Gene: LECT2

3950
chm-II|chm2
leukocyte cell derived chemotaxin 2
protein-coding
5q31.1
Ensembl:ENSG00000145826 MIM:602882 Vega:OTTHUMG00000129146 UniprotKB:O14960
NC_000005.10
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
5.577e-1 (AD)  5.512e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
RGS80.504
ADAMTS50.494
LGI20.49
IGF10.469
GPR260.469
SYTL50.468
HS6ST30.467
TACR10.465
SIAH30.464
CALN10.463

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OLAH-0.32
IGFALS-0.313
APOM-0.311
OTOS-0.304
RDH5-0.303
CDKN2C-0.303
MEF2B-0.299
TP73-0.293
PLIN4-0.285
EFHD1-0.283

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of LECT2 mRNA"22698814|2890350
C0364231-aminomethylphosphonic acid"[Herbicides co-treated with 1-aminomethylphosphonic acid co-treated with mecoprop co-treated with acetochlor co-treated with 2,4-Dichlorophenoxyacetic Acid] results in decreased expression of LECT2 mRNA"20566314
C0364231-aminomethylphosphonic acid[Herbicides co-treated with 1-aminomethylphosphonic acid] results in decreased expression of LECT2 mRNA20566314
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of LECT2 mRNA"21346803
C0284513,4,3',4'-tetrachlorobiphenyl"3,4,3',4'-tetrachlorobiphenyl inhibits the reaction [Dietary Fats results in increased expression of LECT2 mRNA]"19467301
D000082AcetaminophenAcetaminophen results in decreased expression of LECT2 mRNA26690555
D000082AcetaminophenAcetaminophen affects the expression of LECT2 mRNA17562736
C043377acetochlor"[Herbicides co-treated with 1-aminomethylphosphonic acid co-treated with mecoprop co-treated with acetochlor co-treated with 2,4-Dichlorophenoxyacetic Acid] results in decreased expression of LECT2 mRNA"20566314
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of LECT2 mRNA27153756
C547126AZM551248AZM551248 results in decreased expression of LECT2 mRNA22323515
C006780bisphenol A[bisphenol A co-treated with Testosterone] results in increased expression of LECT2 mRNA26496021
C006780bisphenol Abisphenol A results in decreased expression of LECT2 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of LECT2 gene28505145
D002509CephaloridineCephaloridine results in decreased expression of LECT2 mRNA18500788
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in decreased expression of LECT2 mRNA18804290
D002734Chlorophyll"[Chlorophyll co-treated with dibenzo(a,l)pyrene] results in decreased expression of LECT2 mRNA"22079312
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of LECT2 mRNA20938992
C074702chromium hexavalent ionchromium hexavalent ion affects the expression of LECT2 mRNA28472532
C018021cobaltous chloridecobaltous chloride results in decreased expression of LECT2 mRNA24386269
D016572CyclosporineCyclosporine results in decreased expression of LECT2 mRNA27989131
D0150842,4-Dichlorophenoxyacetic Acid"[Herbicides co-treated with 1-aminomethylphosphonic acid co-treated with mecoprop co-treated with acetochlor co-treated with 2,4-Dichlorophenoxyacetic Acid] results in decreased expression of LECT2 mRNA"20566314
C041517dibenzo(a,l)pyrene"[Chlorophyll co-treated with dibenzo(a,l)pyrene] results in decreased expression of LECT2 mRNA"22079312
D004041Dietary Fats"3,4,3',4'-tetrachlorobiphenyl inhibits the reaction [Dietary Fats results in increased expression of LECT2 mRNA]"19467301
D004041Dietary FatsDietary Fats results in increased expression of LECT2 mRNA18457598|1946730
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with Phenobarbital] results in increased expression of LECT2 mRNA24535843
D004052DiethylnitrosamineDiethylnitrosamine results in decreased expression of LECT2 mRNA24535843
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with Thioacetamide] results in decreased expression of LECT2 mRNA28943392
C015835dimethyl-4-toluidinedimethyl-4-toluidine results in decreased expression of LECT2 mRNA27638505
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of LECT2 mRNA17108234
C024565ethylene dichlorideethylene dichloride results in decreased expression of LECT2 mRNA28189721
C082360fipronilfipronil results in decreased expression of LECT2 mRNA23962444
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of LECT2 mRNA20938992
C010974glyphosate[Surface-Active Agents co-treated with glyphosate] results in increased expression of LECT2 mRNA22467014
D006540Herbicides"[Herbicides co-treated with 1-aminomethylphosphonic acid co-treated with mecoprop co-treated with acetochlor co-treated with 2,4-Dichlorophenoxyacetic Acid] results in decreased expression of LECT2 mRNA"20566314
D006540Herbicides[Herbicides co-treated with 1-aminomethylphosphonic acid] results in decreased expression of LECT2 mRNA20566314
D017313FenretinideFenretinide results in decreased expression of LECT2 mRNA28973697
C045463leflunomideleflunomide results in increased expression of LECT2 mRNA24136188
D001556LindaneLindane results in decreased expression of LECT2 mRNA18804290
C008340mecoprop"[Herbicides co-treated with 1-aminomethylphosphonic acid co-treated with mecoprop co-treated with acetochlor co-treated with 2,4-Dichlorophenoxyacetic Acid] results in decreased expression of LECT2 mRNA"20566314
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of LECT2 mRNA20938992
C051752nefazodonenefazodone results in decreased expression of LECT2 mRNA24136188
C012655nimesulidenimesulide results in decreased expression of LECT2 mRNA24136188
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of LECT2 mRNA18709148
D010634Phenobarbital[Diethylnitrosamine co-treated with Phenobarbital] results in increased expression of LECT2 mRNA24535843
D010634PhenobarbitalNR1I3 protein affects the reaction [Phenobarbital results in increased expression of LECT2 mRNA]19482888
D010634PhenobarbitalPhenobarbital results in increased expression of LECT2 mRNA19270015|1948288
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of LECT2 mRNA19710929
C006253pirinixic acidpirinixic acid results in decreased expression of LECT2 mRNA20059764|2381119
C006253pirinixic acidPPARA protein promotes the reaction [pirinixic acid results in decreased expression of LECT2 mRNA]20059764
C045950propiconazolepropiconazole results in increased expression of LECT2 mRNA21278054
D013501Surface-Active Agents[Surface-Active Agents co-treated with glyphosate] results in increased expression of LECT2 mRNA22467014
D013739Testosterone[bisphenol A co-treated with Testosterone] results in increased expression of LECT2 mRNA26496021
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of LECT2 mRNA22298810
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of LECT2 mRNA26377647
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of LECT2 mRNA22298810
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of LECT2 mRNA21215274
D013750TetrachloroethyleneTetrachloroethylene results in decreased expression of LECT2 mRNA28973375
D013853Thioacetamide[Diethylnitrosamine co-treated with Thioacetamide] results in decreased expression of LECT2 mRNA28943392
D013853ThioacetamideThioacetamide results in decreased expression of LECT2 mRNA23411599
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of LECT2 mRNA"24407104
D014635Valproic AcidValproic Acid results in decreased expression of LECT2 mRNA29154799
D001335Vehicle EmissionsVehicle Emissions affects the methylation of LECT2 gene25560391
D014874Water Pollutants, Chemical"Water Pollutants, Chemical results in increased expression of LECT2 mRNA"23246600
D015034Zinc OxideZinc Oxide analog results in decreased expression of LECT2 mRNA27215404
D019287Zinc SulfateZinc Sulfate results in decreased expression of LECT2 mRNA27215404

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI27334921  
GO:0042802identical protein binding-IPI23352894  
GO:0046872metal ion binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0001501skeletal system development-TAS9545637  
GO:0006935chemotaxis-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005615extracellular space-TAS9266841  
GO:0005737cytoplasm-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
26202054Interaction between smoking history and gene expression levels impacts survival of breast cancer patients. (2015 Aug)Andres SABreast Cancer Res Treat