Gene: LCT

3938
LAC|LPH|LPH1
lactase
protein-coding
2q21.3
Ensembl:ENSG00000115850 MIM:603202 Vega:OTTHUMG00000131738 UniprotKB:P09848
NG_008104.2
PubMed
0   ANCO-SNPs
ND
6   
NA (AD)  NA (ND)   (Frontal_Cortex)
9.921e-4 (AD)  8.212e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4K30.598
PATE40.579
FAM205A0.571
OR1I10.566
OR10A70.565
OR2J20.561
MBL20.561
PSG30.558
APOBEC40.55
CD1B0.546

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CDT1-0.258
CENPH-0.246
SP5-0.215
MANSC4-0.211
KAZALD1-0.21
MYCNOS-0.209
SPDEF-0.205
PRSS27-0.203
CLPSL2-0.201
CLDND2-0.2

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00126Vitamin CSmall Molecule50-81-7Approved|NutraceuticalTarget
DB02376D-gluconhydroximo-1,5-lactamSmall MoleculeExperimentalTarget
DB02471Nojirimycine TetrazoleSmall MoleculeExperimentalTarget
DB03389alpha-D-XylopyranoseSmall Molecule-ExperimentalTarget
DB042822-deoxy-2-fluoro-alpha-D-glucoseSmall Molecule-ExperimentalTarget
DB04564GluconolactoneSmall Molecule90-80-2Approved|ExperimentalTarget
DB04659(1S,2S,3R,4S,5S)-2,3,4-TRIHYDROXY-5-(HYDROXYMETHYL)CYCLOHEXYL (1E)-2-PHENYL-N-(SULFOOXY)ETHANIMIDOTHIOATESmall MoleculeExperimentalTarget
DB04779ETHYL (1E)-2-PHENYL-N-(SULFOOXY)ETHANIMIDOTHIOATESmall MoleculeExperimentalTarget
DB085582-HYDROXYMETHYL-6-OCTYLSULFANYL-TETRAHYDRO-PYRAN-3,4,5-TRIOLSmall MoleculeExperimentalTarget
ID Drug Name Action PubMed
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in decreased expression of LCT mRNA"25614096
D000643Ammonium ChlorideAmmonium Chloride affects the expression of LCT mRNA16483693
D001151ArsenicArsenic affects the methylation of LCT gene25304211
D001241AspirinAspirin results in decreased activity of LCT protein16382204
D001241Aspirin[Aspirin results in decreased activity of LCT protein] which results in decreased transport of Glucose16382204
D001241AspirinAspirin results in increased activity of LCT17147060
D001241AspirinAspirin results in increased activity of LCT protein16855794|1860431
D001564Benzo(a)pyrene[Benzo(a)pyrene co-treated with sodium bichromate] results in decreased expression of LCT mRNA21632023
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of LCT mRNA27195522
C006780bisphenol Abisphenol A affects the expression of LCT mRNA25181051
C006780bisphenol A[bisphenol A co-treated with Genistein] results in increased methylation of LCT gene28505145
D019256Cadmium ChlorideCadmium Chloride results in increased expression of LCT mRNA19031917
D000068579CelecoxibCelecoxib results in increased activity of LCT protein18604318
C074702chromium hexavalent ionchromium hexavalent ion affects the expression of LCT mRNA28472532
D016572CyclosporineCyclosporine results in increased methylation of LCT promoter27989131
C014347decitabinedecitabine results in increased expression of LCT mRNA18845559
D003907DexamethasoneDexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of LCT mRNA]27941970
D004026DieldrinDieldrin results in decreased expression of LCT mRNA28385952
D005632FructoseFructose results in increased expression of LCT mRNA11242478
D005643FucoseLCT protein results in increased hydrolysis of Fucose14701853
D005690GalactoseLCT protein results in increased hydrolysis of Galactose14701853
D019833GenisteinGenistein results in decreased expression of LCT mRNA22553218
D019833Genistein[bisphenol A co-treated with Genistein] results in increased methylation of LCT gene28505145
D005947Glucose[Aspirin results in decreased activity of LCT protein] which results in decreased transport of Glucose16382204
D005947GlucoseLCT protein results in increased hydrolysis of Glucose14701853
D005947Glucose[nimesulide results in decreased activity of LCT protein] which results in decreased transport of Glucose16382204
D020719GlucuronidesLCT protein results in increased hydrolysis of Glucuronides14701853
C016527isoquercitrin[migalastat results in decreased activity of LCT protein] which results in decreased hydrolysis of isoquercitrin12663055
C031895lead chromatelead chromate results in decreased expression of LCT mRNA23584427
D008358MannoseLCT protein results in increased hydrolysis of Mannose14701853
C059539midostaurinmidostaurin results in decreased expression of LCT mRNA20980353
C090092migalastatmigalastat results in decreased activity of LCT protein12663055
C090092migalastat[migalastat results in decreased activity of LCT protein] which results in decreased hydrolysis of isoquercitrin12663055
C090092migalastat[migalastat results in decreased activity of LCT protein] which results in decreased hydrolysis of spiraeoside12663055
C090092migalastat[migalastat results in decreased activity of LCT protein] which results in decreased uptake of Quercetin12663055
C496111nimbidiolnimbidiol results in decreased activity of LCT protein22803678
C012655nimesulidenimesulide affects the activity of LCT protein18604318
C012655nimesulidenimesulide results in decreased activity of LCT protein16382204
C012655nimesulide[nimesulide results in decreased activity of LCT protein] which results in decreased transport of Glucose16382204
C012655nimesulidenimesulide results in increased activity of LCT17147060
C012655nimesulidenimesulide results in increased activity of LCT protein16855794
C006253pirinixic acidpirinixic acid results in decreased expression of LCT mRNA17426115
D010936Plant ExtractsPlant Extracts results in decreased expression of LCT mRNA23557933
C058229polydatinLCT protein results in increased hydrolysis of polydatin analog17009167
D011192Potassium DichromatePotassium Dichromate results in increased expression of LCT mRNA23608068
D011374ProgesteroneProgesterone results in increased expression of LCT mRNA22238285
D011794QuercetinQuercetin results in increased expression of LCT mRNA21632981
D011794Quercetin[migalastat results in decreased activity of LCT protein] which results in decreased uptake of Quercetin12663055
C016104sodium bichromate[Benzo(a)pyrene co-treated with sodium bichromate] results in decreased expression of LCT mRNA21632023
C016104sodium bichromatesodium bichromate results in decreased expression of LCT mRNA22561333
C080613spiraeoside[migalastat results in decreased activity of LCT protein] which results in decreased hydrolysis of spiraeoside12663055
D013395SucroseSucrose results in increased expression of LCT mRNA11242478
D013792ThalidomideThalidomide results in increased expression of LCT mRNA28892372
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased methylation of LCT gene26756918
D014994XyloseLCT protein results in increased hydrolysis of Xylose14701853

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000016lactase activity-IBA21873635  
GO:0000016lactase activity-TAS-  
GO:0008422beta-glucosidase activity-IBA21873635  
GO:0017042glycosylceramidase activity-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005975carbohydrate metabolic process-IEA-  
GO:0044245polysaccharide digestion-TAS-  
GO:1901657glycosyl compound metabolic process-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0005886plasma membrane-TAS-  
GO:0005887integral component of plasma membrane-TAS2460343  
GO:0016020membrane-TAS2460343  
GO:0016324apical plasma membrane-IEA-  
KEGG ID KEGG Term
hsa00052Galactose metabolism
hsa01100Metabolic pathways
hsa04973Carbohydrate digestion and absorption
Reactome ID Reactome Term Evidence
R-HSA-1643685DiseaseTAS
R-HSA-189085Digestion of dietary carbohydrateTAS
R-HSA-5659898Intestinal saccharidase deficienciesTAS
R-HSA-5663084Diseases of carbohydrate metabolismTAS
R-HSA-5668914Diseases of metabolismTAS
R-HSA-8935690DigestionTAS
R-HSA-8963743Digestion and absorptionTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
24994038Mutations of EGFR or KRAS and expression of chemotherapy-related genes based on small biopsy samples in stage IIIB and IV inoperable non-small cell lung cancer. (2014 Dec)Deng LLJ Cancer Res Clin Oncol
16015262Genetically defined adult-type hypolactasia and self-reported lactose intolerance as risk factors of osteoporosis in Finnish postmenopausal women. (2005 Oct)Enattah NEur J Clin Nutr
25366782Associations between clinical characteristics and oncogene expression in patients with non-small cell lung cancer. (2014 Oct 31)Han YGenet Mol Res
28043144Association of EGFR and KRAS mutations with expression of p-AKT, DR5 and DcR1 in non-small cell lung cancer. (2017)Zhao XDNeoplasma
20363096Deregulated expression of miR-21, miR-143 and miR-181a in non small cell lung cancer is related to clinicopathologic characteristics or patient prognosis. (2010 Jul)Gao WBiomed Pharmacother
15365657Molecularly defined lactose malabsorption, peak bone mass and bone turnover rate in young finnish men. (2004 Dec)Enattah NCalcif Tissue Int