Gene: LEP

3952
LEPD|OB|OBS
leptin
protein-coding
7q32.1
Ensembl:ENSG00000174697 MIM:164160 Vega:OTTHUMG00000157564 UniprotKB:P41159
NG_007450.1
PubMed
0   ANCO-SNPs
OD|ND|AD
14   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.554e-1 (AD)  6.612e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CIDEC0.751
ADIPOQ0.744
VCY0.672
LIPN0.647
TLR80.647
TCN10.643
CCR30.639
HAL0.611
GPR1410.601
TMEM710.6

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ASPDH-0.279
SAC3D1-0.26
ATP2C2-0.259
WFDC1-0.258
C15orf59-0.254
SST-0.248
CORT-0.247
RNFT2-0.246
ARSF-0.245
ZNF628-0.245

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0631591-(2-(3-(4-methoxyphenyl)propoxy)-4-methoxyphenylethyl)-1H-imidazole1-(2-(3-(4-methoxyphenyl)propoxy)-4-methoxyphenylethyl)-1H-imidazole inhibits the reaction [LEP protein results in increased transport of Calcium]20107083
C0703791,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester"1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [[Glucose co-treated with INS1 protein] results in increased secretion of LEP protein]"10780946
C0024481,2-linoleoylphosphatidylcholine"1,2-linoleoylphosphatidylcholine inhibits the reaction [LEP protein results in increased expression of COL1A1 mRNA]"16996477
C0024481,2-linoleoylphosphatidylcholine"1,2-linoleoylphosphatidylcholine inhibits the reaction [Vitamin K 3 results in increased expression of LEP mRNA]"16996477
C0024481,2-linoleoylphosphatidylcholine"[1,2-linoleoylphosphatidylcholine co-treated with S-Adenosylmethionine] inhibits the reaction [LEP protein results in increased abundance of Hydrogen Peroxide]"16996477
C0150681-(3-chlorophenyl)piperazine1-(3-chlorophenyl)piperazine inhibits the reaction [Corticosterone results in decreased expression of LEP protein]28186389
C0150681-(3-chlorophenyl)piperazine"8-(5-(5-amino-2,4-dimethoxyphenyl)-5-oxopentyl)-1,3,8-triazaspiro(4.5)decane-2,4-dione inhibits the reaction [1-(3-chlorophenyl)piperazine inhibits the reaction [Corticosterone results in decreased expression of LEP protein]]"28186389
C0513601,3-dipropyl-8-cyclopentylxanthine"1,3-dipropyl-8-cyclopentylxanthine inhibits the reaction [Dipyridamole results in increased expression of LEP protein]"10746648
C09724015-deoxy-delta(12,14)-prostaglandin J2"15-deoxy-delta(12,14)-prostaglandin J2 results in increased secretion of LEP protein"11092516
C09724015-deoxy-delta(12,14)-prostaglandin J2"[Dexamethasone co-treated with 15-deoxy-delta(12,14)-prostaglandin J2] results in decreased secretion of LEP protein"11092516
C09724015-deoxy-delta(12,14)-prostaglandin J2"[15-deoxy-delta(12,14)-prostaglandin J2 binds to and results in increased activity of PPARG protein] which results in decreased secretion of LEP protein"16037295
C0602291-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione"1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [LEP protein results in increased transport of Calcium]"20107083
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in increased expression of LEP mRNA"24559133
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in decreased expression of LEP mRNA"27291303
C0939732-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [LEP protein inhibits the reaction [8-Bromo Cyclic Adenosine Monophosphate results in increased expression of STAR protein]]19849856
C0939732-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [LEP protein results in increased expression of CYP19A1 mRNA]28571770
C0939732-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [LEP protein results in increased expression of CYP19A1 protein]28571770
C0939732-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Vitamin K 3 results in increased expression of LEP mRNA]16996477
C0939732-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one[2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one results in decreased activity of [MAPK1 protein co-treated with MAPK3 protein]] inhibits the reaction [[bisphenol A co-treated with LEP protein] results in decreased activity of CASP3 protein]23850738
C0939732-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one[2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one results in decreased activity of [MAPK1 protein co-treated with MAPK3 protein]] inhibits the reaction [[Estradiol co-treated with LEP protein] results in decreased activity of CASP3 protein]23850738
C0939732-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one[2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one results in decreased activity of [MAPK1 protein co-treated with MAPK3 protein]] inhibits the reaction [[LEP protein co-treated with bisphenol A] results in decreased expression of CASP3 protein]23850738
C0939732-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one[2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one results in decreased activity of [MAPK1 protein co-treated with MAPK3 protein]] inhibits the reaction [[LEP protein co-treated with Estradiol] results in decreased expression of CASP3 protein]23850738
C0939732-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one results in decreased susceptibility to LEP protein19849856
C0939732-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one[2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one co-treated with BQ 788] results in decreased expression of LEP protein16391412
C0939732-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [LEP protein inhibits the reaction [rosiglitazone results in increased expression of PPARG mRNA]]21352814
C0939732-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [LEP protein results in increased expression of COL1A1 mRNA]16996477
C0192732,2-bis(4-glycidyloxyphenyl)propane"2,2-bis(4-glycidyloxyphenyl)propane results in increased expression of LEP mRNA"22763116
C0612822-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine inhibits the reaction [Caffeine results in decreased expression of LEP mRNA]26367767
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of LEP mRNA"24978599
C0140242,4,5,2',4',5'-hexachlorobiphenyl"2,4,5,2',4',5'-hexachlorobiphenyl promotes the reaction [Dietary Fats results in increased expression of LEP protein]"23618531
C0140242,4,5,2',4',5'-hexachlorobiphenyl"2,4,5,2',4',5'-hexachlorobiphenyl results in increased expression of LEP mRNA"24978599
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of LEP mRNA"24978599
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl] results in increased expression of LEP mRNA"24978599
C0098282,4,5,2',5'-pentachlorobiphenyl"[2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of LEP mRNA"24978599
C0098282,4,5,2',5'-pentachlorobiphenyl"[2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl] results in increased expression of LEP mRNA"24978599
C0098282,4,5,2',5'-pentachlorobiphenyl"[2,4,5,2',5'-pentachlorobiphenyl co-treated with PCB 180] results in increased expression of LEP mRNA"24978599
C0859112-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [LEP protein results in increased expression of CYP19A1 mRNA]28571770
C0859112-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [LEP protein results in increased expression of CYP19A1 protein]28571770
C0859112-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased expression of LEP mRNA19254925|2135124
C0859112-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased secretion of LEP protein19254925|2135124
C0859112-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [LEP protein results in decreased abundance of Reactive Oxygen Species]17993459
C0859112-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased susceptibility to LEP protein17993459
C07699627-hydroxycholesterol27-hydroxycholesterol results in decreased expression of LEP mRNA20157255
C07699627-hydroxycholesterol27-hydroxycholesterol results in decreased expression of LEP protein20157255
C07699627-hydroxycholesterolLEP protein inhibits the reaction [27-hydroxycholesterol results in increased expression of APP protein]20157255
C07699627-hydroxycholesterolLEP protein inhibits the reaction [27-hydroxycholesterol results in increased expression of MAPT protein modified form]20157255
C07699627-hydroxycholesterolLEP protein inhibits the reaction [27-hydroxycholesterol results in increased phosphorylation of MAPT protein]20157255
C1099862-aminoethoxydiphenyl borate2-aminoethoxydiphenyl borate inhibits the reaction [LEP protein results in increased transport of Calcium]20107083
C0978693-(2-ethylphenoxy)-1-(1,2,3,4-tetrahydronaphth-1-ylamino)-2-propanol oxalate"3-(2-ethylphenoxy)-1-(1,2,3,4-tetrahydronaphth-1-ylamino)-2-propanol oxalate inhibits the reaction [amibegron results in decreased expression of LEP mRNA]"9718277
C0230353,4,5,3',4'-pentachlorobiphenyl"[3,4,5,3',4'-pentachlorobiphenyl co-treated with Methionine deficiency co-treated with Choline deficiency] results in decreased expression of LEP protein"28973532
C5307733,5-diethoxycarbonyl-1,4-dihydrocollidine"3,5-diethoxycarbonyl-1,4-dihydrocollidine results in decreased expression of LEP protein"20512997
C5795583-(5-tert-butylisoxazol-3-yl)-2-((3-chlorophenyl)hydrazono)-3-oxopropionitrile"3-(5-tert-butylisoxazol-3-yl)-2-((3-chlorophenyl)hydrazono)-3-oxopropionitrile inhibits the reaction [8-(4-chlorophenylthio)-2'-O-methyladenosine-3',5'-monophosphate acetoxymethyl ester analog results in increased secretion of LEP protein]"27381457
C5795583-(5-tert-butylisoxazol-3-yl)-2-((3-chlorophenyl)hydrazono)-3-oxopropionitrile3-(5-tert-butylisoxazol-3-yl)-2-((3-chlorophenyl)hydrazono)-3-oxopropionitrile inhibits the reaction [Cyclic AMP analog results in increased expression of LEP mRNA]27381457
C5795583-(5-tert-butylisoxazol-3-yl)-2-((3-chlorophenyl)hydrazono)-3-oxopropionitrile3-(5-tert-butylisoxazol-3-yl)-2-((3-chlorophenyl)hydrazono)-3-oxopropionitrile results in decreased expression of LEP mRNA27381457
C5795583-(5-tert-butylisoxazol-3-yl)-2-((3-chlorophenyl)hydrazono)-3-oxopropionitrile3-(5-tert-butylisoxazol-3-yl)-2-((3-chlorophenyl)hydrazono)-3-oxopropionitrile results in decreased secretion of LEP protein27381457
C4411283-N-1(spermine)-7, 24-dihydroxy-5-cholestane 24-sulfate"3-N-1(spermine)-7, 24-dihydroxy-5-cholestane 24-sulfate inhibits the reaction [Dietary Fats results in increased expression of LEP protein]"20075852
C5756314-(4-(2,4-dioxothiazolidin-5-ylidenemethyl)-2-methoxyphenoxy)-3-trifluoromethylbenzonitrile"4-(4-(2,4-dioxothiazolidin-5-ylidenemethyl)-2-methoxyphenoxy)-3-trifluoromethylbenzonitrile affects the expression of LEP mRNA"21218783
C0381934-hydroxybenzoic acid4-hydroxybenzoic acid results in decreased expression of LEP mRNA22956630
C0140364-hydroxyestradiolLEP protein results in increased abundance of 4-hydroxyestradiol24631339
C0415944-nonylphenol4-nonylphenol results in increased expression of LEP protein24388992
C0538766-isopropoxy-9-oxoxanthene-2-carboxylic acid6-isopropoxy-9-oxoxanthene-2-carboxylic acid inhibits the reaction [LEP protein results in increased expression of CYP19A1 mRNA]28571770
C0538766-isopropoxy-9-oxoxanthene-2-carboxylic acid6-isopropoxy-9-oxoxanthene-2-carboxylic acid inhibits the reaction [LEP protein results in increased expression of CYP19A1 protein]28571770
C5556508-(4-chlorophenylthio)-2'-O-methyladenosine-3',5'-monophosphate acetoxymethyl ester"3-(5-tert-butylisoxazol-3-yl)-2-((3-chlorophenyl)hydrazono)-3-oxopropionitrile inhibits the reaction [8-(4-chlorophenylthio)-2'-O-methyladenosine-3',5'-monophosphate acetoxymethyl ester analog results in increased secretion of LEP protein]"27381457
C5556508-(4-chlorophenylthio)-2'-O-methyladenosine-3',5'-monophosphate acetoxymethyl ester"8-(4-chlorophenylthio)-2'-O-methyladenosine-3',5'-monophosphate acetoxymethyl ester analog results in increased secretion of LEP protein"27381457
C5556508-(4-chlorophenylthio)-2'-O-methyladenosine-3',5'-monophosphate acetoxymethyl ester"MK 2206 inhibits the reaction [8-(4-chlorophenylthio)-2'-O-methyladenosine-3',5'-monophosphate acetoxymethyl ester analog results in increased secretion of LEP protein]"27381457
C1078218-(5-(5-amino-2,4-dimethoxyphenyl)-5-oxopentyl)-1,3,8-triazaspiro(4.5)decane-2,4-dione"8-(5-(5-amino-2,4-dimethoxyphenyl)-5-oxopentyl)-1,3,8-triazaspiro(4.5)decane-2,4-dione inhibits the reaction [1-(3-chlorophenyl)piperazine inhibits the reaction [Corticosterone results in decreased expression of LEP protein]]"28186389
D020909AcarboseAcarbose results in decreased expression of LEP protein18290871
D000079AcetaldehydeAcetaldehyde inhibits the reaction [LEP protein results in increased expression of ADIPOR2 protein]17949463
D000079AcetaldehydeLEP protein affects the reaction [Acetaldehyde results in increased expression of ADIPOQ protein]17949463
D000079AcetaldehydeLEP protein affects the reaction [Acetaldehyde results in increased expression of COL1A2 mRNA]15130784
D000079AcetaldehydeLEP protein affects the reaction [Acetaldehyde results in increased expression of TGFB1 protein]15130784
D000082AcetaminophenAcetaminophen results in decreased expression of LEP mRNA26690555
D000082AcetaminophenAcetaminophen affects the expression of LEP mRNA17562736
D000082Acetaminophen[Clofibrate co-treated with Acetaminophen] affects the expression of LEP mRNA17585979
D000082AcetaminophenPPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of LEP mRNA]17585979
C056165acetovanilloneacetovanillone inhibits the reaction [LEP protein affects the abundance of Calcium]16380530
C056165acetovanilloneacetovanillone inhibits the reaction [LEP protein results in increased abundance of Superoxides]16380530
C056165acetovanilloneacetovanillone inhibits the reaction [LEP protein results in increased expression of NCF1 protein]16380530
C056165acetovanilloneacetovanillone inhibits the reaction [LEP protein results in increased expression of NCF2 protein]16380530
D000109AcetylcholineLEP protein inhibits the reaction [Acetylcholine results in increased secretion of INS protein]12734786
D000109AcetylcholineTolbutamide inhibits the reaction [LEP protein inhibits the reaction [Acetylcholine results in increased secretion of INS protein]]12734786
C016957adenosine-3',5'-cyclic phosphorothioate"adenosine-3',5'-cyclic phosphorothioate inhibits the reaction [LEP protein results in increased chemical synthesis of Reactive Oxygen Species]"11342529
C016957adenosine-3',5'-cyclic phosphorothioate"adenosine-3',5'-cyclic phosphorothioate inhibits the reaction [LEP protein results in increased expression of CCL2]"11342529
C016957adenosine-3',5'-cyclic phosphorothioate"adenosine-3',5'-cyclic phosphorothioate results in decreased susceptibility to LEP protein"11342529
D000242Cyclic AMPLEP protein results in increased abundance of Cyclic AMP11342529
D000242Cyclic AMP3-(5-tert-butylisoxazol-3-yl)-2-((3-chlorophenyl)hydrazono)-3-oxopropionitrile inhibits the reaction [Cyclic AMP analog results in increased expression of LEP mRNA]27381457
D000242Cyclic AMPCyclic AMP analog results in increased expression of LEP mRNA27381457
D000255Adenosine Triphosphate[Deoxyglucose results in decreased abundance of Adenosine Triphosphate] which results in decreased secretion of LEP protein10780946
D000255Adenosine Triphosphate[[Glucose co-treated with INS1 protein] results in increased abundance of Adenosine Triphosphate] which results in increased secretion of LEP protein10780946
D012436S-AdenosylmethionineS-Adenosylmethionine inhibits the reaction [LEP protein results in increased expression of COL1A1 mRNA]16996477
D012436S-AdenosylmethionineS-Adenosylmethionine inhibits the reaction [Vitamin K 3 results in increased expression of LEP mRNA]16996477
D012436S-Adenosylmethionine"[1,2-linoleoylphosphatidylcholine co-treated with S-Adenosylmethionine] inhibits the reaction [LEP protein results in increased abundance of Hydrogen Peroxide]"16996477
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of LEP gene27153756
C046926AH 23848AH 23848 inhibits the reaction [LEP protein results in increased expression of CYP19A1 mRNA]28571770
C046926AH 23848AH 23848 inhibits the reaction [LEP protein results in increased expression of CYP19A1 protein]28571770
C103303alitretinoin[alitretinoin co-treated with Clofibrate] results in increased expression of LEP protein9751766
D000493AllopurinolAllopurinol inhibits the reaction [Fructose results in increased expression of LEP protein]22426011
D000517alpha-Chlorohydrinalpha-Chlorohydrin results in decreased expression of LEP mRNA20409345
C095512alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide"alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide inhibits the reaction [LEP protein results in increased expression of CYP19A1 mRNA]"28571770
C095512alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide"alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide inhibits the reaction [LEP protein results in increased expression of CYP19A1 protein]"28571770
C095512alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide"[alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide results in decreased activity of JAK2 protein] inhibits the reaction [[LEP protein co-treated with bisphenol A] results in decreased activity of CASP3 protein]"23850738
C095512alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide"[alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide results in decreased activity of JAK2 protein] inhibits the reaction [[LEP protein co-treated with bisphenol A] results in decreased expression of CASP3 protein]"23850738
C095512alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide"[alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide results in decreased activity of JAK2 protein] inhibits the reaction [[LEP protein co-treated with Estradiol] results in decreased activity of CASP3 protein]"23850738
C095512alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide"[alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide results in decreased activity of JAK2 protein] inhibits the reaction [[LEP protein co-treated with Estradiol] results in decreased expression of CASP3 protein]"23850738
C095512alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide"[alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide results in decreased activity of JAK2 protein] inhibits the reaction [LEP protein results in decreased activity of CASP3 protein]"23850738
C095512alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide"[alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide results in decreased activity of JAK2 protein] inhibits the reaction [LEP protein results in decreased expression of CASP3 protein]"23850738
C095512alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide"alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide inhibits the reaction [LEP protein results in increased transport of Calcium]"20107083
C095512alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide"alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide inhibits the reaction [LEP protein results in decreased susceptibility to Iron]"17993459
C095512alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide"alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide inhibits the reaction [LEP protein results in increased expression of BCL2L1 protein]"17993459
C095512alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide"alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide inhibits the reaction [LEP protein results in increased expression of SOD2 protein]"17993459
C095512alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide"alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide inhibits the reaction [LEP protein results in increased phosphorylation of STAT3 protein]"17993459
C095512alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide"alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide results in decreased susceptibility to LEP protein"17993459
D013196DihydrotestosteroneDihydrotestosterone results in decreased expression of LEP mRNA18801408
C076252amibegron"3-(2-ethylphenoxy)-1-(1,2,3,4-tetrahydronaphth-1-ylamino)-2-propanol oxalate inhibits the reaction [amibegron results in decreased expression of LEP mRNA]"9718277
C076252amibegronamibegron results in decreased expression of LEP mRNA9718277
D017311AmlodipineAmlodipine results in decreased expression of LEP19059660
D017311AmlodipineAmlodipine results in decreased expression of LEP protein18199500
D000643Ammonium ChlorideAmmonium Chloride affects the expression of LEP mRNA16483693
C078814anandamideLEP protein results in decreased abundance of anandamide16154199
C078814anandamideLEP protein results in decreased activity of anandamide16154199
C078814anandamideLEP protein results in decreased transport of anandamide16154199
D047310ApigeninApigenin results in increased expression of LEP mRNA18359623
D047310ApigeninApigenin results in increased expression of LEP protein18359623
C526219apple polyphenol extractapple polyphenol extract inhibits the reaction [[Dietary Sucrose co-treated with Dietary Fats] results in increased expression of LEP mRNA]23529981
C526219apple polyphenol extractapple polyphenol extract inhibits the reaction [[Dietary Sucrose co-treated with Dietary Fats] results in increased methylation of LEP promoter]23529981
C000625385AQ28A compoundLEP protein affects the reaction [AQ28A compound analog binds to PDE10A protein]27247380
D016718Arachidonic AcidArachidonic Acid promotes the reaction [Tetrachlorodibenzodioxin results in decreased expression of LEP mRNA]19063610
C081565arachidonyltrifluoromethanearachidonyltrifluoromethane inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of LEP mRNA]19063610
D001151ArsenicArsenic affects the expression of LEP protein20940111
C015001arsenitearsenite results in decreased methylation of LEP promoter23974009
D017638Asbestos, Crocidolite"Asbestos, Crocidolite results in decreased expression of LEP mRNA"23917077
D001205Ascorbic AcidAscorbic Acid inhibits the reaction [INS1 protein results in increased secretion of LEP protein]20400526
D001205Ascorbic AcidAscorbic Acid results in decreased secretion of LEP protein20400526
D001218AspartameAspartame results in decreased expression of LEP protein11890951
D001241Aspirin"[lipopolysaccharide, Helicobacter pylori co-treated with Aspirin] results in increased expression of LEP protein"15024038
D000069059Atorvastatin CalciumAtorvastatin Calcium affects the reaction [Fructose results in increased expression of LEP protein]21122807
D001280AtrazineAtrazine results in increased expression of LEP mRNA25929836
C562236aza-(6)-gingerolaza-(6)-gingerol inhibits the reaction [Dietary Fats results in increased expression of LEP mRNA]21851089
C562236aza-(6)-gingerolaza-(6)-gingerol inhibits the reaction [Dietary Fats results in increased expression of LEP protein]21851089
D001397Azoxymethane[Azoxymethane co-treated with Dextran Sulfate] results in increased expression of LEP mRNA19931517
D001397Azoxymethane[Azoxymethane co-treated with Dextran Sulfate] results in increased expression of LEP protein19931517
D001397AzoxymethaneAzoxymethane results in increased expression of LEP protein19914226
D001397AzoxymethaneQuercetin inhibits the reaction [Azoxymethane results in increased expression of LEP protein]19914226
C057775benzylparabenbenzylparaben results in decreased expression of LEP mRNA22956630
C057775benzylparabenbenzylparaben results in increased expression of LEP mRNA22956630
D004958Estradiol[2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one results in decreased activity of [MAPK1 protein co-treated with MAPK3 protein]] inhibits the reaction [[Estradiol co-treated with LEP protein] results in decreased activity of CASP3 protein]23850738
D004958Estradiol[2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one results in decreased activity of [MAPK1 protein co-treated with MAPK3 protein]] inhibits the reaction [[LEP protein co-treated with Estradiol] results in decreased expression of CASP3 protein]23850738
D004958Estradiol"[alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide results in decreased activity of JAK2 protein] inhibits the reaction [[LEP protein co-treated with Estradiol] results in decreased activity of CASP3 protein]"23850738
D004958Estradiol"[alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide results in decreased activity of JAK2 protein] inhibits the reaction [[LEP protein co-treated with Estradiol] results in decreased expression of CASP3 protein]"23850738
D004958Estradiol[Estradiol co-treated with LEP protein] results in decreased expression of CASP3 mRNA23850738
D004958Estradiol[Estradiol co-treated with LEP protein] results in decreased expression of CASP3 protein23850738
D004958EstradiolEstradiol promotes the reaction [LEP protein results in decreased activity of CASP3 protein]23850738
D004958EstradiolLEP protein promotes the reaction [Estradiol results in decreased activity of CASP3 protein]23850738
D004958EstradiolEstradiol results in increased expression of LEP mRNA18359623
D004958EstradiolEstradiol results in increased expression of LEP mRNA26164745
D004958EstradiolEstradiol results in increased expression of LEP mRNA23153703
D004958EstradiolEstradiol results in increased secretion of LEP protein23153703
D001629BezafibrateBezafibrate results in decreased expression of LEP10726910
D001629BezafibrateBezafibrate results in decreased expression of LEP protein21549692
D001629BezafibrateBezafibrate inhibits the reaction [Lipopolysaccharides results in increased expression of LEP protein]17379010
D001629BezafibrateBezafibrate results in decreased expression of LEP mRNA11216866|1147305
C543008bis(4-hydroxyphenyl)sulfonebis(4-hydroxyphenyl)sulfone results in decreased expression of LEP mRNA27685785
C543008bis(4-hydroxyphenyl)sulfonebis(4-hydroxyphenyl)sulfone affects the reaction [Dietary Fats results in increased expression of LEP protein]27241191
C543008bis(4-hydroxyphenyl)sulfonebis(4-hydroxyphenyl)sulfone results in increased secretion of LEP protein25111128
C074212bis(maltolato)oxovanadium(IV)bis(maltolato)oxovanadium(IV) results in decreased expression of LEP25168077
C006780bisphenol A[2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one results in decreased activity of [MAPK1 protein co-treated with MAPK3 protein]] inhibits the reaction [[bisphenol A co-treated with LEP protein] results in decreased activity of CASP3 protein]23850738
C006780bisphenol A[2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one results in decreased activity of [MAPK1 protein co-treated with MAPK3 protein]] inhibits the reaction [[LEP protein co-treated with bisphenol A] results in decreased expression of CASP3 protein]23850738
C006780bisphenol A"[alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide results in decreased activity of JAK2 protein] inhibits the reaction [[LEP protein co-treated with bisphenol A] results in decreased activity of CASP3 protein]"23850738
C006780bisphenol A"[alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide results in decreased activity of JAK2 protein] inhibits the reaction [[LEP protein co-treated with bisphenol A] results in decreased expression of CASP3 protein]"23850738
C006780bisphenol A[bisphenol A co-treated with LEP protein] results in decreased expression of CASP3 mRNA23850738
C006780bisphenol A[bisphenol A co-treated with LEP protein] results in decreased expression of CASP3 protein23850738
C006780bisphenol Abisphenol A promotes the reaction [LEP protein results in decreased activity of CASP3 protein]23850738
C006780bisphenol Abisphenol A results in decreased expression of LEP mRNA24349194|2578427
C006780bisphenol Abisphenol A results in decreased expression of LEP protein27145005
C006780bisphenol Abisphenol A results in increased expression of LEP mRNA25878060
C006780bisphenol Abisphenol A results in increased expression of LEP protein27145005
C006780bisphenol ALEP protein promotes the reaction [bisphenol A results in decreased activity of CASP3 protein]23850738
C006780bisphenol Abisphenol A results in decreased expression of LEP protein12030774
C006780bisphenol Abisphenol A promotes the reaction [Dietary Fats results in increased expression of LEP protein]23493373
C006780bisphenol Abisphenol A results in increased expression of LEP20488778
C006780bisphenol Abisphenol A results in increased expression of LEP mRNA18359623|1841771
C006780bisphenol Abisphenol A results in increased expression of LEP protein27145005
D001761BleomycinBleomycin results in increased expression of LEP protein29175452
C032688boric acidboric acid inhibits the reaction [[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased expression of LEP mRNA]28285642
C032688boric acidboric acid results in decreased expression of and results in decreased secretion of LEP protein28285642
C087220BQ 610BQ 610 inhibits the reaction [Indomethacin results in increased expression of LEP protein]16280098
C087220BQ 610BQ 610 results in decreased expression of LEP protein16391412
C086539BQ 788BQ 788 inhibits the reaction [LEP protein affects the abundance of Calcium]16380530
C086539BQ 788BQ 788 inhibits the reaction [LEP protein results in increased abundance of Superoxides]16380530
C086539BQ 788BQ 788 inhibits the reaction [LEP protein results in increased expression of NCF1 protein]16380530
C086539BQ 788BQ 788 inhibits the reaction [LEP protein results in increased expression of NCF2 protein]16380530
C086539BQ 788[2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one co-treated with BQ 788] results in decreased expression of LEP protein16391412
C057368BRL 37344BRL 37344 results in decreased expression of LEP mRNA9002984
C057368BRL 37344BRL 37344 results in decreased expression of LEP protein9002984
C057368BRL 37344BRL 37344 results in decreased stability of LEP mRNA9002984
D0151248-Bromo Cyclic Adenosine Monophosphate2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [LEP protein inhibits the reaction [8-Bromo Cyclic Adenosine Monophosphate results in increased expression of STAR protein]]19849856
D0151248-Bromo Cyclic Adenosine MonophosphateLEP protein inhibits the reaction [8-Bromo Cyclic Adenosine Monophosphate results in increased chemical synthesis of Progesterone]19849856
D0151248-Bromo Cyclic Adenosine MonophosphateLEP protein inhibits the reaction [8-Bromo Cyclic Adenosine Monophosphate results in increased expression of STAR protein]19849856
D0151248-Bromo Cyclic Adenosine MonophosphateLEP protein results in decreased susceptibility to 8-Bromo Cyclic Adenosine Monophosphate19849856
D0151248-Bromo Cyclic Adenosine MonophosphateLEPR protein affects the reaction [LEP protein inhibits the reaction [8-Bromo Cyclic Adenosine Monophosphate results in increased chemical synthesis of Progesterone]]19849856
D0151248-Bromo Cyclic Adenosine MonophosphateLEPR protein affects the reaction [LEP protein inhibits the reaction [8-Bromo Cyclic Adenosine Monophosphate results in increased expression of STAR protein]]19849856
D0151248-Bromo Cyclic Adenosine MonophosphateSB 203580 inhibits the reaction [LEP protein inhibits the reaction [8-Bromo Cyclic Adenosine Monophosphate results in increased expression of STAR protein]]19849856
C025191bromodichloromethanebromodichloromethane promotes the reaction [Dietary Fats results in increased expression of LEP mRNA]23438451
C025191bromodichloromethanebromodichloromethane results in increased expression of LEP mRNA23640861
C025191bromodichloromethaneLEP gene mutant form results in decreased susceptibility to bromodichloromethane23640861
C025191bromodichloromethaneLEP protein affects the reaction [[bromodichloromethane co-treated with Dietary Fats] results in increased expression of CASP3 protein modified form]24211274
C025191bromodichloromethaneLEP protein affects the reaction [[Dietary Fats co-treated with bromodichloromethane] affects the localization of NCF2 protein]23438451
C025191bromodichloromethaneLEP protein results in decreased susceptibility to [Dietary Fats co-treated with bromodichloromethane]23438451
C025191bromodichloromethane[CYP2E1 protein results in increased metabolism of bromodichloromethane] which results in increased expression of LEP protein23438451
D002084Butylated HydroxytolueneButylated Hydroxytoluene inhibits the reaction [Methylnitrosourea results in increased expression of LEP protein]16822543
C038091butylparabenbutylparaben results in decreased expression of LEP mRNA22956630
C038091butylparabenbutylparaben results in increased expression of LEP mRNA22956630
C584509C646 compoundC646 compound results in increased expression of LEP mRNA26191083
D019256Cadmium Chloride[Cadmium Chloride co-treated with methylmercuric chloride] results in increased expression of LEP protein27814245
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of LEP mRNA23921151
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of LEP protein23921151
D019256Cadmium ChlorideCadmium Chloride results in increased expression of LEP protein27634282
D019256Cadmium Chloride[MT1 gene mutant form results in increased susceptibility to Cadmium Chloride] which affects the expression of LEP mRNA23921151
D019256Cadmium ChlorideMT1 protein affects the reaction [Cadmium Chloride results in decreased expression of LEP protein]23921151
D019256Cadmium Chloride[MT2 gene mutant form results in increased susceptibility to Cadmium Chloride] which affects the expression of LEP mRNA23921151
D019256Cadmium ChlorideMT2 protein affects the reaction [Cadmium Chloride results in decreased expression of LEP protein]23921151
C055494caffeic acid phenethyl estercaffeic acid phenethyl ester results in decreased expression of LEP mRNA21467634
C055494caffeic acid phenethyl estercaffeic acid phenethyl ester results in decreased expression of LEP protein21467634
D002110Caffeine2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine inhibits the reaction [Caffeine results in decreased expression of LEP mRNA]26367767
D002110CaffeineCaffeine results in decreased expression of LEP mRNA26367767
D002110CaffeineColforsin inhibits the reaction [Caffeine results in decreased expression of LEP mRNA]26367767
D002110CaffeineCaffeine results in decreased expression of LEP mRNA23727198
D002110CaffeineCaffeine results in decreased expression of LEP mRNA23727198|2636776
D002110CaffeineCaffeine results in decreased expression of LEP protein26367767
D002118Calcium1-(2-(3-(4-methoxyphenyl)propoxy)-4-methoxyphenylethyl)-1H-imidazole inhibits the reaction [LEP protein results in increased transport of Calcium]20107083
D002118Calcium"1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [LEP protein results in increased transport of Calcium]"20107083
D002118Calcium2-aminoethoxydiphenyl borate inhibits the reaction [LEP protein results in increased transport of Calcium]20107083
D002118Calciumacetovanillone inhibits the reaction [LEP protein affects the abundance of Calcium]16380530
D002118Calcium"alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide inhibits the reaction [LEP protein results in increased transport of Calcium]"20107083
D002118CalciumBQ 788 inhibits the reaction [LEP protein affects the abundance of Calcium]16380530
D002118CalciumCalcium promotes the reaction [LEP protein results in increased transport of Calcium]20107083
D002118Calciumcyclo(Trp-Asp-Pro-Val-Leu) inhibits the reaction [LEP protein affects the abundance of Calcium]16380530
D002118Calciumedelfosine inhibits the reaction [LEP protein results in increased transport of Calcium]20107083
D002118CalciumFlufenamic Acid inhibits the reaction [LEP protein results in increased transport of Calcium]20107083
D002118CalciumJAK2 protein promotes the reaction [LEP protein results in increased transport of Calcium]20107083
D002118CalciumLanthanum promotes the reaction [LEP protein results in increased transport of Calcium]20107083
D002118CalciumLEP protein affects the abundance of Calcium16380530
D002118CalciumLEP protein promotes the reaction [TRPC1 protein results in increased transport of Calcium]20107083
D002118CalciumLEP protein promotes the reaction [TRPC4 protein results in increased transport of Calcium]20107083
D002118CalciumLEP protein promotes the reaction [TRPC5 protein results in increased transport of Calcium]20107083
D002118CalciumLEP protein results in decreased abundance of Calcium14657008
D002118CalciumLEP protein results in increased transport of Calcium20107083
D002118Calciumwortmannin inhibits the reaction [LEP protein results in increased transport of Calcium]20107083
D002118CalciumCalcium affects the expression of LEP mRNA15913539
D002118CalciumCalcium deficiency affects the secretion of LEP protein10780946
D002118CalciumCalcium deficiency inhibits the reaction [[Glucose co-treated with INS1 protein] results in increased secretion of LEP protein]10780946
C081643candesartancandesartan promotes the reaction [Ramipril results in increased expression of LEP]17483542
C081643candesartancandesartan results in decreased expression of LEP19059660
C081643candesartanRamipril promotes the reaction [candesartan results in increased expression of LEP]17483542
C081643candesartanLEP protein results in increased susceptibility to candesartan21287150
D002211CapsaicinCapsaicin results in decreased expression of LEP protein17295509|1979806
D002211CapsaicinCapsaicin inhibits the reaction [Dietary Fats results in decreased expression of LEP mRNA]20359164
D002211CapsaicinCapsaicin results in increased expression of LEP mRNA16278290
D002211CapsaicinCapsaicin results in increased expression of LEP protein22150557
D002211Capsaicin[Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of LEP protein]22150557
D002211CapsaicinNaproxen inhibits the reaction [Capsaicin results in increased expression of LEP protein]22150557
D002211CapsaicinSumatriptan inhibits the reaction [Capsaicin results in increased expression of LEP protein]22150557
D002251Carbon TetrachlorideLEP protein affects the reaction [Carbon Tetrachloride results in increased activity of STAT3 protein]12730884
D002251Carbon TetrachlorideLEP protein affects the reaction [Carbon Tetrachloride results in increased degradation of NFKBIA protein]12730884
D002251Carbon TetrachlorideLEP protein affects the reaction [Carbon Tetrachloride results in increased expression of CCND1 protein]12730884
D002251Carbon TetrachlorideLEP protein affects the reaction [Carbon Tetrachloride results in increased expression of IL6 mRNA]12730884
D002251Carbon TetrachlorideLEP protein affects the reaction [Carbon Tetrachloride results in increased expression of IL6 protein]12730884
D002251Carbon TetrachlorideLEP protein affects the reaction [Carbon Tetrachloride results in increased expression of TGFB1 protein]12586293
D002251Carbon TetrachlorideLEP protein affects the reaction [Carbon Tetrachloride results in increased expression of TNF mRNA]12730884
D002251Carbon TetrachlorideLEP protein affects the reaction [Carbon Tetrachloride results in increased expression of TNF protein]12730884
D002251Carbon TetrachlorideLEP protein affects the reaction [Carbon Tetrachloride results in increased localization of RELA protein]12730884
D002251Carbon TetrachlorideLEP protein promotes the reaction [Carbon Tetrachloride results in increased expression of ACTA2 protein]11481614
D002251Carbon TetrachlorideLEP protein promotes the reaction [Carbon Tetrachloride results in increased expression of COL1A1 mRNA]11481614
D002251Carbon TetrachlorideLEP protein promotes the reaction [Carbon Tetrachloride results in increased expression of SERPINH1 mRNA]11481614
D002251Carbon TetrachlorideLEP protein promotes the reaction [Carbon Tetrachloride results in increased expression of TGFB1 mRNA]11481614
D002251Carbon Tetrachloride[Carbon Tetrachloride co-treated with Ethanol] results in increased expression of LEP protein18227024
D002251Carbon Tetrachloride[Carbon Tetrachloride co-treated with Phenobarbital] results in increased expression of LEP mRNA14758566
D002251Carbon Tetrachloride[Carbon Tetrachloride co-treated with Phenobarbital] results in increased expression of LEP protein14758566
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of LEP protein27623180
D002251Carbon Tetrachloride"Drugs, Chinese Herbal inhibits the reaction [[Carbon Tetrachloride co-treated with Ethanol] results in increased expression of LEP protein]"18227024
D002258Carbonyl Cyanide m-Chlorophenyl HydrazoneCarbonyl Cyanide m-Chlorophenyl Hydrazone inhibits the reaction [LEP protein results in increased chemical synthesis of Reactive Oxygen Species]11342529
D002258Carbonyl Cyanide m-Chlorophenyl HydrazoneCarbonyl Cyanide m-Chlorophenyl Hydrazone results in decreased susceptibility to LEP protein11342529
D002392CatechinCatechin inhibits the reaction [Dietary Fats results in increased expression of LEP protein]23365609
D002569CeruleninLEP protein affects the susceptibility to Cerulenin11289036
D002746ChlorpromazineChlorpromazine results in increased expression of LEP protein17512020
D002784CholesterolCholesterol results in increased expression of LEP mRNA18402819
D002784CholesterolCholesterol results in increased expression of LEP protein18402819
D002784CholesterolNiacin inhibits the reaction [Cholesterol results in increased expression of LEP mRNA]18402819
D002784CholesterolNiacin inhibits the reaction [Cholesterol results in increased expression of LEP protein]18402819
D002791Cholesterol, Dietary"Cholesterol, Dietary results in decreased expression of LEP mRNA"20157255
D002791Cholesterol, Dietary"Cholesterol, Dietary results in decreased expression of LEP protein"20157255
D002791Cholesterol, Dietary"[Cholesterol, Dietary co-treated with Dietary Carbohydrates] results in increased expression of LEP protein"22579924
D002791Cholesterol, Dietary"Cholesterol, Dietary results in increased expression of LEP protein"22579924
D002791Cholesterol, Dietary"Plant Preparations inhibits the reaction [Cholesterol, Dietary results in increased expression of LEP protein]"22579924
D002794Choline"[3,4,5,3',4'-pentachlorobiphenyl co-treated with Methionine deficiency co-treated with Choline deficiency] results in decreased expression of LEP protein"28973532
D002794CholineLEP gene mutant form affects the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased activity of GPT protein]24384915
D002794CholineLEP gene mutant form affects the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of ABCC4 mRNA]24384915
D002794Choline[LEP gene mutant form co-treated with Methionine deficiency co-treated with Choline deficiency] results in decreased expression of SLCO1B2 mRNA24384915
D002794Choline[LEP gene mutant form co-treated with Methionine deficiency co-treated with Choline deficiency] results in increased expression of ABCC1 mRNA24384915
D002794Choline[LEP gene mutant form co-treated with Methionine deficiency co-treated with Choline deficiency] results in increased expression of ABCC2 mRNA24384915
D002794Choline[LEP gene mutant form co-treated with Methionine deficiency co-treated with Choline deficiency] results in increased expression of ABCC3 mRNA24384915
D002794CholineLEP gene mutant form results in increased susceptibility to [Methionine co-treated with Choline]27712037
D002794Choline[LEP gene mutant form results in increased susceptibility to [Methionine co-treated with Choline]] which results in decreased abundance of Glucose27712037
D002794Choline[LEP gene mutant form results in increased susceptibility to [Methionine co-treated with Choline]] which results in decreased expression of CYP1A2 mRNA27712037
D002794Choline[LEP gene mutant form results in increased susceptibility to [Methionine co-treated with Choline]] which results in decreased expression of CYP1A2 protein27712037
D002794Choline[LEP gene mutant form results in increased susceptibility to [Methionine co-treated with Choline]] which results in decreased expression of CYP2C29 mRNA27712037
D002794Choline[LEP gene mutant form results in increased susceptibility to [Methionine co-treated with Choline]] which results in decreased expression of CYP2C29 protein27712037
D002794Choline[LEP gene mutant form results in increased susceptibility to [Methionine co-treated with Choline]] which results in decreased expression of CYP2D22 protein27712037
D002794Choline[Methionine deficiency co-treated with Choline deficiency] results in decreased expression of LEP protein28973532
D002857ChromiumChromium affects the expression of LEP protein17403270
D002857Chromium"[Linoleic Acids, Conjugated co-treated with Chromium] results in decreased expression of LEP protein"16933788
D002857ChromiumChromium deficiency results in increased expression of LEP mRNA19846803
D002857ChromiumChromium deficiency results in increased expression of LEP protein19846803
D002857ChromiumChromium results in decreased expression of LEP protein17114815
D002994Clofibrate[Clofibrate co-treated with Acetaminophen] affects the expression of LEP mRNA17585979
D002994ClofibratePPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of LEP mRNA]17585979
D002994Clofibrate[alitretinoin co-treated with Clofibrate] results in increased expression of LEP protein9751766
D003024ClozapineLEP protein affects the susceptibility to Clozapine17502770
D003024ClozapineClozapine results in increased expression of LEP protein16402076
C007095cobaltiprotoporphyrincobaltiprotoporphyrin inhibits the reaction [LEP gene mutant form results in decreased expression of and results in decreased activity of HMOX1 protein]23839791
C007095cobaltiprotoporphyrincobaltiprotoporphyrin inhibits the reaction [LEP gene mutant form results in decreased expression of CPT1A mRNA]23839791
C007095cobaltiprotoporphyrincobaltiprotoporphyrin inhibits the reaction [LEP gene mutant form results in decreased expression of GYS2 mRNA]23839791
C007095cobaltiprotoporphyrincobaltiprotoporphyrin inhibits the reaction [LEP gene mutant form results in decreased expression of PPARA protein]23839791
C007095cobaltiprotoporphyrincobaltiprotoporphyrin inhibits the reaction [LEP gene mutant form results in decreased phosphorylation of AKT1 protein]23839791
C007095cobaltiprotoporphyrincobaltiprotoporphyrin inhibits the reaction [LEP gene mutant form results in increased abundance of Heme]23839791
C007095cobaltiprotoporphyrincobaltiprotoporphyrin inhibits the reaction [LEP gene mutant form results in increased expression of FASN protein]23839791
C007095cobaltiprotoporphyrincobaltiprotoporphyrin promotes the reaction [LEP gene mutant form results in decreased expression of PPARGC1A mRNA]23839791
C007095cobaltiprotoporphyrincobaltiprotoporphyrin promotes the reaction [LEP gene mutant form results in decreased expression of SLC2A1 mRNA]23839791
C007095cobaltiprotoporphyrincobaltiprotoporphyrin promotes the reaction [LEP gene mutant form results in increased expression of FGF21 mRNA]23839791
C007095cobaltiprotoporphyrintin mesoporphyrin inhibits the reaction [cobaltiprotoporphyrin inhibits the reaction [LEP gene mutant form results in decreased activity of HMOX1 protein]]23839791
C007095cobaltiprotoporphyrintin mesoporphyrin inhibits the reaction [cobaltiprotoporphyrin inhibits the reaction [LEP gene mutant form results in decreased expression of CPT1A mRNA]]23839791
C007095cobaltiprotoporphyrintin mesoporphyrin inhibits the reaction [cobaltiprotoporphyrin inhibits the reaction [LEP gene mutant form results in decreased expression of GYS2 mRNA]]23839791
C007095cobaltiprotoporphyrintin mesoporphyrin inhibits the reaction [cobaltiprotoporphyrin inhibits the reaction [LEP gene mutant form results in decreased expression of PPARA protein]]23839791
C007095cobaltiprotoporphyrintin mesoporphyrin inhibits the reaction [cobaltiprotoporphyrin inhibits the reaction [LEP gene mutant form results in decreased phosphorylation of AKT1 protein]]23839791
C007095cobaltiprotoporphyrintin mesoporphyrin inhibits the reaction [cobaltiprotoporphyrin inhibits the reaction [LEP gene mutant form results in increased abundance of Heme]]23839791
C007095cobaltiprotoporphyrintin mesoporphyrin inhibits the reaction [cobaltiprotoporphyrin inhibits the reaction [LEP gene mutant form results in increased expression of FASN protein]]23839791
C007095cobaltiprotoporphyrintin mesoporphyrin inhibits the reaction [cobaltiprotoporphyrin promotes the reaction [LEP gene mutant form results in decreased expression of PPARGC1A mRNA]]23839791
C007095cobaltiprotoporphyrintin mesoporphyrin inhibits the reaction [cobaltiprotoporphyrin promotes the reaction [LEP gene mutant form results in decreased expression of SLC2A1 mRNA]]23839791
C007095cobaltiprotoporphyrintin mesoporphyrin inhibits the reaction [cobaltiprotoporphyrin promotes the reaction [LEP gene mutant form results in increased expression of FGF21 mRNA]]23839791
C007095cobaltiprotoporphyrintin mesoporphyrin promotes the reaction [cobaltiprotoporphyrin inhibits the reaction [LEP gene mutant form results in decreased expression of HMOX1 protein]]23839791
C018021cobaltous chloridecobaltous chloride results in increased expression of LEP mRNA12032628
C018021cobaltous chloridecobaltous chloride results in increased secretion of LEP protein12032628
C018021cobaltous chloridecobaltous chloride results in increased secretion of LEP protein22019852
C018021cobaltous chloridecobaltous chloride results in increased expression of LEP mRNA12032628
C018021cobaltous chloridecobaltous chloride results in increased secretion of LEP protein12032628
D005576ColforsinColforsin inhibits the reaction [Caffeine results in decreased expression of LEP mRNA]26367767
D005576ColforsinColforsin results in decreased expression of LEP mRNA27381457|9002984
D005576ColforsinColforsin results in decreased secretion of LEP protein27381457
D003345Corticosterone1-(3-chlorophenyl)piperazine inhibits the reaction [Corticosterone results in decreased expression of LEP protein]28186389
D003345Corticosterone"8-(5-(5-amino-2,4-dimethoxyphenyl)-5-oxopentyl)-1,3,8-triazaspiro(4.5)decane-2,4-dione inhibits the reaction [1-(3-chlorophenyl)piperazine inhibits the reaction [Corticosterone results in decreased expression of LEP protein]]"28186389
D003345CorticosteroneCorticosterone results in decreased expression of LEP protein28186389
C513821CPU0213CPU0213 inhibits the reaction [Isoproterenol results in increased expression of LEP protein]20307649
D016572CyclosporineCyclosporine results in decreased expression of LEP protein25051504
C072247cyclo(Trp-Asp-Pro-Val-Leu)cyclo(Trp-Asp-Pro-Val-Leu) inhibits the reaction [LEP protein affects the abundance of Calcium]16380530
C072247cyclo(Trp-Asp-Pro-Val-Leu)cyclo(Trp-Asp-Pro-Val-Leu) inhibits the reaction [LEP protein results in increased abundance of Superoxides]16380530
C072247cyclo(Trp-Asp-Pro-Val-Leu)cyclo(Trp-Asp-Pro-Val-Leu) inhibits the reaction [LEP protein results in increased expression of NCF1 protein]16380530
C072247cyclo(Trp-Asp-Pro-Val-Leu)cyclo(Trp-Asp-Pro-Val-Leu) inhibits the reaction [LEP protein results in increased expression of NCF2 protein]16380530
C037304cyhalothrincyhalothrin results in increased expression of LEP protein27348886
D003609DactinomycinDactinomycin inhibits the reaction [LEP protein results in increased expression of COL1A2 mRNA]12704794
D003620DantroleneDantrolene results in decreased expression of LEP protein25051504
D003634DDTDDT results in increased expression of LEP mRNA25014179
C014347decitabinedecitabine results in decreased methylation of LEP promoter17502362
C014347decitabinedecitabine results in increased expression of LEP mRNA17502362
C014347decitabine[decitabine results in increased expression of LEP mRNA] which results in increased expression of MMP13 mRNA17502362
C014347decitabinetrichostatin A promotes the reaction [decitabine results in increased expression of LEP mRNA]17502362
D003676DeferoxamineDeferoxamine results in increased expression of LEP mRNA12032628
D003676DeferoxamineDeferoxamine results in increased secretion of LEP protein12032628
D003676DeferoxamineDeferoxamine results in increased expression of LEP mRNA12032628
D003676DeferoxamineDeferoxamine results in increased secretion of LEP protein12032628
D003687DehydroepiandrosteroneDehydroepiandrosterone results in decreased expression of LEP protein12659879
D013759DronabinolDronabinol results in decreased expression of LEP mRNA26070387
D013759Dronabinoliodopravadoline inhibits the reaction [Dronabinol results in decreased expression of LEP mRNA]26070387
D003840Deoxycholic AcidDeoxycholic Acid results in decreased expression of LEP mRNA23911798
D003847Deoxyglucose[Deoxyglucose results in decreased abundance of Adenosine Triphosphate] which results in decreased secretion of LEP protein10780946
D003847DeoxyglucoseDeoxyglucose results in decreased secretion of LEP protein10780946
D003907Dexamethasone[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS protein] results in increased expression of LEP mRNA26200599
D003907Dexamethasone"[Dexamethasone co-treated with 15-deoxy-delta(12,14)-prostaglandin J2] results in decreased secretion of LEP protein"11092516
D003907Dexamethasone[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of LEP mRNA19186324
D003907Dexamethasone[Dexamethasone co-treated with troglitazone] results in decreased secretion of LEP protein11092516
D003907DexamethasoneDexamethasone results in increased expression of LEP mRNA10946865
D003907DexamethasoneDexamethasone results in increased secretion of LEP protein10946865
D003907DexamethasoneDichlorodiphenyl Dichloroethylene promotes the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS protein] results in increased expression of LEP mRNA]26200599
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in increased expression of LEP mRNA28628672
D003907Dexamethasone[rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with Indomethacin co-treated with INS protein] results in increased expression of LEP mRNA23086663
D003907DexamethasoneT 0070907 inhibits the reaction [[rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with Indomethacin co-treated with INS protein] results in increased expression of LEP mRNA]23086663
D003907DexamethasoneT 0070907 inhibits the reaction [[triflumizol co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with Indomethacin co-treated with INS protein] results in increased expression of LEP mRNA]23086663
D003907Dexamethasone[triflumizol co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with Indomethacin co-treated with INS protein] results in increased expression of LEP mRNA23086663
D003907Dexamethasonetroglitazone inhibits the reaction [Dexamethasone results in increased expression of LEP mRNA]10946865
D003907Dexamethasonetroglitazone inhibits the reaction [Dexamethasone results in increased secretion of LEP protein]10946865
D003907Dexamethasoneboric acid inhibits the reaction [[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased expression of LEP mRNA]28285642
D003907Dexamethasone[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased expression of LEP mRNA28285642
D003907Dexamethasone[INS1 protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine] results in increased secretion of LEP protein27163856
D003907Dexamethasone[licarin A affects the susceptibility to [INS protein co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone]] which results in decreased expression of LEP mRNA29288687
D003907DexamethasonePlant Extracts inhibits the reaction [[INS1 protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine] results in increased secretion of LEP protein]27163856
D003907Dexamethasone[rosiglitazone affects the susceptibility to [INS protein co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone]] which results in decreased expression of LEP mRNA29288687
D003907Dexamethasone[rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of LEP mRNA23086663
D003907Dexamethasonesodium pentaborate inhibits the reaction [[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased expression of LEP mRNA]28285642
D003907DexamethasoneT 0070907 inhibits the reaction [[rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of LEP mRNA]23086663
D003907DexamethasoneT 0070907 inhibits the reaction [[triflumizol co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of LEP mRNA]23086663
D003907Dexamethasone[triflumizol co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of LEP mRNA23086663
D003907DexamethasoneDexamethasone results in increased expression of LEP mRNA23166830
D003907DexamethasoneDexamethasone results in increased expression of LEP protein15824971
D016264Dextran Sulfate[Azoxymethane co-treated with Dextran Sulfate] results in increased expression of LEP mRNA19931517
D016264Dextran Sulfate[Azoxymethane co-treated with Dextran Sulfate] results in increased expression of LEP protein19931517
D003980DiazooxonorleucineDiazooxonorleucine inhibits the reaction [eicosapentaenoic acid ethyl ester results in increased expression of LEP mRNA]10753628
D003980DiazooxonorleucineDiazooxonorleucine inhibits the reaction [eicosapentaenoic acid ethyl ester results in increased secretion of LEP protein]10753628
D003981DiazoxideDiazoxide inhibits the reaction [[Glucose co-treated with INS1 protein] results in increased secretion of LEP protein]10780946
D003981DiazoxideDiazoxide results in decreased secretion of LEP protein10780946
D003994BucladesineBucladesine results in decreased expression of LEP mRNA9002984
D002945CisplatinCisplatin affects the expression of LEP protein25051504
D003633Dichlorodiphenyl DichloroethyleneDichlorodiphenyl Dichloroethylene promotes the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS protein] results in increased expression of LEP mRNA]26200599
D003633Dichlorodiphenyl DichloroethyleneDichlorodiphenyl Dichloroethylene results in increased secretion of LEP protein21044676
D018119StavudineStavudine results in decreased expression of LEP protein17668557
D019259Lamivudine[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in decreased expression of LEP mRNA16931933
D019259Lamivudine[Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in decreased expression of LEP mRNA16931933
D004040Dietary Carbohydrates"[Cholesterol, Dietary co-treated with Dietary Carbohydrates] results in increased expression of LEP protein"22579924
D004041Dietary Fats"2,4,5,2',4',5'-hexachlorobiphenyl promotes the reaction [Dietary Fats results in increased expression of LEP protein]"23618531
D004041Dietary Fats"[2,4-Dinitrophenol co-treated with Dietary Fats] affects the expression of LEP mRNA"24872412
D004041Dietary Fats"3-N-1(spermine)-7, 24-dihydroxy-5-cholestane 24-sulfate inhibits the reaction [Dietary Fats results in increased expression of LEP protein]"20075852
D004041Dietary Fatsaza-(6)-gingerol inhibits the reaction [Dietary Fats results in increased expression of LEP mRNA]21851089
D004041Dietary Fatsaza-(6)-gingerol inhibits the reaction [Dietary Fats results in increased expression of LEP protein]21851089
D004041Dietary Fatsbis(4-hydroxyphenyl)sulfone affects the reaction [Dietary Fats results in increased expression of LEP protein]27241191
D004041Dietary Fatsbisphenol A promotes the reaction [Dietary Fats results in increased expression of LEP protein]23493373
D004041Dietary Fatsbromodichloromethane promotes the reaction [Dietary Fats results in increased expression of LEP mRNA]23438451
D004041Dietary FatsCYP1B1 protein affects the reaction [Dietary Fats results in increased expression of LEP protein]27036855
D004041Dietary Fats[Dietary Fats affects the susceptibility to Tetrachlorodibenzodioxin] which results in decreased expression of LEP protein28774668
D004041Dietary FatsDietary Fats inhibits the reaction [LEP protein results in increased phosphorylation of STAT3 protein]22276206
D004041Dietary FatsDietary Fats promotes the reaction [imidacloprid results in increased secretion of LEP protein]27960282
D004041Dietary FatsDietary Fats results in decreased susceptibility to LEP protein27417254
D004041Dietary FatsDietary Fats results in increased expression of LEP mRNA20132043|2185108
D004041Dietary FatsDietary Fats results in increased expression of LEP protein20075852|2133239
D004041Dietary FatsDietary Fats results in increased methylation of LEP promoter24316659
D004041Dietary FatsDietary Fats results in increased secretion of LEP protein19030233|2796028
D004041Dietary FatsDiethylstilbestrol inhibits the reaction [Dietary Fats results in increased expression of LEP protein]23493373
D004041Dietary Fatsgingerol inhibits the reaction [Dietary Fats results in increased expression of LEP mRNA]21851089
D004041Dietary Fatsgingerol inhibits the reaction [Dietary Fats results in increased expression of LEP protein]21851089
D004041Dietary Fatsimidacloprid promotes the reaction [Dietary Fats results in increased secretion of LEP protein]27960282
D004041Dietary FatsLEP protein affects the reaction [[bromodichloromethane co-treated with Dietary Fats] results in increased expression of CASP3 protein modified form]24211274
D004041Dietary FatsLEP protein affects the reaction [[Dietary Fats co-treated with bromodichloromethane] affects the localization of NCF2 protein]23438451
D004041Dietary FatsLEP protein results in decreased susceptibility to [Dietary Fats co-treated with bromodichloromethane]23438451
D004041Dietary Fats"methyl 2-cyano-3,12-dioxoolean-1,9-dien-28-oate inhibits the reaction [Dietary Fats results in decreased susceptibility to LEP protein]"27417254
D004041Dietary Fats"methyl 2-cyano-3,12-dioxoolean-1,9-dien-28-oate inhibits the reaction [Dietary Fats results in increased expression of LEP protein]"27417254
D004041Dietary Fatsnaringin inhibits the reaction [Dietary Fats results in increased expression of LEP protein]22198281
D004041Dietary Fatsorlistat inhibits the reaction [Dietary Fats results in increased expression of LEP protein]21332399
D004041Dietary FatsPlant Extracts inhibits the reaction [Dietary Fats results in increased expression of LEP mRNA]20132043
D004041Dietary FatsQuercetin inhibits the reaction [Dietary Fats results in increased expression of LEP protein]24465016
D004041Dietary Fatsrimonabant inhibits the reaction [Dietary Fats results in increased secretion of LEP protein]19030233
D004041Dietary Fatsapple polyphenol extract inhibits the reaction [[Dietary Sucrose co-treated with Dietary Fats] results in increased expression of LEP mRNA]23529981
D004041Dietary Fatsapple polyphenol extract inhibits the reaction [[Dietary Sucrose co-treated with Dietary Fats] results in increased methylation of LEP promoter]23529981
D004041Dietary FatsCapsaicin inhibits the reaction [Dietary Fats results in decreased expression of LEP mRNA]20359164
D004041Dietary FatsCatechin inhibits the reaction [Dietary Fats results in increased expression of LEP protein]23365609
D004041Dietary Fats[Dietary Fats co-treated with Dietary Sucrose] results in increased expression of LEP mRNA22738222
D004041Dietary FatsDietary Fats results in decreased expression of LEP mRNA20404018
D004041Dietary FatsDietary Fats results in decreased expression of LEP protein20404018
D004041Dietary FatsDietary Fats results in increased expression of LEP mRNA20359164|2139455
D004041Dietary FatsDietary Fats results in increased expression of LEP protein23365609|2462283
D004041Dietary FatsDietary Fats results in increased secretion of LEP protein23038630
D004041Dietary Fats[Dietary Sucrose co-treated with Dietary Fats] results in increased expression of LEP mRNA23529981
D004041Dietary Fats[Dietary Sucrose co-treated with Dietary Fats] results in increased methylation of LEP promoter23529981
D004041Dietary FatsMargarine inhibits the reaction [Dietary Fats results in increased secretion of LEP protein]23038630
D004041Dietary Fatsmorin analog inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of LEP protein]24854284
D004041Dietary Fats[Olive Oil co-treated with Dietary Fats] results in increased secretion of LEP protein23038630
D004041Dietary Fatsorlistat inhibits the reaction [Dietary Fats results in increased expression of LEP protein]25087745
D004041Dietary Fatspiperine inhibits the reaction [Dietary Fats results in increased expression of LEP protein]25087745
D004041Dietary FatsPlant Extracts inhibits the reaction [Dietary Fats results in increased expression of LEP protein]23365609
D004041Dietary FatsQuercetin inhibits the reaction [Dietary Fats results in increased expression of LEP protein]24622831
D004041Dietary Fats[Streptozocin co-treated with Dietary Fats] results in increased expression of LEP protein24854284
D004041Dietary FatsVitamin E inhibits the reaction [Dietary Fats results in decreased expression of LEP mRNA]20404018
D004041Dietary FatsVitamin E inhibits the reaction [Dietary Fats results in decreased expression of LEP protein]20404018
D004041Dietary FatsZinc Compounds inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of LEP protein]24854284
D019422Dietary Sucroseapple polyphenol extract inhibits the reaction [[Dietary Sucrose co-treated with Dietary Fats] results in increased expression of LEP mRNA]23529981
D019422Dietary Sucroseapple polyphenol extract inhibits the reaction [[Dietary Sucrose co-treated with Dietary Fats] results in increased methylation of LEP promoter]23529981
D019422Dietary Sucrose[Dietary Fats co-treated with Dietary Sucrose] results in increased expression of LEP mRNA22738222
D019422Dietary Sucrose[Dietary Sucrose co-treated with Dietary Fats] results in increased expression of LEP mRNA23529981
D019422Dietary Sucrose[Dietary Sucrose co-treated with Dietary Fats] results in increased methylation of LEP promoter23529981
D019422Dietary SucroseDietary Sucrose results in increased expression of LEP protein18627777
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in increased expression of LEP mRNA22588786
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in increased expression of LEP protein22588786
D004052DiethylnitrosamineDiethylnitrosamine results in increased expression of LEP protein25051504
D004054DiethylstilbestrolDiethylstilbestrol inhibits the reaction [Dietary Fats results in increased expression of LEP protein]23493373
D004054DiethylstilbestrolDiethylstilbestrol results in decreased secretion of LEP protein25111128
D002117CalcitriolLEP protein results in decreased abundance of Calcitriol14657008
D01565024,25-Dihydroxyvitamin D 3"24,25-Dihydroxyvitamin D 3 results in decreased expression of LEP protein"18379402
D004128DimethylnitrosamineDimethylnitrosamine results in increased expression of LEP mRNA15798949
D004128DimethylnitrosamineDimethylnitrosamine results in increased expression of LEP protein15798949
C550453dioxinodehydroeckoldioxinodehydroeckol results in decreased expression of LEP mRNA20385110
C007517diphenyleneiodoniumdiphenyleneiodonium inhibits the reaction [Indinavir results in decreased expression of LEP protein]17668557
C007517diphenyleneiodoniumdiphenyleneiodonium inhibits the reaction [Lopinavir results in decreased expression of LEP protein]17668557
C007517diphenyleneiodoniumdiphenyleneiodonium inhibits the reaction [Nelfinavir results in decreased expression of LEP protein]17668557
C007517diphenyleneiodoniumdiphenyleneiodonium inhibits the reaction [Ritonavir results in decreased expression of LEP protein]17668557
D004176Dipyridamole"1,3-dipropyl-8-cyclopentylxanthine inhibits the reaction [Dipyridamole results in increased expression of LEP protein]"10746648
D004176DipyridamoleDipyridamole results in increased expression of LEP protein10746648
D0192972,4-Dinitrophenol"[2,4-Dinitrophenol co-treated with Dietary Fats] affects the expression of LEP mRNA"24872412
D004280DobutamineDobutamine results in decreased secretion of LEP protein11022189
D004280DobutamineDobutamine results in decreased expression of LEP mRNA9002984
D004280DobutamineDobutamine results in decreased expression of LEP protein9002984
D004281Docosahexaenoic AcidsDocosahexaenoic Acids results in decreased expression of LEP mRNA15949695
D004281Docosahexaenoic AcidsDocosahexaenoic Acids results in decreased expression of LEP mRNA15949695
D004365Drugs, Chinese Herbal"Drugs, Chinese Herbal inhibits the reaction [[Carbon Tetrachloride co-treated with Ethanol] results in increased expression of LEP protein]"18227024
D004365Drugs, Chinese Herbal"Drugs, Chinese Herbal results in increased expression of LEP protein"18227024
C026659edelfosineedelfosine inhibits the reaction [LEP protein results in increased transport of Calcium]20107083
C098320efavirenzefavirenz results in decreased expression of LEP mRNA21619898
D015118Eicosapentaenoic AcidEicosapentaenoic Acid results in decreased expression of LEP mRNA15949695
D015118Eicosapentaenoic AcidEicosapentaenoic Acid results in decreased expression of LEP mRNA15949695
C035276eicosapentaenoic acid ethyl esterDiazooxonorleucine inhibits the reaction [eicosapentaenoic acid ethyl ester results in increased expression of LEP mRNA]10753628
C035276eicosapentaenoic acid ethyl esterDiazooxonorleucine inhibits the reaction [eicosapentaenoic acid ethyl ester results in increased secretion of LEP protein]10753628
C035276eicosapentaenoic acid ethyl estereicosapentaenoic acid ethyl ester results in increased expression of LEP mRNA10753628
C035276eicosapentaenoic acid ethyl estereicosapentaenoic acid ethyl ester results in increased secretion of LEP protein10753628
D004656EnalaprilLEP protein results in increased susceptibility to Enalapril20614101
D004967EstrogensEstrogens results in increased expression of LEP mRNA25014179
D004977EthambutolEthambutol results in decreased expression of LEP protein25051504
D000431Ethanol[Zinc deficiency co-treated with Ethanol] results in decreased expression of and results in decreased secretion of LEP protein24155903
D000431Ethanol[Carbon Tetrachloride co-treated with Ethanol] results in increased expression of LEP protein18227024
D000431Ethanol"Drugs, Chinese Herbal inhibits the reaction [[Carbon Tetrachloride co-treated with Ethanol] results in increased expression of LEP protein]"18227024
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of LEP protein25051504
D005000EthionamideEthionamide results in decreased expression of LEP protein25051504
C012313ethyl-p-hydroxybenzoateethyl-p-hydroxybenzoate results in decreased expression of LEP mRNA22956630
D005227Fatty AcidsLEP protein results in increased oxidation of Fatty Acids11342529
D005227Fatty Acids[LEP protein results in increased oxidation of Fatty Acids] which results in increased chemical synthesis of Superoxides11342529
D005227Fatty Acids[LEP protein results in increased oxidation of Fatty Acids] which results in increased expression of CCL211342529
D011345Fenofibrate[Fenofibrate co-treated with resveratrol] inhibits the reaction [Fructose results in increased expression of LEP mRNA]26973390
D011345FenofibrateFenofibrate inhibits the reaction [Fructose results in increased expression of LEP mRNA]26973390
D005280FenoterolFenoterol results in decreased secretion of LEP protein11022189
C020748ferrous sulfateferrous sulfate results in increased expression of LEP mRNA21540303
D005411Flame RetardantsESR1 gene mutant form inhibits the reaction [Flame Retardants results in decreased expression of and results in decreased secretion of LEP protein]29112739
D005411Flame RetardantsFlame Retardants results in decreased expression of and results in decreased secretion of LEP protein29112739
C024352fludarabinefludarabine inhibits the reaction [LEP protein inhibits the reaction [rosiglitazone results in increased expression of PPARG mRNA]]21352814
D005439Flufenamic AcidFlufenamic Acid inhibits the reaction [LEP protein results in increased transport of Calcium]20107083
D0150732-Acetylaminofluorene2-Acetylaminofluorene results in increased expression of LEP protein25051504
D005485FlutamideFlutamide results in decreased expression of LEP protein25051504
D004397FonofosFonofos results in increased methylation of LEP promoter22847954
D005620Freund's AdjuvantFreund's Adjuvant inhibits the reaction [Methylnitrosourea results in increased expression of LEP protein]16822543
D005632FructoseAllopurinol inhibits the reaction [Fructose results in increased expression of LEP protein]22426011
D005632FructoseAtorvastatin Calcium affects the reaction [Fructose results in increased expression of LEP protein]21122807
D005632Fructose[Fenofibrate co-treated with resveratrol] inhibits the reaction [Fructose results in increased expression of LEP mRNA]26973390
D005632FructoseFenofibrate inhibits the reaction [Fructose results in increased expression of LEP mRNA]26973390
D005632FructoseFructose results in increased expression of LEP mRNA11741341|1916563
D005632FructoseFructose results in increased expression of LEP protein18627777|2112280
D005632FructoseFructose results in increased secretion of LEP protein10780946|1916563
D005632FructoseQuercetin inhibits the reaction [Fructose results in increased expression of LEP protein]22426011
D005632FructoseQuercetin inhibits the reaction [Fructose results in increased secretion of LEP protein]23533474
D005632Fructoseresveratrol inhibits the reaction [Fructose results in increased expression of LEP mRNA]26973390
D005632FructoseRutin inhibits the reaction [Fructose results in increased expression of LEP protein]22426011
C039281furanfuran results in decreased expression of LEP mRNA25539665
D005688GalactosamineGalactosamine promotes the reaction [LEP gene mutant form results in increased expression of SPP1 mRNA]19913045
D005688GalactosamineGalactosamine promotes the reaction [LEP gene mutant form results in increased expression of SPP1 protein]19913045
D005688GalactosamineLEP gene mutant form results in increased susceptibility to Galactosamine19913045
D005688Galactosamine[LEP gene mutant form results in increased susceptibility to Galactosamine] which results in increased expression of IL12B mRNA19913045
D005688Galactosamine[LEP gene mutant form results in increased susceptibility to Galactosamine] which results in increased expression of IL18 mRNA19913045
D005688Galactosamine[LEP gene mutant form results in increased susceptibility to Galactosamine] which results in increased expression of IL18 protein19913045
D005688Galactosamine[LEP gene mutant form results in increased susceptibility to Galactosamine] which results in increased expression of SPP1 protein19913045
D005688GalactosamineSPP1 promotes the reaction [LEP gene mutant form results in increased susceptibility to Galactosamine]19913045
C056507gemcitabinegemcitabine results in decreased expression of LEP protein20531411
D015248GemfibrozilGemfibrozil results in decreased expression of LEP protein25051504
D015248GemfibrozilGemfibrozil results in increased expression of LEP protein25051504
D019833GenisteinGenistein inhibits the reaction [LEP protein results in increased chemical synthesis of Reactive Oxygen Species]11342529
D019833GenisteinGenistein inhibits the reaction [LEP protein results in increased expression of CCL2]11342529
D019833GenisteinGenistein results in decreased susceptibility to LEP protein11342529
D019833GenisteinGenistein results in decreased expression of LEP mRNA18359623
D019833GenisteinGenistein results in decreased expression of LEP protein18359623
C002963geranylgeranyl pyrophosphategeranylgeranyl pyrophosphate inhibits the reaction [Simvastatin results in decreased expression of LEP mRNA]19254925
C002963geranylgeranyl pyrophosphategeranylgeranyl pyrophosphate inhibits the reaction [Simvastatin results in decreased secretion of LEP protein]19254925
C102521GGTI 298GGTI 298 inhibits the reaction [Simvastatin results in decreased expression of LEP mRNA]19254925
C102521GGTI 298GGTI 298 inhibits the reaction [Simvastatin results in decreased secretion of LEP protein]19254925
C007845gingerolgingerol inhibits the reaction [Dietary Fats results in increased expression of LEP mRNA]21851089
C007845gingerolgingerol inhibits the reaction [Dietary Fats results in increased expression of LEP protein]21851089
C046905glucosamine 6-O-sulfateglucosamine 6-O-sulfate results in decreased expression of LEP mRNA19520133
C001293glucosamine 6-phosphateglucosamine 6-phosphate results in decreased expression of LEP mRNA19427183
D005947GlucoseGlucose promotes the reaction [LEP protein results in increased chemical synthesis of Reactive Oxygen Species]11342529
D005947GlucoseGlucose results in increased susceptibility to LEP protein11342529
D005947GlucoseLEP protein promotes the reaction [Glucose results in increased chemical synthesis of Reactive Oxygen Species]11342529
D005947Glucose[LEP gene mutant form results in increased susceptibility to [Methionine co-treated with Choline]] which results in decreased abundance of Glucose27712037
D005947Glucose"1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [[Glucose co-treated with INS1 protein] results in increased secretion of LEP protein]"10780946
D005947GlucoseCalcium deficiency inhibits the reaction [[Glucose co-treated with INS1 protein] results in increased secretion of LEP protein]10780946
D005947GlucoseDiazoxide inhibits the reaction [[Glucose co-treated with INS1 protein] results in increased secretion of LEP protein]10780946
D005947Glucose[[Glucose co-treated with INS1 protein] results in increased abundance of Adenosine Triphosphate] which results in increased secretion of LEP protein10780946
D005947Glucose[Glucose co-treated with INS1 protein] results in increased secretion of LEP protein10780946
D005947GlucoseGlucose results in increased expression of LEP mRNA10780946
D005947GlucoseGlucose results in increased expression of LEP protein18627777|2439961
D005947GlucoseGlucose results in increased secretion of LEP protein10780946
D005947GlucoseINS1 protein promotes the reaction [Glucose results in increased expression of LEP mRNA]10780946
D005947GlucoseINS1 protein promotes the reaction [Glucose results in increased secretion of LEP protein]10780946
D005947GlucoseLEP promotes the reaction [Glucose results in increased secretion of INS1 protein]9751766
D005947Glucosenaringin inhibits the reaction [Glucose results in increased expression of LEP protein]24399619
D005947Glucosenickel chloride inhibits the reaction [[Glucose co-treated with INS1 protein] results in increased secretion of LEP protein]10780946
C010974glyphosateglyphosate results in increased expression of LEP mRNA25636363
D006418Hemecobaltiprotoporphyrin inhibits the reaction [LEP gene mutant form results in increased abundance of Heme]23839791
D006418HemeLEP gene mutant form results in increased abundance of Heme23839791
D006418Hemetin mesoporphyrin inhibits the reaction [cobaltiprotoporphyrin inhibits the reaction [LEP gene mutant form results in increased abundance of Heme]]23839791
D006569HesperidinHesperidin results in decreased expression of LEP protein21820093
D006569Hesperidin[naringin co-treated with Hesperidin] results in decreased expression of LEP protein21820093
D017313FenretinideFenretinide results in decreased expression of LEP mRNA28973697
D006861Hydrogen PeroxideHydrogen Peroxide affects the expression of LEP mRNA21179406
D006861Hydrogen PeroxideHydrogen Peroxide results in decreased expression of LEP mRNA26339600
D006861Hydrogen Peroxide"[1,2-linoleoylphosphatidylcholine co-treated with S-Adenosylmethionine] inhibits the reaction [LEP protein results in increased abundance of Hydrogen Peroxide]"16996477
D006861Hydrogen PeroxideLEP protein results in increased abundance of Hydrogen Peroxide16996477
C431085hydroxyfasudilhydroxyfasudil results in decreased expression of LEP mRNA19254925
C431085hydroxyfasudilhydroxyfasudil results in decreased secretion of LEP protein19254925
C492448ICG 001ICG 001 results in increased expression of LEP mRNA26191083
C082359imidaclopridDietary Fats promotes the reaction [imidacloprid results in increased secretion of LEP protein]27960282
C082359imidaclopridimidacloprid promotes the reaction [Dietary Fats results in increased secretion of LEP protein]27960282
C082359imidaclopridimidacloprid results in increased secretion of LEP protein27960282
D019469Indinavirdiphenyleneiodonium inhibits the reaction [Indinavir results in decreased expression of LEP protein]17668557
D019469IndinavirIndinavir results in decreased expression of LEP protein17668557
D019469Indinavir[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in decreased expression of LEP mRNA16931933
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in increased expression of LEP mRNA28628672
D007213Indomethacin[rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with Indomethacin co-treated with INS protein] results in increased expression of LEP mRNA23086663
D007213IndomethacinT 0070907 inhibits the reaction [[rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with Indomethacin co-treated with INS protein] results in increased expression of LEP mRNA]23086663
D007213IndomethacinT 0070907 inhibits the reaction [[triflumizol co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with Indomethacin co-treated with INS protein] results in increased expression of LEP mRNA]23086663
D007213Indomethacin[triflumizol co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with Indomethacin co-treated with INS protein] results in increased expression of LEP mRNA23086663
D007213IndomethacinBQ 610 inhibits the reaction [Indomethacin results in increased expression of LEP protein]16280098
D007213IndomethacinEDN1 protein promotes the reaction [Indomethacin results in increased expression of LEP protein]16280098
D007213IndomethacinIndomethacin results in increased expression of LEP protein16280098|2505150
D007213IndomethacinLEP protein inhibits the reaction [Indomethacin results in decreased activity of GSR protein]18181030
C094023iodopravadolineiodopravadoline inhibits the reaction [Dronabinol results in decreased expression of LEP mRNA]26070387
D007501Iron"alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide inhibits the reaction [LEP protein results in decreased susceptibility to Iron]"17993459
D007501IronLEP protein inhibits the reaction [Iron results in increased abundance of Reactive Oxygen Species]17993459
D007501IronLEP protein results in decreased susceptibility to Iron17993459
D0150561-Methyl-3-isobutylxanthine[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS protein] results in increased expression of LEP mRNA26200599
D0150561-Methyl-3-isobutylxanthine[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of LEP mRNA19186324
D0150561-Methyl-3-isobutylxanthineDichlorodiphenyl Dichloroethylene promotes the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS protein] results in increased expression of LEP mRNA]26200599
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in increased expression of LEP mRNA28628672
D0150561-Methyl-3-isobutylxanthine[rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with Indomethacin co-treated with INS protein] results in increased expression of LEP mRNA23086663
D0150561-Methyl-3-isobutylxanthineT 0070907 inhibits the reaction [[rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with Indomethacin co-treated with INS protein] results in increased expression of LEP mRNA]23086663
D0150561-Methyl-3-isobutylxanthineT 0070907 inhibits the reaction [[triflumizol co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with Indomethacin co-treated with INS protein] results in increased expression of LEP mRNA]23086663
D0150561-Methyl-3-isobutylxanthine[triflumizol co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with Indomethacin co-treated with INS protein] results in increased expression of LEP mRNA23086663
D0150561-Methyl-3-isobutylxanthineboric acid inhibits the reaction [[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased expression of LEP mRNA]28285642
D0150561-Methyl-3-isobutylxanthine[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased expression of LEP mRNA28285642
D0150561-Methyl-3-isobutylxanthine[INS1 protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine] results in increased secretion of LEP protein27163856
D0150561-Methyl-3-isobutylxanthine[licarin A affects the susceptibility to [INS protein co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone]] which results in decreased expression of LEP mRNA29288687
D0150561-Methyl-3-isobutylxanthinePlant Extracts inhibits the reaction [[INS1 protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine] results in increased secretion of LEP protein]27163856
D0150561-Methyl-3-isobutylxanthine[rosiglitazone affects the susceptibility to [INS protein co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone]] which results in decreased expression of LEP mRNA29288687
D0150561-Methyl-3-isobutylxanthine[rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of LEP mRNA23086663
D0150561-Methyl-3-isobutylxanthinesodium pentaborate inhibits the reaction [[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased expression of LEP mRNA]28285642
D0150561-Methyl-3-isobutylxanthineT 0070907 inhibits the reaction [[rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of LEP mRNA]23086663
D0150561-Methyl-3-isobutylxanthineT 0070907 inhibits the reaction [[triflumizol co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of LEP mRNA]23086663
D0150561-Methyl-3-isobutylxanthine[triflumizol co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of LEP mRNA23086663
D007529IsoflavonesIsoflavones results in increased expression of LEP protein22155228
D007545IsoproterenolIsoproterenol results in decreased secretion of LEP protein11022189
D007545IsoproterenolPropranolol inhibits the reaction [Isoproterenol results in decreased secretion of LEP protein]11022189
D007545IsoproterenolIsoproterenol results in increased secretion of LEP protein25111128
D007545IsoproterenolCPU0213 inhibits the reaction [Isoproterenol results in increased expression of LEP protein]20307649
D007545IsoproterenolIsoproterenol results in increased expression of LEP protein20307649
D007608Kainic AcidLEP protein results in decreased susceptibility to Kainic Acid17993459
D007811LanthanumLanthanum promotes the reaction [LEP protein results in increased transport of Calcium]20107083
D007854LeadLead results in decreased expression of and results in decreased secretion of LEP protein24709140
C432503licarin A[licarin A affects the susceptibility to [INS protein co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone]] which results in decreased expression of LEP mRNA29288687
D001556LindaneLindane affects the expression of LEP mRNA17785943
D044243Linoleic Acids, Conjugated"[Linoleic Acids, Conjugated co-treated with Chromium] results in decreased expression of LEP protein"16933788
D044243Linoleic Acids, Conjugated"Linoleic Acids, Conjugated results in decreased expression of LEP protein"16933788
D044243Linoleic Acids, Conjugated"Linoleic Acids, Conjugated results in increased expression of LEP protein"17322064
C440499lipopolysaccharide, Escherichia coli O111 B4"lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of LEP protein"21621857
C442865lipopolysaccharide, Helicobacter pylori"[lipopolysaccharide, Helicobacter pylori co-treated with Aspirin] results in increased expression of LEP protein"15024038
C442865lipopolysaccharide, Helicobacter pylori"lipopolysaccharide, Helicobacter pylori results in increased expression of LEP mRNA"15024038
C442865lipopolysaccharide, Helicobacter pylori"lipopolysaccharide, Helicobacter pylori results in increased expression of LEP protein"15024038
D008070Lipopolysaccharides[nickel chloride co-treated with Lipopolysaccharides] results in increased secretion of LEP protein18437699
D008070LipopolysaccharidesLipopolysaccharides results in decreased expression of LEP mRNA12057914
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of LEP mRNA12057914
D008070Lipopolysaccharides[Monocrotaline co-treated with Lipopolysaccharides] results in increased secretion of LEP protein21327618
D008070LipopolysaccharidesTF mRNA affects the reaction [[Monocrotaline co-treated with Lipopolysaccharides] results in increased secretion of LEP protein]21327618
D008070LipopolysaccharidesBezafibrate inhibits the reaction [Lipopolysaccharides results in increased expression of LEP protein]17379010
D008070LipopolysaccharidesLipopolysaccharides inhibits the reaction [Thioacetamide results in increased expression of LEP protein]17621560
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of LEP protein17379010
D000069478Lisdexamfetamine DimesylateLisdexamfetamine Dimesylate results in decreased expression of LEP protein24014142
C059516loganinloganin affects the expression of LEP protein21864639
D061466Lopinavirdiphenyleneiodonium inhibits the reaction [Lopinavir results in decreased expression of LEP protein]17668557
D061466LopinavirLopinavir results in decreased expression of LEP protein17668557
C106335macrophage stimulatory lipopeptide 2[macrophage stimulatory lipopeptide 2 co-treated with nickel sulfate] results in increased expression of LEP mRNA18832182
D008345ManganeseLEP gene mutant form results in decreased abundance of Manganese10965932
C097284manganese(III)-tetrakis(4-benzoic acid)porphyrinmanganese(III)-tetrakis(4-benzoic acid)porphyrin inhibits the reaction [LEP protein results in increased chemical synthesis of Reactive Oxygen Species]11342529
C097284manganese(III)-tetrakis(4-benzoic acid)porphyrinmanganese(III)-tetrakis(4-benzoic acid)porphyrin results in decreased susceptibility to LEP protein11342529
D008383MargarineMargarine inhibits the reaction [Dietary Fats results in increased secretion of LEP protein]23038630
D008550MelatoninMelatonin results in decreased expression of LEP mRNA20738756
D008550MelatoninMelatonin results in decreased expression of LEP protein19028472
D008627Mercuric ChlorideMercuric Chloride results in decreased expression of LEP mRNA22019852
D008627Mercuric ChlorideMercuric Chloride results in decreased secretion of LEP protein22019852
D008687MetforminMetformin results in increased expression of LEP protein20869956
D016210Methacholine ChlorideLEP gene mutant form results in increased susceptibility to Methacholine Chloride12794034
D008691MethadoneMethadone results in increased expression of LEP protein15717844
D008694MethamphetamineLEP protein results in decreased susceptibility to Methamphetamine20486923
D008701MethapyrileneMethapyrilene results in decreased expression of LEP protein25051504
D008715Methionine"[3,4,5,3',4'-pentachlorobiphenyl co-treated with Methionine deficiency co-treated with Choline deficiency] results in decreased expression of LEP protein"28973532
D008715MethionineLEP gene mutant form affects the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased activity of GPT protein]24384915
D008715MethionineLEP gene mutant form affects the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of ABCC4 mRNA]24384915
D008715Methionine[LEP gene mutant form co-treated with Methionine deficiency co-treated with Choline deficiency] results in decreased expression of SLCO1B2 mRNA24384915
D008715Methionine[LEP gene mutant form co-treated with Methionine deficiency co-treated with Choline deficiency] results in increased expression of ABCC1 mRNA24384915
D008715Methionine[LEP gene mutant form co-treated with Methionine deficiency co-treated with Choline deficiency] results in increased expression of ABCC2 mRNA24384915
D008715Methionine[LEP gene mutant form co-treated with Methionine deficiency co-treated with Choline deficiency] results in increased expression of ABCC3 mRNA24384915
D008715MethionineLEP gene mutant form results in increased susceptibility to [Methionine co-treated with Choline]27712037
D008715Methionine[LEP gene mutant form results in increased susceptibility to [Methionine co-treated with Choline]] which results in decreased abundance of Glucose27712037
D008715Methionine[LEP gene mutant form results in increased susceptibility to [Methionine co-treated with Choline]] which results in decreased expression of CYP1A2 mRNA27712037
D008715Methionine[LEP gene mutant form results in increased susceptibility to [Methionine co-treated with Choline]] which results in decreased expression of CYP1A2 protein27712037
D008715Methionine[LEP gene mutant form results in increased susceptibility to [Methionine co-treated with Choline]] which results in decreased expression of CYP2C29 mRNA27712037
D008715Methionine[LEP gene mutant form results in increased susceptibility to [Methionine co-treated with Choline]] which results in decreased expression of CYP2C29 protein27712037
D008715Methionine[LEP gene mutant form results in increased susceptibility to [Methionine co-treated with Choline]] which results in decreased expression of CYP2D22 protein27712037
D008715Methionine[Methionine deficiency co-treated with Choline deficiency] results in decreased expression of LEP protein28973532
D008727MethotrexateMethotrexate affects the expression of LEP mRNA18502557
C445068methyl 2-cyano-3,12-dioxoolean-1,9-dien-28-oate"methyl 2-cyano-3,12-dioxoolean-1,9-dien-28-oate inhibits the reaction [Dietary Fats results in decreased susceptibility to LEP protein]"27417254
C445068methyl 2-cyano-3,12-dioxoolean-1,9-dien-28-oate"methyl 2-cyano-3,12-dioxoolean-1,9-dien-28-oate inhibits the reaction [Dietary Fats results in increased expression of LEP protein]"27417254
C004925methylmercuric chloride[Cadmium Chloride co-treated with methylmercuric chloride] results in increased expression of LEP protein27814245
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine affects the expression of LEP protein"17910739
D008770MethylnitrosoureaButylated Hydroxytoluene inhibits the reaction [Methylnitrosourea results in increased expression of LEP protein]16822543
D008770MethylnitrosoureaFreund's Adjuvant inhibits the reaction [Methylnitrosourea results in increased expression of LEP protein]16822543
D008770MethylnitrosoureaIFNG protein inhibits the reaction [Methylnitrosourea results in increased expression of LEP protein]16822543
D008770MethylnitrosoureaMethylnitrosourea results in increased expression of LEP protein16822543
C015358methylparabenmethylparaben results in decreased expression of LEP mRNA22956630
D0156551-Methyl-4-phenylpyridiniumLEP protein promotes the reaction [1-Methyl-4-phenylpyridinium results in increased expression of SLC25A14 mRNA]19763737
D008798Mevalonic AcidMevalonic Acid inhibits the reaction [Simvastatin results in decreased expression of LEP mRNA]19254925
D008798Mevalonic AcidMevalonic Acid inhibits the reaction [Simvastatin results in decreased secretion of LEP protein]19254925
C548887MK 2206"MK 2206 inhibits the reaction [8-(4-chlorophenylthio)-2'-O-methyladenosine-3',5'-monophosphate acetoxymethyl ester analog results in increased secretion of LEP protein]"27381457
D016686Monocrotaline[Monocrotaline co-treated with Lipopolysaccharides] results in increased secretion of LEP protein21327618
D016686MonocrotalineTF mRNA affects the reaction [[Monocrotaline co-treated with Lipopolysaccharides] results in increased secretion of LEP protein]21327618
D016686MonocrotalineMonocrotaline affects the expression of LEP protein25051504
C008548morinmorin analog inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of LEP protein]24854284
C063509N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamideN-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [LEP protein results in increased chemical synthesis of Reactive Oxygen Species]11342529
C063509N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamideN-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [LEP protein results in increased expression of CCL2]11342529
C063509N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamideN-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [LEP protein results in increased expression of CYP19A1 protein]28571770
C063509N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamideN-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide results in decreased susceptibility to LEP protein11342529
C063509N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamideN-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Simvastatin results in decreased expression of LEP mRNA]19254925
C080955N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamideN-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide inhibits the reaction [LEP protein results in increased expression of CYP19A1 mRNA]28571770
C080955N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamideN-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide inhibits the reaction [LEP protein results in increased expression of CYP19A1 protein]28571770
C048599N(6)-cyclopentyladenosineN(6)-cyclopentyladenosine results in increased expression of LEP protein10746648
C048599N(6)-cyclopentyladenosineN(6)-cyclopentyladenosine results in increased secretion of LEP protein11060898
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of LEP protein"20381574
D0150581-Naphthylisothiocyanate1-Naphthylisothiocyanate affects the expression of LEP protein25051504
D009288Naproxen[Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of LEP protein]22150557
D009288NaproxenNaproxen inhibits the reaction [Capsaicin results in increased expression of LEP protein]22150557
C005274naringinnaringin inhibits the reaction [Dietary Fats results in increased expression of LEP protein]22198281
C005274naringin[naringin co-treated with Hesperidin] results in decreased expression of LEP protein21820093
C005274naringinnaringin inhibits the reaction [Glucose results in increased expression of LEP protein]24399619
D019888Nelfinavirdiphenyleneiodonium inhibits the reaction [Nelfinavir results in decreased expression of LEP protein]17668557
D019888NelfinavirNelfinavir results in decreased expression of LEP protein17668557
D019888NelfinavirNelfinavir results in decreased secretion of LEP protein19033543
D019829NevirapineNevirapine results in increased expression of LEP mRNA21619898
D009525NiacinNiacin results in increased expression of LEP protein16887123
D009525NiacinNiacin results in increased expression of LEP mRNA21236357
D009525NiacinNiacin inhibits the reaction [Cholesterol results in increased expression of LEP mRNA]18402819
D009525NiacinNiacin inhibits the reaction [Cholesterol results in increased expression of LEP protein]18402819
D009532NickelNickel results in decreased expression of LEP mRNA25583101
C022838nickel chloride[nickel chloride co-treated with Lipopolysaccharides] results in increased secretion of LEP protein18437699
C022838nickel chloridenickel chloride inhibits the reaction [[Glucose co-treated with INS1 protein] results in increased secretion of LEP protein]10780946
C029938nickel sulfate[macrophage stimulatory lipopeptide 2 co-treated with nickel sulfate] results in increased expression of LEP mRNA18832182
C029938nickel sulfatenickel sulfate results in increased expression of LEP mRNA18832182
D009538NicotineNicotine results in decreased susceptibility to LEP protein23623838
D009538NicotineNicotine results in increased expression of LEP protein23623838|2915503
D009569Nitric OxideLEP protein affects the reaction [IL1B protein results in increased chemical synthesis of Nitric Oxide]9312173
C025256nonylphenolnonylphenol results in increased expression of LEP mRNA18417718
D019301Oleic AcidOleic Acid results in decreased expression of LEP mRNA9002984
D019301Oleic AcidOleic Acid results in increased expression of LEP mRNA23395669
D019301Oleic Acidsophocarpine inhibits the reaction [Oleic Acid results in increased expression of LEP mRNA]23395669
C474055octylphenoloctylphenol results in decreased expression of LEP protein18417718
C474055octylphenoloctylphenol results in increased expression of LEP mRNA18417718
D019319Okadaic AcidOkadaic Acid affects the expression of LEP mRNA10628429
C076029olanzapineolanzapine results in increased expression of LEP protein11927762|1951297
D009828Oleanolic AcidOleanolic Acid results in increased expression of LEP protein20188082
C108709oleoyl-estroneoleoyl-estrone affects the expression of LEP protein10340814
C108709oleoyl-estroneoleoyl-estrone results in decreased expression of LEP mRNA20184727
D000069463Olive Oil[Olive Oil co-treated with Dietary Fats] results in increased secretion of LEP protein23038630
D000069463Olive OilOlive Oil results in decreased secretion of LEP protein23038630
D015525Fatty Acids, Omega-3"[Fatty Acids, Omega-3 deficiency co-treated with Vehicle Emissions] results in increased expression of LEP protein"29175182
D015525Fatty Acids, Omega-3"Fatty Acids, Omega-3 results in decreased expression of LEP mRNA"15949695
C055122orlistatorlistat inhibits the reaction [Dietary Fats results in increased expression of LEP protein]21332399
C055122orlistatorlistat inhibits the reaction [Dietary Fats results in increased expression of LEP protein]25087745
D010100OxygenOxygen deficiency results in increased expression of LEP mRNA12032628|2346666
D010100OxygenOxygen deficiency results in increased secretion of LEP protein12032628
D010100OxygenOxygen deficiency results in decreased expression of LEP mRNA21531777|2353931
D010100OxygenOxygen deficiency results in decreased expression of LEP protein23539316
D010126OzoneIL1RL1 protein affects the reaction [[LEP gene mutant form results in increased susceptibility to Ozone] which results in increased expression of CCL4 protein]27472835
D010126OzoneIL1RL1 protein affects the reaction [[LEP gene mutant form results in increased susceptibility to Ozone] which results in increased expression of CXCL1 protein]27472835
D010126OzoneIL1RL1 protein affects the reaction [[LEP gene mutant form results in increased susceptibility to Ozone] which results in increased expression of IL13 protein]27472835
D010126OzoneIL1RL1 protein affects the reaction [[LEP gene mutant form results in increased susceptibility to Ozone] which results in increased expression of IL5 protein]27472835
D010126OzoneIL1RL1 protein affects the reaction [[LEP gene mutant form results in increased susceptibility to Ozone] which results in increased expression of IL6 protein]27472835
D010126OzoneLEP gene mutant form promotes the reaction [Ozone results in increased expression of CCL11 protein]12794034
D010126OzoneLEP gene mutant form promotes the reaction [Ozone results in increased expression of CXCL1 protein]12794034
D010126OzoneLEP gene mutant form promotes the reaction [Ozone results in increased expression of IL6 protein]12794034
D010126OzoneLEP gene mutant form results in increased susceptibility to Ozone12794034|1600255
D010126Ozone[LEP gene mutant form results in increased susceptibility to Ozone] which results in increased expression of CCL11 protein27472835
D010126Ozone[LEP gene mutant form results in increased susceptibility to Ozone] which results in increased expression of CCL4 protein27472835
D010126Ozone[LEP gene mutant form results in increased susceptibility to Ozone] which results in increased expression of CCL5 protein27472835
D010126Ozone[LEP gene mutant form results in increased susceptibility to Ozone] which results in increased expression of CSF3 protein27472835
D010126Ozone[LEP gene mutant form results in increased susceptibility to Ozone] which results in increased expression of CXCL10 protein27472835
D010126Ozone[LEP gene mutant form results in increased susceptibility to Ozone] which results in increased expression of CXCL1 protein27472835
D010126Ozone[LEP gene mutant form results in increased susceptibility to Ozone] which results in increased expression of CXCL9 protein27472835
D010126Ozone[LEP gene mutant form results in increased susceptibility to Ozone] which results in increased expression of IL10 protein27472835
D010126Ozone[LEP gene mutant form results in increased susceptibility to Ozone] which results in increased expression of IL12B protein27472835
D010126Ozone[LEP gene mutant form results in increased susceptibility to Ozone] which results in increased expression of IL13 protein27472835
D010126Ozone[LEP gene mutant form results in increased susceptibility to Ozone] which results in increased expression of IL1A protein27472835
D010126Ozone[LEP gene mutant form results in increased susceptibility to Ozone] which results in increased expression of IL2 protein27472835
D010126Ozone[LEP gene mutant form results in increased susceptibility to Ozone] which results in increased expression of IL5 protein27472835
D010126Ozone[LEP gene mutant form results in increased susceptibility to Ozone] which results in increased expression of IL6 protein27472835
D010126Ozone[LEP gene mutant form results in increased susceptibility to Ozone] which results in increased expression of IL9 protein27472835
D010126Ozone[LEP gene mutant form results in increased susceptibility to Ozone] which results in increased expression of LIF protein27472835
D010126OzoneLEP protein affects the reaction [Ozone results in increased expression of IL33 protein]27472835
D010126OzoneLEP protein results in increased susceptibility to Ozone12794034
D010126OzoneOzone results in increased expression of LEP24103449
D010126OzoneOzone results in increased expression of LEP protein25838073
C519374Panax notoginseng extractPanax notoginseng extract results in decreased expression of LEP protein24749347
D010269ParaquatParaquat affects the expression of LEP mRNA18198484
D010278ParathionParathion results in increased methylation of LEP promoter22847954
D052638Particulate MatterParticulate Matter results in decreased expression of LEP protein21873646
C410127PCB 180"[2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of LEP mRNA"24978599
C410127PCB 180"[2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of LEP mRNA"24978599
C410127PCB 180"[2,4,5,2',5'-pentachlorobiphenyl co-treated with PCB 180] results in increased expression of LEP mRNA"24978599
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in increased expression of LEP mRNA28011154
D020913PerindoprilPerindopril results in decreased expression of LEP protein18083506
D037342Pertussis ToxinPertussis Toxin results in decreased secretion of LEP protein15690317
D010575PesticidesPesticides results in increased secretion of LEP protein25463530
D010575PesticidesPON1 protein polymorphism affects the reaction [Pesticides results in increased secretion of LEP protein]25463530
D015232DinoprostoneDinoprostone results in increased expression of LEP protein11060898
D015232DinoprostoneDinoprostone results in increased secretion of LEP protein11060898
D015232DinoprostoneLEP protein results in increased abundance of Dinoprostone16015682
D010622PhencyclidinePhencyclidine results in increased expression of LEP mRNA12105081
D010634Phenobarbital[Carbon Tetrachloride co-treated with Phenobarbital] results in increased expression of LEP mRNA14758566
D010634Phenobarbital[Carbon Tetrachloride co-treated with Phenobarbital] results in increased expression of LEP protein14758566
D010634PhenobarbitalPhenobarbital affects the expression of LEP protein25051504
D010710PhosphatesLEP protein results in decreased abundance of Phosphates14657008
D010713PhosphatidylcholinesPhosphatidylcholines results in decreased expression of LEP mRNA23911798
C008890phosphoramidonphosphoramidon results in decreased expression of LEP protein16391412
C060836pioglitazonepioglitazone results in increased expression of LEP protein15655531
C008922piperinepiperine inhibits the reaction [Dietary Fats results in increased expression of LEP protein]25087745
C006253pirinixic acidpirinixic acid inhibits the reaction [rosiglitazone results in increased expression of LEP protein]16306350
C108475pitavastatinpitavastatin inhibits the reaction [LEP gene mutant form results in increased expression of CCL2 mRNA]18323514
C108475pitavastatinpitavastatin inhibits the reaction [LEP gene mutant form results in increased expression of IL6 mRNA]18323514
C108475pitavastatinpitavastatin inhibits the reaction [LEP gene mutant form results in increased expression of TNF mRNA]18323514
D010936Plant ExtractsPlant Extracts inhibits the reaction [Dietary Fats results in increased expression of LEP mRNA]20132043
D010936Plant ExtractsPlant Extracts inhibits the reaction [[INS1 protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine] results in increased secretion of LEP protein]27163856
D010936Plant ExtractsPlant Extracts inhibits the reaction [Dietary Fats results in increased expression of LEP protein]23365609
D028321Plant Preparations"Plant Preparations inhibits the reaction [Cholesterol, Dietary results in increased expression of LEP protein]"22579924
C060540polyhexamethyleneguanidinepolyhexamethyleneguanidine results in increased expression of LEP protein29175452
D011192Potassium DichromatePotassium Dichromate results in increased expression of LEP mRNA11678601
D017035PravastatinPravastatin inhibits the reaction [LEP gene mutant form results in increased expression of CCL2 mRNA]18323514
D017035PravastatinPravastatin inhibits the reaction [LEP gene mutant form results in increased expression of IL6 mRNA]18323514
D017035PravastatinPravastatin inhibits the reaction [LEP gene mutant form results in increased expression of TNF mRNA]18323514
D011374Progesterone[LEP protein co-treated with IGF1 protein] results in increased abundance of Progesterone17154301
D011374ProgesteroneLEP protein inhibits the reaction [8-Bromo Cyclic Adenosine Monophosphate results in increased chemical synthesis of Progesterone]19849856
D011374ProgesteroneLEPR protein affects the reaction [LEP protein inhibits the reaction [8-Bromo Cyclic Adenosine Monophosphate results in increased chemical synthesis of Progesterone]]19849856
D011374ProgesteroneProgesterone results in decreased secretion of LEP protein16048798
D011374ProgesteroneProgesterone results in increased expression of LEP mRNA15713686
D011374ProgesteroneProgesterone results in increased expression of LEP mRNA23153703
D011374ProgesteroneProgesterone results in increased secretion of LEP protein23153703
D011374Progesterone[TP53 protein co-treated with LEP protein] results in increased secretion of Progesterone22151798
D011433PropranololPropranolol inhibits the reaction [Isoproterenol results in decreased secretion of LEP protein]11022189
D011433PropranololPropranolol results in increased expression of LEP protein24250662
C006068propylparabenpropylparaben results in decreased expression of LEP mRNA22956630
C006068propylparabenpropylparaben results in increased expression of LEP mRNA22956630
C456319PS1145PS1145 inhibits the reaction [LEP protein results in increased phosphorylation of STAT3 protein]27226618
C043680ptaquilosideptaquiloside results in decreased expression of LEP mRNA23274088
C432165pyrazolanthronepyrazolanthrone inhibits the reaction [LEP protein results in increased expression of CYP19A1 mRNA]28571770
C432165pyrazolanthronepyrazolanthrone inhibits the reaction [LEP protein results in increased expression of CYP19A1 protein]28571770
D019289Pyruvic AcidINS1 protein promotes the reaction [Pyruvic Acid results in increased secretion of LEP protein]10780946
D019289Pyruvic AcidPyruvic Acid results in increased secretion of LEP protein10780946
D011794QuercetinQuercetin results in increased expression of LEP mRNA22230496
D011794QuercetinQuercetin results in increased expression of LEP protein22230496
D011794QuercetinQuercetin affects the reaction [LEP protein affects the expression of NOS2 mRNA]22713545
D011794QuercetinQuercetin affects the reaction [LEP protein affects the expression of SLC2A4 mRNA]22713545
D011794QuercetinQuercetin affects the reaction [LEP protein affects the expression of SLC2A4 protein]22713545
D011794QuercetinQuercetin affects the reaction [LEP protein affects the expression of TNF mRNA]22713545
D011794QuercetinQuercetin inhibits the reaction [Azoxymethane results in increased expression of LEP protein]19914226
D011794QuercetinQuercetin inhibits the reaction [Dietary Fats results in increased expression of LEP protein]24465016
D011794QuercetinQuercetin results in decreased expression of LEP mRNA19914226
D011794QuercetinQuercetin results in decreased secretion of LEP protein19914226
D011794QuercetinQuercetin inhibits the reaction [Dietary Fats results in increased expression of LEP protein]24622831
D011794QuercetinQuercetin inhibits the reaction [Fructose results in increased expression of LEP protein]22426011
D011794QuercetinQuercetin inhibits the reaction [Fructose results in increased secretion of LEP protein]23533474
C432703ragaglitazarragaglitazar results in increased expression of LEP protein15655531
D017257Ramiprilcandesartan promotes the reaction [Ramipril results in increased expression of LEP]17483542
D017257RamiprilRamipril promotes the reaction [candesartan results in increased expression of LEP]17483542
D017257RamiprilRamipril results in decreased expression of LEP19059660
D017382Reactive Oxygen Species"adenosine-3',5'-cyclic phosphorothioate inhibits the reaction [LEP protein results in increased chemical synthesis of Reactive Oxygen Species]"11342529
D017382Reactive Oxygen SpeciesCarbonyl Cyanide m-Chlorophenyl Hydrazone inhibits the reaction [LEP protein results in increased chemical synthesis of Reactive Oxygen Species]11342529
D017382Reactive Oxygen SpeciesGenistein inhibits the reaction [LEP protein results in increased chemical synthesis of Reactive Oxygen Species]11342529
D017382Reactive Oxygen SpeciesGlucose promotes the reaction [LEP protein results in increased chemical synthesis of Reactive Oxygen Species]11342529
D017382Reactive Oxygen SpeciesLEP protein promotes the reaction [Glucose results in increased chemical synthesis of Reactive Oxygen Species]11342529
D017382Reactive Oxygen SpeciesLEP protein results in increased chemical synthesis of Reactive Oxygen Species11342529
D017382Reactive Oxygen Speciesmanganese(III)-tetrakis(4-benzoic acid)porphyrin inhibits the reaction [LEP protein results in increased chemical synthesis of Reactive Oxygen Species]11342529
D017382Reactive Oxygen SpeciesN-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [LEP protein results in increased chemical synthesis of Reactive Oxygen Species]11342529
D017382Reactive Oxygen SpeciesRotenone inhibits the reaction [LEP protein results in increased chemical synthesis of Reactive Oxygen Species]11342529
D017382Reactive Oxygen SpeciesThenoyltrifluoroacetone inhibits the reaction [LEP protein results in increased chemical synthesis of Reactive Oxygen Species]11342529
D017382Reactive Oxygen Species2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [LEP protein results in decreased abundance of Reactive Oxygen Species]17993459
D017382Reactive Oxygen SpeciesLEP protein inhibits the reaction [Iron results in increased abundance of Reactive Oxygen Species]17993459
D017382Reactive Oxygen SpeciesLEP protein results in decreased abundance of Reactive Oxygen Species17993459
D017382Reactive Oxygen SpeciesSOD2 protein inhibits the reaction [LEP protein results in increased chemical synthesis of Reactive Oxygen Species]11342529
D017382Reactive Oxygen SpeciesUCP1 protein inhibits the reaction [LEP protein results in increased chemical synthesis of Reactive Oxygen Species]11342529
C025474rebaudioside Arebaudioside A affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of ACOX1 mRNA]25554529
C025474rebaudioside Arebaudioside A affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of CAT mRNA]25554529
C025474rebaudioside Arebaudioside A affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of CPT1A mRNA]25554529
C025474rebaudioside Arebaudioside A affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of DGAT2 mRNA]25554529
C025474rebaudioside Arebaudioside A affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of FOXO1 mRNA]25554529
C025474rebaudioside Arebaudioside A affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of G6PC mRNA]25554529
C025474rebaudioside Arebaudioside A affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of INSR mRNA]25554529
C025474rebaudioside Arebaudioside A affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of IRS1 mRNA]25554529
C025474rebaudioside Arebaudioside A affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of IRS2 mRNA]25554529
C025474rebaudioside Arebaudioside A affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of LIPC mRNA]25554529
C025474rebaudioside Arebaudioside A affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of MTOR mRNA]25554529
C025474rebaudioside Arebaudioside A affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of NFKB1 mRNA]25554529
C025474rebaudioside Arebaudioside A affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of NFKBIA mRNA]25554529
C025474rebaudioside Arebaudioside A affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of PCK1 mRNA]25554529
C025474rebaudioside Arebaudioside A affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of PPARA mRNA]25554529
C025474rebaudioside Arebaudioside A affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of PPARD mRNA]25554529
C025474rebaudioside Arebaudioside A affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of PPARGC1A mRNA]25554529
C025474rebaudioside Arebaudioside A affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of PPARG mRNA]25554529
C025474rebaudioside Arebaudioside A affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of SCD1 mRNA]25554529
C025474rebaudioside Arebaudioside A affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of SIRT1 mRNA]25554529
C025474rebaudioside Arebaudioside A affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of SLC27A1 mRNA]25554529
C025474rebaudioside Arebaudioside A affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of SLC2A2 mRNA]25554529
C025474rebaudioside Arebaudioside A affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of SOD2 mRNA]25554529
D012110ReserpineReserpine results in increased expression of LEP mRNA10050748
C059514resveratrolresveratrol results in decreased expression of LEP mRNA21713995
C059514resveratrolresveratrol results in decreased expression of LEP protein23536519
C059514resveratrolresveratrol metabolite results in decreased expression of LEP mRNA23717508
C059514resveratrolresveratrol metabolite results in decreased secretion of LEP protein23717508
C059514resveratrolresveratrol results in decreased expression of LEP mRNA23717508|2533817
C059514resveratrolresveratrol results in decreased expression of LEP protein24812660
C059514resveratrolresveratrol results in decreased secretion of LEP protein23717508
C059514resveratrol[Fenofibrate co-treated with resveratrol] inhibits the reaction [Fructose results in increased expression of LEP mRNA]26973390
C059514resveratrolresveratrol inhibits the reaction [Fructose results in increased expression of LEP mRNA]26973390
C499731resveratrol-4'-O-glucuronideresveratrol-4'-O-glucuronide results in decreased expression of LEP mRNA23717508
C499731resveratrol-4'-O-glucuronideresveratrol-4'-O-glucuronide results in decreased secretion of LEP protein23717508
D015474IsotretinoinIsotretinoin results in increased expression of LEP mRNA19212007
C072026rhodostominrhodostomin results in decreased expression of LEP mRNA16197920
D012293RifampinRifampin results in increased expression of LEP protein25051504
C089032rimonabantrimonabant inhibits the reaction [Dietary Fats results in increased secretion of LEP protein]19030233
D019438Ritonavirdiphenyleneiodonium inhibits the reaction [Ritonavir results in decreased expression of LEP protein]17668557
D019438RitonavirRitonavir results in decreased expression of LEP protein17668557
C089730rosiglitazone[rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with Indomethacin co-treated with INS protein] results in increased expression of LEP mRNA23086663
C089730rosiglitazonerosiglitazone results in decreased expression of LEP mRNA10548525|1594969
C089730rosiglitazonerosiglitazone results in increased expression of LEP mRNA12814394|2276311
C089730rosiglitazonerosiglitazone results in increased expression of LEP protein18394743
C089730rosiglitazonerosiglitazone results in increased secretion of LEP protein12814394
C089730rosiglitazoneT 0070907 inhibits the reaction [[rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with Indomethacin co-treated with INS protein] results in increased expression of LEP mRNA]23086663
C089730rosiglitazonepirinixic acid inhibits the reaction [rosiglitazone results in increased expression of LEP protein]16306350
C089730rosiglitazone[rosiglitazone affects the susceptibility to [INS protein co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone]] which results in decreased expression of LEP mRNA29288687
C089730rosiglitazone[rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of LEP mRNA23086663
C089730rosiglitazonerosiglitazone results in increased expression of LEP mRNA22763116
C089730rosiglitazoneT 0070907 inhibits the reaction [[rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of LEP mRNA]23086663
C089730rosiglitazonerosiglitazone results in decreased expression of LEP protein15998575
C089730rosiglitazone2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [LEP protein inhibits the reaction [rosiglitazone results in increased expression of PPARG mRNA]]21352814
C089730rosiglitazonefludarabine inhibits the reaction [LEP protein inhibits the reaction [rosiglitazone results in increased expression of PPARG mRNA]]21352814
C089730rosiglitazoneLEP protein inhibits the reaction [rosiglitazone results in increased expression of PPARG mRNA]21352814
D012402RotenoneRotenone inhibits the reaction [LEP protein results in increased chemical synthesis of Reactive Oxygen Species]11342529
D012402RotenoneRotenone results in decreased susceptibility to LEP protein11342529
D012406RoxarsoneRoxarsone results in decreased expression of LEP mRNA18414637
D012431RutinRutin inhibits the reaction [Fructose results in increased expression of LEP protein]22426011
D019258Saquinavir[Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in decreased expression of LEP mRNA16931933
C093642SB 203580SB 203580 inhibits the reaction [LEP protein inhibits the reaction [8-Bromo Cyclic Adenosine Monophosphate results in increased expression of STAR protein]]19849856
C093642SB 203580SB 203580 inhibits the reaction [Vitamin K 3 results in increased expression of LEP mRNA]16996477
C093642SB 203580SB 203580 results in decreased susceptibility to LEP protein19849856
C093642SB 203580SB 203580 inhibits the reaction [LEP protein results in increased expression of COL1A1 mRNA]16996477
D012643SeleniumLEP gene mutant form results in decreased abundance of Selenium10965932
D017632Asbestos, Serpentine"Asbestos, Serpentine results in decreased expression of LEP mRNA"23917077
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of LEP mRNA23806026
D019821Simvastatingeranylgeranyl pyrophosphate inhibits the reaction [Simvastatin results in decreased expression of LEP mRNA]19254925
D019821Simvastatingeranylgeranyl pyrophosphate inhibits the reaction [Simvastatin results in decreased secretion of LEP protein]19254925
D019821SimvastatinGGTI 298 inhibits the reaction [Simvastatin results in decreased expression of LEP mRNA]19254925
D019821SimvastatinGGTI 298 inhibits the reaction [Simvastatin results in decreased secretion of LEP protein]19254925
D019821SimvastatinMevalonic Acid inhibits the reaction [Simvastatin results in decreased expression of LEP mRNA]19254925
D019821SimvastatinMevalonic Acid inhibits the reaction [Simvastatin results in decreased secretion of LEP protein]19254925
D019821SimvastatinN-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Simvastatin results in decreased expression of LEP mRNA]19254925
D019821SimvastatinSimvastatin results in decreased expression of LEP mRNA19254925
D019821SimvastatinSimvastatin results in decreased expression of LEP mRNA alternative form19254925
D019821SimvastatinSimvastatin results in decreased secretion of LEP protein19254925
D012906SmokeSmoke results in decreased nitrosation of LEP protein21652289
C017947sodium arsenitesodium arsenite results in increased expression of LEP mRNA25879800
C017947sodium arsenitesodium arsenite affects the expression of LEP mRNA28206643
C017947sodium arsenitesodium arsenite affects the expression of LEP protein25367288
C538809sodium pentaboratesodium pentaborate inhibits the reaction [[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased expression of LEP mRNA]28285642
C538809sodium pentaboratesodium pentaborate results in decreased expression of and results in decreased secretion of LEP protein28285642
D018038Sodium SeleniteSodium Selenite results in decreased expression of LEP mRNA23274088
C035933sophocarpinesophocarpine inhibits the reaction [Oleic Acid results in increased expression of LEP mRNA]23395669
C012042steviolsteviol affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of ACACA mRNA]25554529
C012042steviolsteviol affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of ACOX1 mRNA]25554529
C012042steviolsteviol affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of CAT mRNA]25554529
C012042steviolsteviol affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of CPT1A mRNA]25554529
C012042steviolsteviol affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of DGAT2 mRNA]25554529
C012042steviolsteviol affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of FASN mRNA]25554529
C012042steviolsteviol affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of FOXO1 mRNA]25554529
C012042steviolsteviol affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of G6PC mRNA]25554529
C012042steviolsteviol affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of GPAM mRNA]25554529
C012042steviolsteviol affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of INSR mRNA]25554529
C012042steviolsteviol affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of IRS1 mRNA]25554529
C012042steviolsteviol affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of IRS2 mRNA]25554529
C012042steviolsteviol affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of LIPC mRNA]25554529
C012042steviolsteviol affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of MTOR mRNA]25554529
C012042steviolsteviol affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of NFKB1 mRNA]25554529
C012042steviolsteviol affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of NFKBIA mRNA]25554529
C012042steviolsteviol affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of PCK1 mRNA]25554529
C012042steviolsteviol affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of PLIN2 mRNA]25554529
C012042steviolsteviol affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of PPARA mRNA]25554529
C012042steviolsteviol affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of PPARD mRNA]25554529
C012042steviolsteviol affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of PPARGC1A mRNA]25554529
C012042steviolsteviol affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of PPARG mRNA]25554529
C012042steviolsteviol affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of PRKAA1 mRNA]25554529
C012042steviolsteviol affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of SCD1 mRNA]25554529
C012042steviolsteviol affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of SIRT1 mRNA]25554529
C012042steviolsteviol affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of SLC27A1 mRNA]25554529
C012042steviolsteviol affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of SLC2A2 mRNA]25554529
C012042steviolsteviol affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of SOD2 mRNA]25554529
C012043steviosidestevioside affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of ACOX1 mRNA]25554529
C012043steviosidestevioside affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of CAT mRNA]25554529
C012043steviosidestevioside affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of CPT1A mRNA]25554529
C012043steviosidestevioside affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of DGAT2 mRNA]25554529
C012043steviosidestevioside affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of FOXO1 mRNA]25554529
C012043steviosidestevioside affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of G6PC mRNA]25554529
C012043steviosidestevioside affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of INSR mRNA]25554529
C012043steviosidestevioside affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of IRS1 mRNA]25554529
C012043steviosidestevioside affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of IRS2 mRNA]25554529
C012043steviosidestevioside affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of LIPC mRNA]25554529
C012043steviosidestevioside affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of MTOR mRNA]25554529
C012043steviosidestevioside affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of NFKB1 mRNA]25554529
C012043steviosidestevioside affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of NFKBIA mRNA]25554529
C012043steviosidestevioside affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of PCK1 mRNA]25554529
C012043steviosidestevioside affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of PLIN2 mRNA]25554529
C012043steviosidestevioside affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of PPARA mRNA]25554529
C012043steviosidestevioside affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of PPARD mRNA]25554529
C012043steviosidestevioside affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of PPARGC1A mRNA]25554529
C012043steviosidestevioside affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of PPARG mRNA]25554529
C012043steviosidestevioside affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of SCD1 mRNA]25554529
C012043steviosidestevioside affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of SIRT1 mRNA]25554529
C012043steviosidestevioside affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of SLC27A1 mRNA]25554529
C012043steviosidestevioside affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of SLC2A2 mRNA]25554529
C012043steviosidestevioside affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of SOD2 mRNA]25554529
D013311Streptozocinmorin analog inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of LEP protein]24854284
D013311Streptozocin[Streptozocin co-treated with Dietary Fats] results in increased expression of LEP protein24854284
D013311StreptozocinZinc Compounds inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of LEP protein]24854284
D018170Sumatriptan[Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of LEP protein]22150557
D018170SumatriptanSumatriptan inhibits the reaction [Capsaicin results in increased expression of LEP protein]22150557
D013481Superoxides[LEP protein results in increased oxidation of Fatty Acids] which results in increased chemical synthesis of Superoxides11342529
D013481Superoxidesacetovanillone inhibits the reaction [LEP protein results in increased abundance of Superoxides]16380530
D013481SuperoxidesBQ 788 inhibits the reaction [LEP protein results in increased abundance of Superoxides]16380530
D013481Superoxidescyclo(Trp-Asp-Pro-Val-Leu) inhibits the reaction [LEP protein results in increased abundance of Superoxides]16380530
D013481SuperoxidesLEP protein results in increased abundance of Superoxides16380530
D013549Sweetening AgentsSweetening Agents results in increased expression of LEP protein18627777
C458508T 0070907T 0070907 inhibits the reaction [[rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with Indomethacin co-treated with INS protein] results in increased expression of LEP mRNA]23086663
C458508T 0070907T 0070907 inhibits the reaction [[triflumizol co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with Indomethacin co-treated with INS protein] results in increased expression of LEP mRNA]23086663
C458508T 0070907T 0070907 inhibits the reaction [[rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of LEP mRNA]23086663
C458508T 0070907T 0070907 inhibits the reaction [[triflumizol co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of LEP mRNA]23086663
C030141taurine-ursodeoxycholate conjugatetaurine-ursodeoxycholate conjugate inhibits the reaction [LEP gene mutant form results in decreased expression of CES3B mRNA]21079772
C030141taurine-ursodeoxycholate conjugatetaurine-ursodeoxycholate conjugate inhibits the reaction [LEP gene mutant form results in decreased expression of CSAD mRNA]21079772
C030141taurine-ursodeoxycholate conjugatetaurine-ursodeoxycholate conjugate inhibits the reaction [LEP gene mutant form results in decreased expression of CYP4A12B mRNA]21079772
C030141taurine-ursodeoxycholate conjugatetaurine-ursodeoxycholate conjugate inhibits the reaction [LEP gene mutant form results in decreased expression of DUSP1 mRNA]21079772
C030141taurine-ursodeoxycholate conjugatetaurine-ursodeoxycholate conjugate inhibits the reaction [LEP gene mutant form results in decreased expression of LIPG mRNA]21079772
C030141taurine-ursodeoxycholate conjugatetaurine-ursodeoxycholate conjugate inhibits the reaction [LEP gene mutant form results in increased expression of ACACA mRNA]21079772
C030141taurine-ursodeoxycholate conjugatetaurine-ursodeoxycholate conjugate inhibits the reaction [LEP gene mutant form results in increased expression of ACACB mRNA]21079772
C030141taurine-ursodeoxycholate conjugatetaurine-ursodeoxycholate conjugate inhibits the reaction [LEP gene mutant form results in increased expression of AQP4 mRNA]21079772
C030141taurine-ursodeoxycholate conjugatetaurine-ursodeoxycholate conjugate inhibits the reaction [LEP gene mutant form results in increased expression of BDH1 mRNA]21079772
C030141taurine-ursodeoxycholate conjugatetaurine-ursodeoxycholate conjugate inhibits the reaction [LEP gene mutant form results in increased expression of CYP2A22 mRNA]21079772
C030141taurine-ursodeoxycholate conjugatetaurine-ursodeoxycholate conjugate inhibits the reaction [LEP gene mutant form results in increased expression of CYP2B13 mRNA]21079772
C030141taurine-ursodeoxycholate conjugatetaurine-ursodeoxycholate conjugate inhibits the reaction [LEP gene mutant form results in increased expression of ELOVL5 mRNA]21079772
C030141taurine-ursodeoxycholate conjugatetaurine-ursodeoxycholate conjugate inhibits the reaction [LEP gene mutant form results in increased expression of ELOVL6 mRNA]21079772
C030141taurine-ursodeoxycholate conjugatetaurine-ursodeoxycholate conjugate inhibits the reaction [LEP gene mutant form results in increased expression of FADS2 mRNA]21079772
C030141taurine-ursodeoxycholate conjugatetaurine-ursodeoxycholate conjugate inhibits the reaction [LEP gene mutant form results in increased expression of FASN mRNA]21079772
C030141taurine-ursodeoxycholate conjugatetaurine-ursodeoxycholate conjugate inhibits the reaction [LEP gene mutant form results in increased expression of FMO3 mRNA]21079772
C030141taurine-ursodeoxycholate conjugatetaurine-ursodeoxycholate conjugate inhibits the reaction [LEP gene mutant form results in increased expression of GPAM mRNA]21079772
C030141taurine-ursodeoxycholate conjugatetaurine-ursodeoxycholate conjugate inhibits the reaction [LEP gene mutant form results in increased expression of GSTA1 mRNA]21079772
C030141taurine-ursodeoxycholate conjugatetaurine-ursodeoxycholate conjugate inhibits the reaction [LEP gene mutant form results in increased expression of GSTA2 mRNA]21079772
C030141taurine-ursodeoxycholate conjugatetaurine-ursodeoxycholate conjugate inhibits the reaction [LEP gene mutant form results in increased expression of GSTM2 mRNA]21079772
C030141taurine-ursodeoxycholate conjugatetaurine-ursodeoxycholate conjugate inhibits the reaction [LEP gene mutant form results in increased expression of GSTM3 mRNA]21079772
C030141taurine-ursodeoxycholate conjugatetaurine-ursodeoxycholate conjugate inhibits the reaction [LEP gene mutant form results in increased expression of LRTM1 mRNA]21079772
C030141taurine-ursodeoxycholate conjugatetaurine-ursodeoxycholate conjugate inhibits the reaction [LEP gene mutant form results in increased expression of ME1 mRNA]21079772
C030141taurine-ursodeoxycholate conjugatetaurine-ursodeoxycholate conjugate inhibits the reaction [LEP gene mutant form results in increased expression of OSBPL3 mRNA]21079772
C030141taurine-ursodeoxycholate conjugatetaurine-ursodeoxycholate conjugate inhibits the reaction [LEP gene mutant form results in increased expression of PLS1 mRNA]21079772
C030141taurine-ursodeoxycholate conjugatetaurine-ursodeoxycholate conjugate inhibits the reaction [LEP gene mutant form results in increased expression of SCD2 mRNA]21079772
C030141taurine-ursodeoxycholate conjugatetaurine-ursodeoxycholate conjugate inhibits the reaction [LEP gene mutant form results in increased expression of SLC35F2 mRNA]21079772
C030141taurine-ursodeoxycholate conjugatetaurine-ursodeoxycholate conjugate inhibits the reaction [LEP gene mutant form results in increased expression of SREBF1 mRNA]21079772
C030141taurine-ursodeoxycholate conjugatetaurine-ursodeoxycholate conjugate inhibits the reaction [LEP gene mutant form results in increased expression of SULT1E1 mRNA]21079772
C030141taurine-ursodeoxycholate conjugatetaurine-ursodeoxycholate conjugate inhibits the reaction [LEP gene mutant form results in increased expression of SULT2A4 mRNA]21079772
C030141taurine-ursodeoxycholate conjugatetaurine-ursodeoxycholate conjugate inhibits the reaction [LEP gene mutant form results in increased expression of SULT3A1 mRNA]21079772
C030141taurine-ursodeoxycholate conjugatetaurine-ursodeoxycholate conjugate inhibits the reaction [LEP gene mutant form results in increased expression of THEMIS mRNA]21079772
C030141taurine-ursodeoxycholate conjugatetaurine-ursodeoxycholate conjugate inhibits the reaction [LEP gene mutant form results in increased expression of TUBB2A mRNA]21079772
C030141taurine-ursodeoxycholate conjugatetaurine-ursodeoxycholate conjugate promotes the reaction [LEP gene mutant form results in decreased expression of ABCB11 mRNA]21079772
C030141taurine-ursodeoxycholate conjugatetaurine-ursodeoxycholate conjugate promotes the reaction [LEP gene mutant form results in decreased expression of ACSS2 mRNA]21079772
C030141taurine-ursodeoxycholate conjugatetaurine-ursodeoxycholate conjugate promotes the reaction [LEP gene mutant form results in decreased expression of CYP7A1 mRNA]21079772
C030141taurine-ursodeoxycholate conjugatetaurine-ursodeoxycholate conjugate promotes the reaction [LEP gene mutant form results in decreased expression of ELOVL3 mRNA]21079772
C030141taurine-ursodeoxycholate conjugatetaurine-ursodeoxycholate conjugate promotes the reaction [LEP gene mutant form results in decreased expression of KEG1 mRNA]21079772
C030141taurine-ursodeoxycholate conjugatetaurine-ursodeoxycholate conjugate promotes the reaction [LEP gene mutant form results in decreased expression of LIPC mRNA]21079772
C030141taurine-ursodeoxycholate conjugatetaurine-ursodeoxycholate conjugate promotes the reaction [LEP gene mutant form results in decreased expression of NUDT7 mRNA]21079772
C030141taurine-ursodeoxycholate conjugatetaurine-ursodeoxycholate conjugate promotes the reaction [LEP gene mutant form results in increased expression of AACS mRNA]21079772
C030141taurine-ursodeoxycholate conjugatetaurine-ursodeoxycholate conjugate promotes the reaction [LEP gene mutant form results in increased expression of CD36 mRNA]21079772
C030141taurine-ursodeoxycholate conjugatetaurine-ursodeoxycholate conjugate promotes the reaction [LEP gene mutant form results in increased expression of LCN2 mRNA]21079772
C030141taurine-ursodeoxycholate conjugatetaurine-ursodeoxycholate conjugate promotes the reaction [LEP gene mutant form results in increased expression of MT1 mRNA]21079772
C001803tempoltempol inhibits the reaction [LEP protein results in decreased activity of PON1 protein]15829432
C012568terbufosterbufos results in increased methylation of LEP promoter22847954
D013726TerbutalineTerbutaline results in decreased expression of LEP mRNA9002984
D013726TerbutalineTerbutaline results in decreased expression of LEP protein9002984
C045037testosterone-3-carboxymethyloxime-bovine serum albumin conjugatetestosterone-3-carboxymethyloxime-bovine serum albumin conjugate affects the expression of LEP mRNA20189893
D013749TetrachlorodibenzodioxinArachidonic Acid promotes the reaction [Tetrachlorodibenzodioxin results in decreased expression of LEP mRNA]19063610
D013749Tetrachlorodibenzodioxinarachidonyltrifluoromethane inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of LEP mRNA]19063610
D013749Tetrachlorodibenzodioxin[Dietary Fats affects the susceptibility to Tetrachlorodibenzodioxin] which results in decreased expression of LEP protein28774668
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of LEP mRNA21570461|2637764
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of LEP mRNA19063610
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with LEP protein] affects the expression of AGRP mRNA15977195
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with LEP protein] affects the expression of CARTPT mRNA15977195
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with LEP protein] affects the expression of HCRT mRNA15977195
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with LEP protein] affects the expression of HCRTR2 mRNA15977195
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with LEP protein] affects the expression of HDC mRNA15977195
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with LEP protein] affects the expression of INSR mRNA15977195
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with LEP protein] affects the expression of MC4R mRNA15977195
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with LEP protein] affects the expression of NPY5R mRNA15977195
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with LEP protein] affects the expression of NPY mRNA15977195
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with LEP protein] affects the expression of PMCH mRNA15977195
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with LEP protein] affects the expression of POMC mRNA15977195
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with LEP protein] affects the expression of SDC3 mRNA15977195
D013804ThenoyltrifluoroacetoneThenoyltrifluoroacetone inhibits the reaction [LEP protein results in increased chemical synthesis of Reactive Oxygen Species]11342529
D013804ThenoyltrifluoroacetoneThenoyltrifluoroacetone results in decreased susceptibility to LEP protein11342529
D013853ThioacetamideLEP gene mutant form results in decreased susceptibility to Thioacetamide12085344
D013853ThioacetamideLEP protein affects the reaction [Thioacetamide results in increased expression of ACTA2 protein]12085344
D013853ThioacetamideLEP protein affects the reaction [Thioacetamide results in increased expression of COL1A1 mRNA]12085344
D013853ThioacetamideLEP protein affects the reaction [Thioacetamide results in increased expression of TGFB1 mRNA]12085344
D013853ThioacetamideLEP protein promotes the reaction [Thioacetamide results in increased expression of COL1A1 mRNA]11481614
D013853ThioacetamideLEP protein results in increased susceptibility to Thioacetamide12085344
D013853Thioacetamide[Thioacetamide co-treated with LEP protein] results in increased expression of COL1A1 mRNA16097051
D013853ThioacetamideLipopolysaccharides inhibits the reaction [Thioacetamide results in increased expression of LEP protein]17621560
D013853ThioacetamideThioacetamide results in increased expression of LEP protein17621560
D008063Thioctic AcidThioctic Acid results in decreased expression of LEP mRNA21351249
D008063Thioctic AcidThioctic Acid results in decreased secretion of LEP protein21351249
D008063Thioctic AcidThioctic Acid results in decreased expression of LEP mRNA21351249
D008063Thioctic AcidThioctic Acid results in decreased expression of LEP protein21351249
C055421tin mesoporphyrintin mesoporphyrin inhibits the reaction [cobaltiprotoporphyrin inhibits the reaction [LEP gene mutant form results in decreased activity of HMOX1 protein]]23839791
C055421tin mesoporphyrintin mesoporphyrin inhibits the reaction [cobaltiprotoporphyrin inhibits the reaction [LEP gene mutant form results in decreased expression of CPT1A mRNA]]23839791
C055421tin mesoporphyrintin mesoporphyrin inhibits the reaction [cobaltiprotoporphyrin inhibits the reaction [LEP gene mutant form results in decreased expression of GYS2 mRNA]]23839791
C055421tin mesoporphyrintin mesoporphyrin inhibits the reaction [cobaltiprotoporphyrin inhibits the reaction [LEP gene mutant form results in decreased expression of PPARA protein]]23839791
C055421tin mesoporphyrintin mesoporphyrin inhibits the reaction [cobaltiprotoporphyrin inhibits the reaction [LEP gene mutant form results in decreased phosphorylation of AKT1 protein]]23839791
C055421tin mesoporphyrintin mesoporphyrin inhibits the reaction [cobaltiprotoporphyrin inhibits the reaction [LEP gene mutant form results in increased abundance of Heme]]23839791
C055421tin mesoporphyrintin mesoporphyrin inhibits the reaction [cobaltiprotoporphyrin inhibits the reaction [LEP gene mutant form results in increased expression of FASN protein]]23839791
C055421tin mesoporphyrintin mesoporphyrin inhibits the reaction [cobaltiprotoporphyrin promotes the reaction [LEP gene mutant form results in decreased expression of PPARGC1A mRNA]]23839791
C055421tin mesoporphyrintin mesoporphyrin inhibits the reaction [cobaltiprotoporphyrin promotes the reaction [LEP gene mutant form results in decreased expression of SLC2A1 mRNA]]23839791
C055421tin mesoporphyrintin mesoporphyrin inhibits the reaction [cobaltiprotoporphyrin promotes the reaction [LEP gene mutant form results in increased expression of FGF21 mRNA]]23839791
C055421tin mesoporphyrintin mesoporphyrin promotes the reaction [cobaltiprotoporphyrin inhibits the reaction [LEP gene mutant form results in decreased expression of HMOX1 protein]]23839791
C009495titanium dioxidetitanium dioxide results in decreased expression of LEP mRNA23131501
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of LEP protein27793746
D014044TolbutamideTolbutamide inhibits the reaction [LEP protein inhibits the reaction [Acetylcholine results in increased secretion of INS protein]]12734786
C011559tributyltintributyltin results in increased expression of LEP mRNA28011154
C011559tributyltintributyltin results in increased secretion of LEP protein28161095
C012589trichostatin Atrichostatin A promotes the reaction [decitabine results in increased expression of LEP mRNA]17502362
C012589trichostatin Atrichostatin A results in increased expression of LEP mRNA17502362
C053549triflumizolT 0070907 inhibits the reaction [[triflumizol co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with Indomethacin co-treated with INS protein] results in increased expression of LEP mRNA]23086663
C053549triflumizol[triflumizol co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with Indomethacin co-treated with INS protein] results in increased expression of LEP mRNA23086663
C053549triflumizolT 0070907 inhibits the reaction [[triflumizol co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of LEP mRNA]23086663
C053549triflumizol[triflumizol co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of LEP mRNA23086663
D014280TriglyceridesLEP protein results in decreased abundance of Triglycerides12372423
C005445triphenyl phosphate"ESR1 gene mutant form inhibits the reaction [[tris(1,3-dichloro-2-propyl)phosphate co-treated with triphenyl phosphate co-treated with Tritolyl Phosphates] results in decreased expression of and results in decreased secretion of LEP protein]"29112739
C005445triphenyl phosphate"[tris(1,3-dichloro-2-propyl)phosphate co-treated with triphenyl phosphate co-treated with Tritolyl Phosphates] results in decreased expression of and results in decreased secretion of LEP protein"29112739
C016805tris(1,3-dichloro-2-propyl)phosphate"ESR1 gene mutant form inhibits the reaction [[tris(1,3-dichloro-2-propyl)phosphate co-treated with triphenyl phosphate co-treated with Tritolyl Phosphates] results in decreased expression of and results in decreased secretion of LEP protein]"29112739
C016805tris(1,3-dichloro-2-propyl)phosphate"[tris(1,3-dichloro-2-propyl)phosphate co-treated with triphenyl phosphate co-treated with Tritolyl Phosphates] results in decreased expression of and results in decreased secretion of LEP protein"29112739
D014317Tritolyl Phosphates"ESR1 gene mutant form inhibits the reaction [[tris(1,3-dichloro-2-propyl)phosphate co-treated with triphenyl phosphate co-treated with Tritolyl Phosphates] results in decreased expression of and results in decreased secretion of LEP protein]"29112739
D014317Tritolyl Phosphates"[tris(1,3-dichloro-2-propyl)phosphate co-treated with triphenyl phosphate co-treated with Tritolyl Phosphates] results in decreased expression of and results in decreased secretion of LEP protein"29112739
C057693troglitazone[Dexamethasone co-treated with troglitazone] results in decreased secretion of LEP protein11092516
C057693troglitazonetroglitazone inhibits the reaction [Dexamethasone results in increased expression of LEP mRNA]10946865
C057693troglitazonetroglitazone inhibits the reaction [Dexamethasone results in increased secretion of LEP protein]10946865
C057693troglitazonetroglitazone results in decreased expression of LEP protein10946865|9727893
C057693troglitazonetroglitazone results in increased secretion of LEP protein11092516
C057693troglitazonetroglitazone results in decreased expression of LEP mRNA10753628
C057693troglitazonetroglitazone results in decreased expression of LEP mRNA9502777
C057693troglitazonetroglitazone results in decreased expression of LEP protein11909685|1582497
C057693troglitazone[INS protein co-treated with troglitazone] results in increased secretion of LEP protein11092516
C057693troglitazone[troglitazone binds to and results in increased activity of PPARG protein] which results in decreased secretion of LEP protein16037295
C057693troglitazonetroglitazone inhibits the reaction [INS protein results in increased expression of LEP]8772734
C057693troglitazonetroglitazone results in decreased expression of LEP8772734
C005466ursolic acidursolic acid results in increased expression of LEP protein20869956
D014638VanadatesVanadates results in increased expression of LEP protein11899024
D014639VanadiumVanadium promotes the reaction [LEP protein results in increased expression of UCP1 protein]16195403
D014639VanadiumVanadium promotes the reaction [LEP protein results in increased phosphorylation of STAT3 protein]16195403
D001335Vehicle Emissions"[Fatty Acids, Omega-3 deficiency co-treated with Vehicle Emissions] results in increased expression of LEP protein"29175182
C025643vinclozolinvinclozolin results in decreased expression of LEP mRNA23160963
D014801Vitamin ALEP gene mutant form promotes the reaction [Vitamin A results in increased expression of UCP1 mRNA]16493122
D014810Vitamin EVitamin E inhibits the reaction [Dietary Fats results in decreased expression of LEP mRNA]20404018
D014810Vitamin EVitamin E inhibits the reaction [Dietary Fats results in decreased expression of LEP protein]20404018
D024483Vitamin K 3"1,2-linoleoylphosphatidylcholine inhibits the reaction [Vitamin K 3 results in increased expression of LEP mRNA]"16996477
D024483Vitamin K 32-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Vitamin K 3 results in increased expression of LEP mRNA]16996477
D024483Vitamin K 3S-Adenosylmethionine inhibits the reaction [Vitamin K 3 results in increased expression of LEP mRNA]16996477
D024483Vitamin K 3SB 203580 inhibits the reaction [Vitamin K 3 results in increased expression of LEP mRNA]16996477
D024483Vitamin K 3Vitamin K 3 results in increased expression of LEP mRNA16996477
D014874Water Pollutants, Chemical"Water Pollutants, Chemical promotes the reaction [LEP gene mutant form results in decreased expression of ARNTL mRNA]"24525044
D014874Water Pollutants, Chemical"Water Pollutants, Chemical promotes the reaction [LEP gene mutant form results in increased expression of ALAS1 mRNA]"24525044
D014874Water Pollutants, Chemical"Water Pollutants, Chemical promotes the reaction [LEP gene mutant form results in increased expression of DBP mRNA]"24525044
D014874Water Pollutants, Chemical"Water Pollutants, Chemical promotes the reaction [LEP gene mutant form results in increased expression of PER1 mRNA]"24525044
C009687wortmanninwortmannin inhibits the reaction [LEP protein results in increased transport of Calcium]20107083
C009687wortmanninwortmannin results in decreased expression of LEP mRNA19254925
C009687wortmanninwortmannin results in decreased secretion of LEP protein19254925
C009687wortmanninwortmannin results in decreased susceptibility to LEP protein17993459
C501648WP9QY peptideWP9QY peptide inhibits the reaction [LEP protein results in increased phosphorylation of STAT3 protein]27226618
C009689xanthonexanthone inhibits the reaction [LEP protein results in increased activity of ACE2 protein]25205467
C009689xanthonexanthone inhibits the reaction [LEP protein results in increased expression of ACE2]25205467
D015215ZidovudineZidovudine results in decreased expression of LEP protein17668557
D015215Zidovudine[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in decreased expression of LEP mRNA16931933
D015215Zidovudine[Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in decreased expression of LEP mRNA16931933
D015032ZincIL6 promoter polymorphism affects the reaction [Zinc results in decreased expression of LEP mRNA]18316168
D015032ZincLEP gene mutant form results in decreased abundance of Zinc10965932
D015032ZincMT1A gene polymorphism affects the reaction [Zinc results in decreased expression of LEP mRNA]18316168
D015032ZincZinc results in decreased expression of LEP mRNA18316168
D015032Zinc[Zinc deficiency co-treated with Ethanol] results in decreased expression of and results in decreased secretion of LEP protein24155903
D015032ZincZinc deficiency results in decreased expression of LEP protein25088245
D015032ZincZinc deficiency results in increased expression of LEP protein20660286
C016837zinc chloridezinc chloride results in increased expression of LEP mRNA21540303
D017967Zinc CompoundsZinc Compounds inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of LEP protein]24854284
D019287Zinc SulfateZinc Sulfate deficiency results in decreased expression of and results in decreased secretion of LEP protein11568307
D019287Zinc SulfateZinc Sulfate deficiency results in decreased expression of LEP mRNA11568307
D015054ZymosanLEP protein affects the susceptibility to Zymosan15142272

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005179hormone activity-IBA21873635  
GO:0051428peptide hormone receptor binding-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0000122negative regulation of transcription by RNA polymerase II-IEA-  
GO:0001525angiogenesis-IDA19910644  21771332  
GO:0001542ovulation from ovarian follicle-IEA-  
GO:0001666response to hypoxia-IEA-  
GO:0001890placenta development-IDA17957153  
GO:0001936regulation of endothelial cell proliferation-IDA11460888  
GO:0002021response to dietary excess-IEA-  
GO:0003300cardiac muscle hypertrophy-IEA-  
GO:0006006glucose metabolic process-IEA-  
GO:0006111regulation of gluconeogenesis-IEA-  
GO:0006112energy reserve metabolic process-IBA21873635  
GO:0006114glycerol biosynthetic process-IEA-  
GO:0006629lipid metabolic process-IBA21873635  
GO:0006635fatty acid beta-oxidation-IEA-  
GO:0006909phagocytosis-IEA-  
GO:0007260tyrosine phosphorylation of STAT protein-IBA21873635  
GO:0007565female pregnancy-IEA-  
GO:0007623circadian rhythm-IEA-  
GO:0008203cholesterol metabolic process-IEA-  
GO:0008206bile acid metabolic process-IEA-  
GO:0008217regulation of blood pressure-IEA-  
GO:0008343adult feeding behavior-ISS-  
GO:0010469regulation of signaling receptor activity-IEA-  
GO:0010507negative regulation of autophagy-IDA25060689  
GO:0010888negative regulation of lipid storage-IEA-  
GO:0014068positive regulation of phosphatidylinositol 3-kinase signaling-IBA21873635  
GO:0014068positive regulation of phosphatidylinositol 3-kinase signaling-IDA24340098  
GO:0014068positive regulation of phosphatidylinositol 3-kinase signaling-ISS-  
GO:0014823response to activity-IEA-  
GO:0019953sexual reproduction-IMP8589726  
GO:0021954central nervous system neuron development-IEA-  
GO:0030073insulin secretion-IEA-  
GO:0030217T cell differentiation-ISS-  
GO:0030300regulation of intestinal cholesterol absorption-IEA-  
GO:0032008positive regulation of TOR signaling-IBA21873635  
GO:0032008positive regulation of TOR signaling-IDA25060689  
GO:0032099negative regulation of appetite-ISS-  
GO:0032310prostaglandin secretion-IDA19688109  
GO:0032355response to estradiol-IEA-  
GO:0032615interleukin-12 production-IEA-  
GO:0032760positive regulation of tumor necrosis factor production-IEA-  
GO:0032814regulation of natural killer cell activation-IDA12504075  
GO:0032817regulation of natural killer cell proliferation-IDA12504075  
GO:0032868response to insulin-IBA21873635  
GO:0033197response to vitamin E-IEA-  
GO:0033210leptin-mediated signaling pathway-ISS-  
GO:0033686positive regulation of luteinizing hormone secretion-IEA-  
GO:0035360positive regulation of peroxisome proliferator activated receptor signaling pathway-IEA-  
GO:0035630bone mineralization involved in bone maturation-IEA-  
GO:0038108negative regulation of appetite by leptin-mediated signaling pathway-IBA21873635  
GO:0038108negative regulation of appetite by leptin-mediated signaling pathway-ISS-  
GO:0042102positive regulation of T cell proliferation-IDA25060689  
GO:0042269regulation of natural killer cell mediated cytotoxicity-IDA12504075  
GO:0042307positive regulation of protein import into nucleus-IEA-  
GO:0042445hormone metabolic process-IEA-  
GO:0042531positive regulation of tyrosine phosphorylation of STAT protein-IEA-  
GO:0042593glucose homeostasis-IEA-  
GO:0042755eating behavior-IEA-  
GO:0043066negative regulation of apoptotic process-IEA-  
GO:0043270positive regulation of ion transport-IEA-  
GO:0043410positive regulation of MAPK cascade-IDA24340098  
GO:0043410positive regulation of MAPK cascade-ISS-  
GO:0044320cellular response to leptin stimulus-IDA17344214  
GO:0045471response to ethanol-IEA-  
GO:0045765regulation of angiogenesis-IDA11460888  
GO:0045906negative regulation of vasoconstriction-IEA-  
GO:0046325negative regulation of glucose import-IDA24340098  
GO:0046427positive regulation of JAK-STAT cascade-IDA17344214  
GO:0046628positive regulation of insulin receptor signaling pathway-IEA-  
GO:0046850regulation of bone remodeling-ISS-  
GO:0046881positive regulation of follicle-stimulating hormone secretion-IEA-  
GO:0048639positive regulation of developmental growth-IDA17957153  
GO:0050796regulation of insulin secretion-IEA-  
GO:0050810regulation of steroid biosynthetic process-IEA-  
GO:0050892intestinal absorption-IDA24340098  
GO:0050901leukocyte tethering or rolling-IEA-  
GO:0050999regulation of nitric-oxide synthase activity-IDA15899045  
GO:0051726regulation of cell cycle-IDA17344214  
GO:0051897positive regulation of protein kinase B signaling-ISS-  
GO:0060587regulation of lipoprotein lipid oxidation-IEA-  
GO:0060612adipose tissue development-IEA-  
GO:0061037negative regulation of cartilage development-IEA-  
GO:0070093negative regulation of glucagon secretion-IEA-  
GO:0071298cellular response to L-ascorbic acid-IEA-  
GO:0071300cellular response to retinoic acid-IEA-  
GO:0072604interleukin-6 secretion-IDA19688109  
GO:0072606interleukin-8 secretion-IDA19688109  
GO:0090335regulation of brown fat cell differentiation-ISS-  
GO:0098868bone growth-ISS-  
GO:1900015regulation of cytokine production involved in inflammatory response-IDA19688109  
GO:1900745positive regulation of p38MAPK cascade-IBA21873635  
GO:1900745positive regulation of p38MAPK cascade-IDA24340098  
GO:1904651positive regulation of fat cell apoptotic process-IEA-  
GO:1990051activation of protein kinase C activity-IBA21873635  
GO:1990051activation of protein kinase C activity-IDA24340098  
GO:2000379positive regulation of reactive oxygen species metabolic process-IEA-  
GO:2000486negative regulation of glutamine transport-IEA-  
GO:2000491positive regulation of hepatic stellate cell activation-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-TAS-  
GO:0005615extracellular space-IBA21873635  
GO:0005615extracellular space-ISS-  
GO:0005737cytoplasm-IEA-  
KEGG ID KEGG Term
hsa04060Cytokine-cytokine receptor interaction
hsa04080Neuroactive ligand-receptor interaction
hsa04630Jak-STAT signaling pathway
hsa04920Adipocytokine signaling pathway
Reactome ID Reactome Term Evidence
R-HSA-1266738Developmental BiologyTAS
R-HSA-162582Signal TransductionIEA
R-HSA-2586552Signaling by LeptinIEA
R-HSA-2980736Peptide hormone metabolismTAS
R-HSA-381340Transcriptional regulation of white adipocyte differentiationTAS
R-HSA-381771Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)TAS
R-HSA-392499Metabolism of proteinsTAS
R-HSA-400508Incretin synthesis, secretion, and inactivationTAS
R-HSA-422085Synthesis, secretion, and deacylation of GhrelinTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
29312594Investigation of TCF7L2, LEP and LEPR polymorphisms with esophageal squamous cell carcinomas. (2017 Dec 12)Qiu HOncotarget
16261186Microsatellite polymorphism of the human leptin gene (LEP) and risk of cardiovascular disease. (2006 Feb)Porreca EInt J Obes (Lond)
20930547DNA methylation of IGF2, GNASAS, INSIGF and LEP and being born small for gestational age. (2011 Feb)Tobi EWEpigenetics
14997327Dermal echogenicity: a biological indicator of individual cumulative UVR exposure? (2004 Apr)Sandby-Moller JArch Dermatol Res
28616916[Relationship Between LEP G2548A Polymorphism and Cholesterol Gallstone]. (2017 May)Chen JSichuan Da Xue Xue Bao Yi Xue Ban
29044854Targeted proteomic analysis of habitual coffee consumption. (2018 Feb)Cornelis MCJ Intern Med
19562039Targeting 160 candidate genes for blood pressure regulation with a genome-wide genotyping array. (2009 Jun 29)Sober SPLoS One
17587397Genetic variation and decreased risk for obesity in the Atherosclerosis Risk in Communities Study. (2007 Jul)Hart Sailors MLDiabetes Obes Metab
18604373Leptin G-2548A promoter polymorphism is associated with increased plasma leptin and BMI in Brazilian women. (2008 Jun)Hinuy HMArq Bras Endocrinol Metabol
23593308The leptin gene family and colorectal cancer: interaction with smoking behavior and family history of cancer. (2013)Liu LPLoS One
24140454Leptin receptor Arg109 homozygotes display decreased total mortality as well as lower incidence of cardiovascular disease and related death. (2014 Jan 15)Aijala MGene
25462909DNA methylation of the LEP gene is associated with craving during alcohol withdrawal. (2015 Jan)Hillemacher TPsychoneuroendocrinology
27703650Genetic Variations in Leptin and Leptin Receptor and Susceptibility to Colorectal Cancer and Obesity. (2016 Jun)Mahmoudi TIran J Cancer Prev
17031518Effect of genetic variation in the leptin gene promoter and the leptin receptor gene on obesity risk in a population-based case-control study in Spain. (2006)Portoles OEur J Epidemiol