Gene: LEPR

3953
CD295|LEP-R|LEPRD|OB-R|OBR
leptin receptor
protein-coding
1p31.3
Ensembl:ENSG00000116678 MIM:601007 Vega:OTTHUMG00000009115 UniprotKB:P48357
NG_015831.2
PubMed
OD|ND
19   
NA (AD)  NA (ND)   (Frontal_Cortex)
8.235e-3 (AD)  7.255e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
LY750.838
PGR0.817
CYYR10.805
CFH0.8
MECOM0.793
RNF144B0.788
FLI10.786
BNC20.785
PDE5A0.785
EMCN0.782

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ASPDH-0.534
HAGHL-0.439
C9orf24-0.425
NANOS3-0.42
HES6-0.416
WNT7B-0.409
FAM43B-0.408
MAGIX-0.407
ARSF-0.407
SPATA2L-0.406

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB05098LeptinSmall Molecule169494-85-3InvestigationalTarget
DB09046MetreleptinBiotechDrug186018-45-1ApprovedTarget
ID Drug Name Action PubMed
C0264861,2,5,6-dibenzanthracene"1,2,5,6-dibenzanthracene results in increased expression of LEPR mRNA"26377693
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of LEPR mRNA"22698814
C5321622-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine"LEPR affects the reaction [2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine results in decreased phosphorylation of AKT1 protein]"22949526
C0297902,2',3',4,4',5-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of LEPR mRNA"25510870
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in increased expression of LEPR mRNA"29112739
C5112952,2',4,4'-tetrabromodiphenyl ether"ESR1 gene mutant form inhibits the reaction [2,2',4,4'-tetrabromodiphenyl ether results in increased expression of LEPR mRNA]"29112739
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of LEPR mRNA"19114083
C0294972,3-bis(3'-hydroxybenzyl)butyrolactone"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in decreased expression of LEPR mRNA"19167446
C0817662,4,4'-trichlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of LEPR mRNA"25510870
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of LEPR mRNA"25510870
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of LEPR mRNA"24978599
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of LEPR mRNA"24978599
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl] results in decreased expression of LEPR mRNA"24978599
C0098282,4,5,2',5'-pentachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of LEPR mRNA"25510870
C0098282,4,5,2',5'-pentachlorobiphenyl"[2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of LEPR mRNA"24978599
C0098282,4,5,2',5'-pentachlorobiphenyl"[2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl] results in decreased expression of LEPR mRNA"24978599
C0098282,4,5,2',5'-pentachlorobiphenyl"[2,4,5,2',5'-pentachlorobiphenyl co-treated with PCB 180] results in decreased expression of LEPR mRNA"24978599
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of LEPR mRNA"21346803
C0859112-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [LEPR gene mutant form results in decreased expression of SOD2 protein]23159718
C0859112-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [LEPR gene mutant form results in increased phosphorylation of AKT1 protein]23159718
C0859112-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [LEPR gene mutant form results in increased phosphorylation of FOXO3 protein]23159718
C0094072,5,2',5'-tetrachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of LEPR mRNA"25510870
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of LEPR mRNA"21346803
C0080392-hydroxyisobutyric acidLEPR affects the abundance of 2-hydroxyisobutyric acid20567778
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane affects the expression of LEPR mRNA"18648102
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of LEPR mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide inhibits the reaction [LEPR gene mutant form results in decreased expression of SOD2 protein]"23159718
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide inhibits the reaction [LEPR gene mutant form results in increased phosphorylation of AKT1 protein]"23159718
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide inhibits the reaction [LEPR gene mutant form results in increased phosphorylation of FOXO3 protein]"23159718
C0757734-phenylbutyric acid4-phenylbutyric acid affects the reaction [LEPR gene mutant form affects the splicing of XBP1 mRNA]23274897
C0757734-phenylbutyric acid4-phenylbutyric acid inhibits the reaction [LEPR gene mutant form results in decreased expression of GPD2 mRNA]23274897
C0757734-phenylbutyric acid4-phenylbutyric acid inhibits the reaction [LEPR gene mutant form results in decreased expression of MAFA mRNA]23274897
C0757734-phenylbutyric acid4-phenylbutyric acid inhibits the reaction [LEPR gene mutant form results in decreased expression of NKX6-1 mRNA]23274897
C0757734-phenylbutyric acid4-phenylbutyric acid inhibits the reaction [LEPR gene mutant form results in decreased expression of PCX mRNA]23274897
C0757734-phenylbutyric acid4-phenylbutyric acid inhibits the reaction [LEPR gene mutant form results in decreased expression of PDX1 mRNA]23274897
C0757734-phenylbutyric acid4-phenylbutyric acid promotes the reaction [LEPR gene mutant form results in increased expression of EDEM1 mRNA]23274897
C0757734-phenylbutyric acid4-phenylbutyric acid promotes the reaction [LEPR gene mutant form results in increased expression of FKBP11 mRNA]23274897
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of LEPR mRNA"27188386
C0776467,12-benz(a)anthraquinone"7,12-benz(a)anthraquinone results in increased expression of LEPR mRNA"26141390
D000082AcetaminophenAcetaminophen affects the expression of LEPR mRNA25064622
C056165acetovanilloneacetovanillone inhibits the reaction [LEPR gene mutant form results in decreased susceptibility to Acetylcholine]19478208
C056165acetovanilloneacetovanillone inhibits the reaction [LEPR gene mutant form results in increased abundance of Superoxides]19478208
D000109Acetylcholineacetovanillone inhibits the reaction [LEPR gene mutant form results in decreased susceptibility to Acetylcholine]19478208
D000109AcetylcholineLEPR gene mutant form results in decreased susceptibility to Acetylcholine19478208
D000109Acetylcholineresveratrol inhibits the reaction [LEPR gene mutant form results in decreased susceptibility to Acetylcholine]19478208
D000109Acetylcholinetempol inhibits the reaction [LEPR gene mutant form results in decreased susceptibility to Acetylcholine]19478208
D000109AcetylcholineTNF gene mutant form affects the reaction [LEPR gene mutant form results in decreased susceptibility to Acetylcholine]19478208
C014949acetylhydrazineacetylhydrazine results in decreased expression of LEPR mRNA15282401
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of LEPR mRNA27153756
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of LEPR mRNA23630614
D000481AllantoinLEPR affects the abundance of Allantoin20567778
D000493AllopurinolAllopurinol inhibits the reaction [Fructose results in increased expression of and results in increased phosphorylation of LEPR protein]22426011
C019419alpha-hydroxyisocaproic acidLEPR affects the abundance of alpha-hydroxyisocaproic acid20567778
C001918alpha-ketoadipic acidLEPR affects the abundance of alpha-ketoadipic acid20567778
C016211alpha-keto-beta-methylvaleric acidLEPR affects the abundance of alpha-keto-beta-methylvaleric acid20567778
C029743alpha-ketoglutaric acidLEPR affects the abundance of alpha-ketoglutaric acid20567778
C001505alpha-ketoisovalerateLEPR affects the abundance of alpha-ketoisovalerate20567778
D000638AmiodaroneAmiodarone affects the expression of LEPR mRNA25064622
D000643Ammonium ChlorideAmmonium Chloride affects the expression of LEPR mRNA16483693
D001125Argininosuccinic AcidLEPR affects the abundance of Argininosuccinic Acid20567778
D001151ArsenicArsenic affects the methylation of LEPR gene25304211
D001151ArsenicArsenic results in decreased expression of LEPR mRNA19654921
C005948astaxanthineastaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of AIFM1 mRNA]16964424
C005948astaxanthineastaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of APP mRNA]16964424
C005948astaxanthineastaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of CAT mRNA]16964424
C005948astaxanthineastaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of CNTD1 mRNA]16964424
C005948astaxanthineastaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of COX15 mRNA]16964424
C005948astaxanthineastaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of COX5A mRNA]16964424
C005948astaxanthineastaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of COX5B mRNA]16964424
C005948astaxanthineastaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of COX6B1 mRNA]16964424
C005948astaxanthineastaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of COX6C mRNA]16964424
C005948astaxanthineastaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of FOXO3 mRNA]16964424
C005948astaxanthineastaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of GNA13 mRNA]16964424
C005948astaxanthineastaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of GPX3 mRNA]16964424
C005948astaxanthineastaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of GRN mRNA]16964424
C005948astaxanthineastaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of HMGB1 mRNA]16964424
C005948astaxanthineastaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of HOXA9 mRNA]16964424
C005948astaxanthineastaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of IDH1 mRNA]16964424
C005948astaxanthineastaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of ND6 mRNA]16964424
C005948astaxanthineastaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of NDUFA1 mRNA]16964424
C005948astaxanthineastaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of NDUFA5 mRNA]16964424
C005948astaxanthineastaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of NDUFC2 mRNA]16964424
C005948astaxanthineastaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of NDUFV2 mRNA]16964424
C005948astaxanthineastaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of NME2 mRNA]16964424
C005948astaxanthineastaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of PPP1CB mRNA]16964424
C005948astaxanthineastaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of PRDX1 mRNA]16964424
C005948astaxanthineastaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of RPS2 mRNA]16964424
C005948astaxanthineastaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of SOD1 mRNA]16964424
C005948astaxanthineastaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of SPP1 mRNA]16964424
C005948astaxanthineastaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of TGM2 mRNA]16964424
C005948astaxanthineastaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of TKT mRNA]16964424
C005948astaxanthineastaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of UBB mRNA]16964424
C005948astaxanthineastaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of UQCRB mRNA]16964424
C005948astaxanthineastaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of UQCRC2 mRNA]16964424
C030935benz(a)anthracene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of LEPR mRNA27858113
C006703benzo(b)fluoranthene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of LEPR mRNA27858113
D019324beta-Naphthoflavone[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in decreased expression of LEPR mRNA18164116
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of LEPR mRNA22316170
D001564Benzo(a)pyrene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of LEPR mRNA27858113
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of LEPR mRNA19770486
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of LEPR mRNA21839799
D004958EstradiolEstradiol results in decreased expression of LEPR mRNA19167446
D004958EstradiolEstradiol results in decreased expression of LEPR mRNA14664709
D004958Estradiol[bisphenol A co-treated with Estradiol] results in decreased expression of LEPR mRNA26496021
D004958EstradiolLEPR protein affects the abundance of Estradiol15093691
C006780bisphenol Abisphenol A results in increased expression of LEPR mRNA22343039
C006780bisphenol Abisphenol A results in increased expression of LEPR protein22343039
C006780bisphenol A[bisphenol A co-treated with Estradiol] results in decreased expression of LEPR mRNA26496021
C006780bisphenol Abisphenol A results in decreased expression of LEPR mRNA25181051
D001786Blood GlucoseLEPR gene mutant form inhibits the reaction [sodium arsenite results in increased abundance of Blood Glucose]25367288
D001786Blood GlucoseLEPR gene mutant form results in increased abundance of Blood Glucose25367288
D001786Blood Glucosesodium arsenite inhibits the reaction [LEPR gene mutant form results in increased abundance of Blood Glucose]25367288
D0151248-Bromo Cyclic Adenosine MonophosphateLEPR protein affects the reaction [LEP protein inhibits the reaction [8-Bromo Cyclic Adenosine Monophosphate results in increased chemical synthesis of Progesterone]]19849856
D0151248-Bromo Cyclic Adenosine MonophosphateLEPR protein affects the reaction [LEP protein inhibits the reaction [8-Bromo Cyclic Adenosine Monophosphate results in increased expression of STAR protein]]19849856
C025191bromodichloromethaneLEPR protein affects the reaction [[Dietary Fats co-treated with bromodichloromethane] affects the localization of NCF2 protein]23438451
C025191bromodichloromethaneLEPR protein results in decreased susceptibility to [Dietary Fats co-treated with bromodichloromethane]23438451
C018475butyraldehydebutyraldehyde results in decreased expression of LEPR mRNA26079696
D020148Butyric AcidLEPR affects the abundance of Butyric Acid20567778
D002110CaffeineCaffeine results in decreased expression of LEPR mRNA26367767
D002110CaffeineCaffeine results in increased expression of LEPR mRNA22583948
D002118CalciumCalcium affects the expression of LEPR mRNA15913539
D002251Carbon Tetrachloride"Drugs, Chinese Herbal inhibits the reaction [[Carbon Tetrachloride co-treated with Ethanol] results in increased expression of LEPR protein]"18227024
D002331CarnitineLEPR affects the abundance of Carnitine20567778
D002746ChlorpromazineChlorpromazine affects the expression of LEPR mRNA25064622
D008076Cholesterol, HDL"LEPR polymorphism affects the abundance of Cholesterol, HDL"14625131
D008078Cholesterol, LDL"LEPR polymorphism affects the abundance of Cholesterol, LDL"14625131
D002794CholineLEPR affects the abundance of Choline20567778
D002794CholineLEPR gene mutant form affects the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased activity of GPT protein]24384915
D002794CholineLEPR gene mutant form affects the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of ABCB1A mRNA]24384915
D002794CholineLEPR gene mutant form affects the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of ABCC4 mRNA]24384915
D002794Choline[LEPR gene mutant form co-treated with Methionine deficiency co-treated with Choline deficiency] results in increased expression of ABCB1A protein24384915
D002794Choline[LEPR gene mutant form co-treated with Methionine deficiency co-treated with Choline deficiency] results in increased expression of ABCC3 mRNA24384915
D002794Choline[LEPR gene mutant form co-treated with Methionine deficiency co-treated with Choline deficiency] results in increased expression of ABCC3 protein24384915
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of LEPR mRNA20938992
D002857ChromiumLEPR gene mutant form promotes the reaction [[Niacin binds to Chromium] which results in decreased expression of BTC mRNA]16940432
D002857ChromiumLEPR gene mutant form promotes the reaction [[Niacin binds to Chromium] which results in decreased expression of CIDEA mRNA]16940432
D002857ChromiumLEPR gene mutant form promotes the reaction [[Niacin binds to Chromium] which results in decreased expression of DDHD1 mRNA]16940432
D002857ChromiumLEPR gene mutant form promotes the reaction [[Niacin binds to Chromium] which results in decreased expression of NET1 mRNA]16940432
D002857ChromiumLEPR gene mutant form promotes the reaction [[Niacin binds to Chromium] which results in decreased expression of PCK1 mRNA]16940432
D002857ChromiumLEPR gene mutant form promotes the reaction [[Niacin binds to Chromium] which results in decreased expression of TTPA mRNA]16940432
D002857ChromiumLEPR gene mutant form promotes the reaction [[Niacin binds to Chromium] which results in decreased expression of UCP1 mRNA]16940432
D002857ChromiumLEPR gene mutant form promotes the reaction [[Niacin binds to Chromium] which results in increased expression of ASPH mRNA]16940432
D002857ChromiumLEPR gene mutant form promotes the reaction [[Niacin binds to Chromium] which results in increased expression of CASQ1 mRNA]16940432
D002857ChromiumLEPR gene mutant form promotes the reaction [[Niacin binds to Chromium] which results in increased expression of EDNRB mRNA]16940432
D002857ChromiumLEPR gene mutant form promotes the reaction [[Niacin binds to Chromium] which results in increased expression of ENO3 mRNA]16940432
D002857ChromiumLEPR gene mutant form promotes the reaction [[Niacin binds to Chromium] which results in increased expression of GPI1 mRNA]16940432
D002857ChromiumLEPR gene mutant form promotes the reaction [[Niacin binds to Chromium] which results in increased expression of NRAP mRNA]16940432
D002857ChromiumLEPR gene mutant form promotes the reaction [[Niacin binds to Chromium] which results in increased expression of PI16 mRNA]16940432
D002857ChromiumLEPR gene mutant form promotes the reaction [[Niacin binds to Chromium] which results in increased expression of RALGAPA1 mRNA]16940432
D002857ChromiumLEPR gene mutant form promotes the reaction [[Niacin binds to Chromium] which results in increased expression of SRL mRNA]16940432
D002857ChromiumLEPR gene mutant form promotes the reaction [[Niacin binds to Chromium] which results in increased expression of TLN1 mRNA]16940432
D002857ChromiumLEPR gene mutant form promotes the reaction [[Niacin binds to Chromium] which results in increased expression of TPM1 mRNA]16940432
C031180chrysene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of LEPR mRNA27858113
D002922CiguatoxinsCiguatoxins affects the expression of LEPR mRNA18353800
D019343Citric AcidLEPR affects the abundance of Citric Acid20567778
D002994ClofibrateClofibrate results in increased expression of LEPR mRNA22008536
D002995Clofibric Acid[Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of LEPR mRNA17602206
D003375Coumestrol"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in decreased expression of LEPR mRNA"19167446
D003375CoumestrolCoumestrol results in decreased expression of LEPR mRNA19167446
C513821CPU0213CPU0213 inhibits the reaction [Isoproterenol results in increased expression of LEPR mRNA]20307649
C513821CPU0213CPU0213 inhibits the reaction [Isoproterenol results in increased expression of LEPR protein]20307649
D003404CreatinineLEPR affects the abundance of Creatinine20567778
D016572CyclosporineCyclosporine affects the expression of LEPR mRNA25064622
D016572CyclosporineCyclosporine results in decreased expression of LEPR mRNA27989131
D003561CytarabineCytarabine results in decreased expression of LEPR mRNA21198554
C531198dactolisibLEPR affects the reaction [dactolisib results in decreased phosphorylation of AKT1 protein]22949526
C010902decabromobiphenyl etherdecabromobiphenyl ether results in decreased expression of LEPR mRNA23640034
C010902decabromobiphenyl etherdecabromobiphenyl ether results in increased expression of LEPR mRNA23640034|2391405
C014347decitabinedecitabine results in decreased expression of LEPR22560341
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of LEPR mRNA21266533
D003999Dichloroacetic AcidDichloroacetic Acid results in increased expression of LEPR mRNA28962523
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in decreased expression of LEPR mRNA27392435
D004008DiclofenacDiclofenac affects the expression of LEPR mRNA26934552
D004008DiclofenacDiclofenac results in increased expression of LEPR protein26934552
C000944dicrotophosdicrotophos results in increased expression of LEPR mRNA28302478
D004041Dietary FatsDietary Fats results in decreased expression of LEPR mRNA25016146
D004041Dietary FatsDietary Fats results in increased expression of LEPR mRNA22276206
D004041Dietary FatsLEPR protein affects the reaction [[Dietary Fats co-treated with bromodichloromethane] affects the localization of NCF2 protein]23438451
D004041Dietary FatsLEPR protein promotes the reaction [Dietary Fats results in increased expression of SOCS3 mRNA]22276206
D004041Dietary FatsLEPR protein results in decreased susceptibility to [Dietary Fats co-treated with bromodichloromethane]23438451
D004041Dietary FatsDietary Fats results in decreased expression of LEPR mRNA18721800|2271538
D004041Dietary Fats[LEPR gene mutant form co-treated with Dietary Fats] results in decreased expression of SLCO1A1 mRNA24384915
D004041Dietary Fats[LEPR gene mutant form co-treated with Dietary Fats] results in increased activity of GPT protein24384915
C014476diethyl maleatediethyl maleate results in decreased expression of LEPR mRNA21161181
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with Phenobarbital] results in decreased expression of LEPR mRNA24535843
D004052DiethylnitrosamineDiethylnitrosamine results in increased expression of LEPR mRNA24535843
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in decreased expression of LEPR mRNA18164116
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of LEPR mRNA17602206
D004280DobutamineLEPR protein affects the susceptibility to Dobutamine20175764
D004365Drugs, Chinese Herbal"Drugs, Chinese Herbal inhibits the reaction [[Carbon Tetrachloride co-treated with Ethanol] results in increased expression of LEPR protein]"18227024
D004970EstroneEstrone inhibits the reaction [LEPR gene mutant form inhibits the reaction [EGFR protein results in increased phosphorylation of EGFR protein]]1753381
D004970EstroneEstrone inhibits the reaction [LEPR gene mutant form results in decreased expression of EGFR mRNA]1753381
D000431Ethanol[Zinc deficiency co-treated with Ethanol] results in increased expression of LEPR mRNA24155903
D000431Ethanol"Drugs, Chinese Herbal inhibits the reaction [[Carbon Tetrachloride co-treated with Ethanol] results in increased expression of LEPR protein]"18227024
D000431EthanolEthanol results in decreased expression of LEPR mRNA16098508
D000431EthanolLEPR gene mutant form inhibits the reaction [Ethanol results in increased expression of MT1A mRNA]15475485
D000431EthanolLEPR gene mutant form inhibits the reaction [Ethanol results in increased expression of MT1A protein]15475485
D000431EthanolLEPR gene mutant form inhibits the reaction [Ethanol results in increased expression of MT2A mRNA]15475485
D000431EthanolLEPR gene mutant form promotes the reaction [Ethanol results in increased expression of TNF mRNA]15475485
D000431EthanolLEPR gene mutant form results in increased susceptibility to Ethanol15475485
D000431Ethanol[LEPR gene mutant form results in increased susceptibility to Ethanol] which results in decreased abundance of Zinc15475485
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of LEPR mRNA25064622
D004997Ethinyl EstradiolESR1 gene mutant form inhibits the reaction [Ethinyl Estradiol results in increased expression of LEPR mRNA]29112739
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of LEPR mRNA17942748|2911273
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of LEPR mRNA17942748
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of LEPR mRNA26865667
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of LEPR mRNA17351261
D005038EthylnitrosoureaEthylnitrosourea results in increased mutagenesis of LEPR gene16724327
C074031exenatideexenatide inhibits the reaction [LEPR gene mutant form results in decreased expression of SLC30A8 mRNA]21461562
C074031exenatideexenatide inhibits the reaction [LEPR gene mutant form results in decreased expression of SLC30A8 protein]21461562
D005411Flame RetardantsESR1 gene mutant form inhibits the reaction [Flame Retardants results in increased expression of LEPR mRNA]29112739
D005411Flame RetardantsFlame Retardants results in increased expression of LEPR mRNA29112739
D005485FlutamideFlutamide results in decreased expression of LEPR mRNA24136188
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of LEPR mRNA20938992
C030544formic acidLEPR affects the abundance of formic acid20567778
D005632FructoseAllopurinol inhibits the reaction [Fructose results in increased expression of and results in increased phosphorylation of LEPR protein]22426011
D005632FructoseFructose results in increased expression of and results in increased phosphorylation of LEPR protein22426011
D005632FructoseQuercetin inhibits the reaction [Fructose results in increased expression of and results in increased phosphorylation of LEPR protein]22426011
D005632FructoseRutin inhibits the reaction [Fructose results in increased expression of and results in increased phosphorylation of LEPR protein]22426011
C032005fumaric acidLEPR affects the abundance of fumaric acid20567778
C039281furanfuran results in increased methylation of LEPR gene22079235
C000090galactaric acidLEPR affects the abundance of galactaric acid20567778
D005688GalactosamineGalactosamine promotes the reaction [LEPR gene mutant form results in increased expression of SPP1 mRNA]19913045
D005688GalactosamineGalactosamine promotes the reaction [LEPR gene mutant form results in increased expression of SPP1 protein]19913045
D005688GalactosamineLEPR gene mutant form results in increased susceptibility to Galactosamine19913045
D005688Galactosamine[LEPR gene mutant form results in increased susceptibility to Galactosamine] which results in increased expression of IL12B mRNA19913045
D005688Galactosamine[LEPR gene mutant form results in increased susceptibility to Galactosamine] which results in increased expression of IL1819913045
D005688Galactosamine[LEPR gene mutant form results in increased susceptibility to Galactosamine] which results in increased expression of IL18 mRNA19913045
D005688Galactosamine[LEPR gene mutant form results in increased susceptibility to Galactosamine] which results in increased expression of IL18 protein19913045
D005688Galactosamine[LEPR gene mutant form results in increased susceptibility to Galactosamine] which results in increased expression of SPP1 protein19913045
D005688GalactosamineSPP1 promotes the reaction [LEPR gene mutant form results in increased susceptibility to Galactosamine]19913045
C419708gefitinibgefitinib results in decreased expression of LEPR mRNA16685379
D019833GenisteinGenistein results in decreased expression of LEPR mRNA26865667
D005947GlucoseHesperidin affects the reaction [LEPR protein affects the abundance of Glucose]16427799
D005947GlucoseLEPR affects the abundance of Glucose20567778
D005947GlucoseLEPR protein affects the abundance of Glucose16427799
D005947GlucoseLEPR results in decreased susceptibility to Glucose20567778
D005947Glucosenaringin affects the reaction [LEPR protein affects the abundance of Glucose]16427799
D005947GlucoseGlucose results in increased expression of LEPR protein24399619
D005947Glucosenaringin inhibits the reaction [Glucose results in increased expression of LEPR protein]24399619
C035736glutaric acidLEPR affects the abundance of glutaric acid20567778
C004312glycidolglycidol results in decreased expression of LEPR mRNA24915197
D006247HarmineHarmine affects the reaction [LEPR protein affects the susceptibility to INS1 protein]27805061
D006569HesperidinHesperidin affects the reaction [LEPR protein affects the abundance of Glucose]16427799
D006569HesperidinHesperidin affects the reaction [LEPR protein affects the activity of FASN protein]16427799
D006569HesperidinHesperidin affects the reaction [LEPR protein affects the activity of G6PD protein]16427799
D006569HesperidinHesperidin affects the reaction [LEPR protein affects the activity of HMGCR protein]16427799
D006569HesperidinHesperidin affects the reaction [LEPR protein affects the expression of GCK mRNA]16427799
D006569HesperidinHesperidin affects the reaction [LEPR protein affects the expression of PPARG protein]16427799
D006569HesperidinHesperidin affects the reaction [LEPR protein affects the expression of SLC2A2 protein]16427799
D006569HesperidinHesperidin affects the reaction [LEPR protein affects the expression of SLC2A4 protein]16427799
C037652hexanoic acidLEPR affects the abundance of hexanoic acid20567778
C000625835HFPO2 compoundHFPO2 compound results in increased expression of LEPR mRNA27553808
C000625836HFPO4 compoundHFPO4 compound results in increased expression of LEPR mRNA27553808
C029424hydrazinehydrazine results in increased expression of LEPR mRNA15370871
D006852HydrochlorothiazideLEPR mutant form results in increased susceptibility to Hydrochlorothiazide22949526
D006861Hydrogen PeroxideLEPR mutant form results in increased susceptibility to Hydrogen Peroxide27151219
D007200IndicanLEPR affects the abundance of Indican20567778
C541917INT 131INT 131 inhibits the reaction [LEPR protein affects the expression of INS1 protein]19452630
C020380isobutyric acidLEPR affects the abundance of isobutyric acid20567778
C034527isocaproic acidLEPR affects the abundance of isocaproic acid20567778
D007545IsoproterenolCPU0213 inhibits the reaction [Isoproterenol results in increased expression of LEPR mRNA]20307649
D007545IsoproterenolCPU0213 inhibits the reaction [Isoproterenol results in increased expression of LEPR protein]20307649
D007545IsoproterenolIsoproterenol results in increased expression of LEPR mRNA20307649
D007545IsoproterenolIsoproterenol results in increased expression of LEPR protein20307649
C008216isovaleric acidLEPR affects the abundance of isovaleric acid20567778
C544151jinfukang[Cisplatin co-treated with jinfukang] results in decreased expression of LEPR mRNA27392435
D007657Ketone BodiesKetone Bodies results in decreased expression of LEPR mRNA16807920
D019344Lactic AcidLEPR affects the abundance of Lactic Acid20567778
D008070LipopolysaccharidesLipopolysaccharides inhibits the reaction [Thioacetamide results in decreased expression of LEPR mRNA]17621560
C030290malonic acidLEPR affects the abundance of malonic acid20567778
D008383MargarineMargarine results in increased expression of LEPR mRNA23038630
D008628MercuryMercury results in decreased expression of LEPR mRNA16823088
D008715MethionineLEPR affects the abundance of Methionine20567778
D008715MethionineLEPR gene mutant form affects the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased activity of GPT protein]24384915
D008715MethionineLEPR gene mutant form affects the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of ABCB1A mRNA]24384915
D008715MethionineLEPR gene mutant form affects the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of ABCC4 mRNA]24384915
D008715Methionine[LEPR gene mutant form co-treated with Methionine deficiency co-treated with Choline deficiency] results in increased expression of ABCB1A protein24384915
D008715Methionine[LEPR gene mutant form co-treated with Methionine deficiency co-treated with Choline deficiency] results in increased expression of ABCC3 mRNA24384915
D008715Methionine[LEPR gene mutant form co-treated with Methionine deficiency co-treated with Choline deficiency] results in increased expression of ABCC3 protein24384915
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of LEPR mRNA20938992
D008764Methylmalonic AcidLEPR affects the abundance of Methylmalonic Acid20567778
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of LEPR mRNA23179753
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of LEPR mRNA28001369
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of LEPR mRNA26011545
D015735MifepristoneMifepristone results in increased expression of LEPR mRNA19439560
D015735MifepristoneMifepristone results in decreased expression of LEPR mRNA25972201
C548887MK 2206LEPR affects the reaction [MK 2206 results in decreased phosphorylation of AKT1 protein]22949526
D009020MorphineMorphine results in increased expression of LEPR mRNA20144693
C016590N(1)-methyl-4-pyridone-5-carboxamideLEPR affects the abundance of N(1)-methyl-4-pyridone-5-carboxamide20567778
C024058N(1)-methylnicotinamideLEPR affects the abundance of N(1)-methylnicotinamide20567778
C583365N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide"N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide results in increased expression of LEPR mRNA"29244179
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of LEPR mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of LEPR mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of LEPR mRNA"25620056
C005274naringinnaringin affects the reaction [LEPR protein affects the abundance of Glucose]16427799
C005274naringinnaringin affects the reaction [LEPR protein affects the activity of FASN protein]16427799
C005274naringinnaringin affects the reaction [LEPR protein affects the activity of G6PD protein]16427799
C005274naringinnaringin affects the reaction [LEPR protein affects the activity of HMGCR protein]16427799
C005274naringinnaringin affects the reaction [LEPR protein affects the expression of G6PC mRNA]16427799
C005274naringinnaringin affects the reaction [LEPR protein affects the expression of GCK mRNA]16427799
C005274naringinnaringin affects the reaction [LEPR protein affects the expression of PCK1 mRNA]16427799
C005274naringinnaringin affects the reaction [LEPR protein affects the expression of PPARG protein]16427799
C005274naringinnaringin affects the reaction [LEPR protein affects the expression of SLC2A2 protein]16427799
C005274naringinnaringin affects the reaction [LEPR protein affects the expression of SLC2A4 protein]16427799
C005274naringinnaringin inhibits the reaction [Glucose results in increased expression of LEPR protein]24399619
D009525NiacinLEPR gene mutant form promotes the reaction [[Niacin binds to Chromium] which results in decreased expression of BTC mRNA]16940432
D009525NiacinLEPR gene mutant form promotes the reaction [[Niacin binds to Chromium] which results in decreased expression of CIDEA mRNA]16940432
D009525NiacinLEPR gene mutant form promotes the reaction [[Niacin binds to Chromium] which results in decreased expression of DDHD1 mRNA]16940432
D009525NiacinLEPR gene mutant form promotes the reaction [[Niacin binds to Chromium] which results in decreased expression of NET1 mRNA]16940432
D009525NiacinLEPR gene mutant form promotes the reaction [[Niacin binds to Chromium] which results in decreased expression of PCK1 mRNA]16940432
D009525NiacinLEPR gene mutant form promotes the reaction [[Niacin binds to Chromium] which results in decreased expression of TTPA mRNA]16940432
D009525NiacinLEPR gene mutant form promotes the reaction [[Niacin binds to Chromium] which results in decreased expression of UCP1 mRNA]16940432
D009525NiacinLEPR gene mutant form promotes the reaction [[Niacin binds to Chromium] which results in increased expression of ASPH mRNA]16940432
D009525NiacinLEPR gene mutant form promotes the reaction [[Niacin binds to Chromium] which results in increased expression of CASQ1 mRNA]16940432
D009525NiacinLEPR gene mutant form promotes the reaction [[Niacin binds to Chromium] which results in increased expression of EDNRB mRNA]16940432
D009525NiacinLEPR gene mutant form promotes the reaction [[Niacin binds to Chromium] which results in increased expression of ENO3 mRNA]16940432
D009525NiacinLEPR gene mutant form promotes the reaction [[Niacin binds to Chromium] which results in increased expression of GPI1 mRNA]16940432
D009525NiacinLEPR gene mutant form promotes the reaction [[Niacin binds to Chromium] which results in increased expression of NRAP mRNA]16940432
D009525NiacinLEPR gene mutant form promotes the reaction [[Niacin binds to Chromium] which results in increased expression of PI16 mRNA]16940432
D009525NiacinLEPR gene mutant form promotes the reaction [[Niacin binds to Chromium] which results in increased expression of RALGAPA1 mRNA]16940432
D009525NiacinLEPR gene mutant form promotes the reaction [[Niacin binds to Chromium] which results in increased expression of SRL mRNA]16940432
D009525NiacinLEPR gene mutant form promotes the reaction [[Niacin binds to Chromium] which results in increased expression of TLN1 mRNA]16940432
D009525NiacinLEPR gene mutant form promotes the reaction [[Niacin binds to Chromium] which results in increased expression of TPM1 mRNA]16940432
D009532NickelNickel results in decreased expression of LEPR mRNA24768652
C037645nicotinamide N-oxideLEPR affects the abundance of nicotinamide N-oxide20567778
D009538NicotineNicotine results in decreased expression of LEPR mRNA29155039
D009538NicotineNicotine results in increased expression of LEPR mRNA22265867
C005211N'-methyl-2-pyridone-5-carboxamideLEPR affects the abundance of N'-methyl-2-pyridone-5-carboxamide20567778
C038780n-pentanoic acidLEPR affects the abundance of n-pentanoic acid20567778
C572462octaphlorethol A[octaphlorethol A co-treated with LEPR gene mutant form] results in increased expression of SLC2A4 protein26939912
C572462octaphlorethol A[octaphlorethol A co-treated with LEPR gene mutant form] results in increased phosphorylation of AKT1 protein26939912
C572462octaphlorethol Aoctaphlorethol A inhibits the reaction [LEPR gene mutant form results in increased expression of FASN mRNA]26939912
C572462octaphlorethol Aoctaphlorethol A inhibits the reaction [LEPR gene mutant form results in increased expression of G6PC mRNA]26939912
C572462octaphlorethol Aoctaphlorethol A inhibits the reaction [LEPR gene mutant form results in increased expression of INS1 protein]26939912
C572462octaphlorethol Aoctaphlorethol A inhibits the reaction [LEPR gene mutant form results in increased expression of PCK1 mRNA]26939912
D000069463Olive OilOlive Oil analog affects the expression of LEPR mRNA17349074
D000069463Olive OilOlive Oil results in decreased expression of LEPR mRNA23038630
D015525Fatty Acids, Omega-3"Fatty Acids, Omega-3 results in increased expression of LEPR mRNA"15949695
D009963Orotic AcidLEPR affects the abundance of Orotic Acid20567778
D010100OxygenOxygen deficiency results in increased expression of LEPR mRNA26516004
D010126OzoneLEPR gene mutant form promotes the reaction [Ozone results in increased expression of CCL11 protein]16373670
D010126OzoneLEPR gene mutant form promotes the reaction [Ozone results in increased expression of CXCL1 protein]16373670
D010126OzoneLEPR gene mutant form promotes the reaction [Ozone results in increased expression of CXCL2 protein]16373670
D010126OzoneLEPR gene mutant form promotes the reaction [Ozone results in increased expression of IL6 protein]16373670
D010126OzoneLEPR gene mutant form results in increased susceptibility to Ozone16373670
C016030pantogabpantogab results in increased expression of LEPR mRNA17379144
D010269ParaquatParaquat affects the expression of LEPR mRNA25064622
C410127PCB 180"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of LEPR mRNA"25510870
C410127PCB 180"[2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of LEPR mRNA"24978599
C410127PCB 180"[2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of LEPR mRNA"24978599
C410127PCB 180"[2,4,5,2',5'-pentachlorobiphenyl co-treated with PCB 180] results in decreased expression of LEPR mRNA"24978599
C046012pentanalpentanal results in decreased expression of LEPR mRNA26079696
C023036perfluorooctanoic acidperfluorooctanoic acid results in increased expression of LEPR mRNA17681415
D010634Phenobarbital[Diethylnitrosamine co-treated with Phenobarbital] results in decreased expression of LEPR mRNA24535843
D010634PhenobarbitalPhenobarbital affects the expression of LEPR mRNA23091169
D010634PhenobarbitalPhenobarbital results in increased expression of LEPR mRNA22008536
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of LEPR mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of LEPR mRNA26272509
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of LEPR mRNA19710929
C006253pirinixic acidpirinixic acid results in increased expression of LEPR mRNA18301758|1844570
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in decreased expression of LEPR mRNA19162173
D011374ProgesteroneLEPR protein affects the reaction [LEP protein inhibits the reaction [8-Bromo Cyclic Adenosine Monophosphate results in increased chemical synthesis of Progesterone]]19849856
D011433PropranololPropranolol results in increased expression of LEPR mRNA24250662
D011441PropylthiouracilPropylthiouracil affects the expression of LEPR mRNA24780913
C432165pyrazolanthroneLEPR protein affects the susceptibility to pyrazolanthrone22933112
D011794QuercetinQuercetin results in increased expression of LEPR mRNA22230496
D011794QuercetinQuercetin results in increased expression of LEPR protein22230496
D011794QuercetinQuercetin inhibits the reaction [Fructose results in increased expression of and results in increased phosphorylation of LEPR protein]22426011
D011929RazoxaneRazoxane results in decreased expression of LEPR mRNA19915844
C059514resveratrolresveratrol inhibits the reaction [LEPR gene mutant form results in decreased susceptibility to Acetylcholine]19478208
C059514resveratrolresveratrol inhibits the reaction [LEPR gene mutant form results in increased abundance of Superoxides]19478208
C013672riddelliineriddelliine results in increased expression of LEPR mRNA18047727
C089730rosiglitazonerosiglitazone inhibits the reaction [LEPR protein affects the expression of INS1 protein]19452630
D012431RutinRutin inhibits the reaction [Fructose results in increased expression of and results in increased phosphorylation of LEPR protein]22426011
C093642SB 203580LEPR protein affects the susceptibility to SB 20358022933112
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of LEPR mRNA25895662
D019821SimvastatinLEPR polymorphism affects the susceptibility to Simvastatin14625131|1885499
C017947sodium arseniteLEPR gene mutant form inhibits the reaction [sodium arsenite results in increased abundance of Blood Glucose]25367288
C017947sodium arseniteLEPR gene mutant form inhibits the reaction [sodium arsenite results in increased secretion of INS1 protein]25367288
C017947sodium arsenitesodium arsenite inhibits the reaction [LEPR gene mutant form results in increased abundance of Blood Glucose]25367288
C016104sodium bichromatesodium bichromate results in decreased expression of LEPR mRNA25993096
D017673Sodium Chloride, Dietary"LEPR gene mutant form results in increased susceptibility to Sodium Chloride, Dietary"22949526
D017673Sodium Chloride, Dietary"LEPR gene mutant form results in increased susceptibility to Sodium Chloride, Dietary deficiency"22949526
D053260SootSoot results in decreased expression of LEPR mRNA26551751
D019802Succinic AcidLEPR affects the abundance of Succinic Acid20567778
D013395SucroseLEPR affects the abundance of Sucrose20567778
D013481Superoxidesacetovanillone inhibits the reaction [LEPR gene mutant form results in increased abundance of Superoxides]19478208
D013481SuperoxidesLEPR gene mutant form results in increased abundance of Superoxides19478208
D013481Superoxidesresveratrol inhibits the reaction [LEPR gene mutant form results in increased abundance of Superoxides]19478208
D013619TacrineTacrine results in increased expression of LEPR mRNA12832660
D013654TaurineLEPR affects the abundance of Taurine20567778
C001803tempoltempol inhibits the reaction [LEPR gene mutant form results in decreased susceptibility to Acetylcholine]19478208
D013739TestosteroneLEPR protein affects the abundance of Testosterone15093691
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of LEPR mRNA22298810
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of LEPR mRNA20106945
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of LEPR mRNA26377647|2892240
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of LEPR mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of LEPR mRNA26290441
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of LEPR mRNA15977195|2229881
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of LEPR mRNA20959002|2172422
D013752TetracyclineTetracycline affects the expression of LEPR mRNA25064622
D013853ThioacetamideThioacetamide affects the expression of LEPR mRNA25064622
D013853ThioacetamideThioacetamide results in increased expression of LEPR mRNA17997003
D013853ThioacetamideLEPR gene mutant form inhibits the reaction [Thioacetamide results in increased expression of TGFB1 mRNA]11984526
D013853ThioacetamideLEPR protein affects the reaction [Thioacetamide results in increased expression of TGFB1 mRNA]11984526
D013853ThioacetamideLipopolysaccharides inhibits the reaction [Thioacetamide results in decreased expression of LEPR mRNA]17621560
D013853ThioacetamideThioacetamide results in decreased expression of LEPR mRNA17621560|2341159
D013853ThioacetamideThioacetamide results in decreased expression of LEPR protein17621560
C009495titanium dioxidetitanium dioxide results in decreased expression of LEPR mRNA23557971
D019772TopotecanLEPR protein affects the susceptibility to Topotecan16217747
D014241TrichloroethyleneTrichloroethylene results in increased expression of LEPR mRNA25549359
C012589trichostatin Atrichostatin A results in decreased expression of LEPR22560341
C012589trichostatin Atrichostatin A results in decreased expression of LEPR mRNA24935251
C009560trigonellineLEPR affects the abundance of trigonelline20567778
C015559trimellitic anhydridetrimellitic anhydride results in decreased expression of LEPR mRNA19042947
C040533trimethyltin chloridetrimethyltin chloride results in increased expression of LEPR mRNA23000284
C005445triphenyl phosphate"ESR1 gene mutant form inhibits the reaction [[tris(1,3-dichloro-2-propyl)phosphate co-treated with triphenyl phosphate co-treated with Tritolyl Phosphates] results in increased expression of LEPR mRNA]"29112739
C005445triphenyl phosphate"[tris(1,3-dichloro-2-propyl)phosphate co-treated with triphenyl phosphate co-treated with Tritolyl Phosphates] results in increased expression of LEPR mRNA"29112739
C016805tris(1,3-dichloro-2-propyl)phosphate"ESR1 gene mutant form inhibits the reaction [[tris(1,3-dichloro-2-propyl)phosphate co-treated with triphenyl phosphate co-treated with Tritolyl Phosphates] results in increased expression of LEPR mRNA]"29112739
C016805tris(1,3-dichloro-2-propyl)phosphate"[tris(1,3-dichloro-2-propyl)phosphate co-treated with triphenyl phosphate co-treated with Tritolyl Phosphates] results in increased expression of LEPR mRNA"29112739
D014317Tritolyl Phosphates"ESR1 gene mutant form inhibits the reaction [[tris(1,3-dichloro-2-propyl)phosphate co-treated with triphenyl phosphate co-treated with Tritolyl Phosphates] results in increased expression of LEPR mRNA]"29112739
D014317Tritolyl Phosphates"[tris(1,3-dichloro-2-propyl)phosphate co-treated with triphenyl phosphate co-treated with Tritolyl Phosphates] results in increased expression of LEPR mRNA"29112739
D014635Valproic AcidValproic Acid affects the expression of LEPR mRNA25064622
D014635Valproic AcidValproic Acid affects the expression of LEPR mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of LEPR mRNA23179753|2493525
D014635Valproic AcidValproic Acid results in increased expression of LEPR mRNA24489787
D001335Vehicle EmissionsVehicle Emissions affects the methylation of LEPR gene25560391
D010205Pantothenic AcidLEPR affects the abundance of Pantothenic Acid20567778
D015032Zinc[Zinc deficiency co-treated with Ethanol] results in increased expression of LEPR mRNA24155903
D015032Zinc[LEPR gene mutant form results in increased susceptibility to Ethanol] which results in decreased abundance of Zinc15475485
D015054ZymosanLEPR protein affects the susceptibility to Zymosan15142272

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004888transmembrane signaling receptor activity-TAS9537324  
GO:0004896cytokine receptor activity-IBA21873635  
GO:0005515protein binding-IPI11279102  17474147  18042720  19910644  
GO:0017046peptide hormone binding-IBA21873635  
GO:0019955cytokine binding-IBA21873635  
GO:0038021leptin receptor activity-ISS-  
GO:0042802identical protein binding-IPI16116438  
GO ID GO Term Qualifier Evidence PubMed
GO:0001525angiogenesis-IMP21771332  
GO:0006112energy reserve metabolic process-TAS9537324  
GO:0006909phagocytosis-IEA-  
GO:0007166cell surface receptor signaling pathway-TAS9537324  
GO:0007275multicellular organism development-TAS9537324  
GO:0008203cholesterol metabolic process-IEA-  
GO:0010507negative regulation of autophagy-IDA25060689  
GO:0019953sexual reproduction-ISS-  
GO:0030217T cell differentiation-ISS-  
GO:0033210leptin-mediated signaling pathway-IBA21873635  
GO:0033210leptin-mediated signaling pathway-ISS-  
GO:0042593glucose homeostasis-ISS-  
GO:0044320cellular response to leptin stimulus-IBA21873635  
GO:0044321response to leptin-ISS-  
GO:0045721negative regulation of gluconeogenesis-IEA-  
GO:0046850regulation of bone remodeling-ISS-  
GO:0051346negative regulation of hydrolase activity-IEA-  
GO:0060259regulation of feeding behavior-ISS-  
GO:0097009energy homeostasis-ISS-  
GO:0098868bone growth-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-IEA-  
GO:0009897external side of plasma membrane-IBA21873635  
GO:0016021integral component of membrane-IEA-  
GO:0016323basolateral plasma membrane-IEA-  
GO:0043235receptor complex-IBA21873635  
GO:0043235receptor complex-IDA23382219  
KEGG ID KEGG Term
hsa04060Cytokine-cytokine receptor interaction
hsa04080Neuroactive ligand-receptor interaction
hsa04630Jak-STAT signaling pathway
hsa04920Adipocytokine signaling pathway
Reactome ID Reactome Term Evidence
R-HSA-162582Signal TransductionIEA
R-HSA-2586552Signaling by LeptinIEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
25714446Sex, age and smoking, but not genetic variation in LEPR (rs1137101), are associated with depressive symptoms. (2015 Jun)Reis TCPsychiatr Genet
28386678Identification of novel potential genetic predictors of urothelial bladder carcinoma susceptibility in Pakistani population. (2017 Oct)Ali SHBFam Cancer
25438524[Interaction of polymorphisms of Leptin receptor gene Gln223Arg, MnSOD9Ala/Val genes and smoking in nonalcoholic fatty liver disease]. (2014 Sep)Zhang CWei Sheng Yan Jiu
20585554On the use of variance per genotype as a tool to identify quantitative trait interaction effects: a report from the Women's Genome Health Study. (2010 Jun 17)Pare GPLoS Genet
12075579Genetic factors as predictors of weight gain in young adult Dutch men and women. (2002 Apr)van Rossum CTInt J Obes Relat Metab Disord
29312594Investigation of TCF7L2, LEP and LEPR polymorphisms with esophageal squamous cell carcinomas. (2017 Dec 12)Qiu HOncotarget
23875062The methylation of the LEPR/LEPROT genotype at the promoter and body regions influence concentrations of leptin in girls and BMI at age 18 years if their mother smoked during pregnancy. (2013)Yousefi MInt J Mol Epidemiol Genet
24570271The association between genetic variants of RUNX2, ADIPOQ and vertebral fracture in Korean postmenopausal women. (2015 Mar)Kim KCJ Bone Miner Metab
17243864Leptin receptor genotype at Gln223Arg is associated with body composition, BMD, and vertebral fracture in postmenopausal Danish women. (2007 Apr)Fairbrother ULJ Bone Miner Res
19562039Targeting 160 candidate genes for blood pressure regulation with a genome-wide genotyping array. (2009 Jun 29)Sober SPLoS One
20874424Leptin receptor Lys109Arg and Gln223Arg polymorphisms are associated with early atherosclerosis. (2010 Oct)Saukko MMetab Syndr Relat Disord
23054017The joint effect of cigarette smoking and polymorphisms on LRP5, LEPR, near MC4R and SH2B1 genes on metabolic syndrome susceptibility in Taiwan. (2013 Jan)Yang CWMol Biol Rep
23593308The leptin gene family and colorectal cancer: interaction with smoking behavior and family history of cancer. (2013)Liu LPLoS One
24140454Leptin receptor Arg109 homozygotes display decreased total mortality as well as lower incidence of cardiovascular disease and related death. (2014 Jan 15)Aijala MGene
24772364Leptin Receptor Gene Gln223Arg Polymorphism Is Not Associated with Hypertension: A Preliminary Population-Based Cross-Sectional Study. (2014)Pena GdCardiol Res Pract
27703650Genetic Variations in Leptin and Leptin Receptor and Susceptibility to Colorectal Cancer and Obesity. (2016 Jun)Mahmoudi TIran J Cancer Prev
17031518Effect of genetic variation in the leptin gene promoter and the leptin receptor gene on obesity risk in a population-based case-control study in Spain. (2006)Portoles OEur J Epidemiol
24834182Association of leptin receptor gene Gln223Arg polymorphism with susceptibility to colorectal cancer. (2011 Fall)Karimi KGastroenterol Hepatol Bed Bench
16343040Changes in placental adipocytokine gene expression associated with gestational diabetes mellitus. (2006)Meller MPhysiol Res