Gene info: ID 3934

Gene: LCN2

GENE ID: 3934

Synonyms: 24p3|MSFI|NGAL|p25

Description: lipocalin 2

Gene type: protein-coding

Location: 9q34.11

dbXrefs: Ensembl:ENSG00000148346 MIM:600181 Vega:OTTHUMG00000020734 UniprotKB:P80188

RefSeq: NC_000009.12

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: ND

# Publications: 4

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 2.614e-1 (AD) 6.705e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
MMP8	0.748
CEACAM8	0.705
BPI	0.699
DEFA3	0.695
FCAR	0.675
LILRA5	0.672
TCN1	0.665
DEFA4	0.65
LTF	0.65
PGLYRP1	0.638

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
MAGIX	-0.335
SP9	-0.335
CORT	-0.331
STAR	-0.326
C16orf46	-0.324
SMKR1	-0.322
PRKCZ	-0.322
RBM24	-0.321
SHH	-0.319
MYADML2	-0.318

ID	Drug Name	Drug Type	CAS Num	Status	Role
DB01631	Methyl Nonanoate (Ester)	Small Molecule		Experimental	Target
DB01672	2,3-Dihydroxy-Benzoic Acid	Small Molecule	303-38-8	Experimental	Target
DB01926	Carboxymycobactin S	Small Molecule		Experimental	Target
DB02710	2,3,-Dihydroxybenzoylserine	Small Molecule	127658-43-9	Experimental	Target
DB04043	Carboxymycobactin T	Small Molecule		Experimental	Target
DB04476	Trencam-3,2-Hopo	Small Molecule		Experimental	Target

ID	Drug Name	Action	PubMed
C006718	1,12-benzoperylene	"1,12-benzoperylene results in increased expression of LCN2 mRNA"	26377693
C070046	1,2-dioleoyloxy-3-(trimethylammonium)propane	"[Cholesterol co-treated with 1,2-dioleoyloxy-3-(trimethylammonium)propane] results in increased expression of LCN2 mRNA"	22129739
C028474	1,4-bis(2-(3,5-dichloropyridyloxy))benzene	"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of LCN2 mRNA"	22698814\|2890350
C027132	1-anilino-8-naphthalenesulfonate	1-anilino-8-naphthalenesulfonate binds to LCN2 protein	16461020
C511295	2,2',4,4'-tetrabromodiphenyl ether	"2,2',4,4'-tetrabromodiphenyl ether results in increased expression of LCN2 mRNA"	27291303
C014211	2,3,7,8-tetrachlorodibenzofuran	"2,3,7,8-tetrachlorodibenzofuran results in increased expression of LCN2 mRNA"	25768209
C014211	2,3,7,8-tetrachlorodibenzofuran	"2,3,7,8-tetrachlorodibenzofuran results in increased expression of LCN2 protein"	25768209
C014211	2,3,7,8-tetrachlorodibenzofuran	"AHR protein promotes the reaction [2,3,7,8-tetrachlorodibenzofuran results in increased expression of LCN2 mRNA]"	25768209
C049584	2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine	"2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of LCN2 mRNA"	15215175
C031278	2-chloroethyl ethyl sulfide	2-chloroethyl ethyl sulfide results in increased expression of LCN2 protein	22446026
C031278	2-chloroethyl ethyl sulfide	NOS2 protein affects the reaction [2-chloroethyl ethyl sulfide results in increased expression of LCN2 protein]	22446026
C023035	3,4,5,3',4'-pentachlorobiphenyl	"3,4,5,3',4'-pentachlorobiphenyl results in increased expression of LCN2 mRNA"	20959002
C014464	3,4-dichloroaniline	"3,4-dichloroaniline results in increased expression of LCN2 mRNA"	24172598
C014464	3,4-dichloroaniline	"3,4-dichloroaniline results in increased expression of LCN2 mRNA"	24172598
C434003	3-(4-methylphenylsulfonyl)-2-propenenitrile	3-(4-methylphenylsulfonyl)-2-propenenitrile inhibits the reaction [sodium arsenite results in increased expression of LCN2 mRNA]	24570342
C549543	3-hydroxy-4-prenyl-5-methoxystilbene-2-carboxylic acid	3-hydroxy-4-prenyl-5-methoxystilbene-2-carboxylic acid results in increased expression of LCN2 mRNA	25716159
C009505	4,4'-diaminodiphenylmethane	"4,4'-diaminodiphenylmethane results in increased expression of LCN2 mRNA"	25380136
C002202	4-oxoretinoic acid	4-oxoretinoic acid results in increased expression of LCN2 mRNA	15982314
D000082	Acetaminophen	Acetaminophen results in decreased expression of LCN2 mRNA	27888128
D000082	Acetaminophen	Acetaminophen results in decreased secretion of LCN2 protein	27888128
D000082	Acetaminophen	Acetaminophen affects the expression of LCN2 mRNA	17562736
D000082	Acetaminophen	Acetaminophen results in increased expression of LCN2 mRNA	20100502\|2246145
D000082	Acetaminophen	IL22 protein promotes the reaction [Acetaminophen results in increased expression of LCN2 mRNA]	23375450
D000082	Acetaminophen	LGALS3 protein affects the reaction [Acetaminophen results in increased expression of LCN2 mRNA]	22461450
D000082	Acetaminophen	Acetaminophen affects the expression of LCN2 mRNA	20623750
C053001	adefovir	adefovir results in increased secretion of LCN2 protein	27742868
C106812	adefovir dipivoxil	adefovir dipivoxil results in increased secretion of LCN2 protein	24714768
C006418	adrenocorticotropin zinc	adrenocorticotropin zinc results in increased expression of LCN2 mRNA	19920212
D016604	Aflatoxin B1	Aflatoxin B1 results in increased expression of LCN2 mRNA	19770486
C103303	alitretinoin	alitretinoin results in increased expression of LCN2 mRNA	15982314
D000517	alpha-Chlorohydrin	alpha-Chlorohydrin results in increased expression of LCN2 mRNA	20409345
D000537	Aluminum Oxide	"[Nanotubes, Carbon co-treated with Aluminum Oxide] results in increased secretion of LCN2 protein"	25598225
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of LCN2 mRNA	16483693
D000666	Amphotericin B	Amphotericin B results in increased expression of LCN2 protein	28321043
C059765	amphotericin B, deoxycholate drug combination	"amphotericin B, deoxycholate drug combination results in increased expression of LCN2 mRNA"	22863853
C000228	aristolochic acid I	[aristolochic acid I co-treated with aristolochic acid II] results in increased expression of LCN2 protein	23912714
C042310	aristolochic acid II	[aristolochic acid I co-treated with aristolochic acid II] results in increased expression of LCN2 protein	23912714
C006632	arsenic trioxide	arsenic trioxide results in increased expression of LCN2 mRNA	19763917
D017638	Asbestos, Crocidolite	"Asbestos, Crocidolite results in increased expression of LCN2 mRNA"	23917077
D001241	Aspirin	Aspirin inhibits the reaction [Azoxymethane results in decreased expression of LCN2 mRNA]	20043115
C547126	AZM551248	AZM551248 results in decreased expression of LCN2 mRNA	22323515
D001397	Azoxymethane	Aspirin inhibits the reaction [Azoxymethane results in decreased expression of LCN2 mRNA]	20043115
D001397	Azoxymethane	Azoxymethane results in decreased expression of LCN2 mRNA	20043115
D001414	Bacitracin	Bacitracin results in increased expression of LCN2 mRNA	18289764
C017049	bathophenanthroline disulfonic acid	bathophenanthroline disulfonic acid results in decreased expression of LCN2 mRNA	17350462
C017049	bathophenanthroline disulfonic acid	bathophenanthroline disulfonic acid results in decreased expression of LCN2 protein	17350462
C017049	bathophenanthroline disulfonic acid	ferric ammonium citrate inhibits the reaction [bathophenanthroline disulfonic acid results in decreased expression of LCN2 protein]	17350462
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of LCN2 mRNA	22316170
D001564	Benzo(a)pyrene	Benzo(a)pyrene affects the expression of LCN2 mRNA	22342234
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of LCN2 mRNA	19770486
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of LCN2 mRNA	22228805\|2261060
D004958	Estradiol	[Estradiol co-treated with Medroxyprogesterone Acetate] results in decreased expression of LCN2 mRNA	15866426
D004958	Estradiol	[Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of LCN2 mRNA	19619570
D004958	Estradiol	Estradiol promotes the reaction [ESR1 protein binds to LCN2 promoter]	19698761
D004958	Estradiol	Estradiol results in increased expression of LCN2 mRNA	19619570
D004958	Estradiol	Estradiol affects the expression of LCN2 mRNA	15598610
D004958	Estradiol	Estradiol inhibits the reaction [Lipopolysaccharides results in increased expression of LCN2 mRNA]	16977382
D004958	Estradiol	Estradiol results in increased expression of LCN2 mRNA	15289156\|1668458
D004958	Estradiol	Tetrachlorodibenzodioxin inhibits the reaction [Estradiol results in increased expression of LCN2 mRNA]	24052564
D004958	Estradiol	[Estradiol co-treated with Plant Preparations] results in increased expression of LCN2 mRNA	26945725
D004958	Estradiol	Estradiol results in increased expression of LCN2 mRNA	15456929\|2694572
C053541	bicalutamide	bicalutamide results in increased expression of LCN2 mRNA	15638997
C006780	bisphenol A	bisphenol A affects the expression of LCN2 mRNA	27082013
C006780	bisphenol A	bisphenol A results in decreased expression of LCN2 mRNA	27312807
C006780	bisphenol A	[XRCC6 gene mutant form results in increased susceptibility to potassium bromate] affects the reaction [bisphenol A affects the expression of LCN2 mRNA]	27082013
C006780	bisphenol A	bisphenol A affects the expression of LCN2 mRNA	25181051
C006780	bisphenol A	bisphenol A results in increased expression of LCN2 mRNA	15456929
D001761	Bleomycin	Bleomycin results in increased expression of LCN2 mRNA	26345256
D001761	Bleomycin	Bleomycin results in increased expression of LCN2 protein	26345256
C053342	brevetoxin	brevetoxin analog results in decreased expression of LCN2 mRNA	14529743
D019328	Buthionine Sulfoximine	LY6G protein affects the reaction [[zomepirac co-treated with Buthionine Sulfoximine co-treated with tri-o-cresyl phosphate] results in increased expression of LCN2 mRNA]	29154782
D019328	Buthionine Sulfoximine	[zomepirac co-treated with Buthionine Sulfoximine co-treated with tri-o-cresyl phosphate] results in increased expression of LCN2 mRNA	29154782
D019328	Buthionine Sulfoximine	Buthionine Sulfoximine results in increased expression of LCN2 mRNA	23939143
D019328	Buthionine Sulfoximine	Diclofenac promotes the reaction [Buthionine Sulfoximine results in increased expression of LCN2 mRNA]	23939143
D020122	tert-Butylhydroperoxide	tert-Butylhydroperoxide results in decreased secretion of LCN2 protein	27888128
C018475	butyraldehyde	butyraldehyde results in increased expression of LCN2 mRNA	26079696
C584509	C646 compound	C646 compound results in increased expression of LCN2 mRNA	26191083
D019256	Cadmium Chloride	Cadmium Chloride results in decreased secretion of LCN2 protein	27888128
D019256	Cadmium Chloride	Cadmium Chloride results in increased expression of LCN2 mRNA	21457566
D019256	Cadmium Chloride	Cadmium Chloride results in increased expression of LCN2 mRNA	24982889
D019256	Cadmium Chloride	Cadmium Chloride affects the expression of LCN2 mRNA	22110744
D019256	Cadmium Chloride	Cadmium Chloride results in increased expression of LCN2 mRNA	25993096
D002185	Cannabidiol	Cannabidiol results in increased expression of LCN2 mRNA	21542829
D002251	Carbon Tetrachloride	Carbon Tetrachloride affects the expression of LCN2 mRNA	17484886
D002251	Carbon Tetrachloride	Carbon Tetrachloride results in increased expression of LCN2 mRNA	27339419
D002251	Carbon Tetrachloride	[Ethanol co-treated with Carbon Tetrachloride] results in increased expression of LCN2 mRNA	28285099
D002251	Carbon Tetrachloride	PLG gene mutant form promotes the reaction [Carbon Tetrachloride results in increased expression of LCN2 mRNA]	16006527
D002330	Carmustine	LCN2 protein results in increased susceptibility to Carmustine	19860839
D002330	Carmustine	[LCN2 protein co-treated with Carmustine] results in increased cleavage of and results in increased activity of CASP3 protein	19860839
D002330	Carmustine	LCN2 protein promotes the reaction [Carmustine results in decreased phosphorylation of AKT1 protein]	19860839
D002330	Carmustine	LCN2 protein results in increased susceptibility to Carmustine	19860839
C026690	cerous chloride	cerous chloride results in increased expression of LCN2 mRNA	23573234
D002738	Chloroquine	Chloroquine results in increased expression of LCN2 mRNA	19393257
D002784	Cholesterol	"[Cholesterol co-treated with 1,2-dioleoyloxy-3-(trimethylammonium)propane] results in increased expression of LCN2 mRNA"	22129739
C418118	CI 1044	CI 1044 results in increased expression of LCN2 mRNA	17569694
C019304	ciprofibrate	ciprofibrate results in increased expression of LCN2 mRNA	12771043
D002953	Citrinin	Citrinin results in increased expression of LCN2 mRNA	23856526
C018021	cobaltous chloride	cobaltous chloride results in decreased expression of LCN2 mRNA	19376846
D003300	Copper	[NSC 689534 binds to Copper] which results in increased expression of LCN2 mRNA	20971185
D003300	Copper	Copper results in increased secretion of LCN2 protein	19635393
D003474	Curcumin	Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of LCN2 mRNA]	18200517
D003474	Curcumin	Curcumin inhibits the reaction [maleic acid results in increased secretion of LCN2 protein]	25119790
C004632	cyanuric acid	[cyanuric acid co-treated with melamine] results in increased expression of LCN2 mRNA	21784140
C004632	cyanuric acid	[melamine co-treated with cyanuric acid] results in increased expression of LCN2 mRNA	23022069
D003520	Cyclophosphamide	[Cyclophosphamide co-treated with Mecamylamine] results in increased expression of LCN2 mRNA	18433785
D003520	Cyclophosphamide	Cyclophosphamide results in increased expression of LCN2 mRNA	15331540\|1843378
D003520	Cyclophosphamide	Cyclophosphamide results in increased expression of LCN2 mRNA	20623750
D016572	Cyclosporine	Cyclosporine results in increased expression of LCN2 mRNA	20106945\|2556210
D016572	Cyclosporine	Cyclosporine results in increased expression of LCN2 mRNA	23958496\|2758566
D016572	Cyclosporine	ethyl 6-(N-(2-chloro-4-fluorophenyl)sulfamoyl)cyclohex-1-ene-1-carboxylate inhibits the reaction [Cyclosporine results in increased expression of LCN2 mRNA]	27585667
D016572	Cyclosporine	TLR4 gene mutant form inhibits the reaction [Cyclosporine results in increased expression of LCN2 mRNA]	27585667
D016572	Cyclosporine	Cyclosporine results in decreased expression of LCN2 mRNA	21865292
D016572	Cyclosporine	Cyclosporine results in increased expression of LCN2 mRNA	21865292
C010902	decabromobiphenyl ether	decabromobiphenyl ether results in increased expression of LCN2 mRNA	23640034
C415250	deferasirox	deferasirox results in increased expression of LCN2 protein	21439361
C415250	deferasirox	deferasirox results in increased expression of LCN2 protein	21439361
D003676	Deferoxamine	Deferoxamine affects the reaction [Magnetite Nanoparticles results in increased expression of LCN2 mRNA]	23086747
D003676	Deferoxamine	Deferoxamine inhibits the reaction [LCN2 protein results in decreased secretion of VEGFA protein]	17114340
D003676	Deferoxamine	Deferoxamine results in increased expression of LCN2 mRNA	23086747
D013759	Dronabinol	Dronabinol results in increased expression of LCN2 mRNA	21542829
D003907	Dexamethasone	[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of LCN2 mRNA	16054899
D003907	Dexamethasone	Dexamethasone results in decreased secretion of LCN2 protein	28003376
D003907	Dexamethasone	Dexamethasone results in increased expression of LCN2 mRNA	23493372\|2394649
D003907	Dexamethasone	Dexamethasone inhibits the reaction [Freund's Adjuvant results in increased expression of LCN2 mRNA]	21149847
D016264	Dextran Sulfate	Dextran Sulfate results in increased expression of LCN2 mRNA	23894361
D003993	Dibutyl Phthalate	Dibutyl Phthalate results in increased expression of LCN2 mRNA	21266533
D002945	Cisplatin	[Cisplatin co-treated with jinfukang] results in increased expression of LCN2 mRNA	27392435
D002945	Cisplatin	Cisplatin results in decreased secretion of LCN2 protein	27888128
D002945	Cisplatin	Cisplatin results in increased expression of LCN2 mRNA	27392435
D002945	Cisplatin	Cisplatin results in increased expression of LCN2 protein	28904298
D002945	Cisplatin	Cisplatin results in increased expression of LCN2 mRNA	24001450
D002945	Cisplatin	Ondansetron promotes the reaction [Cisplatin results in increased expression of LCN2 mRNA]	24001450
D002945	Cisplatin	SLC47A1 gene mutant form promotes the reaction [Cisplatin results in increased expression of LCN2 mRNA]	24001450
D002945	Cisplatin	Cisplatin results in increased expression of LCN2 mRNA	18289764
D002945	Cisplatin	Cisplatin results in increased expression of LCN2 protein	15033597
D002945	Cisplatin	Cisplatin results in increased secretion of LCN2 protein	28885000
D002945	Cisplatin	LCN2 protein results in increased susceptibility to Cisplatin	19860839
D004008	Diclofenac	Diclofenac results in increased expression of LCN2 mRNA	26934552
D004008	Diclofenac	"Diclofenac inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of LCN2 protein]"	23939143
D004008	Diclofenac	Diclofenac promotes the reaction [Buthionine Sulfoximine results in increased expression of LCN2 mRNA]	23939143
D004008	Diclofenac	Diclofenac results in increased expression of LCN2 mRNA	23939143
D004026	Dieldrin	Dieldrin affects the expression of LCN2 mRNA	22546817
D004041	Dietary Fats	Dietary Fats affects the expression of LCN2 mRNA	19680557
D004041	Dietary Fats	Dietary Fats results in decreased expression of LCN2 mRNA	18042831
D004041	Dietary Fats	Dietary Fats results in increased expression of LCN2 mRNA	22609946
D004041	Dietary Fats	NEIL1 affects the reaction [Dietary Fats results in increased expression of LCN2 mRNA]	21285402
D019422	Dietary Sucrose	Dietary Sucrose results in increased expression of LCN2 mRNA	26033743
D004051	Diethylhexyl Phthalate	Diethylhexyl Phthalate results in increased expression of LCN2 mRNA	19850644
D004051	Diethylhexyl Phthalate	PPARA protein promotes the reaction [Diethylhexyl Phthalate results in increased expression of LCN2 mRNA]	19850644
D004052	Diethylnitrosamine	[Diethylnitrosamine co-treated with Phenobarbital] results in increased expression of LCN2 mRNA	24535843
D004052	Diethylnitrosamine	Diethylnitrosamine results in increased expression of LCN2 mRNA	12771043\|2453584
D004052	Diethylnitrosamine	[Diethylnitrosamine co-treated with Thioacetamide] results in increased expression of LCN2 mRNA	28943392
D004054	Diethylstilbestrol	Diethylstilbestrol results in increased expression of LCN2 mRNA	15289156
D004054	Diethylstilbestrol	Diethylstilbestrol results in decreased expression of LCN2 mRNA	21658437
D002117	Calcitriol	Calcitriol results in increased expression of LCN2 mRNA	26485663
D004128	Dimethylnitrosamine	Dimethylnitrosamine results in increased expression of LCN2 mRNA	17072980\|2538013
D004237	Diuron	Diuron metabolite results in increased expression of LCN2 mRNA	24172598
D004317	Doxorubicin	Doxorubicin results in increased expression of LCN2 mRNA	15033991\|2104076
D004317	Doxorubicin	[[MT1 protein co-treated with MT2 protein] affects the susceptibility to Doxorubicin] which affects the expression of LCN2 mRNA	21040762
D004317	Doxorubicin	Doxorubicin results in increased secretion of LCN2 protein	28885000
D004318	Doxycycline	Doxycycline inhibits the reaction [Isoproterenol results in increased expression of LCN2 mRNA]	18089841
D000431	Ethanol	[Ethanol co-treated with Carbon Tetrachloride] results in increased expression of LCN2 mRNA	28285099
D000431	Ethanol	Ethanol results in decreased expression of LCN2 mRNA	16946407
D004997	Ethinyl Estradiol	Ethinyl Estradiol inhibits the reaction [IL1B protein results in increased expression of LCN2 mRNA]	12072388
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in increased expression of LCN2 mRNA	16467188\|1794274
D004997	Ethinyl Estradiol	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of LCN2 mRNA	17942748
C507035	ethyl 6-(N-(2-chloro-4-fluorophenyl)sulfamoyl)cyclohex-1-ene-1-carboxylate	ethyl 6-(N-(2-chloro-4-fluorophenyl)sulfamoyl)cyclohex-1-ene-1-carboxylate inhibits the reaction [Cyclosporine results in increased expression of LCN2 mRNA]	27585667
D005047	Etoposide	LCN2 protein results in increased susceptibility to Etoposide	19860839
C013531	ferric ammonium citrate	ferric ammonium citrate inhibits the reaction [bathophenanthroline disulfonic acid results in decreased expression of LCN2 protein]	17350462
D015725	Fluconazole	Fluconazole results in increased expression of LCN2 mRNA	20623750
D005620	Freund's Adjuvant	Dexamethasone inhibits the reaction [Freund's Adjuvant results in increased expression of LCN2 mRNA]	21149847
D005620	Freund's Adjuvant	Freund's Adjuvant results in increased expression of LCN2 mRNA	21149847
C069837	fullerene C60	fullerene C60 results in increased expression of LCN2 mRNA	20471445
C039281	furan	furan results in increased expression of LCN2 mRNA	24183702
D019833	Genistein	Genistein results in increased expression of LCN2 mRNA	15289156
D005839	Gentamicins	Gentamicins results in increased expression of LCN2 mRNA	25034533
D005839	Gentamicins	Gentamicins results in increased expression of LCN2 protein	25034533
D005839	Gentamicins	Gentamicins results in decreased secretion of LCN2 protein	27888128
D005839	Gentamicins	Gentamicins results in increased expression of LCN2 protein	28904298
D005839	Gentamicins	Gentamicins results in increased expression of and results in increased secretion of LCN2 protein	19349640
D005839	Gentamicins	Gentamicins results in increased expression of LCN2 mRNA	17636248\|1828976
D005839	Gentamicins	Gentamicins results in increased expression of LCN2 protein	20118187
D005839	Gentamicins	Gentamicins results in increased secretion of LCN2 protein	20816719
D005897	Glafenine	Glafenine results in increased expression of LCN2 mRNA	24136188
D005944	Glucosamine	Glucosamine results in decreased expression of LCN2 mRNA	17178593
D006581	Hexachlorobenzene	Hexachlorobenzene results in increased expression of LCN2 mRNA	15159207
C001335	hexachlorobutadiene	hexachlorobutadiene affects the expression of LCN2 mRNA	21905055
C001335	hexachlorobutadiene	hexachlorobutadiene results in decreased expression of LCN2 mRNA	21905055
C001335	hexachlorobutadiene	hexachlorobutadiene results in increased expression of LCN2 protein	21259293
D017313	Fenretinide	Fenretinide results in increased expression of LCN2 mRNA	16671099
D017313	Fenretinide	Fenretinide results in increased expression of LCN2 protein	16671099
D017313	Fenretinide	Fenretinide results in increased expression of LCN2 mRNA	28973697
D003900	Desoxycorticosterone	"[Desoxycorticosterone co-treated with Sodium Chloride, Dietary] results in increased expression of LCN2 mRNA"	21135038
D003900	Desoxycorticosterone	"Mineralocorticoid Receptor Antagonists inhibits the reaction [[Desoxycorticosterone co-treated with Sodium Chloride, Dietary] results in increased expression of LCN2 mRNA]"	21135038
C492448	ICG 001	ICG 001 results in increased expression of LCN2 mRNA	26191083
C082770	IMM 125	IMM 125 results in increased expression of LCN2 mRNA	20118187
C057937	iomeprol	palmidrol analog inhibits the reaction [[Streptozocin co-treated with iomeprol] results in increased expression of LCN2 protein]	26474837
C057937	iomeprol	[Streptozocin co-treated with iomeprol] results in increased expression of LCN2 protein	26474837
D007501	Iron	Iron results in increased expression of LCN2 mRNA	17350462
D007501	Iron	Iron results in increased expression of LCN2 protein	17350462
D007501	Iron	LCN2 protein affects the metabolism of Iron	17194590
D007501	Iron	LCN2 protein binds to and affects the transport of Iron	17350462
D007501	Iron	LCN2 protein binds to Iron	17114340
D015056	1-Methyl-3-isobutylxanthine	[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of LCN2 mRNA	16054899
D007538	Isoniazid	Isoniazid results in increased expression of LCN2 mRNA	20623750
D007545	Isoproterenol	Doxycycline inhibits the reaction [Isoproterenol results in increased expression of LCN2 mRNA]	18089841
D007545	Isoproterenol	Isoproterenol results in increased expression of LCN2 mRNA	18089841\|2000320
C544151	jinfukang	[Cisplatin co-treated with jinfukang] results in increased expression of LCN2 mRNA	27392435
C098607	JP8 aviation fuel	JP8 aviation fuel results in increased expression of LCN2 protein	20233090
C410337	K 7174	K 7174 results in increased expression of LCN2 mRNA	24086573
D007654	Ketoconazole	Ketoconazole results in decreased expression of LCN2 mRNA	18289764
D007840	Latex	Latex analog results in increased expression of LCN2 mRNA	24768652
C008261	lead acetate	lead acetate results in decreased expression of LCN2 mRNA	22641619
C482199	lipopolysaccharide, E coli O55-B5	"[lipopolysaccharide, E coli O55-B5 co-treated with Particulate Matter] results in increased expression of LCN2 mRNA"	15522845
C482199	lipopolysaccharide, E coli O55-B5	"[lipopolysaccharide, E coli O55-B5 co-treated with Vehicle Emissions] results in increased expression of LCN2 mRNA"	15522845
C482199	lipopolysaccharide, E coli O55-B5	"lipopolysaccharide, E coli O55-B5 results in increased expression of LCN2 mRNA"	15522845\|2330616
C482199	lipopolysaccharide, E coli O55-B5	"Particulate Matter promotes the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of LCN2 mRNA]"	15522845
C482199	lipopolysaccharide, E coli O55-B5	"Vehicle Emissions promotes the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of LCN2 mRNA]"	15522845
C482199	lipopolysaccharide, E coli O55-B5	"Diclofenac inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of LCN2 protein]"	23939143
C482199	lipopolysaccharide, E coli O55-B5	"lipopolysaccharide, E coli O55-B5 results in increased expression of LCN2 mRNA"	23939143
C482199	lipopolysaccharide, E coli O55-B5	"lipopolysaccharide, E coli O55-B5 results in increased expression of LCN2 protein"	23939143
D008070	Lipopolysaccharides	Estradiol inhibits the reaction [Lipopolysaccharides results in increased expression of LCN2 mRNA]	16977382
D008070	Lipopolysaccharides	LCN2 protein inhibits the reaction [Lipopolysaccharides results in increased expression of CCL2 mRNA]	18292240
D008070	Lipopolysaccharides	LCN2 protein inhibits the reaction [Lipopolysaccharides results in increased expression of CSF2 mRNA]	18292240
D008070	Lipopolysaccharides	LCN2 protein inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]	18292240
D008070	Lipopolysaccharides	LCN2 protein inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]	18292240
D008070	Lipopolysaccharides	LCN2 protein inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]	18292240
D008070	Lipopolysaccharides	LCN2 protein inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]	18292240
D008070	Lipopolysaccharides	Lipopolysaccharides results in increased expression of LCN2 mRNA	16977382\|1732100
D008070	Lipopolysaccharides	Lipopolysaccharides results in increased expression of LCN2 protein	21943033
D008070	Lipopolysaccharides	Lipopolysaccharides results in increased expression of LCN2 mRNA	25613284
C068538	liposomal amphotericin B	liposomal amphotericin B results in increased expression of LCN2 mRNA	22863853
D058185	Magnetite Nanoparticles	Deferoxamine affects the reaction [Magnetite Nanoparticles results in increased expression of LCN2 mRNA]	23086747
D058185	Magnetite Nanoparticles	[Magnetite Nanoparticles co-treated with Succimer] results in increased expression of LCN2 mRNA	25522732
D058185	Magnetite Nanoparticles	Magnetite Nanoparticles results in increased expression of LCN2 mRNA	23086747
D058185	Magnetite Nanoparticles	[Polyethyleneimine co-treated with Magnetite Nanoparticles] results in increased expression of LCN2 mRNA	26378955
D058185	Magnetite Nanoparticles	[Succimer binds to Magnetite Nanoparticles] which results in increased expression of LCN2 mRNA	21641980\|2308674
D058185	Magnetite Nanoparticles	[Succimer co-treated with Magnetite Nanoparticles] results in increased expression of LCN2 mRNA	26378955
C030272	maleic acid	Curcumin inhibits the reaction [maleic acid results in increased secretion of LCN2 protein]	25119790
C030272	maleic acid	maleic acid results in increased secretion of LCN2 protein	25119790
D008464	Mecamylamine	[Cyclophosphamide co-treated with Mecamylamine] results in increased expression of LCN2 mRNA	18433785
D017258	Medroxyprogesterone Acetate	[Estradiol co-treated with Medroxyprogesterone Acetate] results in decreased expression of LCN2 mRNA	15866426
C011907	melamine	[cyanuric acid co-treated with melamine] results in increased expression of LCN2 mRNA	21784140
C011907	melamine	[melamine co-treated with cyanuric acid] results in increased expression of LCN2 mRNA	23022069
C011907	melamine	melamine results in increased expression of LCN2	23052191
D008627	Mercuric Chloride	Mercuric Chloride results in decreased secretion of LCN2 protein	27888128
D008627	Mercuric Chloride	Mercuric Chloride results in increased expression of LCN2 mRNA	27720909
D008627	Mercuric Chloride	Mercuric Chloride results in increased expression of LCN2 mRNA	16507785\|2514565
D008628	Mercury	Mercury results in increased expression of LCN2 mRNA	25145654
D008713	Methimazole	Methimazole results in increased expression of LCN2 mRNA	22504374
D008731	Methoxychlor	Methoxychlor results in increased methylation of LCN2 gene	23303685
C017501	methylamphotericin B	methylamphotericin B results in increased expression of LCN2 mRNA	22863853
C004925	methylmercuric chloride	methylmercuric chloride results in increased expression of LCN2 mRNA	27720909
C004925	methylmercuric chloride	methylmercuric chloride results in increased expression of LCN2 mRNA	28536007
D008770	Methylnitrosourea	Methylnitrosourea results in increased expression of LCN2 mRNA	17412507
D000451	Mineralocorticoid Receptor Antagonists	"Mineralocorticoid Receptor Antagonists inhibits the reaction [[Desoxycorticosterone co-treated with Sodium Chloride, Dietary] results in increased expression of LCN2 mRNA]"	21135038
C406082	monomethylarsonous acid	monomethylarsonous acid results in decreased expression of LCN2 mRNA	22108045
D009020	Morphine	Morphine results in increased expression of LCN2 mRNA	20144693
C500085	muraglitazar	muraglitazar results in decreased expression of LCN2 mRNA	21515302
C583365	N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide	"N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide results in decreased expression of LCN2 mRNA"	29244179
C583365	N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide	"N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide results in increased expression of LCN2 mRNA"	29244179
D037742	Nanotubes, Carbon	"Nanotubes, Carbon analog results in increased expression of LCN2 mRNA"	25554681\|2562005
D037742	Nanotubes, Carbon	"[Nanotubes, Carbon co-treated with Aluminum Oxide] results in increased secretion of LCN2 protein"	25598225
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in increased expression of LCN2 mRNA"	25554681\|2562005
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in increased secretion of LCN2 protein"	25598225
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in increased expression of LCN2 mRNA"	19836432\|2491129
D015058	1-Naphthylisothiocyanate	1-Naphthylisothiocyanate results in increased expression of LCN2 mRNA	27853831
D015058	1-Naphthylisothiocyanate	pirinixic acid inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of LCN2 mRNA]	27853831
D015058	1-Naphthylisothiocyanate	PPARA protein affects the reaction [pirinixic acid inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of LCN2 mRNA]]	27853831
D015058	1-Naphthylisothiocyanate	1-Naphthylisothiocyanate results in increased expression of LCN2 mRNA	18289764\|2538013
D010866	Natamycin	Natamycin results in increased expression of LCN2 mRNA	22863853
D009532	Nickel	Nickel results in increased expression of LCN2 mRNA	24768652\|2558310
D009532	Nickel	Nickel results in increased expression of LCN2 mRNA	12540486
C022838	nickel chloride	nickel chloride affects the expression of LCN2 mRNA	22546817
C028007	nickel monoxide	nickel monoxide results in increased expression of LCN2 mRNA	19167457
C029938	nickel sulfate	nickel sulfate results in increased expression of LCN2 mRNA	16100012
C007350	nitrofen	nitrofen results in decreased expression of LCN2 mRNA	27592368
C007350	nitrofen	nitrofen results in increased expression of LCN2 mRNA	23114405
C007350	nitrofen	nitrofen results in increased expression of LCN2 protein	23114405
C558013	NSC 689534	[NSC 689534 binds to Copper] which results in increased expression of LCN2 mRNA	20971185
D009761	Nystatin	Nystatin results in increased expression of LCN2 mRNA	22863853
C025589	ochratoxin A	ochratoxin A results in increased expression of LCN2	25218026
C025589	ochratoxin A	ochratoxin A results in increased expression of LCN2 mRNA	18308701
D000069463	Olive Oil	Olive Oil analog affects the expression of LCN2 mRNA	17349074
D017294	Ondansetron	Ondansetron promotes the reaction [Cisplatin results in increased expression of LCN2 mRNA]	24001450
D010047	Ovalbumin	[Ovalbumin affects the susceptibility to Particulate Matter] which results in decreased expression of LCN2 mRNA	19176365
D010100	Oxygen	Oxygen results in increased expression of LCN2 mRNA	22911455
D010126	Ozone	[Ozone co-treated with NOTCH3 gene mutant form] results in increased expression of LCN2 mRNA	25658374
D010126	Ozone	Ozone results in increased expression of LCN2 mRNA	12763052\|1709563
D010126	Ozone	Ozone results in increased expression of LCN2 protein	22300504
D010126	Ozone	TTPA protein affects the reaction [Ozone results in increased expression of LCN2 mRNA]	19555225
C005958	palmidrol	palmidrol analog inhibits the reaction [[Streptozocin co-treated with iomeprol] results in increased expression of LCN2 protein]	26474837
D000073878	Palm Oil	Palm Oil affects the expression of LCN2 mRNA	19680557
D000073878	Palm Oil	Palm Oil results in decreased expression of LCN2 mRNA	18042831
C016030	pantogab	pantogab results in increased expression of LCN2 mRNA	17379144
D010269	Paraquat	[ABCB1A gene mutant form results in increased susceptibility to Paraquat] which results in increased expression of LCN2 mRNA	25015657
D010269	Paraquat	[ABCB1B gene mutant form results in increased susceptibility to Paraquat] which results in increased expression of LCN2 mRNA	25015657
D010269	Paraquat	Paraquat results in increased expression of LCN2 mRNA	26345256
D010269	Paraquat	Paraquat results in increased expression of LCN2 protein	26345256
D052638	Particulate Matter	Particulate Matter results in increased expression of LCN2 mRNA	28341207
D052638	Particulate Matter	"[lipopolysaccharide, E coli O55-B5 co-treated with Particulate Matter] results in increased expression of LCN2 mRNA"	15522845
D052638	Particulate Matter	"Particulate Matter promotes the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of LCN2 mRNA]"	15522845
D052638	Particulate Matter	Particulate Matter results in decreased expression of LCN2 mRNA	28655636
D052638	Particulate Matter	Particulate Matter results in increased expression of LCN2 mRNA	21381634
D052638	Particulate Matter	[Ovalbumin affects the susceptibility to Particulate Matter] which results in decreased expression of LCN2 mRNA	19176365
C076994	perfluorooctane sulfonic acid	perfluorooctane sulfonic acid results in increased expression of LCN2 mRNA	28973641
D010476	Perfume	Perfume results in decreased expression of LCN2 mRNA	24768652
D010634	Phenobarbital	[Diethylnitrosamine co-treated with Phenobarbital] results in increased expression of LCN2 mRNA	24535843
D010634	Phenobarbital	Phenobarbital affects the expression of LCN2 mRNA	23091169
D010634	Phenobarbital	Phenobarbital results in increased expression of LCN2 mRNA	19270015
C006253	pirinixic acid	pirinixic acid inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of LCN2 mRNA]	27853831
C006253	pirinixic acid	pirinixic acid results in decreased expression of LCN2 mRNA	17321000
C006253	pirinixic acid	pirinixic acid results in increased expression of LCN2 mRNA	18445702
C006253	pirinixic acid	PPARA protein affects the reaction [pirinixic acid inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of LCN2 mRNA]]	27853831
C006253	pirinixic acid	PPARA protein affects the reaction [pirinixic acid results in decreased expression of LCN2 mRNA]	17321000
D028321	Plant Preparations	[Estradiol co-treated with Plant Preparations] results in increased expression of LCN2 mRNA	26945725
D011094	Polyethyleneimine	[Polyethyleneimine co-treated with Magnetite Nanoparticles] results in increased expression of LCN2 mRNA	26378955
C019536	potassium bromate	[XRCC6 gene mutant form results in increased susceptibility to potassium bromate] affects the reaction [bisphenol A affects the expression of LCN2 mRNA]	27082013
C009007	potassium persulfate	potassium persulfate results in increased expression of LCN2 protein	20815409
D011239	Prednisolone	Prednisolone results in decreased secretion of LCN2 protein	28003376
D011285	Pregnenolone Carbonitrile	Pregnenolone Carbonitrile results in increased expression of LCN2 mRNA	28903501
D011374	Progesterone	Progesterone affects the expression of LCN2 mRNA	17251523
C045950	propiconazole	propiconazole results in increased expression of LCN2 mRNA	21278054
C005556	propionaldehyde	propionaldehyde results in increased expression of LCN2 mRNA	26079696
D011441	Propylthiouracil	Propylthiouracil results in increased expression of LCN2 mRNA	22504374
D047428	Protein Kinase Inhibitors	Protein Kinase Inhibitors results in decreased secretion of LCN2 protein	28003376
D011692	Puromycin Aminonucleoside	Puromycin Aminonucleoside results in increased secretion of LCN2 protein	20438795
D011791	Quartz	Quartz results in increased expression of LCN2 mRNA	19836432
D020849	Raloxifene Hydrochloride	Raloxifene Hydrochloride affects the expression of LCN2 mRNA	14699072
C059514	resveratrol	resveratrol results in decreased expression of LCN2 protein	25505154
C059514	resveratrol	[resveratrol co-treated with Streptozocin] results in increased expression of LCN2 mRNA	25905778
C059514	resveratrol	resveratrol results in decreased expression of LCN2 protein	25895148
C059514	resveratrol	resveratrol results in increased expression of LCN2 mRNA	25905778
D015474	Isotretinoin	Isotretinoin results in increased expression of LCN2 mRNA	15982314\|1876912
D012312	Ritodrine	Ritodrine results in increased expression of LCN2 mRNA	23370008
C089730	rosiglitazone	[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of LCN2 mRNA	16054899
D017632	Asbestos, Serpentine	"Asbestos, Serpentine results in increased expression of LCN2 mRNA"	16251409
D012822	Silicon Dioxide	Silicon Dioxide analog results in decreased expression of LCN2 mRNA	25895662
D012822	Silicon Dioxide	Silicon Dioxide results in increased expression of LCN2 mRNA	23221170\|2634525
D012822	Silicon Dioxide	Silicon Dioxide results in increased expression of LCN2 protein	26345256
D012822	Silicon Dioxide	Silicon Dioxide results in increased expression of LCN2 mRNA	22431001
D020123	Sirolimus	Sirolimus results in increased expression of LCN2 mRNA	21865292
D012906	Smoke	Smoke results in decreased expression of LCN2 mRNA	21095227
C009277	sodium arsenate	sodium arsenate results in increased expression of LCN2 mRNA	21795629
C017947	sodium arsenite	3-(4-methylphenylsulfonyl)-2-propenenitrile inhibits the reaction [sodium arsenite results in increased expression of LCN2 mRNA]	24570342
C017947	sodium arsenite	LCN2 mutant form inhibits the reaction [sodium arsenite results in decreased expression of NFKBIB protein]	24570342
C017947	sodium arsenite	LCN2 mutant form inhibits the reaction [sodium arsenite results in increased expression of BCL2L1 mRNA]	24570342
C017947	sodium arsenite	LCN2 mutant form inhibits the reaction [sodium arsenite results in increased expression of CXCL1 mRNA]	24570342
C017947	sodium arsenite	LCN2 mutant form inhibits the reaction [sodium arsenite results in increased expression of CXCL2 mRNA]	24570342
C017947	sodium arsenite	LCN2 mutant form inhibits the reaction [sodium arsenite results in increased expression of CXCL3 mRNA]	24570342
C017947	sodium arsenite	LCN2 mutant form inhibits the reaction [sodium arsenite results in increased expression of CXCL8 mRNA]	24570342
C017947	sodium arsenite	LCN2 mutant form inhibits the reaction [sodium arsenite results in increased expression of DAPK1 mRNA]	24570342
C017947	sodium arsenite	LCN2 mutant form inhibits the reaction [sodium arsenite results in increased expression of IL1A mRNA]	24570342
C017947	sodium arsenite	LCN2 mutant form inhibits the reaction [sodium arsenite results in increased expression of IL1B mRNA]	24570342
C017947	sodium arsenite	LCN2 mutant form inhibits the reaction [sodium arsenite results in increased expression of IL1R1 mRNA]	24570342
C017947	sodium arsenite	LCN2 mutant form inhibits the reaction [sodium arsenite results in increased expression of IL6 mRNA]	24570342
C017947	sodium arsenite	LCN2 mutant form inhibits the reaction [sodium arsenite results in increased expression of PTGS2 mRNA]	24570342
C017947	sodium arsenite	LCN2 mutant form inhibits the reaction [sodium arsenite results in increased phosphorylation of CHUK protein]	24570342
C017947	sodium arsenite	sodium arsenite promotes the reaction [NFKB1 protein binds to LCN2 promoter]	24570342
C017947	sodium arsenite	sodium arsenite promotes the reaction [RELA protein binds to LCN2 promoter]	24570342
C017947	sodium arsenite	sodium arsenite results in decreased methylation of LCN2 gene	24570342
C017947	sodium arsenite	sodium arsenite results in decreased methylation of LCN2 promoter	24570342
C017947	sodium arsenite	sodium arsenite results in increased expression of LCN2 mRNA	24570342
C017947	sodium arsenite	sodium arsenite results in increased expression of LCN2 protein	24570342
C016104	sodium bichromate	sodium bichromate results in increased expression of LCN2 mRNA	25993096
D017673	Sodium Chloride, Dietary	"[Desoxycorticosterone co-treated with Sodium Chloride, Dietary] results in increased expression of LCN2 mRNA"	21135038
D017673	Sodium Chloride, Dietary	"Mineralocorticoid Receptor Antagonists inhibits the reaction [[Desoxycorticosterone co-treated with Sodium Chloride, Dietary] results in increased expression of LCN2 mRNA]"	21135038
D012999	Soman	Soman results in increased expression of LCN2 mRNA	19281266
D053260	Soot	Soot results in increased expression of LCN2 mRNA	22461453\|2655175
D013311	Streptozocin	palmidrol analog inhibits the reaction [[Streptozocin co-treated with iomeprol] results in increased expression of LCN2 protein]	26474837
D013311	Streptozocin	[resveratrol co-treated with Streptozocin] results in increased expression of LCN2 mRNA	25905778
D013311	Streptozocin	[Streptozocin co-treated with iomeprol] results in increased expression of LCN2 protein	26474837
D004113	Succimer	[Magnetite Nanoparticles co-treated with Succimer] results in increased expression of LCN2 mRNA	25522732
D004113	Succimer	[Succimer binds to Magnetite Nanoparticles] which results in increased expression of LCN2 mRNA	21641980\|2308674
D004113	Succimer	[Succimer co-treated with Magnetite Nanoparticles] results in increased expression of LCN2 mRNA	26378955
D016559	Tacrolimus	Tacrolimus results in increased expression of LCN2 mRNA	21865292
C013698	tallow	tallow affects the expression of LCN2 mRNA	19680557
D013629	Tamoxifen	Tamoxifen affects the expression of LCN2 mRNA	14699072
D013629	Tamoxifen	Tamoxifen affects the expression of LCN2 mRNA	20937368
C030141	taurine-ursodeoxycholate conjugate	taurine-ursodeoxycholate conjugate promotes the reaction [LEP gene mutant form results in increased expression of LCN2 mRNA]	21079772
D013749	Tetrachlorodibenzodioxin	[Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of LCN2 mRNA	19619570
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of LCN2 mRNA	19619570
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of LCN2 mRNA	28922406
D013749	Tetrachlorodibenzodioxin	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of LCN2 mRNA	17942748
D013749	Tetrachlorodibenzodioxin	[Tetrachlorodibenzodioxin co-treated with TIPARP gene mutant form] results in decreased expression of LCN2 mRNA	25975270
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin inhibits the reaction [EGF protein results in increased expression of LCN2 mRNA]	15667827
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin inhibits the reaction [Estradiol results in increased expression of LCN2 mRNA]	24052564
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of LCN2 mRNA	16611356
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of LCN2 mRNA	17949056\|2821309
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of LCN2 mRNA	20959002\|2121527
D019284	Thapsigargin	Thapsigargin promotes the reaction [DDIT3 protein binds to LCN2 promoter]	22800509
D019284	Thapsigargin	Thapsigargin results in increased expression of and results in increased secretion of LCN2 protein	22800509
D019284	Thapsigargin	Thapsigargin results in increased expression of LCN2 mRNA	22800509
D013853	Thioacetamide	[Diethylnitrosamine co-treated with Thioacetamide] results in increased expression of LCN2 mRNA	28943392
C009495	titanium dioxide	titanium dioxide affects the expression of LCN2 mRNA	17656681
C009495	titanium dioxide	titanium dioxide results in decreased expression of LCN2 mRNA	23131501
C009495	titanium dioxide	titanium dioxide results in increased expression of LCN2 mRNA	21259345\|2340900
C009495	titanium dioxide	titanium dioxide results in increased expression of LCN2 protein	28646487
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution results in decreased expression of LCN2 mRNA	27404394
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution results in increased expression of LCN2 mRNA	27865774
D014028	Tobacco Smoke Pollution	[APOE gene mutant form affects the susceptibility to Tobacco Smoke Pollution] which results in increased expression of LCN2 mRNA	24096154
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution affects the expression of LCN2 mRNA	20133372
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution results in increased expression of LCN2 mRNA	28111298
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution results in increased expression of LCN2 protein	27818348
D014212	Tretinoin	Tretinoin metabolite results in increased expression of LCN2 mRNA	15982314
D014212	Tretinoin	Tretinoin results in increased expression of LCN2 mRNA	15982314\|1624948
D014212	Tretinoin	Tretinoin results in increased expression of LCN2 protein	16671099
D014212	Tretinoin	Tretinoin results in increased secretion of LCN2 protein	16671099
D014241	Trichloroethylene	Trichloroethylene results in decreased expression of LCN2 mRNA	28973375
D014241	Trichloroethylene	Trichloroethylene results in increased expression of LCN2 mRNA	25549359
C046488	trimethyltin	trimethyltin results in increased expression of LCN2 mRNA	24002884
D014302	Trinitrobenzenesulfonic Acid	Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of LCN2 mRNA]	18200517
D014302	Trinitrobenzenesulfonic Acid	Trinitrobenzenesulfonic Acid results in increased expression of LCN2 mRNA	17982090\|1820051
D014303	Trinitrotoluene	Trinitrotoluene affects the expression of LCN2 mRNA	21346803
C025541	tri-o-cresyl phosphate	LY6G protein affects the reaction [[zomepirac co-treated with Buthionine Sulfoximine co-treated with tri-o-cresyl phosphate] results in increased expression of LCN2 mRNA]	29154782
C025541	tri-o-cresyl phosphate	[zomepirac co-treated with Buthionine Sulfoximine co-treated with tri-o-cresyl phosphate] results in increased expression of LCN2 mRNA	29154782
C016805	tris(1,3-dichloro-2-propyl)phosphate	"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of LCN2 mRNA"	26179874
C057693	troglitazone	troglitazone results in increased expression of LCN2 mRNA	21515302
D014415	Tunicamycin	LCN2 mRNA affects the susceptibility to Tunicamycin	22800509
D014415	Tunicamycin	Tunicamycin results in increased expression of LCN2 mRNA	22800509
D014635	Valproic Acid	Valproic Acid results in increased expression of LCN2 mRNA	29154799
D014635	Valproic Acid	Valproic Acid results in increased methylation of LCN2 gene	29154799
D014640	Vancomycin	Vancomycin results in increased expression of LCN2 mRNA	18289764
D001335	Vehicle Emissions	"[lipopolysaccharide, E coli O55-B5 co-treated with Vehicle Emissions] results in increased expression of LCN2 mRNA"	15522845
D001335	Vehicle Emissions	Vehicle Emissions affects the expression of LCN2 mRNA	18192680
D001335	Vehicle Emissions	"Vehicle Emissions promotes the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of LCN2 mRNA]"	15522845
D001335	Vehicle Emissions	Vehicle Emissions results in decreased expression of LCN2 mRNA	28655636
D001335	Vehicle Emissions	Vehicle Emissions results in increased expression of LCN2 mRNA	19729031
C025643	vinclozolin	vinclozolin affects the expression of LCN2 mRNA	19015723
C025643	vinclozolin	vinclozolin results in decreased expression of LCN2 mRNA	23034163
C029297	vinylidene chloride	vinylidene chloride results in increased expression of LCN2 mRNA	26682919
C088658	zoledronic acid	zoledronic acid results in increased expression of LCN2 mRNA	24714768
C088658	zoledronic acid	zoledronic acid results in increased secretion of LCN2 protein	24714768
C020549	zomepirac	LY6G protein affects the reaction [[zomepirac co-treated with Buthionine Sulfoximine co-treated with tri-o-cresyl phosphate] results in increased expression of LCN2 mRNA]	29154782
C020549	zomepirac	[zomepirac co-treated with Buthionine Sulfoximine co-treated with tri-o-cresyl phosphate] results in increased expression of LCN2 mRNA	29154782

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005506	iron ion binding	-	ISS	-
GO:0036094	small molecule binding	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0006811	ion transport	-	IEA	-
GO:0006879	cellular iron ion homeostasis	-	TAS	-
GO:0006915	apoptotic process	-	IEA	-
GO:0015891	siderophore transport	-	ISS	-
GO:0019221	cytokine-mediated signaling pathway	-	TAS	-
GO:0019730	antimicrobial humoral response	-	TAS	-
GO:0043312	neutrophil degranulation	-	TAS	-
GO:0045087	innate immune response	-	ISS	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005576	extracellular region	-	HDA	27068509
GO:0005576	extracellular region	-	ISS	-
GO:0005576	extracellular region	-	TAS	-
GO:0005615	extracellular space	-	HDA	16502470 22664934
GO:0005615	extracellular space	-	IDA	25645918
GO:0035580	specific granule lumen	-	TAS	-
GO:0070062	extracellular exosome	-	HDA	19056867 23533145

KEGG ID	KEGG Term

Reactome ID	Reactome Term	Evidence
R-HSA-1280215	Cytokine Signaling in Immune system	TAS
R-HSA-168249	Innate Immune System	TAS
R-HSA-168256	Immune System	TAS
R-HSA-382551	Transport of small molecules	TAS
R-HSA-382551	Transport of small molecules	IEA
R-HSA-449147	Signaling by Interleukins	TAS
R-HSA-6785807	Interleukin-4 and 13 signaling	TAS
R-HSA-6798695	Neutrophil degranulation	TAS
R-HSA-6799990	Metal sequestration by antimicrobial proteins	TAS
R-HSA-6803157	Antimicrobial peptides	TAS
R-HSA-917937	Iron uptake and transport	TAS
R-HSA-917937	Iron uptake and transport	IEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
27542180	A Graphical Model of Smoking-Induced Global Instability in Lung Cancer. (2018 Jan-Feb)	Wang Y	IEEE/ACM Trans Comput Biol Bioinform
21885675	Circulating lipocalin 2 is associated with body fat distribution at baseline but is not an independent predictor of insulin resistance: the prospective Cyprus Metabolism Study. (2011 Nov)	Liu X	Eur J Endocrinol
24920892	Increased serum levels of lipocalin-1 and -2 in patients with stable chronic obstructive pulmonary disease. (2014)	Wang XR	Int J Chron Obstruct Pulmon Dis
28256718	Lipocalin-2 is expressed by activated granulocytes and keratinocytes in affected skin and reflects disease activity in acne inversa/hidradenitis suppurativa. (2017 Nov)	Wolk K	Br J Dermatol