Gene: LDHC

3948
CT32|LDH3|LDHX
lactate dehydrogenase C
protein-coding
11p15.1
Ensembl:ENSG00000166796 MIM:150150 Vega:OTTHUMG00000167722 UniprotKB:P07864
NG_011816.1
PubMed
0   ANCO-SNPs
ND
1   
2.090e-2 (AD)  4.077e-1 (ND)   (Frontal_Cortex)
2.684e-2 (AD)  1.624e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
KRT40.348
GC0.341
TIGD40.331
AMBP0.314
PCSK50.313
KRT130.309
FNBP1L0.309
PVRIG0.308
ZNF4170.305
CAPN140.301

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
NPIPB15-0.212
IDO2-0.201
CMA1-0.189
MYBPC2-0.186
LCE2C-0.167
KRT3-0.165
SCGB2A2-0.165
HOXC11-0.164
KRTAP10-4-0.164
SCGB1A1-0.163

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00157NADHSmall Molecule58-68-4Approved|NutraceuticalTarget
ID Drug Name Action PubMed
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of LDHC mRNA"19114083
D000643Ammonium ChlorideAmmonium Chloride affects the expression of LDHC mRNA16483693
C032456antimycinantimycin results in decreased activity of LDHC protein3769483
C026987aroclor 1260aroclor 1260 results in decreased expression of LDHC protein27581792
C026987aroclor 1260Plant Extracts inhibits the reaction [aroclor 1260 results in decreased expression of LDHC protein]27581792
C026987aroclor 1260Thioctic Acid inhibits the reaction [aroclor 1260 results in decreased expression of LDHC protein]27581792
C006780bisphenol Abisphenol A results in increased expression of LDHC mRNA26063408
D002104CadmiumCadmium results in decreased expression of LDHC mRNA26187450
D019256Cadmium ChlorideCadmium Chloride results in decreased activity of LDHC protein21664405
D004390ChlorpyrifosChlorpyrifos results in increased activity of LDHC protein23364943
C010902decabromobiphenyl etherdecabromobiphenyl ether results in decreased expression of LDHC mRNA23640034
D004121Dimethyl SulfoxideDimethyl Sulfoxide affects the expression of LDHC mRNA24834073
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of LDHC mRNA17555576
C034096ethoxyacetic acidethoxyacetic acid results in decreased activity of LDHC protein4035690
C024565ethylene dichlorideethylene dichloride results in decreased expression of LDHC mRNA28973639
C024565ethylene dichlorideethylene dichloride results in decreased expression of LDHC protein28973639
D005557FormaldehydeFormaldehyde results in decreased expression of LDHC mRNA23649840
D006072GossypolGossypol analog results in decreased activity of LDHC protein3769483
D006072GossypolGossypol results in decreased activity of LDHC protein3769483
C017461lead nitratelead nitrate results in decreased expression of LDHC mRNA21628963
D008070LipopolysaccharidesLipopolysaccharides results in decreased expression of LDHC protein21195065
D008070LipopolysaccharidesThioctic Acid inhibits the reaction [Lipopolysaccharides results in decreased expression of LDHC protein]21195065
D008095Lithocholic AcidLithocholic Acid results in decreased activity of LDHC protein3769483
D008713MethimazoleMethimazole results in increased expression of LDHC mRNA22504374
C013598methoxyacetic acidmethoxyacetic acid results in decreased activity of LDHC protein4035690
C063855microcystin RRmicrocystin RR results in decreased expression of LDHC protein19111056
C003297nandrolone decanoatenandrolone decanoate results in decreased activity of LDHC protein25542992
C003297nandrolone decanoateTaurine inhibits the reaction [nandrolone decanoate results in decreased activity of LDHC protein]25542992
D009285NaphthoquinonesNaphthoquinones results in decreased activity of LDHC protein3769483
C017095n-butoxyacetic acidn-butoxyacetic acid results in decreased activity of LDHC protein4035690
C025589ochratoxin Aochratoxin A results in decreased acetylation of LDHC promoter29098329
D010634PhenobarbitalPhenobarbital results in increased expression of LDHC mRNA21335049
D010852PicrotoxinPicrotoxin results in increased expression of LDHC mRNA15170462
D010936Plant ExtractsPlant Extracts inhibits the reaction [aroclor 1260 results in decreased expression of LDHC protein]27581792
D011192Potassium DichromatePotassium Dichromate results in increased expression of LDHC mRNA23608068
D011441PropylthiouracilPropylthiouracil results in increased expression of LDHC mRNA22504374
D012822Silicon DioxideSilicon Dioxide results in increased expression of LDHC mRNA21602193
C017947sodium arsenitesodium arsenite results in increased expression of LDHC mRNA27287256
C016104sodium bichromatesodium bichromate results in increased expression of LDHC mRNA22561333
D012969Sodium FluorideSodium Fluoride results in increased expression of LDHC protein27548804
C031618sodium nitratesodium nitrate results in decreased activity of LDHC protein19922758
D013629TamoxifenTamoxifen affects the expression of LDHC mRNA17555576
D013654TaurineTaurine inhibits the reaction [nandrolone decanoate results in decreased activity of LDHC protein]25542992
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of LDHC mRNA21570461
D0156472,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine"2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine results in increased expression of LDHC protein"25852303
D008063Thioctic AcidThioctic Acid inhibits the reaction [aroclor 1260 results in decreased expression of LDHC protein]27581792
D008063Thioctic AcidThioctic Acid inhibits the reaction [Lipopolysaccharides results in decreased expression of LDHC protein]21195065
D014112ToxapheneToxaphene results in increased expression of LDHC protein1269500
D014118Toxins, Biological"Toxins, Biological affects the expression of LDHC mRNA"19682533
D014212TretinoinTretinoin results in decreased expression of LDHC mRNA23724009
D014874Water Pollutants, Chemical"Water Pollutants, Chemical results in increased activity of LDHC protein"25179371

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004459L-lactate dehydrogenase activity-EXP1996957  11276087  
GO ID GO Term Qualifier Evidence PubMed
GO:0005975carbohydrate metabolic process-IEA-  
GO:0006090pyruvate metabolic process-TAS-  
GO:0006754ATP biosynthetic process-IEA-  
GO:0019244lactate biosynthetic process from pyruvate-IEA-  
GO:0019516lactate oxidation-IEA-  
GO:0030317flagellated sperm motility-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-HDA21630459  
GO:0005829cytosol-TAS-  
GO:0031514motile cilium-IEA-  
GO:0070062extracellular exosome-HDA23533145  
KEGG ID KEGG Term
hsa00010Glycolysis / Gluconeogenesis
hsa00270Cysteine and methionine metabolism
hsa00620Pyruvate metabolism
hsa00640Propanoate metabolism
hsa01100Metabolic pathways
Reactome ID Reactome Term Evidence
R-HSA-1428517The citric acid (TCA) cycle and respiratory electron transportTAS
R-HSA-1430728MetabolismTAS
R-HSA-70268Pyruvate metabolismTAS
R-HSA-71406Pyruvate metabolism and Citric Acid (TCA) cycleTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
17553591Chromosomal aberrations of malignant pleural effusions of lung adenocarcinoma: different cytogenetic changes are correlated with genders and smoking habits. (2007 Sep)Yen CCLung Cancer