Gene: LCN1

3933
PMFA|TLC|TP|VEGP
lipocalin 1
protein-coding
9q34.3
Ensembl:ENSG00000160349 MIM:151675 Vega:OTTHUMG00000020908 UniprotKB:P31025
NC_000009.12
PubMed
0   ANCO-SNPs
ND
1   
6.190e-1 (AD)  2.141e-1 (ND)   (Frontal_Cortex)
8.949e-1 (AD)  6.617e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
KCNK70.411
YDJC0.346
ADAP10.344
TPGS10.337
HSD11B1L0.335
CCDC85B0.332
BAIAP2L20.322
FAM173A0.32
DHRS7C0.317
ASPDH0.316

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
TSSK4-0.339
CD109-0.339
TAS2R5-0.33
NOXRED1-0.317
ESR1-0.316
LPIN3-0.313
NT5C2-0.305
SLC30A10-0.304
TIGD4-0.304
OVCH1-0.303

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00755TretinoinSmall Molecule302-79-4Approved|Investigational|NutraceuticalTarget
ID Drug Name Action PubMed
C05440011-(dansylamino)undecanoic acid11-(dansylamino)undecanoic acid binds to LCN1 protein16461020
C0271321-anilino-8-naphthalenesulfonate1-anilino-8-naphthalenesulfonate binds to LCN1 protein16461020
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of LCN1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of LCN1 mRNA"27188386
C006632arsenic trioxidearsenic trioxide results in decreased expression of LCN1 mRNA25258189
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of LCN1 mRNA22316170
C006780bisphenol Abisphenol A results in decreased expression of LCN1 mRNA25181051
D002104CadmiumCadmium results in increased expression of LCN1 mRNA24376830
D020245p-Chloromercuribenzoic Acid"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of LCN1 mRNA"27188386
D020245p-Chloromercuribenzoic Acidp-Chloromercuribenzoic Acid results in increased expression of LCN1 mRNA26272509
D004397FonofosFonofos results in increased methylation of LCN1 promoter22847954
D010278ParathionParathion results in increased methylation of LCN1 promoter22847954
C009007potassium persulfatepotassium persulfate results in increased expression of LCN1 protein20815409
C012568terbufosterbufos results in increased methylation of LCN1 promoter22847954
D014212TretinoinTretinoin binds to LCN1 protein16461020
D014635Valproic AcidValproic Acid results in increased methylation of LCN1 gene29154799

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004869cysteine-type endopeptidase inhibitor activity-TAS8999869  
GO:0005102signaling receptor binding-IPI11287427  
GO:0008270zinc ion binding-IDA15489503  
GO:0031404chloride ion binding-IDA15489503  
GO:0036094small molecule binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0001895retina homeostasis-HEP23580065  
GO:0006508proteolysis-TAS8999869  
GO:0010951negative regulation of endopeptidase activity-IEA-  
GO:0015909long-chain fatty acid transport-TAS-  
GO:0050896response to stimulus-IEA-  
GO:0050909sensory perception of taste-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-TAS-  
GO:0005615extracellular space-HDA22664934  23580065  
GO:0005615extracellular space-IDA8999869  21805676  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-382551Transport of small moleculesTAS
R-HSA-425397Transport of vitamins, nucleosides, and related moleculesTAS
R-HSA-425407SLC-mediated transmembrane transportTAS
R-HSA-804914Transport of fatty acidsTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
24920892Increased serum levels of lipocalin-1 and -2 in patients with stable chronic obstructive pulmonary disease. (2014)Wang XRInt J Chron Obstruct Pulmon Dis