Gene: LCP1

3936
CP64|HEL-S-37|L-PLASTIN|LC64P|LPL|PLS2
lymphocyte cytosolic protein 1
protein-coding
13q14.13
Ensembl:ENSG00000136167 MIM:153430 Vega:OTTHUMG00000016864 UniprotKB:P13796
NC_000013.11
SNP Mapped
2   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
5.609e-1 (AD)  3.588e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs372540087chr13:46180600-46180605 (GRCh38.p7)delAGAalcohol dependenceIndel(Insertion and Deletion)
rs9567638chr13:46180599 (GRCh38.p7)T>Calcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SERPINA10.929
SASH30.924
GPSM30.923
SPI10.922
FCER1G0.922
IFI300.921
FCGR2A0.919
ITGB20.915
HCK0.915
CD300A0.913

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
MARCH4-0.525
SLC7A4-0.523
KCNIP3-0.52
ZSCAN1-0.519
DLK2-0.514
TMEM179-0.509
ABCC12-0.497
SPRN-0.493
ADRA1D-0.491
EXTL1-0.489

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5172321,2-dibromo-4-(1,2-dibromoethyl)cyclohexane"1,2-dibromo-4-(1,2-dibromoethyl)cyclohexane results in increased expression of LCP1 mRNA"24375616
C5172321,2-dibromo-4-(1,2-dibromoethyl)cyclohexane"1,2-dibromo-4-(1,2-dibromoethyl)cyclohexane results in increased expression of LCP1 mRNA"27473015
C5172321,2-dibromo-4-(1,2-dibromoethyl)cyclohexane"AR protein affects the reaction [1,2-dibromo-4-(1,2-dibromoethyl)cyclohexane results in increased expression of LCP1 mRNA]"27473015
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of LCP1 mRNA"25380136
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of LCP1 mRNA"27188386
C517041(4-amino-1,4-dihydro-3-(2-pyridyl)-5-thioxo-1,2,4-triazole)copper(II)"(4-amino-1,4-dihydro-3-(2-pyridyl)-5-thioxo-1,2,4-triazole)copper(II) results in increased expression of LCP1 mRNA"19561079
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of LCP1 mRNA"27188386
D000082AcetaminophenAcetaminophen results in decreased expression of LCP1 mRNA22230336|2906747
D000082AcetaminophenAcetaminophen results in increased expression of LCP1 mRNA26690555
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of LCP1 mRNA19770486
D013196DihydrotestosteroneAR protein affects the reaction [Dihydrotestosterone results in increased expression of LCP1 mRNA]27473015
D013196DihydrotestosteroneDihydrotestosterone results in increased expression of LCP1 mRNA27473015
D000535Aluminum[APP protein modified form binds to Aluminum] which results in increased expression of LCP1 mRNA21298039
C059765amphotericin B, deoxycholate drug combination"amphotericin B, deoxycholate drug combination results in increased expression of LCP1 mRNA"22863853
C023650anilineaniline results in increased nitrosation of LCP1 protein21708182
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of LCP1 mRNA24449571
D001151ArsenicArsenic affects the methylation of LCP1 gene25304211
C006632arsenic trioxidearsenic trioxide results in decreased expression of LCP1 protein25419056
C006632arsenic trioxidearsenic trioxide results in increased expression of LCP1 mRNA22521957
D001372Aza CompoundsAza Compounds results in decreased expression of LCP1 mRNA20521778
D001372Aza CompoundsAza Compounds results in increased expression of LCP1 mRNA20521778
C547126AZM551248AZM551248 results in increased expression of LCP1 mRNA22323515
C028559bathocuproine sulfonate[bathocuproine sulfonate co-treated with pyrrolidine dithiocarbamic acid] inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of LCP1 mRNA]15477007
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased mutagenesis of LCP1 gene25435355
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of LCP1 mRNA21569818
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of LCP1 mRNA22228805
C006780bisphenol Abisphenol A affects the expression of LCP1 mRNA21786754
C006780bisphenol Abisphenol A results in increased expression of LCP1 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of LCP1 gene28505145
D002065BuspironeBuspirone results in decreased expression of LCP1 mRNA24136188
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in increased expression of LCP1 mRNA14729362
D019256Cadmium ChlorideCadmium Chloride results in increased expression of LCP1 mRNA25993096
C059041calyculin Acalyculin A results in increased phosphorylation of LCP1 protein14769871
C059041calyculin AKT 5926 inhibits the reaction [calyculin A results in increased phosphorylation of LCP1 protein]14769871
D002220CarbamazepineCarbamazepine affects the expression of LCP1 mRNA25979313
D002251Carbon TetrachlorideCarbon Tetrachloride affects the expression of LCP1 mRNA17484886
D000068579CelecoxibCelecoxib results in decreased expression of LCP1 mRNA28201806
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in decreased expression of LCP1 mRNA23650126
D002922CiguatoxinsCiguatoxins affects the expression of LCP1 mRNA18353800
D002994ClofibrateClofibrate results in decreased expression of LCP1 mRNA17585979
D003471CuprizoneCuprizone results in increased expression of LCP1 mRNA27523638
D003474CurcuminCurcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of LCP1 mRNA]18200517
D016572CyclosporineCyclosporine results in increased expression of LCP1 mRNA25562108|2798913
D016572CyclosporineCyclosporine results in decreased expression of LCP1 mRNA19770486
C007262deoxynivalenoldeoxynivalenol affects the phosphorylation of LCP1 protein23811945
C007262deoxynivalenoldeoxynivalenol results in increased phosphorylation of LCP1 protein23352502
C016366dibenzothiophenedibenzothiophene results in increased expression of LCP1 mRNA23656968
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of LCP1 mRNA21266533
D002945CisplatinCisplatin results in decreased expression of LCP1 mRNA22023808
C036042dicyclohexyl phthalatedicyclohexyl phthalate affects the expression of LCP1 mRNA26924002
D004041Dietary FatsDietary Fats results in decreased expression of LCP1 mRNA18042831
C472511dimethylarsinous aciddimethylarsinous acid results in increased expression of LCP1 mRNA23876855
D004128DimethylnitrosamineDimethylnitrosamine results in increased expression of LCP1 mRNA25380136
C024629dimethyl phthalatedimethyl phthalate affects the expression of LCP1 mRNA26924002
D004147DioxinsDioxins affects the expression of LCP1 mRNA20463971
D004726EndosulfanEndosulfan results in increased expression of LCP1 mRNA21036383
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of LCP1 protein20227414
C061365flusilazoleflusilazole results in decreased expression of LCP1 mRNA22382673
D005485FlutamideFlutamide results in decreased expression of LCP1 mRNA24136188
D005839GentamicinsGentamicins results in increased expression of LCP1 mRNA22061828
D007211IndolesIndoles results in decreased expression of LCP1 mRNA20521778
D007211IndolesIndoles results in increased expression of LCP1 mRNA20521778
D015759Ionomycin[bathocuproine sulfonate co-treated with pyrrolidine dithiocarbamic acid] inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of LCP1 mRNA]15477007
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of LCP1 mRNA15477007
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of LCP1 mRNA25613284
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of LCP1 mRNA24796395
C063769KT 5926KT 5926 inhibits the reaction [calyculin A results in increased phosphorylation of LCP1 protein]14769871
C063769KT 5926KT 5926 inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of LCP1 protein]14769871
C008261lead acetatelead acetate results in increased expression of LCP1 mRNA20542052
D018021Lithium ChlorideLithium Chloride results in increased expression of LCP1 mRNA23527032
D008627Mercuric ChlorideMercuric Chloride affects the expression of LCP1 mRNA20353558
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in decreased expression of LCP1 protein24806433
C517284monomethyl phthalatemonomethyl phthalate affects the expression of LCP1 mRNA26924002
D009151Mustard GasMustard Gas results in increased expression of LCP1 mRNA25102026
C583365N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide"N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide results in increased expression of LCP1 mRNA"29244179
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of LCP1 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of LCP1 mRNA"25554681|2562005
D0150581-Naphthylisothiocyanate1-Naphthylisothiocyanate results in increased expression of LCP1 mRNA25380136
D009532NickelNickel results in increased expression of LCP1 mRNA24768652|2558310
D009538NicotineLCP1 gene SNP affects the susceptibility to Nicotine18438686
C012655nimesulidenimesulide results in decreased expression of LCP1 mRNA24136188
D010098OxycodoneOxycodone results in decreased expression of LCP1 mRNA23439660
D000073878Palm OilPalm Oil results in decreased expression of LCP1 mRNA18042831
D010433Pentylenetetrazole[Pentylenetetrazole co-treated with Vigabatrin] affects the expression of LCP1 mRNA21503142
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of LCP1 mRNA27614199
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of LCP1 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of LCP1 mRNA26272509
C006253pirinixic acidpirinixic acid results in decreased expression of LCP1 mRNA17426115|1844570
C006253pirinixic acidPPARA protein promotes the reaction [pirinixic acid results in decreased expression of LCP1 mRNA]20059764
D011078Polychlorinated BiphenylsPolychlorinated Biphenyls affects the expression of LCP1 mRNA21334430
D011374ProgesteroneProgesterone results in decreased expression of LCP1 mRNA23012394
D011374ProgesteroneProgesterone results in increased expression of LCP1 mRNA20864642|2154024
C513428pyrachlostrobinpyrachlostrobin results in increased expression of LCP1 mRNA27029645
C020972pyrrolidine dithiocarbamic acid[bathocuproine sulfonate co-treated with pyrrolidine dithiocarbamic acid] inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of LCP1 mRNA]15477007
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of LCP1 mRNA25895662
D012834SilverSilver results in increased expression of LCP1 mRNA27131904
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of LCP1 mRNA22298810
D013755Tetradecanoylphorbol Acetate[bathocuproine sulfonate co-treated with pyrrolidine dithiocarbamic acid] inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of LCP1 mRNA]15477007
D013755Tetradecanoylphorbol AcetateKT 5926 inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of LCP1 protein]14769871
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of LCP1 mRNA15477007
D013755Tetradecanoylphorbol AcetateTetradecanoylphorbol Acetate results in increased phosphorylation of LCP1 protein14769871
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of LCP1 mRNA25613284
C009495titanium dioxidetitanium dioxide results in increased expression of LCP1 mRNA23409001|2355797
D014118Toxins, Biological"Toxins, Biological affects the expression of LCP1 mRNA"19682533
C015559trimellitic anhydridetrimellitic anhydride results in increased expression of LCP1 mRNA19042947
D014302Trinitrobenzenesulfonic AcidCurcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of LCP1 mRNA]18200517
D014302Trinitrobenzenesulfonic AcidTrinitrobenzenesulfonic Acid results in increased expression of LCP1 mRNA18200517
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of LCP1 mRNA"26179874
D014520UrethaneUrethane results in decreased expression of LCP1 mRNA28818685
D014635Valproic AcidValproic Acid results in decreased methylation of LCP1 gene29154799
D014635Valproic AcidValproic Acid results in increased expression of LCP1 mRNA23179753|2800136
D014638VanadatesVanadates results in increased expression of LCP1 mRNA22714537
D014640VancomycinVancomycin results in decreased expression of LCP1 mRNA18930951
D020888Vigabatrin[Pentylenetetrazole co-treated with Vigabatrin] affects the expression of LCP1 mRNA21503142
C025643vinclozolinvinclozolin affects the expression of LCP1 mRNA19015723|2303416
C088658zoledronic acidzoledronic acid results in increased expression of LCP1 mRNA24714768

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003779actin binding-NAS2252891  
GO:0005178integrin binding-IPI20183869  
GO:0005509calcium ion binding-NAS2378651  
GO:0042802identical protein binding-IEA-  
GO:0051015actin filament binding-IBA21873635  
GO:0051015actin filament binding-IMP16636079  
GO:0051020GTPase binding-IPI24337748  
GO ID GO Term Qualifier Evidence PubMed
GO:0002286T cell activation involved in immune response-IDA17294403  
GO:0010737protein kinase A signaling-IMP16636079  
GO:0016477cell migration-IMP16636079  
GO:0022617extracellular matrix disassembly-IMP24236012  
GO:0031100animal organ regeneration-IEA-  
GO:0033157regulation of intracellular protein transport-IDA17294403  
GO:0035722interleukin-12-mediated signaling pathway-TAS-  
GO:0044319wound healing, spreading of cellsNOTIMP16636079  
GO:0051017actin filament bundle assembly-IBA21873635  
GO:0051017actin filament bundle assembly-IMP16636079  
GO:0051639actin filament network formation-IBA21873635  
GO:0071803positive regulation of podosome assembly-IMP24236012  
GO ID GO Term Qualifier Evidence PubMed
GO:0001725stress fibercolocalizes_withIMP16636079  
GO:0001726ruffle-IMP16636079  
GO:0001891phagocytic cup-IEA-  
GO:0002102podosome-IDA24236012  
GO:0005615extracellular space-HDA16502470  22664934  
GO:0005737cytoplasm-IBA21873635  
GO:0005737cytoplasm-IDA16636079  
GO:0005737cytoplasm-NAS2378651  
GO:0005829cytosol-IDA2111166  17294403  
GO:0005884actin filament-IBA21873635  
GO:0005884actin filament-IMP16636079  
GO:0005886plasma membrane-IDA-  
GO:0005925focal adhesion-IMP16636079  
GO:0015629actin cytoskeleton-IDA-  
GO:0030054cell junction-TAS-  
GO:0030175filopodium-IMP16636079  
GO:0032432actin filament bundle-IBA21873635  
GO:0032432actin filament bundle-IMP16636079  
GO:0032587ruffle membrane-IEA-  
GO:0048471perinuclear region of cytoplasmcolocalizes_withIDA20183869  
GO:0070062extracellular exosome-HDA19056867  20458337  23533145  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1280215Cytokine Signaling in Immune systemTAS
R-HSA-168256Immune SystemTAS
R-HSA-447115Interleukin-12 family signalingTAS
R-HSA-449147Signaling by InterleukinsTAS
R-HSA-8950505Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulationTAS
R-HSA-9020591Interleukin-12 signalingTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal