Gene info: ID 3931

Gene: LCAT

GENE ID: 3931

Synonyms: -

Description: lecithin-cholesterol acyltransferase

Gene type: protein-coding

Location: 16q22.1

dbXrefs: Ensembl:ENSG00000213398 MIM:606967 Vega:OTTHUMG00000137551 UniprotKB:P04180

RefSeq: NG_009778.1

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: ND|AD

# Publications: 32

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 2.352e-1 (AD) 3.563e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
SLC12A4	0.827
RENBP	0.786
C1QTNF5	0.78
RARRES2	0.775
FAM181B	0.772
FKBP10	0.769
ENTPD2	0.766
DDAH2	0.761
HMG20B	0.761
TAX1BP3	0.76

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
GABRG3	-0.535
IL12RB2	-0.523
TYRP1	-0.522
CHRM2	-0.499
RAB27B	-0.495
MKX	-0.492
IL1RAPL2	-0.49
OSBPL10	-0.489
CHSY3	-0.482
EPHA5	-0.481

There is no DrugBank record for this gene !

ID	Drug Name	Action	PubMed
C017251	1,2-oleoylphosphatidylcholine	"LCAT protein binds to 1,2-oleoylphosphatidylcholine"	16780378
C076996	27-hydroxycholesterol	LCAT protein results in increased metabolism of 27-hydroxycholesterol	7744831
C027576	4-hydroxy-2-nonenal	4-hydroxy-2-nonenal results in decreased expression of LCAT mRNA	12419474
D000082	Acetaminophen	Acetaminophen results in increased expression of LCAT mRNA	21420995
D000082	Acetaminophen	[Clofibrate co-treated with Acetaminophen] affects the expression of LCAT mRNA	17585979
D000082	Acetaminophen	PPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of LCAT mRNA]	17585979
D016604	Aflatoxin B1	Aflatoxin B1 results in decreased expression of LCAT mRNA	27153756
D016604	Aflatoxin B1	Aflatoxin B1 results in decreased expression of LCAT mRNA	19770486
C006453	alliin	alliin inhibits the reaction [Isoproterenol results in decreased activity of LCAT protein]	16640830
D024502	alpha-Tocopherol	[Quercetin co-treated with alpha-Tocopherol] inhibits the reaction [Cadmium results in decreased activity of LCAT protein]	21535577
D024502	alpha-Tocopherol	[Quercetin co-treated with alpha-Tocopherol] inhibits the reaction [Isoproterenol results in decreased activity of LCAT protein]	19595682
D000638	Amiodarone	Amiodarone affects the expression of LCAT mRNA	19483382
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of LCAT mRNA	16483693
D001553	Benzbromarone	Benzbromarone affects the expression of LCAT mRNA	19483382
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of LCAT mRNA	26238291
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of LCAT mRNA	19770486
D015123	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of LCAT mRNA"	20382639
C006780	bisphenol A	bisphenol A results in decreased methylation of LCAT promoter	27312807
C006780	bisphenol A	bisphenol A results in increased expression of LCAT mRNA	25181051
D020122	tert-Butylhydroperoxide	tert-Butylhydroperoxide results in decreased expression of LCAT mRNA	12419474
D002104	Cadmium	Cadmium results in decreased activity of LCAT protein	21535577
D002104	Cadmium	myricetin inhibits the reaction [[Streptozocin co-treated with Cadmium] results in decreased activity of LCAT protein]	25240712
D002104	Cadmium	[Quercetin co-treated with alpha-Tocopherol] inhibits the reaction [Cadmium results in decreased activity of LCAT protein]	21535577
D002104	Cadmium	[Streptozocin co-treated with Cadmium] results in decreased activity of LCAT protein	25240712
D002713	Chlorine	Chlorine results in decreased expression of LCAT mRNA	18636392
D002713	Chlorine	[Ozone co-treated with Chlorine] affects the expression of LCAT mRNA	18636392
D002726	Chlorogenic Acid	Chlorogenic Acid results in decreased susceptibility to [[Streptozocin co-treated with Niacinamide] results in decreased activity of LCAT protein]	20696151
D002726	Chlorogenic Acid	[tetrahydrocurcumin co-treated with Chlorogenic Acid] results in decreased susceptibility to [[Streptozocin co-treated with Niacinamide] results in decreased activity of LCAT protein]	20696151
D002784	Cholesterol	LCAT protein results in increased acylation of Cholesterol	4847537
D002791	Cholesterol, Dietary	"[Fructose co-treated with Dietary Fats co-treated with Cholesterol, Dietary] results in increased expression of LCAT mRNA"	19509184
D002788	Cholesterol Esters	Dichlorvos inhibits the reaction [[LCAT protein results in increased metabolism of Lecithins] which results in increased chemical synthesis of Cholesterol Esters]	4847537
D002788	Cholesterol Esters	Fenitrothion inhibits the reaction [[LCAT protein results in increased metabolism of Lecithins] which results in increased chemical synthesis of Cholesterol Esters]	4847537
D002788	Cholesterol Esters	[LCAT protein results in increased metabolism of Lecithins] which results in increased chemical synthesis of Cholesterol Esters	4847537
D002788	Cholesterol Esters	Methyl Parathion inhibits the reaction [[LCAT protein results in increased metabolism of Lecithins] which results in increased chemical synthesis of Cholesterol Esters]	4847537
D002788	Cholesterol Esters	polyserine inhibits the reaction [[LCAT protein results in increased metabolism of Lecithins] which results in increased chemical synthesis of Cholesterol Esters]	4847537
D002794	Choline	[Choline deficiency co-treated with Methionine deficiency] results in increased expression of LCAT mRNA	25178843
D002794	Choline	Choline results in increased expression of LCAT mRNA	25178843
D002994	Clofibrate	[Clofibrate co-treated with Acetaminophen] affects the expression of LCAT mRNA	17585979
D002994	Clofibrate	Clofibrate results in decreased expression of LCAT mRNA	17585979
D002994	Clofibrate	PPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of LCAT mRNA]	17585979
D002994	Clofibrate	Clofibrate affects the expression of LCAT mRNA	19483382
D002994	Clofibrate	Clofibrate results in decreased expression of LCAT mRNA	11328961
D002995	Clofibric Acid	Clofibric Acid affects the expression of LCAT mRNA	17602206
D003300	Copper	Copper results in decreased activity of LCAT protein	7751820
D003300	Copper	Copper deficiency results in increased expression of LCAT mRNA	19821111
D019327	Copper Sulfate	Copper Sulfate results in decreased expression of LCAT mRNA	19549813
C029892	cupric chloride	cupric chloride results in increased expression of LCAT mRNA	17211630
D003471	Cuprizone	Cuprizone results in increased expression of LCAT mRNA	26577399
D016572	Cyclosporine	Cyclosporine results in decreased expression of LCAT mRNA	25562108\|2798913
C014347	decitabine	decitabine affects the expression of LCAT mRNA	23300844
C521776	Desmodium gangeticum extract	Desmodium gangeticum extract inhibits the reaction [Isoproterenol results in decreased activity of LCAT protein]	15740881
D003907	Dexamethasone	Dexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of LCAT mRNA]	27941970
D002945	Cisplatin	Cisplatin affects the expression of LCAT mRNA	23300844
D004006	Dichlorvos	Dichlorvos inhibits the reaction [[LCAT protein results in increased metabolism of Lecithins] which results in increased chemical synthesis of Cholesterol Esters]	4847537
D004006	Dichlorvos	Dichlorvos results in decreased activity of LCAT protein	4847537
D004041	Dietary Fats	"[Fructose co-treated with Dietary Fats co-treated with Cholesterol, Dietary] results in increased expression of LCAT mRNA"	19509184
D004041	Dietary Fats	Dietary Fats results in decreased expression of LCAT protein	25087745
D004041	Dietary Fats	orlistat inhibits the reaction [Dietary Fats results in decreased expression of LCAT protein]	25087745
D004041	Dietary Fats	piperine inhibits the reaction [Dietary Fats results in decreased expression of LCAT protein]	25087745
D004052	Diethylnitrosamine	Diethylnitrosamine results in decreased expression of LCAT mRNA	19638242
C015835	dimethyl-4-toluidine	dimethyl-4-toluidine results in decreased expression of LCAT mRNA	27638505
D004317	Doxorubicin	Doxorubicin results in increased expression of LCAT mRNA	26873546
D004785	Environmental Pollutants	Environmental Pollutants results in decreased expression of LCAT mRNA	12655031
C045651	epigallocatechin gallate	epigallocatechin gallate inhibits the reaction [Isoproterenol results in decreased activity of LCAT protein]	20024955
D000431	Ethanol	Ethanol results in decreased activity of LCAT protein	28442378
D000431	Ethanol	zingerone inhibits the reaction [Ethanol results in decreased activity of LCAT protein]	28442378
D005001	Ethionine	Ethionine affects the expression of LCAT mRNA	19483382
D005020	Ethyl Methanesulfonate	Ethyl Methanesulfonate results in increased expression of LCAT mRNA	23649840
D005278	Fenitrothion	Fenitrothion inhibits the reaction [[LCAT protein results in increased metabolism of Lecithins] which results in increased chemical synthesis of Cholesterol Esters]	4847537
D005278	Fenitrothion	Fenitrothion results in decreased activity of LCAT protein	4847537
D005419	Flavonoids	Flavonoids results in decreased expression of LCAT mRNA	18035473
D005419	Flavonoids	Flavonoids results in increased expression of LCAT mRNA	18035473
D005557	Formaldehyde	Formaldehyde results in increased expression of LCAT mRNA	23649840
D005632	Fructose	"[Fructose co-treated with Dietary Fats co-treated with Cholesterol, Dietary] results in increased expression of LCAT mRNA"	19509184
C056933	fumonisin B1	fumonisin B1 results in decreased expression of LCAT mRNA	16221962
C039281	furan	furan results in decreased expression of LCAT mRNA	15120968
D005688	Galactosamine	Galactosamine results in decreased activity of LCAT protein	6631239
D017313	Fenretinide	Fenretinide results in increased expression of LCAT mRNA	28973697
D006861	Hydrogen Peroxide	Hydrogen Peroxide results in decreased expression of LCAT mRNA	12419474
D007545	Isoproterenol	alliin inhibits the reaction [Isoproterenol results in decreased activity of LCAT protein]	16640830
D007545	Isoproterenol	Desmodium gangeticum extract inhibits the reaction [Isoproterenol results in decreased activity of LCAT protein]	15740881
D007545	Isoproterenol	epigallocatechin gallate inhibits the reaction [Isoproterenol results in decreased activity of LCAT protein]	20024955
D007545	Isoproterenol	Isoproterenol results in decreased activity of LCAT protein	15740881\|1664083
D007545	Isoproterenol	naringin inhibits the reaction [Isoproterenol results in decreased activity of LCAT protein]	16906524
D007545	Isoproterenol	[Quercetin co-treated with alpha-Tocopherol] inhibits the reaction [Isoproterenol results in decreased activity of LCAT protein]	19595682
C410337	K 7174	K 7174 results in decreased expression of LCAT mRNA	24086573
D054709	Lecithins	Dichlorvos inhibits the reaction [[LCAT protein results in increased metabolism of Lecithins] which results in increased chemical synthesis of Cholesterol Esters]	4847537
D054709	Lecithins	Fenitrothion inhibits the reaction [[LCAT protein results in increased metabolism of Lecithins] which results in increased chemical synthesis of Cholesterol Esters]	4847537
D054709	Lecithins	LCAT protein results in increased metabolism of Lecithins	4847537
D054709	Lecithins	[LCAT protein results in increased metabolism of Lecithins] which results in increased chemical synthesis of Cholesterol Esters	4847537
D054709	Lecithins	Methyl Parathion inhibits the reaction [[LCAT protein results in increased metabolism of Lecithins] which results in increased chemical synthesis of Cholesterol Esters]	4847537
D054709	Lecithins	polyserine inhibits the reaction [[LCAT protein results in increased metabolism of Lecithins] which results in increased chemical synthesis of Cholesterol Esters]	4847537
D008070	Lipopolysaccharides	Lipopolysaccharides results in decreased expression of LCAT mRNA	12057914
D008095	Lithocholic Acid	[Lithocholic Acid co-treated with Pregnenolone Carbonitrile] results in decreased expression of LCAT mRNA	20359477
D008095	Lithocholic Acid	Lithocholic Acid results in decreased expression of LCAT mRNA	20359477
D008715	Methionine	[Choline deficiency co-treated with Methionine deficiency] results in increased expression of LCAT mRNA	25178843
D008748	Methylcholanthrene	Methylcholanthrene results in decreased expression of LCAT mRNA	11328961
C004925	methylmercuric chloride	methylmercuric chloride results in increased expression of LCAT mRNA	28001369
D008741	Methyl Methanesulfonate	Methyl Methanesulfonate results in increased expression of LCAT mRNA	23649840
D008743	Methyl Parathion	Methyl Parathion inhibits the reaction [[LCAT protein results in increased metabolism of Lecithins] which results in increased chemical synthesis of Cholesterol Esters]	4847537
D008743	Methyl Parathion	Methyl Parathion results in decreased activity of LCAT protein	4847537
D009151	Mustard Gas	Mustard Gas results in increased expression of LCAT mRNA	15674843
C040015	myricetin	myricetin inhibits the reaction [[Streptozocin co-treated with Cadmium] results in decreased activity of LCAT protein]	25240712
D037742	Nanotubes, Carbon	"Nanotubes, Carbon analog results in increased expression of LCAT mRNA"	25620056
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in increased expression of LCAT mRNA"	25620056
C005274	naringin	naringin inhibits the reaction [Isoproterenol results in decreased activity of LCAT protein]	16906524
D019829	Nevirapine	Nevirapine results in increased expression of LCAT protein	19667106
C464660	obeticholic acid	obeticholic acid results in decreased expression of LCAT mRNA	27939613
D019787	Linoleic Acid	Linoleic Acid analog results in increased expression of LCAT mRNA	27939595
D009853	Omeprazole	Omeprazole affects the expression of LCAT mRNA	19483382
C055122	orlistat	orlistat inhibits the reaction [Dietary Fats results in decreased expression of LCAT protein]	25087745
D010126	Ozone	[Ozone co-treated with Chlorine] affects the expression of LCAT mRNA	18636392
C471071	perfluorohexanesulfonic acid	perfluorohexanesulfonic acid results in decreased expression of LCAT mRNA	21705711
C076994	perfluorooctane sulfonic acid	perfluorooctane sulfonic acid results in decreased expression of LCAT mRNA	21705711
C023036	perfluorooctanoic acid	perfluorooctanoic acid results in decreased expression of LCAT mRNA	17681415
C023036	perfluorooctanoic acid	perfluorooctanoic acid results in decreased expression of LCAT mRNA	19162173
D010634	Phenobarbital	Phenobarbital results in decreased expression of LCAT mRNA	19162173
D010672	Phenytoin	Phenytoin results in increased expression of LCAT mRNA	15136057
C008922	piperine	piperine inhibits the reaction [Dietary Fats results in decreased expression of LCAT protein]	25087745
C006253	pirinixic acid	pirinixic acid affects the expression of LCAT mRNA	19483382
C006253	pirinixic acid	pirinixic acid results in decreased expression of LCAT mRNA	19162173
C006253	pirinixic acid	pirinixic acid results in increased expression of LCAT mRNA	16940010
D011078	Polychlorinated Biphenyls	Polychlorinated Biphenyls affects the expression of LCAT mRNA	21334430
D059808	Polyphenols	Polyphenols results in decreased expression of LCAT mRNA	16293270
C027794	polyserine	polyserine inhibits the reaction [[LCAT protein results in increased metabolism of Lecithins] which results in increased chemical synthesis of Cholesterol Esters]	4847537
D011285	Pregnenolone Carbonitrile	[Lithocholic Acid co-treated with Pregnenolone Carbonitrile] results in decreased expression of LCAT mRNA	20359477
D011441	Propylthiouracil	Propylthiouracil affects the expression of LCAT mRNA	19483382
D054328	Proton Pump Inhibitors	Proton Pump Inhibitors results in decreased expression of LCAT mRNA	25626140
D011794	Quercetin	Quercetin affects the expression of LCAT mRNA	21632981
D011794	Quercetin	[Quercetin co-treated with alpha-Tocopherol] inhibits the reaction [Cadmium results in decreased activity of LCAT protein]	21535577
D011794	Quercetin	[Quercetin co-treated with alpha-Tocopherol] inhibits the reaction [Isoproterenol results in decreased activity of LCAT protein]	19595682
C059514	resveratrol	resveratrol results in decreased expression of LCAT mRNA	19028542
D012822	Silicon Dioxide	Silicon Dioxide results in increased expression of LCAT mRNA	25351596
D019821	Simvastatin	Simvastatin results in increased activity of LCAT protein	21241519
D019821	Simvastatin	Simvastatin results in decreased expression of LCAT mRNA	25055962
C017947	sodium arsenite	sodium arsenite results in increased expression of LCAT mRNA	25697676
D012969	Sodium Fluoride	Sodium Fluoride results in increased expression of LCAT mRNA	27862939
D013311	Streptozocin	Chlorogenic Acid results in decreased susceptibility to [[Streptozocin co-treated with Niacinamide] results in decreased activity of LCAT protein]	20696151
D013311	Streptozocin	myricetin inhibits the reaction [[Streptozocin co-treated with Cadmium] results in decreased activity of LCAT protein]	25240712
D013311	Streptozocin	[Streptozocin co-treated with Cadmium] results in decreased activity of LCAT protein	25240712
D013311	Streptozocin	[Streptozocin co-treated with Niacinamide] results in decreased activity of LCAT protein	20696151
D013311	Streptozocin	[tetrahydrocurcumin co-treated with Chlorogenic Acid] results in decreased susceptibility to [[Streptozocin co-treated with Niacinamide] results in decreased activity of LCAT protein]	20696151
D013311	Streptozocin	tetrahydrocurcumin results in decreased susceptibility to [[Streptozocin co-treated with Niacinamide] results in decreased activity of LCAT protein]	20696151
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of LCAT mRNA	21570461
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to LCAT gene]	28213091
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of LCAT mRNA	28213091\|2823826
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of LCAT mRNA	18796159\|1977048
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of LCAT mRNA	18465118
D013752	Tetracycline	Tetracycline results in decreased expression of LCAT mRNA	24489787
C096277	tetrahydrocurcumin	[tetrahydrocurcumin co-treated with Chlorogenic Acid] results in decreased susceptibility to [[Streptozocin co-treated with Niacinamide] results in decreased activity of LCAT protein]	20696151
C096277	tetrahydrocurcumin	tetrahydrocurcumin results in decreased susceptibility to [[Streptozocin co-treated with Niacinamide] results in decreased activity of LCAT protein]	20696151
D013853	Thioacetamide	Thioacetamide affects the expression of LCAT mRNA	19483382
D013853	Thioacetamide	Thioacetamide results in decreased expression of LCAT mRNA	26222700
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution results in decreased activity of LCAT protein	7751820
C016805	tris(1,3-dichloro-2-propyl)phosphate	"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of LCAT mRNA"	26179874
C013320	tris(2-butoxyethyl) phosphate	tris(2-butoxyethyl) phosphate affects the expression of LCAT mRNA	29024780
D014415	Tunicamycin	Tunicamycin results in increased expression of LCAT mRNA	22378314
D014520	Urethane	Urethane results in decreased expression of LCAT mRNA	28818685
D014635	Valproic Acid	Valproic Acid results in decreased expression of LCAT mRNA	29154799
D014635	Valproic Acid	Valproic Acid results in increased methylation of LCAT gene	29154799
D014635	Valproic Acid	Valproic Acid affects the expression of LCAT mRNA	17292431
D001335	Vehicle Emissions	Vehicle Emissions results in decreased methylation of LCAT gene	25560391
C025643	vinclozolin	vinclozolin results in decreased expression of LCAT mRNA	22570695
D009536	Niacinamide	Chlorogenic Acid results in decreased susceptibility to [[Streptozocin co-treated with Niacinamide] results in decreased activity of LCAT protein]	20696151
D009536	Niacinamide	[Streptozocin co-treated with Niacinamide] results in decreased activity of LCAT protein	20696151
D009536	Niacinamide	[tetrahydrocurcumin co-treated with Chlorogenic Acid] results in decreased susceptibility to [[Streptozocin co-treated with Niacinamide] results in decreased activity of LCAT protein]	20696151
D009536	Niacinamide	tetrahydrocurcumin results in decreased susceptibility to [[Streptozocin co-treated with Niacinamide] results in decreased activity of LCAT protein]	20696151
D015032	Zinc	Zinc affects the expression of LCAT mRNA	16413754
C013738	zingerone	zingerone inhibits the reaction [Ethanol results in decreased activity of LCAT protein]	28442378

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0004607	phosphatidylcholine-sterol O-acyltransferase activity	-	IDA	4335615 10559507 26195816
GO:0004607	phosphatidylcholine-sterol O-acyltransferase activity	-	NAS	11966470
GO:0004607	phosphatidylcholine-sterol O-acyltransferase activity	-	TAS	-
GO:0005515	protein binding	-	IPI	1587806 11435418 17676061
GO:0034186	apolipoprotein A-I binding	-	IPI	1587806

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0006644	phospholipid metabolic process	-	IDA	4335615
GO:0006656	phosphatidylcholine biosynthetic process	-	IDA	11966470
GO:0008203	cholesterol metabolic process	-	IDA	4335615 10559507 26195816
GO:0030301	cholesterol transport	-	IDA	10559507
GO:0034372	very-low-density lipoprotein particle remodeling	-	IDA	15654758
GO:0034375	high-density lipoprotein particle remodeling	-	IDA	4335615 10722751 12167653 15210842
GO:0034375	high-density lipoprotein particle remodeling	-	TAS	-
GO:0034435	cholesterol esterification	-	IDA	3458198 4335615 26195816
GO:0042158	lipoprotein biosynthetic process	-	IEA	-
GO:0042632	cholesterol homeostasis	-	IDA	4335615
GO:0043691	reverse cholesterol transport	-	IDA	4335615
GO:0046470	phosphatidylcholine metabolic process	-	IDA	26195816
GO:0090107	regulation of high-density lipoprotein particle assembly	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005576	extracellular region	-	TAS	-
GO:0005615	extracellular space	-	IDA	3458198 4335615 10559507
GO:0034364	high-density lipoprotein particle	-	IDA	3104518
GO:0070062	extracellular exosome	-	HDA	23533145

KEGG ID	KEGG Term
hsa00564	Glycerophospholipid metabolism

Reactome ID	Reactome Term	Evidence
R-HSA-174824	Plasma lipoprotein assembly, remodeling, and clearance	TAS
R-HSA-382551	Transport of small molecules	TAS
R-HSA-8963899	Plasma lipoprotein remodeling	TAS
R-HSA-8964058	HDL remodeling	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
19405812	Age-associated decrease of high-density lipoprotein-mediated reverse cholesterol transport activity. (2009 Apr)	Berrougui H	Rejuvenation Res
1925941	The cornea and disorders of lipid metabolism. (1991 Jul-Aug)	Barchiesi BJ	Surv Ophthalmol
7918308	Higher plasma lipid transfer protein activities and unfavorable lipoprotein changes in cigarette-smoking men. (1994 Oct)	Dullaart RP	Arterioscler Thromb
29758034	Interactions among genes involved in reverse cholesterol transport and in the response to environmental factors in dyslipidemia in subjects from the Xinjiang rural area. (2018)	Wang X	PLoS One
3919701	Epidemiological correlates of high density lipoprotein subfractions, apolipoproteins A-I, A-II, and D, and lecithin cholesterol acyltransferase. Effects of smoking, alcohol, and adiposity. (1985 Mar-Apr)	Haffner SM	Arteriosclerosis
9684753	Decreased postprandial high density lipoprotein cholesterol and apolipoproteins A-I and E in normolipidemic smoking men: relations with lipid transfer proteins and LCAT activities. (1998 Jul)	Mero N	J Lipid Res
7654778	Gas-phase cigarette smoke inhibits plasma lecithin-cholesterol acyltransferase activity by modification of the enzyme's free thiols. (1995 Aug 24)	Bielicki JK	Biochim Biophys Acta
7474298	CETP and LCAT activities are unrelated to smoking and moderate alcohol consumption in healthy normolipidemic men. (1995 Aug)	Ito T	Jpn Circ J
2719765	Lecithin: cholesterol acyltransferase activity in children and young adults. (1989 May)	Ronnemaa T	Atherosclerosis
23852759	Effects of cigarette smoking on HDL quantity and function: implications for atherosclerosis. (2013 Nov)	He BM	J Cell Biochem
8645374	CETP is a determinant of serum LDL-cholesterol but not HDL-cholesterol in healthy Japanese. (1996 Feb)	Kinoshita M	Atherosclerosis
12370852	Cigarette smoking, high-density lipoprotein cholesterol subfractions, and lecithin: cholesterol acyltransferase in young women. (2002 Oct)	Imamura H	Metabolism
22133847	Carriers of lecithin cholesterol acyltransferase gene mutations have accelerated atherogenesis as assessed by carotid 3.0-T magnetic resonance imaging [corrected]. (2011 Dec 6)	Duivenvoorden R	J Am Coll Cardiol
18485513	HbA1c negatively correlates with LCAT activity in type 2 diabetes. (2008 Jul)	Nakhjavani M	Diabetes Res Clin Pract
8305416	Modification of LCAT activity and HDL structure. New links between cigarette smoke and coronary heart disease risk. (1994 Feb)	McCall MR	Arterioscler Thromb
6657116	[Familial hypoalphalipoproteinemia. Vergani's disease]. (1983 Nov 16)	Dioguardi N	Minerva Med
29748187	Complete and Partial LCAT Deficiency are Differentially Associated with Atherosclerosis. (2018 May 10)	Oldoni F	Circulation
28391892	Current smokers with hyperlipidemia lack elevated prebeta1-high-density lipoprotein concentrations. (2017 Jan - Feb)	Nagao Y	J Clin Lipidol
7473602	Inhibition of lecithin: cholesterol acyltransferase activity in human blood plasma by cigarette smoke extract and reactive aldehydes. (1995 Jun)	Chen C	J Biochem Toxicol
19800416	Plasma lecithin: cholesterol acyltransferase activity modifies the inverse relationship of C-reactive protein with HDL cholesterol in nondiabetic men. (2010 Jan)	Dullaart RP	Biochim Biophys Acta
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