Gene: LDLR

3949
FH|FHC|LDLCQ2
low density lipoprotein receptor
protein-coding
19p13.2
Ensembl:ENSG00000130164 MIM:606945 Vega:OTTHUMG00000171935 UniprotKB:P01130
NG_009060.1
PubMed
0   ANCO-SNPs
ND
27   
NA (AD)  NA (ND)   (Frontal_Cortex)
4.141e-1 (AD)  5.645e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
FOSL20.694
CISH0.68
SBNO20.679
RELT0.677
ITPKC0.676
CCDC90.672
MIDN0.67
NUP980.665
GADD45B0.665
PFKFB30.663

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
RERGL-0.3
OR4F5-0.276
OR4F29-0.272
C20orf85-0.265
P2RY14-0.242
REM1-0.229
DSG1-0.221
SNX22-0.218
ARL5C-0.211
LCE2A-0.206

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00707Porfimer sodiumSmall Molecule87806-31-3Approved|InvestigationalTarget
DB09270UbidecarenoneSmall Molecule303-98-0Approved|Investigational|NutraceuticalCarrier
ID Drug Name Action PubMed
C04923511-dehydro-thromboxane B2Aspirin inhibits the reaction [LDLR gene mutant form promotes the reaction [Arachidonic Acid results in increased abundance of 11-dehydro-thromboxane B2]]20530721
C04923511-dehydro-thromboxane B2dazoxiben inhibits the reaction [LDLR gene mutant form promotes the reaction [Arachidonic Acid results in increased abundance of 11-dehydro-thromboxane B2]]20530721
C04923511-dehydro-thromboxane B2LDLR gene mutant form promotes the reaction [Arachidonic Acid results in increased abundance of 11-dehydro-thromboxane B2]20530721
C04923511-dehydro-thromboxane B2tempol inhibits the reaction [LDLR gene mutant form promotes the reaction [Arachidonic Acid results in increased abundance of 11-dehydro-thromboxane B2]]20530721
C0512461-methylanthracene[1-methylanthracene co-treated with fluoranthene] results in decreased expression of LDLR mRNA28329830
C0939732-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Quercetin results in increased expression of LDLR mRNA]22388943
C0939732-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Quercetin results in increased expression of LDLR protein]22388943
C00358522-hydroxycholesterol22-hydroxycholesterol results in decreased expression of LDLR mRNA16142410
C0294972,3-bis(3'-hydroxybenzyl)butyrolactone"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of LDLR mRNA"19167446
C00799725-hydroxycholesterol25-hydroxycholesterol inhibits the reaction [[resveratrol results in increased activity of and results in increased cleavage of SREBF2 protein] which results in increased expression of LDLR mRNA]22153697
C00799725-hydroxycholesterol25-hydroxycholesterol inhibits the reaction [resveratrol results in increased expression of LDLR mRNA]22153697
C00799725-hydroxycholesterol25-hydroxycholesterol results in decreased expression of LDLR mRNA19260826
C00799725-hydroxycholesterol25-hydroxycholesterol results in decreased expression of LDLR protein19260826
C07699627-hydroxycholesterol27-hydroxycholesterol results in decreased activity of LDLR protein8820113
C07699627-hydroxycholesterol27-hydroxycholesterol results in decreased expression of LDLR mRNA28167099
C07699627-hydroxycholesterol27-hydroxycholesterol results in decreased expression of LDLR protein28167099
C0227762-bromopalmitate2-bromopalmitate results in increased expression of LDLR mRNA23150725
D0000737382-Hydroxypropyl-beta-cyclodextrin2-Hydroxypropyl-beta-cyclodextrin results in increased expression of LDLR mRNA22156476
D0000737382-Hydroxypropyl-beta-cyclodextrin2-Hydroxypropyl-beta-cyclodextrin results in increased expression of LDLR protein22156476
D0000737382-Hydroxypropyl-beta-cyclodextrinTO-901317 inhibits the reaction [2-Hydroxypropyl-beta-cyclodextrin results in increased expression of LDLR protein]22156476
C0230353,4,5,3',4'-pentachlorobiphenyl"LDLR gene mutant form results in increased susceptibility to 3,4,5,3',4'-pentachlorobiphenyl"29216392
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in increased expression of LDLR mRNA"23196670
C5830744,4'-hexafluorisopropylidene diphenol"4,4'-hexafluorisopropylidene diphenol results in increased expression of LDLR mRNA"27567155
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of LDLR mRNA"27188386
C0072104-cymene4-cymene affects the activity of LDLR protein15663186
C5732335,7-dihydroxy-2-methyl-8-(4-(3-hydroxy-1-methyl)-piperidinyl)-4H-1-benzopyran-4-one"[Dietary Fats co-treated with 5,7-dihydroxy-2-methyl-8-(4-(3-hydroxy-1-methyl)-piperidinyl)-4H-1-benzopyran-4-one] results in decreased expression of LDLR mRNA"24646949
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of LDLR mRNA"27188386
C0005950156,7-dimethoxy-2-(pyrrolidin-1-yl)-N-(5-(pyrrolidin-1-yl)pentyl)quinazolin-4-amine"6,7-dimethoxy-2-(pyrrolidin-1-yl)-N-(5-(pyrrolidin-1-yl)pentyl)quinazolin-4-amine results in increased expression of LDLR mRNA"28073004
D000082Acetaminophen"Acetaminophen promotes the reaction [Cholesterol, LDL binds to LDLR protein]"10395027
D000082Acetaminophen"Acetaminophen promotes the reaction [[Cholesterol, LDL binds to LDLR protein] which results in increased degradation of Cholesterol, LDL]"10395027
D000082AcetaminophenAcetaminophen results in increased expression of LDLR mRNA21420995
D016604Aflatoxin B1Aflatoxin B1 affects the expression of LDLR protein20106945
D000395Air Pollutants, Occupational"Air Pollutants, Occupational results in increased expression of LDLR mRNA"23195993
D000420AlbuterolLDLR gene SNP affects the susceptibility to Albuterol15453913
D000517alpha-Chlorohydrinalpha-Chlorohydrin results in decreased expression of LDLR mRNA28522335
D000638AmiodaroneAmiodarone promotes the reaction [Triiodothyronine results in increased expression of LDLR mRNA]9712728
D000638AmiodaroneAmiodarone results in decreased expression of LDLR mRNA9712728
D000638AmiodaroneAmiodarone results in decreased expression of LDLR mRNA8137927|9071962|
D000638AmiodaroneAmiodarone results in decreased expression of LDLR protein12538616|9071962
D000638AmiodaroneTriiodothyronine inhibits the reaction [Amiodarone results in decreased expression of LDLR protein]9071962
D000643Ammonium ChlorideAmmonium Chloride affects the expression of LDLR mRNA16483693
C006578anetholeanethole affects the activity of LDLR protein15663186
D000924Anticholesteremic AgentsAnticholesteremic Agents inhibits the reaction [[Dietary Fats co-treated with Dietary Sucrose] results in decreased expression of LDLR mRNA]28275691
D000924Anticholesteremic AgentsAnticholesteremic Agents results in increased expression of LDLR mRNA28275691
D016718Arachidonic AcidAspirin inhibits the reaction [LDLR gene mutant form promotes the reaction [Arachidonic Acid results in increased abundance of 11-dehydro-thromboxane B2]]20530721
D016718Arachidonic Aciddazoxiben inhibits the reaction [LDLR gene mutant form promotes the reaction [Arachidonic Acid results in increased abundance of 11-dehydro-thromboxane B2]]20530721
D016718Arachidonic AcidLDLR gene mutant form promotes the reaction [Arachidonic Acid results in increased abundance of 11-dehydro-thromboxane B2]20530721
D016718Arachidonic Acidtempol inhibits the reaction [LDLR gene mutant form promotes the reaction [Arachidonic Acid results in increased abundance of 11-dehydro-thromboxane B2]]20530721
D016718Arachidonic AcidAspirin inhibits the reaction [LDLR gene mutant form results in decreased susceptibility to Arachidonic Acid]20530721
D016718Arachidonic Aciddazoxiben inhibits the reaction [LDLR gene mutant form results in decreased susceptibility to Arachidonic Acid]20530721
D016718Arachidonic AcidIndomethacin promotes the reaction [LDLR gene mutant form results in decreased susceptibility to Arachidonic Acid]20530721
D016718Arachidonic AcidLDLR gene mutant form results in decreased susceptibility to Arachidonic Acid20530721
C519728archazolid Barchazolid B results in increased expression of LDLR mRNA25218289
C031942argatrobanargatroban inhibits the reaction [[LDLR gene mutant form results in increased susceptibility to Dietary Fats] which results in increased abundance of Cholesterol]22841818
C031942argatrobanargatroban inhibits the reaction [[LDLR gene mutant form results in increased susceptibility to Dietary Fats] which results in increased abundance of Triglycerides]22841818
D001151ArsenicArsenic affects the methylation of LDLR gene25304211
D017638Asbestos, Crocidolite"Asbestos, Crocidolite results in increased expression of LDLR mRNA"25351596
D001241AspirinAspirin inhibits the reaction [LDLR gene mutant form promotes the reaction [Arachidonic Acid results in increased abundance of 11-dehydro-thromboxane B2]]20530721
D001241Aspirin"Aspirin promotes the reaction [Cholesterol, LDL binds to LDLR protein]"10395027
D001241Aspirin"Aspirin promotes the reaction [[Cholesterol, LDL binds to LDLR protein] which results in increased degradation of Cholesterol, LDL]"10395027
D001241AspirinAspirin inhibits the reaction [LDLR gene mutant form results in decreased susceptibility to Arachidonic Acid]20530721
D000069059Atorvastatin CalciumAtorvastatin Calcium results in increased activity of LDLR protein11728391|1261214
D000069059Atorvastatin CalciumAtorvastatin Calcium results in increased expression of LDLR mRNA10357840|1172839
D000069059Atorvastatin CalciumAtorvastatin Calcium results in increased expression of LDLR mRNA24502637
D001280AtrazineLDLR gene SNP affects the susceptibility to Atrazine22919386
D001280AtrazineAtrazine results in decreased expression of LDLR mRNA26518232
C406592azaspiracidazaspiracid results in increased expression of LDLR mRNA28939011
C028559bathocuproine sulfonatebathocuproine sulfonate inhibits the reaction [copper histidine results in increased expression of LDLR mRNA]24170205
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of LDLR mRNA20064835
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of LDLR mRNA"19150397
D001599BerberineBerberine inhibits the reaction [Clozapine results in increased expression of LDLR mRNA]20564506
D001599BerberineBerberine inhibits the reaction [Risperidone results in increased expression of LDLR mRNA]20564506
D001599BerberineBerberine promotes the reaction [Simvastatin results in increased expression of LDLR mRNA]18640378
D001599BerberineBerberine results in increased expression of LDLR mRNA18640378
D001599BerberineSimvastatin promotes the reaction [Berberine results in increased expression of LDLR mRNA]18640378
D001599BerberineBerberine results in increased stability of LDLR mRNA18640378
D004958EstradiolEstradiol results in increased expression of LDLR mRNA19167446
C483161beta-hydroxy simvastatin acidbeta-hydroxy simvastatin acid affects the expression of LDLR mRNA18192240
C044887beta-methylcholinebeta-methylcholine affects the expression of LDLR mRNA21179406
C053541bicalutamidebicalutamide affects the localization of LDLR protein17440980
C099952bifenthrinbifenthrin results in decreased expression of LDLR mRNA24449165
D001647Bile Acids and Salts[CYP27A1 protein results in increased chemical synthesis of Bile Acids and Salts] promotes the reaction [LDLR protein results in increased uptake of Cholesterol]16477808
D001647Bile Acids and Salts[CYP27A1 protein results in increased chemical synthesis of Bile Acids and Salts] which results in increased expression of LDLR mRNA16477808
D001647Bile Acids and Salts[[[ciklavit results in increased expression of CYP7A1 mRNA] co-treated with [ciklavit results in increased expression of LDLR mRNA]] results in increased metabolism of Cholesterol] which results in increased chemical synthesis of Bile Acids and Salts23287313
C006780bisphenol Abisphenol A results in increased expression of LDLR mRNA25047013|2848355
C006780bisphenol Abisphenol A results in increased expression of LDLR mRNA23704952|2527062
C006780bisphenol Abisphenol A affects the expression of LDLR mRNA21786754
C006780bisphenol Abisphenol A results in increased expression of LDLR mRNA25181051
D0151248-Bromo Cyclic Adenosine Monophosphate8-Bromo Cyclic Adenosine Monophosphate results in increased expression of LDLR mRNA22079614
C027561butylbenzyl phthalatebutylbenzyl phthalate results in decreased expression of LDLR mRNA15728792
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in increased expression of LDLR mRNA12414654
C584509C646 compoundC646 compound results in decreased expression of LDLR mRNA26191083
C584509C646 compoundC646 compound results in increased expression of LDLR mRNA26191083
D002104CadmiumCadmium results in decreased expression of LDLR mRNA12080015
D000074262Canola OilCanola Oil results in increased expression of LDLR mRNA16631440
D002220CarbamazepineCarbamazepine results in decreased expression of LDLR mRNA21123845
D002220CarbamazepineCarbamazepine affects the expression of LDLR mRNA22634333
D002235CarbofuranLDLR gene SNP affects the susceptibility to Carbofuran22919386
D002330CarmustineLDLR protein affects the uptake of Carmustine analog12107554
C084597chlorcyclizinechlorcyclizine results in increased expression of LDLR mRNA21058326
D002746ChlorpromazineChlorpromazine results in increased expression of LDLR mRNA17052361
D002784Cholesterol[CYP27A1 protein results in increased chemical synthesis of Bile Acids and Salts] promotes the reaction [LDLR protein results in increased uptake of Cholesterol]16477808
D002784CholesterolLDLR protein results in increased uptake of Cholesterol16477808
D002784Cholesterol[[ciklavit results in increased expression of CYP7A1 mRNA] co-treated with [ciklavit results in increased expression of LDLR mRNA]] results in decreased abundance of Cholesterol23287313
D002784Cholesterol[[ciklavit results in increased expression of CYP7A1 mRNA] co-treated with [ciklavit results in increased expression of LDLR mRNA]] results in increased metabolism of Cholesterol23287313
D002784Cholesterol[[[ciklavit results in increased expression of CYP7A1 mRNA] co-treated with [ciklavit results in increased expression of LDLR mRNA]] results in increased metabolism of Cholesterol] which results in increased chemical synthesis of Bile Acids and Salts23287313
D002784Cholesterolargatroban inhibits the reaction [[LDLR gene mutant form results in increased susceptibility to Dietary Fats] which results in increased abundance of Cholesterol]22841818
D002784Cholesterol(+)-JQ1 compound inhibits the reaction [LDLR gene mutant form results in increased susceptibility to Cholesterol]25263595
D002784CholesterolLDLR gene mutant form results in increased susceptibility to Cholesterol25263595
D002784Cholesterol[LDLR gene mutant form results in increased susceptibility to Dietary Fats] which results in increased abundance of Cholesterol22841818
D002784Cholesterol[Tobacco Smoke Pollution promotes the reaction [LDLR protein affects the susceptibility to Dietary Fats]] which results in increased abundance of Cholesterol22659316
D002784Cholesterol[Cholesterol deficiency co-treated with Lovastatin] results in increased expression of LDLR mRNA20578043
D002784CholesterolCholesterol inhibits the reaction [[Cholesterol deficiency co-treated with Lovastatin] results in increased expression of LDLR mRNA]20578043
D002784CholesterolCholesterol results in decreased activity of LDLR protein16271152|1631751
D002784CholesterolCholesterol results in decreased expression of LDLR mRNA16271152|1631751
D002784CholesterolSelenium inhibits the reaction [Cholesterol results in decreased activity of LDLR protein]16937255
D002784CholesterolSelenium inhibits the reaction [Cholesterol results in decreased expression of LDLR mRNA]16937255
D002784Cholesterol[turmeric extract co-treated with Cholesterol] results in increased expression of LDLR mRNA21535835
D002784Cholesterolturmeric extract inhibits the reaction [Cholesterol results in decreased expression of LDLR mRNA]21535835
D002791Cholesterol, Dietary"Cholesterol, Dietary results in decreased expression of LDLR mRNA"19509184
D002791Cholesterol, Dietary"[Fructose co-treated with Dietary Fats co-treated with Cholesterol, Dietary] results in decreased expression of LDLR mRNA"19509184
D002791Cholesterol, Dietary"Cholesterol, Dietary deficiency results in increased expression of LDLR mRNA"20926756
D008078Cholesterol, LDL"Cholesterol, LDL binds to LDLR protein"6322751
D008078Cholesterol, LDL"Tetrachlorodibenzodioxin inhibits the reaction [Cholesterol, LDL binds to LDLR protein]"6322751
D008078Cholesterol, LDL"Acetaminophen promotes the reaction [Cholesterol, LDL binds to LDLR protein]"10395027
D008078Cholesterol, LDL"Acetaminophen promotes the reaction [[Cholesterol, LDL binds to LDLR protein] which results in increased degradation of Cholesterol, LDL]"10395027
D008078Cholesterol, LDL"Aspirin promotes the reaction [Cholesterol, LDL binds to LDLR protein]"10395027
D008078Cholesterol, LDL"Aspirin promotes the reaction [[Cholesterol, LDL binds to LDLR protein] which results in increased degradation of Cholesterol, LDL]"10395027
D008078Cholesterol, LDL"Cholesterol, LDL binds to LDLR protein"10395027
D008078Cholesterol, LDL"[Cholesterol, LDL binds to LDLR protein] which results in increased degradation of Cholesterol, LDL"10395027
D008078Cholesterol, LDL"Cyclosporine inhibits the reaction [[Cholesterol, LDL binds to LDLR protein] which results in increased degradation of Cholesterol, LDL]"10395027
D008078Cholesterol, LDL"Flufenamic Acid inhibits the reaction [Cyclosporine inhibits the reaction [[Cholesterol, LDL binds to LDLR protein] which results in increased degradation of Cholesterol, LDL]]"10395027
D008078Cholesterol, LDL"Flufenamic Acid promotes the reaction [Cholesterol, LDL binds to LDLR protein]"10395027
D008078Cholesterol, LDL"Flufenamic Acid promotes the reaction [[Cholesterol, LDL binds to LDLR protein] which results in increased degradation of Cholesterol, LDL]"10395027
D008078Cholesterol, LDL"fluvastatin promotes the reaction [Cholesterol, LDL binds to LDLR protein]"10395027
D008078Cholesterol, LDL"fluvastatin promotes the reaction [Indomethacin promotes the reaction [Cholesterol, LDL binds to LDLR protein]]"10395027
D008078Cholesterol, LDL"Ibuprofen promotes the reaction [Cholesterol, LDL binds to LDLR protein]"10395027
D008078Cholesterol, LDL"Ibuprofen promotes the reaction [[Cholesterol, LDL binds to LDLR protein] which results in increased degradation of Cholesterol, LDL]"10395027
D008078Cholesterol, LDL"Indomethacin promotes the reaction [Cholesterol, LDL binds to LDLR protein]"10395027
D008078Cholesterol, LDL"Indomethacin promotes the reaction [[Cholesterol, LDL binds to LDLR protein] which results in increased degradation of Cholesterol, LDL]"10395027
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of LDLR mRNA20938992
C074702chromium hexavalent ionchromium hexavalent ion affects the expression of LDLR mRNA28472532
D002922CiguatoxinsCiguatoxins affects the expression of LDLR mRNA18353800
C553724ciklavitciklavit inhibits the reaction [Dietary Fats results in decreased expression of LDLR mRNA]23287313
C553724ciklavit[[ciklavit results in increased expression of CYP7A1 mRNA] co-treated with [ciklavit results in increased expression of LDLR mRNA]] results in decreased abundance of Cholesterol23287313
C553724ciklavit[[ciklavit results in increased expression of CYP7A1 mRNA] co-treated with [ciklavit results in increased expression of LDLR mRNA]] results in increased metabolism of Cholesterol23287313
C553724ciklavit[[[ciklavit results in increased expression of CYP7A1 mRNA] co-treated with [ciklavit results in increased expression of LDLR mRNA]] results in increased metabolism of Cholesterol] which results in increased chemical synthesis of Bile Acids and Salts23287313
C553724ciklavitciklavit results in increased expression of LDLR mRNA23287313
D002994ClofibrateClofibrate results in decreased expression of LDLR mRNA17495091
D002994Clofibrate[Clofibrate co-treated with Diethylhexyl Phthalate] results in increased expression of LDLR mRNA9207284
D002994ClofibrateClofibrate results in decreased expression of LDLR mRNA17126302
D003008CloprostenolCloprostenol results in decreased expression of LDLR mRNA15713365
D003024ClozapineClozapine results in increased expression of LDLR mRNA17052361
D003024ClozapineBerberine inhibits the reaction [Clozapine results in increased expression of LDLR mRNA]20564506
D003024ClozapineClozapine results in increased expression of LDLR mRNA20564506
C018021cobaltous chloridecobaltous chloride results in decreased expression of LDLR mRNA19320972
C018021cobaltous chloridecobaltous chloride results in increased expression of LDLR mRNA19376846
D000069472Colesevelam HydrochlorideColesevelam Hydrochloride results in increased expression of LDLR mRNA22120639
D003300CopperCopper results in decreased expression of LDLR mRNA17205981
D003300CopperCopper results in decreased expression of LDLR mRNA17205981
C098468copper histidinebathocuproine sulfonate inhibits the reaction [copper histidine results in increased expression of LDLR mRNA]24170205
C098468copper histidinecopper histidine results in increased expression of LDLR mRNA24170205
D019327Copper SulfateCopper Sulfate results in increased expression of LDLR mRNA12860252|1954981
D003375Coumestrol"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of LDLR mRNA"19167446
C029036crocincrocin inhibits the reaction [Diazinon results in decreased expression of LDLR mRNA]24132704
D003474CurcuminCurcumin inhibits the reaction [INSIG2 protein results in decreased expression of LDLR mRNA]18704882
D003474CurcuminCurcumin results in increased expression of and results in increased activity of LDLR protein18704882
D003474CurcuminCurcumin results in increased expression of LDLR mRNA16713233|1696380
D003474CurcuminCurcumin results in increased expression of LDLR protein16963807
D003474CurcuminCurcumin affects the expression of LDLR mRNA27208389
D003474CurcuminCurcumin results in decreased expression of LDLR18462866
C057862cyanoginosin LRcyanoginosin LR results in increased expression of LDLR mRNA25497113
D003513CycloheximideCycloheximide inhibits the reaction [Quercetin results in increased expression of LDLR protein]22388943
D003513CycloheximideCycloheximide results in decreased expression of LDLR protein22388943
D016572Cyclosporine"Cyclosporine inhibits the reaction [[Cholesterol, LDL binds to LDLR protein] which results in increased degradation of Cholesterol, LDL]"10395027
D016572CyclosporineCyclosporine results in increased expression of LDLR mRNA20106945|2556210
D016572Cyclosporine"Flufenamic Acid inhibits the reaction [Cyclosporine inhibits the reaction [[Cholesterol, LDL binds to LDLR protein] which results in increased degradation of Cholesterol, LDL]]"10395027
D016572CyclosporineCyclosporine results in decreased activity of LDLR protein9703316
C093628cyproconazolecyproconazole affects the expression of LDLR mRNA22045034
C029166dazoxibendazoxiben inhibits the reaction [LDLR gene mutant form promotes the reaction [Arachidonic Acid results in increased abundance of 11-dehydro-thromboxane B2]]20530721
C029166dazoxibendazoxiben inhibits the reaction [LDLR gene mutant form results in decreased susceptibility to Arachidonic Acid]20530721
D003897DesmosterolDesmosterol results in decreased expression of LDLR protein19260826
C036116desethylamiodaronedesethylamiodarone promotes the reaction [Triiodothyronine results in increased expression of LDLR mRNA]9712728
C036116desethylamiodaronedesethylamiodarone results in decreased expression of LDLR mRNA9712728
D017135Desogestrel[Desogestrel co-treated with Ethinyl Estradiol] results in increased expression of LDLR protein17900441
D017135DesogestrelDesogestrel results in increased expression of LDLR protein17900441
D003907DexamethasoneDexamethasone results in increased expression of LDLR mRNA25047013
D003976Diazinoncrocin inhibits the reaction [Diazinon results in decreased expression of LDLR mRNA]24132704
D003976DiazinonDiazinon results in decreased expression of LDLR mRNA24132704
C041517dibenzo(a,l)pyrene"dibenzo(a,l)pyrene results in decreased expression of LDLR mRNA"16269432
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of LDLR mRNA21266533
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of LDLR mRNA15728792|2174549
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in increased expression of LDLR mRNA27392435
D002945CisplatinCisplatin inhibits the reaction [Piroxicam results in decreased expression of LDLR mRNA]21858171
D002945CisplatinCisplatin results in decreased expression of LDLR mRNA27594783
D002945CisplatinCisplatin results in increased expression of LDLR mRNA21151649
D003633Dichlorodiphenyl DichloroethyleneDichlorodiphenyl Dichloroethylene results in decreased expression of LDLR mRNA15885261
C000944dicrotophosdicrotophos results in increased expression of LDLR mRNA28302478
D004026DieldrinDieldrin results in increased expression of LDLR mRNA23041725
D004041Dietary Fatsciklavit inhibits the reaction [Dietary Fats results in decreased expression of LDLR mRNA]23287313
D004041Dietary Fats"[Dietary Fats co-treated with 5,7-dihydroxy-2-methyl-8-(4-(3-hydroxy-1-methyl)-piperidinyl)-4H-1-benzopyran-4-one] results in decreased expression of LDLR mRNA"24646949
D004041Dietary FatsDietary Fats results in decreased expression of LDLR mRNA23287313
D004041Dietary Fats"[Fructose co-treated with Dietary Fats co-treated with Cholesterol, Dietary] results in decreased expression of LDLR mRNA"19509184
D004041Dietary Fatsgamma-sitosterol inhibits the reaction [Dietary Fats results in decreased expression of LDLR mRNA]23287313
D004041Dietary FatsAnticholesteremic Agents inhibits the reaction [[Dietary Fats co-treated with Dietary Sucrose] results in decreased expression of LDLR mRNA]28275691
D004041Dietary Fatsargatroban inhibits the reaction [[LDLR gene mutant form results in increased susceptibility to Dietary Fats] which results in increased abundance of Cholesterol]22841818
D004041Dietary Fatsargatroban inhibits the reaction [[LDLR gene mutant form results in increased susceptibility to Dietary Fats] which results in increased abundance of Triglycerides]22841818
D004041Dietary Fats[Dietary Fats co-treated with Dietary Sucrose] results in decreased expression of LDLR mRNA28275691
D004041Dietary FatsDietary Fats results in decreased expression of LDLR mRNA19030233
D004041Dietary FatsLDLR gene mutant form results in increased susceptibility to Dietary Fats22841818|2465167
D004041Dietary Fats[LDLR gene mutant form results in increased susceptibility to Dietary Fats] which results in increased abundance of Cholesterol22841818
D004041Dietary Fats[LDLR gene mutant form results in increased susceptibility to Dietary Fats] which results in increased abundance of Triglycerides22841818
D004041Dietary Fats[LDLR gene mutant form results in increased susceptibility to Dietary Fats] which results in increased expression of TRP53 protein24651677
D004041Dietary FatsLDLR protein affects the susceptibility to Dietary Fats22659316
D004041Dietary FatsTobacco Smoke Pollution promotes the reaction [LDLR protein affects the susceptibility to Dietary Fats]22659316
D004041Dietary Fats[Tobacco Smoke Pollution promotes the reaction [LDLR protein affects the susceptibility to Dietary Fats]] which results in increased abundance of Cholesterol22659316
D004041Dietary FatsDietary Fats results in decreased expression of LDLR mRNA23524313
D004041Dietary FatsDietary Fats results in increased expression of LDLR protein23524313
D004041Dietary Fatsresveratrol inhibits the reaction [[Sucrose co-treated with Dietary Fats] results in decreased expression of LDLR mRNA]23127599
D004041Dietary Fatsresveratrol inhibits the reaction [[Sucrose co-treated with Dietary Fats] results in decreased expression of LDLR protein]23127599
D004041Dietary Fats[Sucrose co-treated with Dietary Fats] results in decreased expression of LDLR mRNA23127599
D004041Dietary Fats[Sucrose co-treated with Dietary Fats] results in decreased expression of LDLR protein23127599
D019422Dietary SucroseAnticholesteremic Agents inhibits the reaction [[Dietary Fats co-treated with Dietary Sucrose] results in decreased expression of LDLR mRNA]28275691
D019422Dietary Sucrose[Dietary Fats co-treated with Dietary Sucrose] results in decreased expression of LDLR mRNA28275691
D004051Diethylhexyl Phthalate[APOE gene mutant form results in increased susceptibility to Diethylhexyl Phthalate] which results in decreased expression of LDLR protein25270622
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in decreased expression of LDLR mRNA27405655
D004051Diethylhexyl Phthalate[Clofibrate co-treated with Diethylhexyl Phthalate] results in increased expression of LDLR mRNA9207284
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in decreased expression of LDLR mRNA15728792
C014476diethyl maleatediethyl maleate results in decreased expression of LDLR mRNA21161181
D002117CalcitriolCalcitriol results in increased expression of LDLR mRNA26485663
C051904dinophysistoxin 1dinophysistoxin 1 results in increased expression of LDLR mRNA28939011
C034171di-n-pentyl phthalatedi-n-pentyl phthalate results in decreased expression of LDLR mRNA15728792
D004221DisulfiramDisulfiram results in decreased expression of LDLR mRNA20530235
D004365Drugs, Chinese Herbal"Drugs, Chinese Herbal results in increased expression of LDLR mRNA"23811387
D004655EmulsionsLDLR protein affects the uptake of Emulsions analog12107554
C045651epigallocatechin gallateepigallocatechin gallate results in increased expression of LDLR mRNA22079256
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of LDLR mRNA22079256
C109476epoxiconazoleepoxiconazole results in increased expression of LDLR mRNA28454766
C091891epsilon-viniferinepsilon-viniferin results in increased expression of LDLR mRNA22153697
D000431EthanolEthanol results in increased expression of LDLR mRNA15353170
D004997Ethinyl Estradiol[Desogestrel co-treated with Ethinyl Estradiol] results in increased expression of LDLR protein17900441
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of LDLR protein17900441
D004997Ethinyl Estradiol[Levonorgestrel co-treated with Ethinyl Estradiol] results in decreased expression of LDLR protein17900441
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of LDLR protein10729376
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of LDLR mRNA17351261
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of LDLR mRNA12963437|1694001
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of LDLR protein12475377
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in decreased expression of LDLR mRNA23649840
D005054EugenolEugenol affects the activity of LDLR protein15663186
D000069438Ezetimibe[Simvastatin co-treated with Ezetimibe] results in increased expression of LDLR mRNA17980884
D000069438EzetimibeEzetimibe results in increased expression of LDLR mRNA17130282
D000069438EzetimibeSimvastatin promotes the reaction [Ezetimibe results in increased expression of LDLR mRNA]17130282
D005228Fatty Acids, Essential"Fatty Acids, Essential deficiency results in increased expression of LDLR mRNA"23333450
D005228Fatty Acids, Essential"NR1H2 gene mutant form inhibits the reaction [Fatty Acids, Essential deficiency results in increased expression of LDLR mRNA]"23333450
D005228Fatty Acids, Essential"NR1H3 gene mutant form inhibits the reaction [Fatty Acids, Essential deficiency results in increased expression of LDLR mRNA]"23333450
D005395Fish OilsFish Oils inhibits the reaction [Ozone results in increased expression of LDLR mRNA]29329427
D005439Flufenamic Acid"Flufenamic Acid inhibits the reaction [Cyclosporine inhibits the reaction [[Cholesterol, LDL binds to LDLR protein] which results in increased degradation of Cholesterol, LDL]]"10395027
D005439Flufenamic Acid"Flufenamic Acid promotes the reaction [Cholesterol, LDL binds to LDLR protein]"10395027
D005439Flufenamic Acid"Flufenamic Acid promotes the reaction [[Cholesterol, LDL binds to LDLR protein] which results in increased degradation of Cholesterol, LDL]"10395027
D005439Flufenamic AcidFlufenamic Acid results in increased expression of LDLR mRNA10395027
D005439Flufenamic AcidFlufenamic Acid results in increased expression of LDLR protein10395027
C007738fluoranthene[1-methylanthracene co-treated with fluoranthene] results in decreased expression of LDLR mRNA28329830
C007738fluoranthenefluoranthene results in decreased expression of LDLR mRNA28329830
C061365flusilazoleflusilazole affects the expression of LDLR mRNA21195148|2263433
D005485FlutamideFlutamide results in decreased expression of LDLR mRNA15885261
C065180fluvastatin[APOB gene SNP co-treated with APOE gene SNP co-treated with HMGCR gene SNP co-treated with LDLR gene SNP co-treated with PCSK9 gene SNP co-treated with ABCA1 gene SNP co-treated with CETP gene SNP co-treated with LIPC gene SNP co-treated with LPL gene SNP] affects the susceptibility to fluvastatin19773416
C065180fluvastatin"fluvastatin promotes the reaction [Cholesterol, LDL binds to LDLR protein]"10395027
C065180fluvastatin"fluvastatin promotes the reaction [Indomethacin promotes the reaction [Cholesterol, LDL binds to LDLR protein]]"10395027
C065180fluvastatinfluvastatin results in increased activity of LDLR protein8593127
C065180fluvastatinfluvastatin results in increased expression of LDLR mRNA9703316
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of LDLR mRNA20938992
D005557FormaldehydeFormaldehyde results in decreased expression of LDLR mRNA23649840
D005632Fructose"[Fructose co-treated with Dietary Fats co-treated with Cholesterol, Dietary] results in decreased expression of LDLR mRNA"19509184
D005707Gallic AcidGallic Acid results in increased expression of LDLR mRNA12612140
C025473gamma-sitosterolgamma-sitosterol inhibits the reaction [Dietary Fats results in decreased expression of LDLR mRNA]23287313
C106014geduningedunin results in increased expression of LDLR mRNA17010675
C007836geraniolgeraniol affects the activity of LDLR protein15663186
D005947Glucose[LDLR gene mutant form results in increased susceptibility to Pravastatin] inhibits the reaction [Glucose results in increased secretion of INS1 protein]26875785
C442817GW 707GW 707 results in increased activity of LDLR protein12524230
C442817GW 707GW 707 results in increased expression of LDLR mRNA12524230
C442817GW 707OSM protein promotes the reaction [GW 707 results in increased activity of LDLR protein]12524230
C442817GW 707OSM protein promotes the reaction [GW 707 results in increased expression of LDLR mRNA]12524230
C442817GW 707Puromycin inhibits the reaction [GW 707 results in increased expression of LDLR mRNA]12524230
D006220HaloperidolHaloperidol results in increased expression of LDLR mRNA17052361
C409722hexaconazolehexaconazole affects the expression of LDLR mRNA21195148
D017313FenretinideFenretinide results in decreased expression of LDLR mRNA15958647
D017313FenretinideFenretinide results in decreased expression of LDLR mRNA28973697
C029424hydrazinehydrazine results in increased expression of LDLR mRNA15282401
D006861Hydrogen PeroxideHydrogen Peroxide results in increased expression of LDLR mRNA26846883
D006861Hydrogen PeroxideHydrogen Peroxide results in increased expression of LDLR mRNA12414654
D006861Hydrogen Peroxide[isoquercitrin co-treated with Hydrogen Peroxide] results in increased expression of LDLR mRNA18032389
D047348Hydrolyzable TanninsHydrolyzable Tannins results in increased expression of LDLR mRNA22153697
D007052Ibuprofen"Ibuprofen promotes the reaction [Cholesterol, LDL binds to LDLR protein]"10395027
D007052Ibuprofen"Ibuprofen promotes the reaction [[Cholesterol, LDL binds to LDLR protein] which results in increased degradation of Cholesterol, LDL]"10395027
C492448ICG 001ICG 001 results in decreased expression of LDLR mRNA26191083
D007213Indomethacin"fluvastatin promotes the reaction [Indomethacin promotes the reaction [Cholesterol, LDL binds to LDLR protein]]"10395027
D007213Indomethacin"Indomethacin promotes the reaction [Cholesterol, LDL binds to LDLR protein]"10395027
D007213Indomethacin"Indomethacin promotes the reaction [[Cholesterol, LDL binds to LDLR protein] which results in increased degradation of Cholesterol, LDL]"10395027
D007213IndomethacinIndomethacin results in increased expression of LDLR mRNA10395027
D007213IndomethacinIndomethacin results in increased expression of LDLR protein10395027
D007213IndomethacinIndomethacin promotes the reaction [LDLR gene mutant form results in decreased susceptibility to Arachidonic Acid]20530721
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of LDLR mRNA25613284
D007529IsoflavonesIsoflavones affects the expression of LDLR mRNA16365062
C016527isoquercitrin[isoquercitrin co-treated with Hydrogen Peroxide] results in increased expression of LDLR mRNA18032389
C544151jinfukang[Cisplatin co-treated with jinfukang] results in increased expression of LDLR mRNA27392435
C544151jinfukangjinfukang results in increased expression of LDLR mRNA27392435
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of LDLR mRNA23430699
C561695(+)-JQ1 compound(+)-JQ1 compound inhibits the reaction [LDLR gene mutant form results in increased susceptibility to Cholesterol]25263595
C410337K 7174K 7174 results in increased expression of LDLR mRNA24086573
D007854LeadLead affects the expression of LDLR22001170
D007854LeadLead results in increased localization of LDLR protein20488202
D007854LeadPRKCD protein promotes the reaction [Lead results in increased localization of LDLR protein]20488202
D007854Leadpuerarin affects the reaction [Lead affects the expression of LDLR]22001170
D007854Leadrottlerin inhibits the reaction [PRKCD protein promotes the reaction [Lead results in increased localization of LDLR protein]]20488202
C008261lead acetatelead acetate results in decreased expression of LDLR mRNA25270620
C045463leflunomideleflunomide results in increased expression of LDLR mRNA28988120
C045463leflunomideleflunomide results in decreased expression of LDLR mRNA19751817
C008281limonenelimonene affects the activity of LDLR protein15663186
C018584linaloollinalool affects the activity of LDLR protein15663186
D008055LipidsLDLR protein affects the uptake of Lipids analog12107554
C482199lipopolysaccharide, E coli O55-B5"[trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in decreased expression of LDLR mRNA"18930950
D008070LipopolysaccharidesLipopolysaccharides results in decreased expression of LDLR mRNA18638454
D008070LipopolysaccharidesLipopolysaccharides results in decreased expression of LDLR protein18638454
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of LDLR mRNA12057914
D008095Lithocholic AcidLithocholic Acid results in decreased expression of LDLR mRNA20359477
D008148LovastatinLovastatin results in increased activity of LDLR protein11728391|8593127
D008148LovastatinLovastatin results in increased expression of LDLR mRNA11728391|1252423
D008148LovastatinOSM protein promotes the reaction [Lovastatin results in increased expression of LDLR mRNA]12524230
D008148Lovastatin[Cholesterol deficiency co-treated with Lovastatin] results in increased expression of LDLR mRNA20578043
D008148LovastatinCholesterol inhibits the reaction [[Cholesterol deficiency co-treated with Lovastatin] results in increased expression of LDLR mRNA]20578043
C015329lycopenelycopene results in increased expression of LDLR mRNA16886892
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of LDLR mRNA20938992
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of LDLR mRNA28001369
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of LDLR mRNA23649840
D015741MetriboloneMetribolone affects the localization of LDLR protein17440980
C406082monomethylarsonous acidmonomethylarsonous acid results in decreased expression of LDLR protein24625837
C511794N'-(3,4-dihydroxybenzylidene)-3-hydroxy-2-naphthahydrazide"N'-(3,4-dihydroxybenzylidene)-3-hydroxy-2-naphthahydrazide results in decreased expression of LDLR mRNA"22205993
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of LDLR mRNA"24389112
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of LDLR mRNA"25448806|2562005
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of LDLR mRNA"25620056
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of LDLR mRNA"25554681
D009285NaphthoquinonesNaphthoquinones results in increased expression of LDLR mRNA23811387
C017096n-butoxyethanoln-butoxyethanol results in increased expression of LDLR mRNA19812364
D009532NickelNickel results in increased expression of LDLR mRNA23195993|2476865
C022838nickel chloridenickel chloride results in decreased expression of LDLR mRNA17312168
C028007nickel monoxidenickel monoxide results in increased expression of LDLR mRNA19167457
D009538NicotineNicotine results in increased expression of LDLR mRNA23416264
D016912LevonorgestrelLevonorgestrel affects the expression of LDLR protein17900441
D016912Levonorgestrel[Levonorgestrel co-treated with Ethinyl Estradiol] results in decreased expression of LDLR protein17900441
C570896NSC305787NSC305787 results in increased expression of LDLR mRNA27137931
C464660obeticholic acidobeticholic acid results in decreased expression of LDLR mRNA27939613
D019319Okadaic AcidOkadaic Acid results in increased expression of LDLR mRNA28939011
C076029olanzapineolanzapine results in increased expression of LDLR mRNA17052361
C076029olanzapineolanzapine promotes the reaction [SREBF1 protein results in increased expression of LDLR mRNA]17651982
C108709oleoyl-estroneoleoyl-estrone results in decreased expression of LDLR mRNA17725831
C016340o,p'-DDT"o,p'-DDT results in decreased expression of LDLR mRNA"18204070
D010126OzoneFish Oils inhibits the reaction [Ozone results in increased expression of LDLR mRNA]29329427
D010126OzoneOzone results in increased expression of LDLR mRNA16330353|2932942
D017239PaclitaxelLDLR protein affects the susceptibility to Paclitaxel16217747
D052638Particulate MatterParticulate Matter results in increased expression of LDLR mRNA16504425
C568608PCI 5002[PCI 5002 co-treated with Zinc] results in increased expression of LDLR mRNA18593933
C023036perfluorooctanoic acidperfluorooctanoic acid results in increased expression of LDLR protein26879310
C023036perfluorooctanoic acidperfluorooctanoic acid results in increased expression of LDLR mRNA17681415|2509218
D010634PhenobarbitalPhenobarbital affects the expression of LDLR mRNA19159669
D010634PhenobarbitalPhenobarbital affects the expression of LDLR mRNA23091169
D010656PhenylephrinePhenylephrine results in increased expression of LDLR mRNA18158353
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of LDLR mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in decreased expression of LDLR mRNA26272509
D010665PhenylpropanolaminePhenylpropanolamine results in increased expression of LDLR mRNA27756839
D010705PhosgenePhosgene affects the expression of LDLR mRNA16300373
C060836pioglitazone[pioglitazone co-treated with U 0126] affects the localization of LDLR protein22593575
C060836pioglitazonepioglitazone results in increased expression of LDLR protein22593575
C006253pirinixic acidpirinixic acid results in decreased expression of LDLR mRNA23150725
C006253pirinixic acidpirinixic acid affects the expression of LDLR mRNA18445702
C006253pirinixic acidpirinixic acid results in decreased expression of LDLR mRNA23811191
C006253pirinixic acidpirinixic acid results in increased expression of LDLR mRNA25270620
C006253pirinixic acidpirinixic acid results in decreased expression of LDLR mRNA17126302
C006253pirinixic acidpirinixic acid results in increased expression of LDLR mRNA19162173
C016908pirinixilpirinixil results in decreased expression of LDLR mRNA9207284
D010894PiroxicamCisplatin inhibits the reaction [Piroxicam results in decreased expression of LDLR mRNA]21858171
D010894PiroxicamPiroxicam results in decreased expression of LDLR mRNA21858171
D028321Plant PreparationsPlant Preparations affects the expression of LDLR mRNA16251609
D011137PolystyrenesPolystyrenes results in decreased expression of LDLR mRNA25102311
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of LDLR mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of LDLR mRNA22079256|2271453
D011192Potassium DichromatePotassium Dichromate results in increased expression of LDLR protein23718831
D017035PravastatinPravastatin results in increased activity of LDLR protein8593127
D017035PravastatinLDLR gene mutant form results in increased susceptibility to Pravastatin26875785
D017035Pravastatin[LDLR gene mutant form results in increased susceptibility to Pravastatin] inhibits the reaction [Glucose results in increased secretion of INS1 protein]26875785
D017035Pravastatin[LDLR gene mutant form results in increased susceptibility to Pravastatin] which affects the expression of BAX protein26875785
D017035Pravastatin[LDLR gene mutant form results in increased susceptibility to Pravastatin] which affects the expression of BCL2 protein26875785
D017035Pravastatin[LDLR gene mutant form results in increased susceptibility to Pravastatin] which results in decreased expression of INS1 protein26875785
D017035Pravastatin[LDLR gene mutant form results in increased susceptibility to Pravastatin] which results in decreased expression of SNAP25 protein26875785
D017035Pravastatin[LDLR gene mutant form results in increased susceptibility to Pravastatin] which results in decreased expression of STX1A protein26875785
D017035Pravastatin[LDLR gene mutant form results in increased susceptibility to Pravastatin] which results in decreased expression of VAMP2 protein26875785
D017035Pravastatin[LDLR gene mutant form results in increased susceptibility to Pravastatin] which results in increased cleavage of CASP3 protein26875785
D017035Pravastatin[LDLR gene mutant form results in increased susceptibility to Pravastatin] which results in increased susceptibility to INS1 protein26875785
D011374ProgesteroneProgesterone results in increased expression of LDLR mRNA18037150|1807036
D011374ProgesteroneProgesterone affects the expression of LDLR mRNA17251523
D011374ProgesteroneProgesterone results in increased expression of LDLR mRNA17170212
D011441PropylthiouracilPropylthiouracil results in decreased expression of LDLR mRNA24780913
C107773pterostilbenepterostilbene results in decreased expression of LDLR mRNA22153697
C033607puerarinpuerarin affects the reaction [Lead affects the expression of LDLR]22001170
C039648pulegonepulegone affects the activity of LDLR protein15663186
D011691PuromycinPuromycin inhibits the reaction [GW 707 results in increased expression of LDLR mRNA]12524230
D011691PuromycinPuromycin inhibits the reaction [Quercetin results in increased expression of LDLR mRNA]22388943
D011691PuromycinPuromycin inhibits the reaction [Quercetin results in increased expression of LDLR protein]22388943
D011691PuromycinPuromycin results in decreased expression of LDLR mRNA22388943
D011691PuromycinPuromycin results in decreased expression of LDLR protein22388943
C432165pyrazolanthronepyrazolanthrone inhibits the reaction [Quercetin results in increased expression of LDLR mRNA]22388943
C432165pyrazolanthronepyrazolanthrone inhibits the reaction [Quercetin results in increased expression of LDLR protein]22388943
D011794Quercetin2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Quercetin results in increased expression of LDLR mRNA]22388943
D011794Quercetin2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Quercetin results in increased expression of LDLR protein]22388943
D011794QuercetinCycloheximide inhibits the reaction [Quercetin results in increased expression of LDLR protein]22388943
D011794QuercetinPuromycin inhibits the reaction [Quercetin results in increased expression of LDLR mRNA]22388943
D011794QuercetinPuromycin inhibits the reaction [Quercetin results in increased expression of LDLR protein]22388943
D011794Quercetinpyrazolanthrone inhibits the reaction [Quercetin results in increased expression of LDLR mRNA]22388943
D011794Quercetinpyrazolanthrone inhibits the reaction [Quercetin results in increased expression of LDLR protein]22388943
D011794QuercetinQuercetin results in increased expression of LDLR mRNA21632981|2238894
D011794QuercetinQuercetin results in increased expression of LDLR protein22388943
D020849Raloxifene HydrochlorideRaloxifene Hydrochloride results in increased expression of LDLR mRNA16497877
C025474rebaudioside Arebaudioside A affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of ACOX1 mRNA]25554529
C025474rebaudioside Arebaudioside A affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of CAT mRNA]25554529
C025474rebaudioside Arebaudioside A affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of CPT1A mRNA]25554529
C025474rebaudioside Arebaudioside A affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of DGAT2 mRNA]25554529
C025474rebaudioside Arebaudioside A affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of FOXO1 mRNA]25554529
C025474rebaudioside Arebaudioside A affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of G6PC mRNA]25554529
C025474rebaudioside Arebaudioside A affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of INSR mRNA]25554529
C025474rebaudioside Arebaudioside A affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of IRS1 mRNA]25554529
C025474rebaudioside Arebaudioside A affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of IRS2 mRNA]25554529
C025474rebaudioside Arebaudioside A affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of LIPC mRNA]25554529
C025474rebaudioside Arebaudioside A affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of MTOR mRNA]25554529
C025474rebaudioside Arebaudioside A affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of NFKB1 mRNA]25554529
C025474rebaudioside Arebaudioside A affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of NFKBIA mRNA]25554529
C025474rebaudioside Arebaudioside A affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of PCK1 mRNA]25554529
C025474rebaudioside Arebaudioside A affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of PPARA mRNA]25554529
C025474rebaudioside Arebaudioside A affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of PPARD mRNA]25554529
C025474rebaudioside Arebaudioside A affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of PPARGC1A mRNA]25554529
C025474rebaudioside Arebaudioside A affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of PPARG mRNA]25554529
C025474rebaudioside Arebaudioside A affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of SCD1 mRNA]25554529
C025474rebaudioside Arebaudioside A affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of SIRT1 mRNA]25554529
C025474rebaudioside Arebaudioside A affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of SLC27A1 mRNA]25554529
C025474rebaudioside Arebaudioside A affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of SLC2A2 mRNA]25554529
C025474rebaudioside Arebaudioside A affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of SOD2 mRNA]25554529
D012110ReserpineReserpine results in increased expression of LDLR protein10729376
C059514resveratrol25-hydroxycholesterol inhibits the reaction [[resveratrol results in increased activity of and results in increased cleavage of SREBF2 protein] which results in increased expression of LDLR mRNA]22153697
C059514resveratrol25-hydroxycholesterol inhibits the reaction [resveratrol results in increased expression of LDLR mRNA]22153697
C059514resveratrolresveratrol results in decreased N-linked glycosylation of LDLR protein22153697
C059514resveratrol[resveratrol results in increased activity of and results in increased cleavage of [SREBF1 protein co-treated with SREBF2 protein]] which results in increased expression of LDLR mRNA22153697
C059514resveratrolresveratrol results in increased expression of and results in increased activity of LDLR protein22153697
C059514resveratrolresveratrol results in increased expression of LDLR mRNA22153697
C059514resveratrolresveratrol results in increased O-linked glycosylation of LDLR protein22153697
C059514resveratrolresveratrol inhibits the reaction [[Sucrose co-treated with Dietary Fats] results in decreased expression of LDLR mRNA]23127599
C059514resveratrolresveratrol inhibits the reaction [[Sucrose co-treated with Dietary Fats] results in decreased expression of LDLR protein]23127599
D015474IsotretinoinIsotretinoin results in decreased expression of LDLR mRNA20436886
D012293RifampinRifampin results in increased expression of LDLR mRNA27806127
D018967RisperidoneBerberine inhibits the reaction [Risperidone results in increased expression of LDLR mRNA]20564506
D018967RisperidoneRisperidone results in increased expression of LDLR mRNA20564506
C089730rosiglitazonerosiglitazone results in decreased expression of LDLR mRNA23150725
C085746rottlerinrottlerin inhibits the reaction [PRKCD protein promotes the reaction [Lead results in increased localization of LDLR protein]]20488202
C110822SDZ CPI 975SDZ CPI 975 results in decreased expression of LDLR mRNA19234235
C094089SDZ FOX 988SDZ FOX 988 results in decreased expression of LDLR mRNA19234235
D012643SeleniumSelenium deficiency results in decreased activity of LDLR protein16317514
D012643SeleniumSelenium deficiency results in decreased expression of LDLR mRNA16317514
D012643SeleniumSelenium inhibits the reaction [Cholesterol results in decreased activity of LDLR protein]16937255
D012643SeleniumSelenium inhibits the reaction [Cholesterol results in decreased expression of LDLR mRNA]16937255
D012643SeleniumSelenium results in increased activity of LDLR protein16271152
D012643SeleniumSelenium results in increased expression of LDLR mRNA16271152
D012822Silicon DioxideSilicon Dioxide analog affects the expression of LDLR mRNA23806026
D012822Silicon DioxideSilicon Dioxide results in increased expression of LDLR mRNA25351596
D012834SilverSilver results in increased expression of LDLR mRNA26014281
D019821SimvastatinHMGCR polymorphism promotes the reaction [[LDLR 3' UTR polymorphism affects the susceptibility to Simvastatin] which affects the expression of APOB]20413733
D019821SimvastatinLDLR 3' UTR polymorphism affects the susceptibility to Simvastatin20413733
D019821Simvastatin[LDLR 3' UTR polymorphism affects the susceptibility to Simvastatin] which affects the expression of APOB20413733
D019821SimvastatinLDLR mutant form affects the susceptibility to Simvastatin10208479|1118128
D019821Simvastatin[Simvastatin co-treated with Ezetimibe] results in increased expression of LDLR mRNA17980884
D019821SimvastatinSimvastatin results in increased activity of LDLR protein11728391|8593127
D019821SimvastatinSimvastatin results in increased expression of LDLR mRNA10357840|1627634
D019821SimvastatinSimvastatin results in increased expression of LDLR protein1627634
D019821SimvastatinSimvastatin results in increased expression of LDLR mRNA22120639
D019821SimvastatinBerberine promotes the reaction [Simvastatin results in increased expression of LDLR mRNA]18640378
D019821SimvastatinSimvastatin promotes the reaction [Berberine results in increased expression of LDLR mRNA]18640378
D019821SimvastatinSimvastatin results in increased expression of LDLR mRNA18640378
D019821SimvastatinSimvastatin promotes the reaction [Ezetimibe results in increased expression of LDLR mRNA]17130282
D019821SimvastatinSimvastatin results in increased expression of LDLR mRNA17130282
C017947sodium arsenitesodium arsenite results in increased expression of LDLR mRNA25524072|2859598
D013024Soybean OilSoybean Oil results in increased expression of LDLR mRNA16631440
C012042steviolsteviol affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of ACACA mRNA]25554529
C012042steviolsteviol affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of ACOX1 mRNA]25554529
C012042steviolsteviol affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of CAT mRNA]25554529
C012042steviolsteviol affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of CPT1A mRNA]25554529
C012042steviolsteviol affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of DGAT2 mRNA]25554529
C012042steviolsteviol affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of FASN mRNA]25554529
C012042steviolsteviol affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of FOXO1 mRNA]25554529
C012042steviolsteviol affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of G6PC mRNA]25554529
C012042steviolsteviol affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of GPAM mRNA]25554529
C012042steviolsteviol affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of INSR mRNA]25554529
C012042steviolsteviol affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of IRS1 mRNA]25554529
C012042steviolsteviol affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of IRS2 mRNA]25554529
C012042steviolsteviol affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of LIPC mRNA]25554529
C012042steviolsteviol affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of MTOR mRNA]25554529
C012042steviolsteviol affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of NFKB1 mRNA]25554529
C012042steviolsteviol affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of NFKBIA mRNA]25554529
C012042steviolsteviol affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of PCK1 mRNA]25554529
C012042steviolsteviol affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of PLIN2 mRNA]25554529
C012042steviolsteviol affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of PPARA mRNA]25554529
C012042steviolsteviol affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of PPARD mRNA]25554529
C012042steviolsteviol affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of PPARGC1A mRNA]25554529
C012042steviolsteviol affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of PPARG mRNA]25554529
C012042steviolsteviol affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of PRKAA1 mRNA]25554529
C012042steviolsteviol affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of SCD1 mRNA]25554529
C012042steviolsteviol affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of SIRT1 mRNA]25554529
C012042steviolsteviol affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of SLC27A1 mRNA]25554529
C012042steviolsteviol affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of SLC2A2 mRNA]25554529
C012042steviolsteviol affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of SOD2 mRNA]25554529
C012043steviosidestevioside affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of ACOX1 mRNA]25554529
C012043steviosidestevioside affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of CAT mRNA]25554529
C012043steviosidestevioside affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of CPT1A mRNA]25554529
C012043steviosidestevioside affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of DGAT2 mRNA]25554529
C012043steviosidestevioside affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of FOXO1 mRNA]25554529
C012043steviosidestevioside affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of G6PC mRNA]25554529
C012043steviosidestevioside affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of INSR mRNA]25554529
C012043steviosidestevioside affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of IRS1 mRNA]25554529
C012043steviosidestevioside affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of IRS2 mRNA]25554529
C012043steviosidestevioside affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of LIPC mRNA]25554529
C012043steviosidestevioside affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of MTOR mRNA]25554529
C012043steviosidestevioside affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of NFKB1 mRNA]25554529
C012043steviosidestevioside affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of NFKBIA mRNA]25554529
C012043steviosidestevioside affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of PCK1 mRNA]25554529
C012043steviosidestevioside affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of PLIN2 mRNA]25554529
C012043steviosidestevioside affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of PPARA mRNA]25554529
C012043steviosidestevioside affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of PPARD mRNA]25554529
C012043steviosidestevioside affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of PPARGC1A mRNA]25554529
C012043steviosidestevioside affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of PPARG mRNA]25554529
C012043steviosidestevioside affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of SCD1 mRNA]25554529
C012043steviosidestevioside affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of SIRT1 mRNA]25554529
C012043steviosidestevioside affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of SLC27A1 mRNA]25554529
C012043steviosidestevioside affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of SLC2A2 mRNA]25554529
C012043steviosidestevioside affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of SOD2 mRNA]25554529
D013395Sucroseresveratrol inhibits the reaction [[Sucrose co-treated with Dietary Fats] results in decreased expression of LDLR mRNA]23127599
D013395Sucroseresveratrol inhibits the reaction [[Sucrose co-treated with Dietary Fats] results in decreased expression of LDLR protein]23127599
D013395Sucrose[Sucrose co-treated with Dietary Fats] results in decreased expression of LDLR mRNA23127599
D013395Sucrose[Sucrose co-treated with Dietary Fats] results in decreased expression of LDLR protein23127599
C025462sulindac sulfidesulindac sulfide results in decreased expression of LDLR mRNA16184548
C436947T 113242T 113242 promotes the reaction [ZBTB17 protein results in increased expression of LDLR mRNA]11545736
C436947T 113242T 113242 promotes the reaction [ZBTB17 protein results in increased expression of LDLR protein]11545736
C436947T 113242T 113242 results in increased expression of LDLR mRNA11545736
C436947T 113242T 113242 results in increased expression of LDLR protein11545736
D014284TriiodothyronineAmiodarone promotes the reaction [Triiodothyronine results in increased expression of LDLR mRNA]9712728
D014284Triiodothyroninedesethylamiodarone promotes the reaction [Triiodothyronine results in increased expression of LDLR mRNA]9712728
D014284TriiodothyronineTriiodothyronine results in increased expression of LDLR mRNA9712728
D014284TriiodothyronineTriiodothyronine inhibits the reaction [Amiodarone results in decreased expression of LDLR protein]9071962
D014284TriiodothyronineTriiodothyronine results in increased expression of LDLR mRNA9071962
D013629TamoxifenTamoxifen results in increased expression of LDLR protein27358406
C001803tempoltempol inhibits the reaction [LDLR gene mutant form promotes the reaction [Arachidonic Acid results in increased abundance of 11-dehydro-thromboxane B2]]20530721
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the activity of LDLR mRNA18336851
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of LDLR mRNA18336851
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of LDLR protein18336851
D013749Tetrachlorodibenzodioxin"Tetrachlorodibenzodioxin inhibits the reaction [Cholesterol, LDL binds to LDLR protein]"6322751
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of LDLR mRNA21570461|2823826
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with TIPARP gene mutant form] results in increased expression of LDLR mRNA25975270
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of LDLR mRNA22539624|2297716
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of LDLR mRNA21215274
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of LDLR mRNA25613284
D019284ThapsigarginThapsigargin results in decreased expression of LDLR mRNA22378314
D013893ThiramThiram results in decreased expression of LDLR mRNA20530235
D013943ThymolThymol affects the activity of LDLR protein15663186
C027385tibolonetibolone results in increased expression of LDLR mRNA15780535
C009495titanium dioxidetitanium dioxide results in increased expression of LDLR mRNA23557971|2776080
C423915TO-901317TO-901317 results in increased expression of LDLR mRNA16142410
C423915TO-901317TO-901317 inhibits the reaction [2-Hydroxypropyl-beta-cyclodextrin results in increased expression of LDLR protein]22156476
D014028Tobacco Smoke PollutionTobacco Smoke Pollution promotes the reaction [LDLR protein affects the susceptibility to Dietary Fats]22659316
D014028Tobacco Smoke Pollution[Tobacco Smoke Pollution promotes the reaction [LDLR protein affects the susceptibility to Dietary Fats]] which results in increased abundance of Cholesterol22659316
D014118Toxins, Biological"Toxins, Biological affects the expression of LDLR mRNA"19682533
D014212TretinoinTretinoin results in increased expression of LDLR mRNA20530235
D014212TretinoinTretinoin results in increased expression of LDLR mRNA15894607
C032910triadimefontriadimefon affects the expression of LDLR mRNA21195148
D014280Triglyceridesargatroban inhibits the reaction [[LDLR gene mutant form results in increased susceptibility to Dietary Fats] which results in increased abundance of Triglycerides]22841818
D014280Triglycerides[LDLR gene mutant form results in increased susceptibility to Dietary Fats] which results in increased abundance of Triglycerides22841818
C005445triphenyl phosphatetriphenyl phosphate results in increased expression of LDLR mRNA28934090
C005445triphenyl phosphatetriphenyl phosphate results in decreased expression of LDLR mRNA26183808
C005445triphenyl phosphatetriphenyl phosphate results in increased expression of LDLR mRNA26049154
C050414tripterinetripterine results in increased expression of LDLR mRNA17010675
C031324tris(chloroethyl)phosphatetris(chloroethyl)phosphate results in decreased expression of LDLR mRNA26183808
C031324tris(chloroethyl)phosphatetris(chloroethyl)phosphate results in increased expression of LDLR mRNA26049154
C057693troglitazone[[troglitazone binds to and results in increased activity of PPARG protein] which results in decreased expression of SREBF2 protein] which results in decreased expression of LDLR mRNA16946405
C057693troglitazonetroglitazone results in decreased expression of LDLR mRNA25572481
C057693troglitazonetroglitazone results in increased activity of LDLR protein9703316
C057693troglitazonetroglitazone results in increased expression of LDLR mRNA9703316
C057693troglitazonetroglitazone promotes the reaction [INS protein results in increased activity of LDLR protein]9703316
C080163trovafloxacin"[trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in decreased expression of LDLR mRNA"18930950
D014415TunicamycinTunicamycin results in decreased expression of LDLR mRNA22378314
C012596turmeric extractturmeric extract results in increased expression of LDLR protein11593527
C012596turmeric extract[turmeric extract co-treated with Cholesterol] results in increased expression of LDLR mRNA21535835
C012596turmeric extractturmeric extract inhibits the reaction [Cholesterol results in decreased expression of LDLR mRNA]21535835
C113580U 0126[pioglitazone co-treated with U 0126] affects the localization of LDLR protein22593575
C113580U 0126U 0126 results in increased expression of LDLR protein22593575
D014520UrethaneUrethane results in increased expression of LDLR mRNA28818685
D014635Valproic AcidValproic Acid affects the expression of LDLR mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of LDLR mRNA23179753|2718838
D014635Valproic AcidValproic Acid affects the expression of LDLR mRNA17963808
D014635Valproic AcidValproic Acid results in decreased expression of LDLR mRNA19136453|2204503
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of LDLR gene25560391
D001335Vehicle EmissionsVehicle Emissions results in increased expression of LDLR mRNA16504425
C025643vinclozolinvinclozolin results in decreased expression of LDLR mRNA23034163
D024483Vitamin K 3Vitamin K 3 results in increased expression of LDLR mRNA12414654
C111237vorinostatvorinostat results in decreased expression of LDLR mRNA27188386
D014874Water Pollutants, Chemical"Water Pollutants, Chemical results in decreased expression of LDLR mRNA"23246600
D015032Zinc[PCI 5002 co-treated with Zinc] results in increased expression of LDLR mRNA18593933
D015032ZincLDLR gene mutant form results in increased susceptibility to Zinc deficiency16140885
D015032Zinc[LDLR gene mutant form results in increased susceptibility to Zinc deficiency] which results in increased expression of PPARG mRNA16140885
D015032Zinc[LDLR gene mutant form results in increased susceptibility to Zinc deficiency] which results in increased expression of VCAM1 mRNA16140885
D015032Zinc[LDLR gene mutant form results in increased susceptibility to Zinc deficiency] which results in increased expression of VCAM1 protein16140885
C088658zoledronic acidzoledronic acid results in increased expression of LDLR mRNA20977926

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0001540amyloid-beta binding-IEA-  
GO:0001618virus receptor activity-IEA-  
GO:0002020protease binding-IPI22081141  22848640  
GO:0005041low-density lipoprotein particle receptor activity-IC22848640  
GO:0005041low-density lipoprotein particle receptor activity-IDA6091915  8626535  
GO:0005041low-density lipoprotein particle receptor activity-IMP6299582  
GO:0005041low-density lipoprotein particle receptor activity-TAS20005821  
GO:0005509calcium ion binding-IEA-  
GO:0005515protein binding-IPI10571240  12221107  17452316  17461796  18250299  18753623  
20223219  22081141  22509010  23589850  24447298  25613181  
GO:0030169low-density lipoprotein particle binding-IMP6299582  
GO:0030229very-low-density lipoprotein particle receptor activity-IDA8626535  
GO:0032050clathrin heavy chain binding-TAS12121421  
GO:0042802identical protein binding-IPI26526611  
GO ID GO Term Qualifier Evidence PubMed
GO:0006629lipid metabolic process-TAS6299582  10827173  
GO:0006897endocytosis-TAS12671190  
GO:0006898receptor-mediated endocytosis-ISS-  
GO:0007616long-term memory-IGI24412220  
GO:0008203cholesterol metabolic process-IEA-  
GO:0010628positive regulation of gene expression-IEA-  
GO:0010629negative regulation of gene expression-IEA-  
GO:0010867positive regulation of triglyceride biosynthetic process-ISS-  
GO:0010899regulation of phosphatidylcholine catabolic process-ISS-  
GO:0010986positive regulation of lipoprotein particle clearance-ISS-  
GO:0015914phospholipid transport-ISS-  
GO:0030299intestinal cholesterol absorption-IMP17142622  
GO:0030301cholesterol transport-IMP17142622  
GO:0030301cholesterol transport-TAS20005821  
GO:0034381plasma lipoprotein particle clearance-TAS20005821  
GO:0034382chylomicron remnant clearance-TAS-  
GO:0034383low-density lipoprotein particle clearance-IMP6299582  17142622  
GO:0034383low-density lipoprotein particle clearance-TAS-  
GO:0042159lipoprotein catabolic process-IEA-  
GO:0042632cholesterol homeostasis-IGI24412220  
GO:0042632cholesterol homeostasis-IMP6299582  17142622  
GO:0042632cholesterol homeostasis-TAS20005821  
GO:0045807positive regulation of endocytosis-ISS-  
GO:0046718viral entry into host cell-IEA-  
GO:0050729positive regulation of inflammatory response-IEA-  
GO:0051246regulation of protein metabolic process-IGI24412220  
GO:0051248negative regulation of protein metabolic process-ISS-  
GO:0061024membrane organization-TAS-  
GO:0061771response to caloric restriction-IGI24412220  
GO:0061889negative regulation of astrocyte activation-ISS-  
GO:0070508cholesterol import-IMP6299582  
GO:0070508cholesterol import-ISS-  
GO:0071398cellular response to fatty acid-IEA-  
GO:0071404cellular response to low-density lipoprotein particle stimulus-IMP6299582  
GO:0090118receptor-mediated endocytosis involved in cholesterol transport-IMP6299582  
GO:0090181regulation of cholesterol metabolic process-IEA-  
GO:0097242amyloid-beta clearance-ISS-  
GO:1900223positive regulation of amyloid-beta clearance-ISS-  
GO:1903979negative regulation of microglial cell activation-ISS-  
GO:1905167positive regulation of lysosomal protein catabolic process-ISS-  
GO:1905907negative regulation of amyloid fibril formation-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005622intracellular-ISS-  
GO:0005764lysosome-IDA15166224  17461796  
GO:0005769early endosome-IDA15166224  17461796  
GO:0005770late endosome-IDA17461796  
GO:0005794Golgi apparatus-IDA17461796  
GO:0005886plasma membrane-TAS-  
GO:0005887integral component of plasma membrane-TAS6327078  
GO:0005905clathrin-coated pit-IDA6091915  15166224  
GO:0009897external side of plasma membrane-IDA15166224  
GO:0009986cell surface-IDA17461796  
GO:0009986cell surface-ISS-  
GO:0010008endosome membrane-TAS-  
GO:0016020membrane-HDA19946888  
GO:0016323basolateral plasma membrane-ISS-  
GO:0030669clathrin-coated endocytic vesicle membrane-TAS-  
GO:0034362low-density lipoprotein particle-IEA-  
GO:0036020endolysosome membrane-TAS-  
GO:0036477somatodendritic compartment-IEA-  
GO:0043235receptor complex-IDA23382219  
GO:0045177apical part of cell-ISS-  
GO:0097443sorting endosome-IEA-  
GO:1990666PCSK9-LDLR complex-IDA22081141  22848640  
KEGG ID KEGG Term
hsa04144Endocytosis
hsa04976Bile secretion
hsa05145Toxoplasmosis
hsa05160Hepatitis C
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismIEA
R-HSA-162582Signal TransductionIEA
R-HSA-174824Plasma lipoprotein assembly, remodeling, and clearanceTAS
R-HSA-174824Plasma lipoprotein assembly, remodeling, and clearanceIEA
R-HSA-196854Metabolism of vitamins and cofactorsIEA
R-HSA-199991Membrane TraffickingTAS
R-HSA-2187338Visual phototransductionIEA
R-HSA-372790Signaling by GPCRIEA
R-HSA-382551Transport of small moleculesTAS
R-HSA-382551Transport of small moleculesIEA
R-HSA-388396GPCR downstream signallingIEA
R-HSA-418594G alpha (i) signalling eventsIEA
R-HSA-5653656Vesicle-mediated transportTAS
R-HSA-6806667Metabolism of fat-soluble vitaminsIEA
R-HSA-8856825Cargo recognition for clathrin-mediated endocytosisTAS
R-HSA-8856828Clathrin-mediated endocytosisTAS
R-HSA-8964026Chylomicron clearanceTAS
R-HSA-8964026Chylomicron clearanceIEA
R-HSA-8964038LDL clearanceTAS
R-HSA-8964043Plasma lipoprotein clearanceTAS
R-HSA-8964043Plasma lipoprotein clearanceIEA
R-HSA-975634Retinoid metabolism and transportIEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
24404629Familial Hypercholesterolemia (1993)Youngblom E-
28101967Host-related factors explaining interindividual variability of carotenoid bioavailability and tissue concentrations in humans. (2017 Jun)Bohn TMol Nutr Food Res
29021777Circulating Cholesterol Levels May Link to the Factors Influencing Parkinson's Risk. (2017)Zhang LFront Neurol
18815661Recent international regulations: low dose-low rate radiation protection and the demise of reason. (2008 May-Aug)Okkalides DHell J Nucl Med
15144588[Interaction of ApoE and LDL-R gene polymorphisms and alcohol drinking and smoking on coronary heart disease]. (2004 Apr 2)Wang CHZhonghua Yi Xue Za Zhi
15864114Genetic and environmental factors affecting the response to statin therapy in patients with molecularly defined familial hypercholesterolaemia. (2005 Apr)Miltiadous GPharmacogenet Genomics
24358207Nicotine-induced expression of low-density lipoprotein receptor in oral epithelial cells. (2013)Ito SPLoS One
9878681Ionizing radiation and genetic risks. VI. Chronic multifactorial diseases: a review of epidemiological and genetical aspects of coronary heart disease, essential hypertension and diabetes mellitus. (1999 Jan)Sankaranarayanan KMutat Res
27846466Increased sortilin and its independent effect on circulating proprotein convertase subtilisin/kexin type 9 (PCSK9) in statin-naive patients with coronary artery disease. (2017 Jan 15)Hu DInt J Cardiol
17090611Influence of LDL-receptor mutation type on age at first cardiovascular event in patients with familial hypercholesterolaemia. (2007 Feb)Souverein OWEur Heart J
23375686Spectrum of mutations and phenotypic expression in patients with autosomal dominant hypercholesterolemia identified in Italy. (2013 Apr)Bertolini SAtherosclerosis
25682442Prevalence of DNA-confirmed familial hypercholesterolaemia in young patients with myocardial infarction. (2015 Mar)Wald DSEur J Intern Med
27236033LDLR, ApoB and ApoE genes polymorphisms and classical risk factors in premature coronary artery disease. (2016 Sep 30)Abd El-Aziz TAGene
17766366Genetic risk for metabolic syndrome: examination of candidate gene polymorphisms related to lipid metabolism in Japanese people. (2008 Jan)Yamada YJ Med Genet
9409302Familial hypercholesterolemia in the Finnish north Karelia. A molecular, clinical, and genealogical study. (1997 Nov)Vuorio AFArterioscler Thromb Vasc Biol
7583549Differences in the phenotypic characteristics of subjects with familial defective apolipoprotein B-100 and familial hypercholesterolemia. (1995 Oct)Miserez ARArterioscler Thromb Vasc Biol
18243212Cardiovascular disease in familial hypercholesterolaemia: influence of low-density lipoprotein receptor mutation type and classic risk factors. (2008 Oct)Alonso RAtherosclerosis
20065615Association of C677T polymorphism in MTHFR gene, high homocysteine and low HDL cholesterol plasma values in heterozygous familial hypercholesterolemia. (2009)Real JTJ Atheroscler Thromb
22893714Familial hypercholesterolemia in the danish general population: prevalence, coronary artery disease, and cholesterol-lowering medication. (2012 Nov)Benn MJ Clin Endocrinol Metab
8399083Phenotypic variation among familial hypercholesterolemics heterozygous for either one of two Afrikaner founder LDL receptor mutations. (1993 Oct)Kotze MJArterioscler Thromb
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