	Methotrexate	Methotrexate results in increased expression of LBP mRNA	24136188
D009151	Mustard Gas	Mustard Gas results in increased expression of LBP mRNA	18955075
D009270	Naloxone	Naloxone results in increased expression of LBP mRNA	17522070
D037742	Nanotubes, Carbon	"Nanotubes, Carbon analog results in increased expression of LBP mRNA"	25554681\|2562005
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in increased expression of LBP mRNA"	25554681\|2562005
D015058	1-Naphthylisothiocyanate	1-Naphthylisothiocyanate results in increased expression of LBP mRNA	15913567
D015058	1-Naphthylisothiocyanate	1-Naphthylisothiocyanate results in increased expression of LBP mRNA	17522070\|2538013
D009532	Nickel	LBP protein binds to Nickel	23896426
D009532	Nickel	Nickel results in increased expression of LBP mRNA	24768652\|2558310
C025256	nonylphenol	nonylphenol results in increased expression of LBP mRNA	17010207
D010047	Ovalbumin	[Ovalbumin affects the susceptibility to Particulate Matter] which results in decreased expression of LBP mRNA	19176365
D017239	Paclitaxel	Paclitaxel results in increased expression of LBP mRNA	18754875
C016030	pantogab	pantogab results in increased expression of LBP mRNA	17379144
D052638	Particulate Matter	[Ovalbumin affects the susceptibility to Particulate Matter] which results in decreased expression of LBP mRNA	19176365
D010400	Penicillin G	[Penicillin G co-treated with Erythromycin] results in increased expression of LBP mRNA	27503388
C086401	pentabromodiphenyl ether	pentabromodiphenyl ether results in increased expression of LBP mRNA	23948077
D010615	Phenacetin	Phenacetin results in increased expression of LBP mRNA	17082564
D010634	Phenobarbital	Phenobarbital results in increased expression of LBP mRNA	21335049
C030299	phenylhydrazine	phenylhydrazine results in increased expression of LBP mRNA	17082564
C006253	pirinixic acid	[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of LBP mRNA	19710929
C006253	pirinixic acid	pirinixic acid results in increased expression of LBP mRNA	18301758\|1844570
D010936	Plant Extracts	Plant Extracts results in decreased expression of LBP mRNA	23557933
D059808	Polyphenols	Polyphenols results in decreased expression of LBP mRNA	16293270
D011285	Pregnenolone Carbonitrile	Pregnenolone Carbonitrile results in decreased expression of LBP mRNA	19162173
D011374	Progesterone	Progesterone results in increased expression of LBP mRNA	21540246
D011802	Quinidine	Quinidine results in increased expression of LBP mRNA	17522070
C059514	resveratrol	resveratrol results in increased expression of LBP mRNA	19228061
C089730	rosiglitazone	[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of LBP mRNA	16054899
D012822	Silicon Dioxide	Silicon Dioxide analog results in decreased expression of LBP mRNA	25895662
D012822	Silicon Dioxide	Silicon Dioxide results in increased expression of LBP mRNA	23221170
D012838	Silymarin	Silymarin inhibits the reaction [Ethanol results in increased expression of LBP mRNA]	24239723
D019821	Simvastatin	Simvastatin results in decreased expression of LBP mRNA	16414398
C016104	sodium bichromate	sodium bichromate results in increased expression of LBP mRNA	25993096
D012999	Soman	Soman results in increased expression of LBP mRNA	19281266
D013467	Sulindac	"[Sulindac co-treated with lipopolysaccharide, E coli O55-B5] affects the expression of LBP mRNA"	20371263
D016559	Tacrolimus	Tacrolimus results in increased expression of LBP mRNA	21865292
C013698	tallow	tallow affects the expression of LBP mRNA	19680557
C047246	temozolomide	LBP mRNA affects the susceptibility to temozolomide	16365179
C020806	tetrabromobisphenol A	tetrabromobisphenol A results in increased expression of LBP mRNA	25461914
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of LBP mRNA	21570461\|2637764
D013749	Tetrachlorodibenzodioxin	[Tetrachlorodibenzodioxin binds to AHR protein] which results in decreased expression of LBP mRNA	16214954
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of LBP mRNA	18796159\|2892240
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of LBP mRNA	15591033
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of LBP mRNA	19692669\|2095900
D013752	Tetracycline	Tetracycline results in increased expression of LBP mRNA	17522070
D013806	Theophylline	Theophylline results in increased expression of LBP mRNA	17522070
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution affects the expression of LBP mRNA	20133372
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution results in decreased expression of LBP mRNA	28111298
C066340	tolcapone	tolcapone results in increased expression of LBP mRNA	24136188
D014212	Tretinoin	Tretinoin results in increased expression of LBP mRNA	16309824
D014302	Trinitrobenzenesulfonic Acid	Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of LBP mRNA]	18200517
D014302	Trinitrobenzenesulfonic Acid	Trinitrobenzenesulfonic Acid results in increased expression of LBP mRNA	18200517
C406224	valdecoxib	valdecoxib results in increased expression of LBP mRNA	24136188
D014635	Valproic Acid	Valproic Acid results in decreased expression of LBP mRNA	29154799
C025643	vinclozolin	vinclozolin results in decreased expression of LBP mRNA	23034163
C029297	vinylidene chloride	vinylidene chloride results in increased expression of LBP mRNA	26682919
D024483	Vitamin K 3	Vitamin K 3 affects the expression of LBP mRNA	20829426
D014874	Water Pollutants, Chemical	"Water Pollutants, Chemical results in decreased expression of LBP mRNA"	25475078
D015032	Zinc	LBP protein binds to Zinc	23896426

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0001530	lipopolysaccharide binding	-	IDA	12594207
GO:0001530	lipopolysaccharide binding	-	IMP	24120359
GO:0001530	lipopolysaccharide binding	-	ISS	2477488
GO:0005102	signaling receptor binding	-	ISS	2477488
GO:0005515	protein binding	-	IPI	15294986 21988832
GO:0070891	lipoteichoic acid binding	-	IDA	12594207
GO:0071723	lipopeptide binding	-	IDA	15294986

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0002224	toll-like receptor signaling pathway	-	TAS	-
GO:0002232	leukocyte chemotaxis involved in inflammatory response	-	IEA	-
GO:0002281	macrophage activation involved in immune response	-	IMP	24120359
GO:0002281	macrophage activation involved in immune response	-	ISS	2402637
GO:0006953	acute-phase response	-	IEP	12932360
GO:0006953	acute-phase response	-	ISS	2477488
GO:0006968	cellular defense response	-	ISS	2402637
GO:0008228	opsonization	-	IC	12932360
GO:0008228	opsonization	-	ISS	2477488
GO:0015920	lipopolysaccharide transport	-	IDA	8985160
GO:0019221	cytokine-mediated signaling pathway	-	TAS	-
GO:0031663	lipopolysaccharide-mediated signaling pathway	-	IDA	8409400 11739189
GO:0032490	detection of molecule of bacterial origin	-	IDA	11528597
GO:0032496	response to lipopolysaccharide	-	IDA	8409400 11739189
GO:0032720	negative regulation of tumor necrosis factor production	-	IDA	11739189
GO:0032722	positive regulation of chemokine production	-	IEA	-
GO:0032755	positive regulation of interleukin-6 production	-	IDA	8409400
GO:0032757	positive regulation of interleukin-8 production	-	IDA	8409400
GO:0032760	positive regulation of tumor necrosis factor production	-	IDA	8409400 12594207
GO:0032760	positive regulation of tumor necrosis factor production	-	IMP	24120359
GO:0032760	positive regulation of tumor necrosis factor production	-	ISS	2402637
GO:0033036	macromolecule localization	-	IDA	15294986
GO:0034142	toll-like receptor 4 signaling pathway	-	TAS	-
GO:0034145	positive regulation of toll-like receptor 4 signaling pathway	-	IDA	11528597
GO:0042535	positive regulation of tumor necrosis factor biosynthetic process	-	IEA	-
GO:0043032	positive regulation of macrophage activation	-	IDA	8409400
GO:0044130	negative regulation of growth of symbiont in host	-	IEA	-
GO:0045087	innate immune response	-	IC	12932360
GO:0045087	innate immune response	-	ISS	2477488
GO:0045919	positive regulation of cytolysis	-	IDA	15294986
GO:0050829	defense response to Gram-negative bacterium	-	IDA	11528597
GO:0050829	defense response to Gram-negative bacterium	-	ISS	2402637
GO:0050830	defense response to Gram-positive bacterium	-	IDA	12932360
GO:0060265	positive regulation of respiratory burst involved in inflammatory response	-	ISS	-
GO:0071222	cellular response to lipopolysaccharide	-	IDA	12594207
GO:0071222	cellular response to lipopolysaccharide	-	IMP	24120359
GO:0071223	cellular response to lipoteichoic acid	-	IDA	12594207
GO:0090023	positive regulation of neutrophil chemotaxis	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005576	extracellular region	-	TAS	-
GO:0005615	extracellular space	-	IDA	2402637 11528597 24120359
GO:0005615	extracellular space	-	ISS	2477488
GO:0009986	cell surface	-	IDA	11528597
GO:0016020	membrane	-	IEA	-
GO:0070062	extracellular exosome	-	HDA	19056867 23533145

KEGG ID	KEGG Term
hsa04620	Toll-like receptor signaling pathway

Reactome ID	Reactome Term	Evidence
R-HSA-1280215	Cytokine Signaling in Immune system	TAS
R-HSA-166016	Toll Like Receptor 4 (TLR4) Cascade	TAS
R-HSA-166020	Transfer of LPS from LBP carrier to CD14	TAS
R-HSA-168249	Innate Immune System	TAS
R-HSA-168256	Immune System	TAS
R-HSA-168898	Toll-Like Receptors Cascades	TAS
R-HSA-449147	Signaling by Interleukins	TAS
R-HSA-5686938	Regulation of TLR by endogenous ligand	TAS
R-HSA-6785807	Interleukin-4 and 13 signaling	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
22355317	Predictors of occurrence and severity of first time low back pain episodes: findings from a military inception cohort. (2012)	George SZ	PLoS One
25772090	Catechol-O-methyltransferase (COMT) gene polymorphisms are associated with baseline disability but not long-term treatment outcome in patients with chronic low back pain. (2015 Nov)	Omair A	Eur Spine J
10447663	Priming of cytokine release and increased levels of bactericidal permeability-increasing protein in the blood of animal facility workers. (1999 Aug)	Borm PJ	Int Arch Occup Environ Health
15289211	Chronic alcoholism causes deleterious conditioning of innate immunity. (2004 Sep-Oct)	Frank J	Alcohol Alcohol
29137477	Circulating lipopolysaccharide-binding protein and carotid intima-media thickness in obstructive sleep apnea. (2018 Mar 16)	Trojova I	Physiol Res
17429701	Spinal mechanical load: a predictor of persistent low back pain? A prospective cohort study. (2007 Jul)	Bakker EW	Eur Spine J
24751659	The association between the history of cardiovascular diseases and chronic low back pain in South Koreans: a cross-sectional study. (2014)	Ha IH	PLoS One
25198368	Relationship between vitamin D deficiency and chronic low back pain in postmenopausal women. (2013)	Rkain H	Curr Rheumatol Rev
22499847	Vertebral endplate changes are not associated with chronic low back pain among Southern European subjects: a case control study. (2012 Sep)	Kovacs FM	AJNR Am J Neuroradiol
2957137	Backache and its prevention. (1987 Sep)	Dwyer AP	Clin Orthop Relat Res
18317198	Is smoking a risk factor for low back pain in adolescents? A prospective cohort study. (2008 Mar 1)	Mikkonen P	Spine (Phila Pa 1976)
27584678	Pain Recurrence After Discectomy for Symptomatic Lumbar Disc Herniation. (2017 May 15)	Suri P	Spine (Phila Pa 1976)
23803696	Innate immunity gene polymorphisms and the risk of colorectal neoplasia. (2013 Nov)	Chang CM	Carcinogenesis
19010986	Lipopolysaccharide-binding protein and CD14 are increased in the bronchoalveolar lavage fluid of smokers. (2009 Feb)	Regueiro V	Eur Respir J
28184307	Low back pain and FokI (rs2228570) polymorphism of vitamin D receptor in athletes. (2017)	Cauci S	BMC Sports Sci Med Rehabil
12642766	Associations between back pain history and lumbar MRI findings. (2003 Mar 15)	Videman T	Spine (Phila Pa 1976)
25239962	Assessing preferences for a university-based smoking cessation program in Lebanon: a discrete choice experiment. (2015 May)	Salloum RG	Nicotine Tob Res
16740168	Patterns of inflammation and the use of reversibility testing in smokers with airway complaints. (2006 Jun 1)	Chavannes NH	BMC Pulm Med
28471875	Genetic predictors of recovery in low back and lumbar radicular pain. (2017 Aug)	Bjorland S	Pain
19718433	Impact of cigarette smoke exposure on innate immunity: a Caenorhabditis elegans model. (2009 Aug 31)	Green RM	PLoS One
28183445	Metabolic endotoxemia and diabetes mellitus: A systematic review. (2017 Mar)	Gomes JMG	Metabolism
26743937	Serum levels of the proinflammatory cytokine interleukin-6 vary based on diagnoses in individuals with lumbar intervertebral disc diseases. (2016 Jan 7)	Weber KT	Arthritis Res Ther
15512548	Low back pain, smoking and employment during pregnancy and after delivery - a 3-month follow-up study. (2000 May)	Lindal E	J Obstet Gynaecol
23349936	Determinants of serum concentrations of lipopolysaccharide-binding protein (LBP) in the adult population: the role of obesity. (2013)	Gonzalez-Quintela A	PLoS One
16175972	Outcome assessment in lumbar spine surgery. (2005 Jun)	Zanoli G	Acta Orthop Suppl
26409414	The importance of identifying and modifying unemployment predictor variables in the evolution of a novel model of care for low back pain in the general population. (2016 Jan 1)	Harris SA	Spine J
24200413	Comparison of spinal fusion and nonoperative treatment in patients with chronic low back pain: long-term follow-up of three randomized controlled trials. (2013 Nov)	Mannion AF	Spine J
17490453	Associations of physical activity and inactivity with low back pain in adolescents. (2008 Apr)	Auvinen J	Scand J Med Sci Sports