Gene: LGALS3

3958
CBP35|GAL3|GALBP|GALIG|L31|LGALS2|MAC2
galectin 3
protein-coding
14q22.3
Ensembl:ENSG00000131981 MIM:153619 Vega:OTTHUMG00000171030 UniprotKB:P17931
NG_017089.1
PubMed
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
3.218e-1 (AD)  8.570e-3 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
GNG50.913
VIM0.905
CNN30.899
RHOC0.896
TMBIM10.887
RAB340.886
PTTG1IP0.876
LRP100.873
RAB130.87
VAMP50.869

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CALHM1-0.591
GPR61-0.572
SLC7A4-0.572
GPR179-0.565
GABRG3-0.564
XKR4-0.56
PPEF1-0.559
ABCC12-0.558
AGMAT-0.553
HTR6-0.546

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB018272,3,5,6-Tetrafluoro-4-Methoxy-BenzamideSmall MoleculeExperimentalTarget
DB04465LactoseSmall Molecule63-42-3Approved|InvestigationalTarget
ID Drug Name Action PubMed
C0264861,2,5,6-dibenzanthracene"1,2,5,6-dibenzanthracene results in increased expression of LGALS3 mRNA"16269432
C0493251,2-dithiol-3-thione"1,2-dithiol-3-thione results in decreased expression of LGALS3 mRNA"19162173
C5486512-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in increased expression of LGALS3 mRNA19933214
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of LGALS3 mRNA"19114083
C0859112-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in increased expression of and affects the localization of LGALS3 protein21821001
C0859112-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one"4-benzyl-2-methyl-1,2,4-thiadiazolidine-3,5-dione inhibits the reaction [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in increased expression of LGALS3 protein]"21821001
C0859112-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-oneCycloheximide inhibits the reaction [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in increased expression of LGALS3 protein]21821001
C0859112-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-oneDactinomycin inhibits the reaction [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in increased expression of LGALS3 protein]21821001
C0859112-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-oneGSK3B mutant form inhibits the reaction [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in increased expression of LGALS3 protein]21821001
C0859112-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-oneLGALS3 inhibits the reaction [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in increased degradation of BCL2L1 protein]21821001
C0859112-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-oneLGALS3 inhibits the reaction [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in increased degradation of MCL1 protein]21821001
C0859112-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-oneLGALS3 results in decreased susceptibility to 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one21821001
C0235142,6-dinitrotoluene"2,6-dinitrotoluene results in increased expression of LGALS3 mRNA"20406850
C0194992-nitrofluorene2-nitrofluorene results in increased expression of LGALS3 mRNA15890375
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of LGALS3 mRNA"23196670
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in increased expression of LGALS3 mRNA"20959002
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of LGALS3 mRNA"25380136
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of LGALS3 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of LGALS3 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of LGALS3 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of LGALS3 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of LGALS3 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of LGALS3 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of LGALS3 mRNA"27188386
C4943564-benzyl-2-methyl-1,2,4-thiadiazolidine-3,5-dione"4-benzyl-2-methyl-1,2,4-thiadiazolidine-3,5-dione inhibits the reaction [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in increased expression of LGALS3 protein]"21821001
C4943564-benzyl-2-methyl-1,2,4-thiadiazolidine-3,5-dione"4-benzyl-2-methyl-1,2,4-thiadiazolidine-3,5-dione inhibits the reaction [Cisplatin results in increased expression of LGALS3 protein]"21821001
C4943564-benzyl-2-methyl-1,2,4-thiadiazolidine-3,5-dione"4-benzyl-2-methyl-1,2,4-thiadiazolidine-3,5-dione inhibits the reaction [N-acetylsphingosine results in increased expression of LGALS3 protein]"21821001
C0185114-dichlorobenzene4-dichlorobenzene results in increased expression of LGALS3 mRNA26975756
C0165834-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of LGALS3 mRNA15890375
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of LGALS3 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of LGALS3 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of LGALS3 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of LGALS3 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of LGALS3 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of LGALS3 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of LGALS3 mRNA"27188386
C0207389,10-dihydro-9,10-dihydroxybenzo(a)pyrene"9,10-dihydro-9,10-dihydroxybenzo(a)pyrene results in increased expression of LGALS3 mRNA"26238291
D000082AcetaminophenAcetaminophen results in decreased expression of LGALS3 mRNA26690555
D000082AcetaminophenAcetaminophen affects the expression of LGALS3 mRNA17562736
D000082AcetaminophenAcetaminophen results in increased expression of LGALS3 mRNA22461450
D000082AcetaminophenAcetaminophen results in increased expression of LGALS3 protein22461450
D000082AcetaminophenLGALS3 protein affects the reaction [Acetaminophen results in increased expression of CCL20 mRNA]22461450
D000082AcetaminophenLGALS3 protein affects the reaction [Acetaminophen results in increased expression of CXCL2 mRNA]22461450
D000082AcetaminophenLGALS3 protein affects the reaction [Acetaminophen results in increased expression of LCN2 mRNA]22461450
D000082AcetaminophenLGALS3 protein affects the reaction [Acetaminophen results in increased expression of MMP9 mRNA]22461450
D000082AcetaminophenLGALS3 protein affects the reaction [Acetaminophen results in increased expression of NOS2 protein]22461450
D000082AcetaminophenLGALS3 protein affects the reaction [Acetaminophen results in increased expression of SLC3A2 mRNA]22461450
D000082AcetaminophenLGALS3 protein affects the reaction [Acetaminophen results in increased expression of TNFRSF1A mRNA]22461450
D000082AcetaminophenLGALS3 protein affects the susceptibility to Acetaminophen22461450
D000082AcetaminophenTNFRSF1A protein affects the reaction [Acetaminophen results in increased expression of LGALS3 mRNA]22461450
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of LGALS3 mRNA27153756
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of LGALS3 mRNA19770486
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of LGALS3 mRNA15890375
D000517alpha-Chlorohydrinalpha-Chlorohydrin results in decreased expression of LGALS3 mRNA28522335
D000643Ammonium ChlorideAmmonium Chloride affects the expression of LGALS3 mRNA16483693
C059765amphotericin B, deoxycholate drug combination"amphotericin B, deoxycholate drug combination results in increased expression of LGALS3 mRNA"22863853
C006632arsenic trioxidearsenic trioxide results in increased expression of LGALS3 mRNA20458559
D001205Ascorbic AcidAscorbic Acid results in increased expression of LGALS3 mRNA15372504
C006703benzo(b)fluoranthenebenzo(b)fluoranthene results in increased expression of LGALS3 mRNA16269432
D019324beta-Naphthoflavonebeta-Naphthoflavone results in increased expression of LGALS3 mRNA19737606
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of LGALS3 mRNA16269432|2010694
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of LGALS3 protein18495319
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of LGALS3 mRNA22228805|2373587
D004958Estradiol[Estradiol co-treated with Bucladesine co-treated with Medroxyprogesterone Acetate] results in decreased expression of LGALS3 mRNA20823114
D004958Estradiol[Estradiol co-treated with Progesterone] results in decreased expression of LGALS3 mRNA20660070
D004958EstradiolEstradiol affects the expression of LGALS3 mRNA15598610
D004958EstradiolEstradiol results in increased expression of LGALS3 mRNA15289156
C095105bexarotenebexarotene results in decreased expression of LGALS3 mRNA16648578
D001629BezafibrateBezafibrate results in increased expression of LGALS3 mRNA17118139
C542674bis((2-oxindol-3-ylimino)-2-(2-aminoethyl)pyridine-N,N')copper(II)"LGALS3 protein promotes the reaction [bis((2-oxindol-3-ylimino)-2-(2-aminoethyl)pyridine-N,N')copper(II) results in increased abundance of Reactive Oxygen Species]"23994248
C542674bis((2-oxindol-3-ylimino)-2-(2-aminoethyl)pyridine-N,N')copper(II)"LGALS3 protein results in increased susceptibility to bis((2-oxindol-3-ylimino)-2-(2-aminoethyl)pyridine-N,N')copper(II)"23994248
C543008bis(4-hydroxyphenyl)sulfonebis(4-hydroxyphenyl)sulfone results in decreased expression of LGALS3 mRNA25912373
C006780bisphenol Abisphenol A results in increased expression of LGALS3 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of LGALS3 gene28505145
D001761BleomycinBleomycin results in increased expression of LGALS3 protein26526764
D001761BleomycinNOS2 protein affects the reaction [Bleomycin results in increased expression of LGALS3 protein]26526764
D002065BuspironeBuspirone results in decreased expression of LGALS3 mRNA24136188
D002101Cacodylic AcidCacodylic Acid results in increased expression of LGALS3 mRNA16122865
D019256Cadmium ChlorideCadmium Chloride affects the expression of LGALS3 mRNA22110744
D019256Cadmium ChlorideCadmium Chloride results in increased expression of LGALS3 mRNA25993096
C059041calyculin Acalyculin A results in increased expression of LGALS3 mRNA25270620
D002251Carbon TetrachlorideCarbon Tetrachloride affects the expression of LGALS3 mRNA17484886
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of LGALS3 mRNA16549783|2379856
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of LGALS3 protein16549783
D002251Carbon TetrachlorideLGALS3 gene mutant form inhibits the reaction [Carbon Tetrachloride results in increased expression of ACTA2 mRNA]16549783
D002251Carbon TetrachlorideLGALS3 gene mutant form inhibits the reaction [Carbon Tetrachloride results in increased expression of ACTA2 protein]16549783
D002251Carbon TetrachlorideMGAT5 protein affects the reaction [Carbon Tetrachloride results in increased expression of LGALS3 mRNA]23798564
D002251Carbon TetrachlorideCarbon Tetrachloride affects the expression of LGALS3 mRNA12734012
D002251Carbon TetrachlorideCarbon Tetrachloride promotes the reaction [PURB protein binds to LGALS3 promoter]16309856
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of LGALS3 mRNA17522070
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of LGALS3 protein12629582|1654978
D002509CephaloridineCephaloridine results in increased expression of LGALS3 mRNA18500788
D002725ChloroformChloroform results in increased expression of LGALS3 mRNA17522070
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of LGALS3 mRNA20938992
C039671ciglitazone[ciglitazone binds to PPARG protein] which results in increased expression of LGALS3 mRNA16197558
D002994ClofibrateClofibrate results in increased expression of LGALS3 mRNA17585979
D003033Coal TarCoal Tar results in increased expression of LGALS3 protein18495319
C018021cobaltous chloridecobaltous chloride results in increased expression of LGALS3 mRNA24386269
D019327Copper SulfateCopper Sulfate results in increased expression of LGALS3 mRNA19549813
D003471CuprizoneCuprizone results in increased expression of LGALS3 mRNA26577399|2752363
C057862cyanoginosin LRcyanoginosin LR results in increased expression of LGALS3 mRNA17654400
D003513CycloheximideCycloheximide inhibits the reaction [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in increased expression of LGALS3 protein]21821001
D016572CyclosporineCyclosporine results in increased expression of LGALS3 mRNA25562108|2798913
D003609DactinomycinDactinomycin inhibits the reaction [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in increased expression of LGALS3 protein]21821001
C014347decitabinedecitabine results in increased expression of LGALS3 mRNA19194470
D003907Dexamethasone[GCS-100 co-treated with Dexamethasone] results in decreased expression of LGALS3 protein16166312
D003907DexamethasoneDexamethasone results in decreased expression of LGALS3 mRNA17522070
C041517dibenzo(a,l)pyrene"dibenzo(a,l)pyrene results in increased expression of LGALS3 protein"18495319
D003994Bucladesine[Estradiol co-treated with Bucladesine co-treated with Medroxyprogesterone Acetate] results in decreased expression of LGALS3 mRNA20823114
D002945Cisplatin"4-benzyl-2-methyl-1,2,4-thiadiazolidine-3,5-dione inhibits the reaction [Cisplatin results in increased expression of LGALS3 protein]"21821001
D002945CisplatinCisplatin results in increased expression of LGALS3 mRNA27392435
D002945CisplatinCisplatin results in increased expression of LGALS3 protein21821001
D002945CisplatinGSK3B mutant form inhibits the reaction [Cisplatin results in increased expression of LGALS3 protein]21821001
D002945CisplatinLGALS3 inhibits the reaction [Cisplatin results in increased degradation of BCL2L1 protein]21821001
D002945CisplatinLGALS3 inhibits the reaction [Cisplatin results in increased degradation of MCL1 protein]21821001
D002945CisplatinLGALS3 protein mutant form results in decreased susceptibility to Cisplatin21750908
D002945CisplatinLGALS3 results in decreased susceptibility to Cisplatin21821001
D004008DiclofenacDiclofenac results in increased expression of LGALS3 mRNA26934552
C000944dicrotophosdicrotophos results in decreased expression of LGALS3 mRNA28302478
D004041Dietary FatsDietary Fats affects the expression of LGALS3 mRNA19680557
D004041Dietary FatsDietary Fats results in decreased expression of LGALS3 mRNA18042831|2501614
D004041Dietary FatsDietary Fats results in increased expression of LGALS3 mRNA22609946
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with Phenobarbital] results in increased expression of LGALS3 mRNA24535843
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with Thioacetamide] results in increased expression of LGALS3 mRNA28943392
D004052DiethylnitrosamineDiethylnitrosamine results in increased expression of LGALS3 mRNA19638242
D004054DiethylstilbestrolDiethylstilbestrol results in increased expression of LGALS3 mRNA15289156
D004054DiethylstilbestrolDiethylstilbestrol results in increased expression of LGALS3 mRNA15890375
D002117CalcitriolCalcitriol results in decreased expression of LGALS3 mRNA12875902
D0151279,10-Dimethyl-1,2-benzanthracene"9,10-Dimethyl-1,2-benzanthracene affects the expression of LGALS3 mRNA"21785161
D004128DimethylnitrosamineDimethylnitrosamine results in increased expression of LGALS3 mRNA17547211
D004128DimethylnitrosamineDimethylnitrosamine results in increased expression of LGALS3 mRNA15890375|2538013
D004237DiuronDiuron results in increased expression of LGALS3 mRNA21551480
D004317DoxorubicinLGALS3 mRNA results in decreased susceptibility to Doxorubicin16322897
C118739entinostatentinostat results in increased expression of LGALS3 mRNA26272509
C118739entinostat"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of LGALS3 mRNA"27188386
D004918Erythromycin EstolateErythromycin Estolate results in increased expression of LGALS3 mRNA17522070
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of LGALS3 mRNA17557909
D005038EthylnitrosoureaEthylnitrosourea results in increased expression of LGALS3 mRNA15954086
D005047EtoposideLGALS3 protein affects the susceptibility to Etoposide16217747
C540355fenamidonefenamidone results in increased expression of LGALS3 mRNA27029645
D005472FluorouracilLGALS3 protein affects the susceptibility to Fluorouracil16217747
D005472FluorouracilLGALS3 protein mutant form results in decreased susceptibility to Fluorouracil21750908
D005480FlurbiprofenFlurbiprofen results in increased expression of LGALS3 mRNA16949054
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of LGALS3 mRNA20938992
D005492Folic AcidFolic Acid results in increased expression of LGALS3 mRNA10980121
C505531GCS-100[GCS-100 co-treated with Dexamethasone] results in decreased expression of LGALS3 protein16166312
D019833GenisteinGenistein results in increased expression of LGALS3 mRNA15289156
D005897GlafenineGlafenine results in increased expression of LGALS3 mRNA24136188
D017313FenretinideFenretinide results in decreased expression of LGALS3 mRNA28973697
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of LGALS3 mRNA25613284
D007545IsoproterenolIsoproterenol results in increased expression of LGALS3 mRNA20003209
C410337K 7174K 7174 results in increased expression of LGALS3 mRNA24086573
D048628KetolidesKetolides analog results in increased expression of LGALS3 mRNA24967691
D007785LactoseLactose binds to LGALS3 protein17385862
C045463leflunomideleflunomide results in increased expression of LGALS3 mRNA28988120
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in increased expression of LGALS3 mRNA"24972896
D008070LipopolysaccharidesLipopolysaccharides results in decreased expression of LGALS3 mRNA25613284
D017258Medroxyprogesterone Acetate[Estradiol co-treated with Bucladesine co-treated with Medroxyprogesterone Acetate] results in decreased expression of LGALS3 mRNA20823114
D008543MelaninsLGALS3 protein results in increased abundance of Melanins23994248
C042720mercuric bromidemercuric bromide results in increased expression of LGALS3 mRNA26272509
C042720mercuric bromide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of LGALS3 mRNA"27188386
D008701MethapyrileneMethapyrilene results in increased expression of LGALS3 mRNA15890375
D008713MethimazoleMethimazole results in increased expression of LGALS3 mRNA20144635
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of LGALS3 mRNA20938992
D008731MethoxychlorMethoxychlor results in increased methylation of LGALS3 gene23303685
D008748MethylcholanthreneMethylcholanthrene results in increased expression of LGALS3 mRNA20713471
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of LGALS3 mRNA23179753
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of LGALS3 mRNA28001369
D008769Methylnitronitrosoguanidine[Methylnitronitrosoguanidine co-treated with Tetradecanoylphorbol Acetate] results in increased expression of LGALS3 mRNA19840844
D008770MethylnitrosoureaMethylnitrosourea results in decreased expression of LGALS3 mRNA25270620
D015735MifepristoneMifepristone results in decreased expression of LGALS3 mRNA25972201
D016685MitomycinLGALS3 protein affects the susceptibility to Mitomycin16217747
C523799MRK 003LGALS3 results in increased susceptibility to MRK 00319903844
C064769N-acetylsphingosine"4-benzyl-2-methyl-1,2,4-thiadiazolidine-3,5-dione inhibits the reaction [N-acetylsphingosine results in increased expression of LGALS3 protein]"21821001
C064769N-acetylsphingosineGSK3B mutant form inhibits the reaction [N-acetylsphingosine results in increased expression of LGALS3 protein]21821001
C064769N-acetylsphingosineLGALS3 inhibits the reaction [N-acetylsphingosine results in increased degradation of BCL2L1 protein]21821001
C064769N-acetylsphingosineLGALS3 inhibits the reaction [N-acetylsphingosine results in increased degradation of MCL1 protein]21821001
C064769N-acetylsphingosineLGALS3 results in decreased susceptibility to N-acetylsphingosine21821001
C064769N-acetylsphingosineN-acetylsphingosine results in increased expression of LGALS3 protein21821001
D009270NaloxoneNaloxone results in increased expression of LGALS3 mRNA17522070
D037742Nanotubes, Carbon"Nanotubes, Carbon affects the expression of LGALS3 mRNA"23845593
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of LGALS3 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of LGALS3 mRNA"25554681|2710602
D0150581-Naphthylisothiocyanate1-Naphthylisothiocyanate results in increased expression of LGALS3 mRNA17522070|2538013
D009532NickelNickel results in increased expression of LGALS3 mRNA12540486
C028007nickel monoxidenickel monoxide results in increased expression of LGALS3 mRNA19167457
C017557nickel subsulfidenickel subsulfide results in increased expression of LGALS3 mRNA21086188
C029938nickel sulfatenickel sulfate results in decreased expression of LGALS3 mRNA18651567
C029938nickel sulfatenickel sulfate affects the expression of LGALS3 mRNA12718980
C002741N-nitrosomorpholineN-nitrosomorpholine results in increased expression of LGALS3 mRNA19716841
C025256nonylphenolnonylphenol results in increased expression of LGALS3 protein16054331
C018620oleoresinsoleoresins results in decreased expression of LGALS3 mRNA20008804
D010098OxycodoneOxycodone results in decreased expression of LGALS3 mRNA23439660
D010100OxygenOxygen deficiency results in increased expression of LGALS3 mRNA17193925
D010100OxygenOxygen results in increased expression of LGALS3 mRNA22911455
D010126OzoneOzone results in increased expression of LGALS3 protein22727909
D000073878Palm OilPalm Oil affects the expression of LGALS3 mRNA19680557
D000073878Palm OilPalm Oil results in decreased expression of LGALS3 mRNA18042831
C496932panobinostat"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of LGALS3 mRNA"27188386
C496932panobinostatpanobinostat results in increased expression of LGALS3 mRNA26272509
C016030pantogabpantogab results in increased expression of LGALS3 mRNA17379144
D010269ParaquatParaquat results in increased expression of LGALS3 protein24521700
C086401pentabromodiphenyl etherpentabromodiphenyl ether results in increased expression of LGALS3 mRNA26705709
C101814perfluoro-n-undecanoic acidperfluoro-n-undecanoic acid results in decreased expression of LGALS3 mRNA23602845
C023036perfluorooctanoic acidperfluorooctanoic acid results in increased expression of LGALS3 protein26879310
D010615PhenacetinPhenacetin results in increased expression of LGALS3 mRNA17082564|1769850
D010634Phenobarbital[Diethylnitrosamine co-treated with Phenobarbital] results in increased expression of LGALS3 mRNA24535843
D010634PhenobarbitalNR1I3 protein affects the reaction [Phenobarbital results in increased expression of LGALS3 mRNA]19482888
D010634PhenobarbitalPhenobarbital results in increased expression of LGALS3 mRNA19482888
D010634PhenobarbitalPhenobarbital results in increased expression of LGALS3 mRNA19162173
C030299phenylhydrazinephenylhydrazine results in increased expression of LGALS3 mRNA17082564|1769850
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of LGALS3 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of LGALS3 mRNA26272509
D010705PhosgenePhosgene affects the expression of LGALS3 mRNA16300373
D010882Piperonyl ButoxidePiperonyl Butoxide results in increased expression of LGALS3 mRNA15890375
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of LGALS3 mRNA19710929
C006253pirinixic acidpirinixic acid results in increased expression of LGALS3 mRNA17118139
C006253pirinixic acidpirinixic acid results in increased expression of LGALS3 mRNA15890375
D010936Plant ExtractsPlant Extracts results in decreased expression of LGALS3 protein25882088
D011134PolysaccharidesPolysaccharides results in decreased expression of LGALS3 protein25882088
D011192Potassium DichromatePotassium Dichromate results in increased expression of LGALS3 protein23718831
D011374ProgesteroneProgesterone affects the expression of LGALS3 mRNA23012394
D011374Progesterone[Estradiol co-treated with Progesterone] results in decreased expression of LGALS3 mRNA20660070
D011374ProgesteroneLGALS3 protein affects the metabolism of Progesterone17242467
D011374ProgesteroneProgesterone results in increased expression of LGALS3 mRNA19690047
D011441PropylthiouracilPropylthiouracil results in increased expression of LGALS3 mRNA24780913
C513428pyrachlostrobinpyrachlostrobin results in increased expression of LGALS3 mRNA27029645
D011794QuercetinQuercetin results in increased expression of LGALS3 mRNA21632981
C037219quinolinequinoline analog results in increased expression of LGALS3 protein18645022
D015125OxyquinolineOxyquinoline results in decreased expression of LGALS3 mRNA21632981
D017382Reactive Oxygen Species"LGALS3 protein promotes the reaction [bis((2-oxindol-3-ylimino)-2-(2-aminoethyl)pyridine-N,N')copper(II) results in increased abundance of Reactive Oxygen Species]"23994248
D017382Reactive Oxygen SpeciesLGALS3 protein results in increased abundance of Reactive Oxygen Species23994248
C059514resveratrol[resveratrol co-treated with Streptozocin] results in increased expression of LGALS3 mRNA25905778
C059514resveratrolresveratrol results in increased expression of LGALS3 mRNA25905778
D012402RotenoneRotenone results in increased expression of LGALS3 mRNA27900601
C541923sandostatinLARsandostatinLAR results in increased expression of LGALS3 mRNA17210224
D012715Sesame OilSesame Oil results in decreased expression of LGALS3 mRNA29191790
D012822Silicon DioxideSilicon Dioxide results in increased expression of LGALS3 mRNA23221170
D012822Silicon DioxideSilicon Dioxide results in increased expression of LGALS3 mRNA21602193|2243100
C016104sodium bichromatesodium bichromate results in increased expression of LGALS3 mRNA25993096
D012969Sodium FluorideSodium Fluoride results in decreased expression of LGALS3 protein28918527
D053260SootSoot results in increased expression of LGALS3 mRNA22461453
D013311Streptozocin[resveratrol co-treated with Streptozocin] results in increased expression of LGALS3 mRNA25905778
D013311StreptozocinStreptozocin results in increased expression of LGALS3 mRNA16684804
D013311Streptozocinvanadyl sulfate inhibits the reaction [Streptozocin results in increased expression of LGALS3 mRNA]16684804
D013467SulindacSulindac inhibits the reaction [CDKN1A protein results in increased expression of LGALS3 mRNA]15190207
C013698tallowtallow affects the expression of LGALS3 mRNA19680557
D013629TamoxifenTamoxifen affects the expression of LGALS3 mRNA14699072
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of LGALS3 mRNA11489354|2010694
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of LGALS3 mRNA21570461|2637764
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of LGALS3 mRNA20159946
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of LGALS3 mRNA17035482|1733744
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of LGALS3 mRNA22298810
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of LGALS3 mRNA20959002|2121527
D013752TetracyclineTetracycline results in increased expression of LGALS3 mRNA17522070
D013755Tetradecanoylphorbol Acetate[Methylnitronitrosoguanidine co-treated with Tetradecanoylphorbol Acetate] results in increased expression of LGALS3 mRNA19840844
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of LGALS3 mRNA25613284
D013806TheophyllineTheophylline results in increased expression of LGALS3 mRNA17522070
D013853ThioacetamideMGAT5 protein affects the reaction [Thioacetamide results in increased expression of LGALS3 mRNA]23798564
D013853ThioacetamideThioacetamide results in increased expression of LGALS3 mRNA23798564
D013853Thioacetamide[Diethylnitrosamine co-treated with Thioacetamide] results in increased expression of LGALS3 mRNA28943392
D013864ThioglycolatesLGALS3 protein affects the susceptibility to Thioglycolates10702423
C009495titanium dioxidetitanium dioxide results in increased expression of LGALS3 mRNA23409001|2355797
D014028Tobacco Smoke PollutionTobacco Smoke Pollution affects the expression of LGALS3 mRNA20133372
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of LGALS3 mRNA28111298
D014212TretinoinTretinoin results in decreased expression of LGALS3 mRNA12875902
D014212TretinoinTretinoin results in increased expression of LGALS3 mRNA23724009
D014212TretinoinTretinoin results in decreased expression of LGALS3 mRNA16604517
D014241TrichloroethyleneTrichloroethylene results in increased methylation of LGALS3 gene27618143
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of LGALS3 mRNA"27188386
C012589trichostatin Atrichostatin A results in increased expression of LGALS3 mRNA24935251|2627250
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of LGALS3 mRNA"26179874
C013320tris(2-butoxyethyl) phosphatetris(2-butoxyethyl) phosphate affects the expression of LGALS3 mRNA29024780
D014415TunicamycinTunicamycin results in increased expression of LGALS3 mRNA17127020
C406224valdecoxibvaldecoxib results in increased expression of LGALS3 mRNA24136188
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of LGALS3 mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of LGALS3 mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of LGALS3 mRNA19101580|2317975
D014635Valproic AcidValproic Acid affects the expression of LGALS3 mRNA17963808
C034028vanadyl sulfatevanadyl sulfate inhibits the reaction [Streptozocin results in increased expression of LGALS3 mRNA]16684804
D014640VancomycinVancomycin results in decreased expression of LGALS3 mRNA18930951
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of LGALS3 gene25560391
C025643vinclozolinvinclozolin affects the expression of LGALS3 mRNA19015723
C025643vinclozolinvinclozolin results in increased expression of LGALS3 mRNA23034163
C029297vinylidene chloridevinylidene chloride results in increased expression of LGALS3 mRNA26682919
C111237vorinostat"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of LGALS3 mRNA"27188386
C111237vorinostatvorinostat results in increased expression of LGALS3 mRNA26272509

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003723RNA binding-HDA22658674  
GO:0005515protein binding-IPI2402511  19016746  19706535  20812334  21712812  24945728  
25315772  25416956  
GO:0019863IgE binding-IDA2261464  
GO:0030246carbohydrate binding-IEA-  
GO:0042056chemoattractant activity-IDA10925302  
GO:0043236laminin binding-IDA2402511  
GO ID GO Term Qualifier Evidence PubMed
GO:0002548monocyte chemotaxis-IDA10925302  
GO:0006397mRNA processing-IEA-  
GO:0008380RNA splicing-IEA-  
GO:0030593neutrophil chemotaxis-IDA10925302  
GO:0030855epithelial cell differentiation-IEP21492153  
GO:0042129regulation of T cell proliferation-IMP8692888  
GO:0043312neutrophil degranulation-TAS-  
GO:0045087innate immune response-IEA-  
GO:0045637regulation of myeloid cell differentiation-TAS-  
GO:0045806negative regulation of endocytosis-IDA19706535  
GO:0048245eosinophil chemotaxis-IDA10925302  
GO:0048246macrophage chemotaxis-IDA10925302  
GO:0050860negative regulation of T cell receptor signaling pathway-ISS19706535  
GO:0050918positive chemotaxis-IDA10925302  
GO:0070232regulation of T cell apoptotic process-IDA8692888  
GO:0071674mononuclear cell migration-IDA10925302  
GO:0071677positive regulation of mononuclear cell migration-IDA10925302  
GO:0090280positive regulation of calcium ion import-IDA10925302  
GO:1902041regulation of extrinsic apoptotic signaling pathway via death domain receptors-IMP8692888  
GO:2000521negative regulation of immunological synapse formation-ISS19706535  
GO:2001189negative regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell-ISS19706535  
GO:2001200positive regulation of dendritic cell differentiationNOTIDA16116184  
GO:2001237negative regulation of extrinsic apoptotic signaling pathway-IDA22761016  
GO ID GO Term Qualifier Evidence PubMed
GO:0001772immunological synapse-IDA19706535  
GO:0005576extracellular region-HDA27068509  
GO:0005615extracellular space-HDA22664934  23580065  
GO:0005634nucleus-IDA7682704  14961764  22761016  
GO:0005681spliceosomal complex-IEA-  
GO:0005737cytoplasm-IDA9447709  14961764  22761016  
GO:0005743mitochondrial inner membrane-IDA19016746  
GO:0005886plasma membrane-TAS-  
GO:0016020membrane-HDA19946888  
GO:0030667secretory granule membrane-TAS-  
GO:0062023collagen-containing extracellular matrix-HDA27559042  
GO:0062023collagen-containing extracellular matrixcolocalizes_withHDA20551380  
GO:0070062extracellular exosome-HDA19056867  19199708  23533145  
GO:0101003ficolin-1-rich granule membrane-TAS-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-168249Innate Immune SystemTAS
R-HSA-168249Innate Immune SystemIEA
R-HSA-168256Immune SystemTAS
R-HSA-168256Immune SystemIEA
R-HSA-212436Generic Transcription PathwayTAS
R-HSA-6798695Neutrophil degranulationTAS
R-HSA-73857RNA Polymerase II TranscriptionTAS
R-HSA-74160Gene expression (Transcription)TAS
R-HSA-879415Advanced glycosylation endproduct receptor signalingIEA
R-HSA-8878166Transcriptional regulation by RUNX2TAS
R-HSA-8878171Transcriptional regulation by RUNX1TAS
R-HSA-8939246RUNX1 regulates transcription of genes involved in differentiation of myeloid cellsTAS
R-HSA-8941333RUNX2 regulates genes involved in differentiation of myeloid cellsTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
27142338Prostate tumor DNA methylation is associated with cigarette smoking and adverse prostate cancer outcomes. (2016 Jul 15)Shui IMCancer