Gene: LBR

3930
DHCR14B|LMN2R|PHA|TDRD18
lamin B receptor
protein-coding
1q42.12
Ensembl:ENSG00000143815 MIM:600024 Vega:OTTHUMG00000037520 UniprotKB:Q14739
NG_008099.1
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.770e-1 (AD)  2.684e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ATL30.898
BNIP20.882
MCMBP0.879
ELF10.872
IQGAP10.869
PAK20.866
CLIC40.864
SYPL10.862
CREB3L20.858
HPS50.857

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F29-0.392
OR4F5-0.389
ABCC12-0.378
CDH22-0.37
HNF1A-0.37
ADRA1D-0.366
MARCH4-0.362
OPRD1-0.362
FBLN7-0.356
NKX6-3-0.35

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0297902,2',3',4,4',5-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of LBR mRNA"25510870
C0817662,4,4'-trichlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of LBR mRNA"25510870
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of LBR mRNA"25510870
C0098282,4,5,2',5'-pentachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of LBR mRNA"25510870
C0094072,5,2',5'-tetrachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of LBR mRNA"25510870
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in increased expression of LBR mRNA"23196670
D000082AcetaminophenAcetaminophen affects the expression of LBR mRNA17562736
D000082Acetaminophen[Clofibrate co-treated with Acetaminophen] affects the expression of LBR mRNA17585979
D000082AcetaminophenPPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of LBR mRNA]17585979
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of LBR mRNA19770486
D000395Air Pollutants, Occupational"Air Pollutants, Occupational results in decreased expression of LBR mRNA"23195993
D000643Ammonium ChlorideAmmonium Chloride affects the expression of LBR mRNA16483693
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of LBR mRNA20064835
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of LBR mRNA"19150397
C006780bisphenol Abisphenol A affects the expression of LBR mRNA21786754
C006780bisphenol Abisphenol A results in increased expression of LBR mRNA25047013
C006780bisphenol A[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of LBR mRNA28628672
C006780bisphenol Abisphenol A affects the expression of LBR mRNA21786754
C006780bisphenol Abisphenol A results in decreased expression of LBR mRNA25181051
C006780bisphenol Abisphenol A results in increased expression of LBR protein24552547
C006780bisphenol Abisphenol A results in increased methylation of LBR gene28505145
C000611646bisphenol F[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of LBR mRNA28628672
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in decreased expression of LBR mRNA12414654
D002104CadmiumCadmium results in decreased expression of LBR mRNA24376830
D019256Cadmium ChlorideCadmium Chloride results in increased expression of LBR mRNA23644582
D019256Cadmium ChlorideCadmium Chloride results in increased methylation of LBR promoter22457795
C074702chromium hexavalent ionchromium hexavalent ion affects the expression of LBR mRNA28472532
D002994Clofibrate[Clofibrate co-treated with Acetaminophen] affects the expression of LBR mRNA17585979
D002994ClofibratePPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of LBR mRNA]17585979
D019327Copper SulfateCopper Sulfate results in decreased expression of LBR mRNA19549813
D003375Coumestrol[Coumestrol co-treated with resveratrol] results in increased expression of LBR mRNA19167446
D003375CoumestrolCoumestrol results in increased expression of LBR mRNA19167446
D016572CyclosporineCyclosporine results in decreased expression of LBR mRNA25562108
D003907DexamethasoneDexamethasone results in increased expression of LBR mRNA25047013
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of LBR mRNA28628672
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of LBR mRNA28628672
D002945CisplatinCisplatin affects the reaction [Piroxicam results in increased expression of LBR mRNA]21858171
D002117CalcitriolCalcitriol results in decreased expression of LBR mRNA21592394
D002117Calcitriol[Testosterone co-treated with Calcitriol] results in decreased expression of LBR mRNA21592394
D004147DioxinsDioxins affects the expression of LBR mRNA20463971
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of LBR mRNA17942748
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of LBR mRNA17942748
D005419FlavonoidsFlavonoids results in decreased expression of LBR mRNA18035473
D005557FormaldehydeFormaldehyde results in decreased expression of LBR mRNA23649840
D017313FenretinideFenretinide results in increased expression of LBR mRNA28973697
D006861Hydrogen PeroxideHydrogen Peroxide affects the expression of LBR mRNA20044591
D006861Hydrogen PeroxideHydrogen Peroxide results in decreased expression of LBR mRNA12414654
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of LBR mRNA28628672
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of LBR mRNA28628672
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of LBR mRNA25613284
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of LBR mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of LBR mRNA28628672
C045463leflunomideleflunomide results in decreased expression of LBR mRNA28988120
D008294MalathionMalathion results in decreased expression of LBR mRNA26494550
D008748MethylcholanthreneMethylcholanthrene results in increased expression of LBR mRNA18804290
D008767Methylmercury CompoundsMethylmercury Compounds results in increased expression of LBR protein26558463
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of LBR mRNA23649840
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in increased expression of LBR protein26558463
D009532NickelNickel results in decreased expression of LBR mRNA23195993
C029938nickel sulfatenickel sulfate results in decreased expression of LBR mRNA22714537
C464660obeticholic acidobeticholic acid results in decreased expression of LBR mRNA27939613
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in decreased expression of LBR mRNA25729387
C410127PCB 180"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of LBR mRNA"25510870
D010416PentachlorophenolPentachlorophenol results in increased expression of LBR mRNA24642059
D010894PiroxicamCisplatin affects the reaction [Piroxicam results in increased expression of LBR mRNA]21858171
D010894PiroxicamPiroxicam results in increased expression of LBR mRNA21858171
D010936Plant ExtractsPlant Extracts results in increased expression of LBR mRNA23557933
D011794QuercetinQuercetin results in decreased expression of LBR mRNA21632981
C059514resveratrol[Coumestrol co-treated with resveratrol] results in increased expression of LBR mRNA19167446
C017947sodium arsenitesodium arsenite results in decreased expression of LBR mRNA19072884
D013739Testosterone[Testosterone co-treated with Calcitriol] results in decreased expression of LBR mRNA21592394
D013739TestosteroneTestosterone results in decreased expression of LBR mRNA21592394
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of LBR mRNA11007951
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of LBR mRNA21570461
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of LBR mRNA17942748
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of LBR mRNA25613284
D013853ThioacetamideThioacetamide results in increased expression of LBR mRNA23411599
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of LBR mRNA28065790
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in decreased expression of LBR mRNA25729387
D014241TrichloroethyleneTrichloroethylene results in increased methylation of LBR gene27618143
C012589trichostatin Atrichostatin A results in decreased expression of LBR mRNA15901671
D014635Valproic AcidValproic Acid results in decreased expression of LBR mRNA15901671
D014635Valproic AcidValproic Acid affects the expression of LBR mRNA25979313
D014635Valproic AcidValproic Acid affects the expression of LBR mRNA17292431|1796380
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of LBR gene25560391
D024483Vitamin K 3Vitamin K 3 results in decreased expression of LBR mRNA12414654

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003677DNA binding-IEA-  
GO:0003723RNA binding-HDA22681889  
GO:0005515protein binding-IPI8663349  15324660  17353931  
GO:0005521lamin binding-TAS8157662  
GO:0016627oxidoreductase activity, acting on the CH-CH group of donors-IBA21873635  
GO:0050613delta14-sterol reductase activity-TAS-  
GO:0070087chromo shadow domain binding-IPI15882967  
GO ID GO Term Qualifier Evidence PubMed
GO:0006695cholesterol biosynthetic process-TAS-  
GO:0016126sterol biosynthetic process-IBA21873635  
GO:0055114oxidation-reduction process-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005635nuclear envelope-TAS-  
GO:0005637nuclear inner membrane-IBA21873635  
GO:0005639integral component of nuclear inner membrane-TAS8157662  
GO:0016020membrane-HDA19946888  
GO:0016021integral component of membrane-IDA15698635  
GO:0030176integral component of endoplasmic reticulum membrane-IBA21873635  
GO:0031965nuclear membrane-IDA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-191273Cholesterol biosynthesisTAS
R-HSA-556833Metabolism of lipidsTAS
R-HSA-8957322Metabolism of steroidsTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
29534178Live birth rates in the first complete IVF cycle among 20 687 women using a freeze-all strategy. (2018 May 1)Zhu QHum Reprod