Gene: LGALS3BP

3959
90K|BTBD17B|CyCAP|M2BP|MAC-2-BP|TANGO10B|gp90
galectin 3 binding protein
protein-coding
17q25.3
Ensembl:ENSG00000108679 MIM:600626 Vega:OTTHUMG00000177572 UniprotKB:Q08380
NC_000017.11
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
3.290e-1 (AD)  2.965e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
IRF90.869
CYP27A10.866
TMEM179B0.843
RRBP10.835
VWA10.834
AGTRAP0.82
PMP220.813
NPC20.811
SCAMP20.811
DYNLT10.81

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.427
OR4F29-0.412
PRSS12-0.399
CDH7-0.397
HS6ST3-0.387
ABCC12-0.385
KCNH5-0.374
GABRG3-0.372
OPRD1-0.37
GPR26-0.369

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0297902,2',3',4,4',5-hexachlorobiphenyl"2,2',3',4,4',5-hexachlorobiphenyl results in decreased expression of LGALS3BP mRNA"23829299
C0094072,5,2',5'-tetrachlorobiphenyl"2,5,2',5'-tetrachlorobiphenyl results in decreased expression of LGALS3BP mRNA"23829299
C4734844-(2-bromo-6-pyrrolidin-1-ylpyridine-4-sulfonyl)phenylamine4-(2-bromo-6-pyrrolidin-1-ylpyridine-4-sulfonyl)phenylamine results in increased expression of LGALS3BP mRNA14610520
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of LGALS3BP mRNA"18648102
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of LGALS3BP mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of LGALS3BP mRNA"27188386
D000082AcetaminophenAcetaminophen results in decreased expression of LGALS3BP mRNA29067470
D000082AcetaminophenAcetaminophen affects the expression of LGALS3BP mRNA17562736
D020106AcrylamideAcrylamide affects the expression of LGALS3BP mRNA28959563
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of LGALS3BP mRNA27153756
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of LGALS3BP mRNA19770486
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of LGALS3BP mRNA22484513|2363061
D000643Ammonium ChlorideAmmonium Chloride affects the expression of LGALS3BP mRNA16483693
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of LGALS3BP mRNA24449571
C006632arsenic trioxidearsenic trioxide results in increased expression of LGALS3BP protein25419056
C006632arsenic trioxide[Tretinoin co-treated with arsenic trioxide] results in increased expression of LGALS3BP mRNA15894607
D001280AtrazineAtrazine results in decreased expression of LGALS3BP mRNA27655631
C547126AZM551248AZM551248 results in increased expression of LGALS3BP mRNA22323515
D019324beta-Naphthoflavone[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of LGALS3BP mRNA18164116
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of LGALS3BP mRNA26001963
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of LGALS3BP mRNA19770486
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of LGALS3BP mRNA23735875
C038328BEP protocolBEP protocol results in increased expression of LGALS3BP mRNA18987330
D004958Estradiol[Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of LGALS3BP mRNA19619570
D004958EstradiolEstradiol results in increased expression of LGALS3BP mRNA19619570|2118537
D004958EstradiolEstradiol results in increased expression of LGALS3BP mRNA15289156|1948475
D004958EstradiolEstradiol results in decreased expression of LGALS3BP mRNA20068009
C006780bisphenol Abisphenol A results in increased expression of LGALS3BP mRNA29275510
C006780bisphenol Abisphenol A results in increased methylation of LGALS3BP promoter27312807
C006780bisphenol Abisphenol A results in increased expression of LGALS3BP mRNA25181051
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in increased expression of LGALS3BP mRNA14729362
D019256Cadmium ChlorideCadmium Chloride results in increased expression of LGALS3BP mRNA25993096
D002251Carbon TetrachlorideCarbon Tetrachloride results in decreased expression of LGALS3BP mRNA16239168
C019304ciprofibrateciprofibrate results in increased expression of LGALS3BP mRNA12771043
C423222cotylenin Acotylenin A results in increased expression of LGALS3BP mRNA16129123
D003471CuprizoneCuprizone results in increased expression of LGALS3BP mRNA26577399|2752363
C057862cyanoginosin LRcyanoginosin LR results in increased expression of LGALS3BP mRNA17654400
D016572CyclosporineCyclosporine results in decreased expression of LGALS3BP mRNA20106945|2556210
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in increased expression of LGALS3BP mRNA27392435
D002945CisplatinCisplatin results in increased expression of LGALS3BP mRNA27392435
D002945Cisplatin[Piroxicam co-treated with Cisplatin] results in decreased expression of LGALS3BP mRNA21858171
D002945CisplatinCisplatin results in increased expression of LGALS3BP mRNA21151649
D004041Dietary FatsDietary Fats results in decreased expression of LGALS3BP mRNA18042831
C014476diethyl maleatediethyl maleate results in decreased expression of LGALS3BP mRNA21161181
D004052DiethylnitrosamineDiethylnitrosamine results in increased expression of LGALS3BP mRNA12771043
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of LGALS3BP mRNA18164116
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with Thioacetamide] results in increased expression of LGALS3BP mRNA28943392
D004052DiethylnitrosamineDiethylnitrosamine results in increased expression of LGALS3BP mRNA19638242
D004054DiethylstilbestrolDiethylstilbestrol results in increased expression of LGALS3BP mRNA15289156
D004791Enzyme Inhibitors[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of LGALS3BP protein23301498
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in increased expression of LGALS3BP mRNA22079256
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of LGALS3BP mRNA17557909
D005472FluorouracilLGALS3BP protein affects the susceptibility to Fluorouracil16217747
C039281furanfuran results in increased expression of LGALS3BP mRNA27387713
D019833GenisteinGenistein results in increased expression of LGALS3BP mRNA15289156
D005839GentamicinsGentamicins results in increased expression of LGALS3BP mRNA22061828
C010176halofuginonehalofuginone results in increased expression of LGALS3BP mRNA17180598
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of LGALS3BP mRNA25613284
C544151jinfukang[Cisplatin co-treated with jinfukang] results in increased expression of LGALS3BP mRNA27392435
C544151jinfukangjinfukang results in increased expression of LGALS3BP mRNA27392435
C098607JP8 aviation fuelJP8 aviation fuel results in decreased expression of LGALS3BP mRNA16835149
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of LGALS3BP mRNA23086925
C410337K 7174K 7174 results in decreased expression of LGALS3BP mRNA24086573
D007649KetamineKetamine results in increased expression of LGALS3BP mRNA20080153
D008070LipopolysaccharidesLipopolysaccharides results in decreased expression of LGALS3BP mRNA21461237
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of LGALS3BP mRNA27339419
D008774MethylphenidateMethylphenidate results in decreased expression of LGALS3BP mRNA22470460
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in increased expression of LGALS3BP mRNA24810058
C568376MT19c compoundMT19c compound results in decreased expression of LGALS3BP mRNA21781307
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of LGALS3BP mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of LGALS3BP mRNA"25554681
C028007nickel monoxidenickel monoxide results in increased expression of LGALS3BP mRNA19167457
C002741N-nitrosomorpholineN-nitrosomorpholine results in increased expression of LGALS3BP mRNA19716841
C558013NSC 689534NSC 689534 results in increased expression of LGALS3BP mRNA20971185
D000073878Palm OilPalm Oil results in decreased expression of LGALS3BP mRNA18042831
C410127PCB 180PCB 180 results in decreased expression of LGALS3BP mRNA23829299
D010416PentachlorophenolPentachlorophenol results in increased expression of LGALS3BP mRNA23892564
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of LGALS3BP protein26879310
D010634PhenobarbitalPhenobarbital results in decreased expression of LGALS3BP mRNA19162173
D010656PhenylephrinePhenylephrine results in decreased expression of LGALS3BP mRNA18158353
C006253pirinixic acidpirinixic acid results in increased expression of LGALS3BP mRNA23811191
D010894Piroxicam[Piroxicam co-treated with Cisplatin] results in decreased expression of LGALS3BP mRNA21858171
D028321Plant PreparationsPlant Preparations results in decreased expression of LGALS3BP protein28284660
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in increased expression of LGALS3BP mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in increased expression of LGALS3BP mRNA22079256
D011441PropylthiouracilPropylthiouracil results in increased expression of LGALS3BP mRNA24780913
C513428pyrachlostrobinpyrachlostrobin results in increased expression of LGALS3BP mRNA27029645
D011794QuercetinQuercetin results in decreased expression of LGALS3BP mRNA15309432
C488333Ro 65-7199Ro 65-7199 affects the expression of LGALS3BP mRNA14610520
D012822Silicon DioxideSilicon Dioxide analog affects the secretion of LGALS3BP protein25895662
D012834SilverSilver affects the expression of LGALS3BP mRNA27131904
D012906SmokeSmoke affects the expression of LGALS3BP mRNA23693141
C017947sodium arsenitesodium arsenite results in decreased expression of and affects the splicing of LGALS3BP mRNA25879800
C016104sodium bichromatesodium bichromate results in increased expression of LGALS3BP mRNA25993096
D012969Sodium FluorideSodium Fluoride results in decreased expression of LGALS3BP protein28918527
D012999SomanSoman results in increased expression of LGALS3BP mRNA19281266
D013467SulindacSulindac inhibits the reaction [CDKN1A protein results in increased expression of LGALS3BP mRNA]15190207
D013629TamoxifenTamoxifen results in increased expression of LGALS3BP mRNA19155303
D013629TamoxifenTamoxifen affects the expression of LGALS3BP mRNA20937368
D013749Tetrachlorodibenzodioxin[Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of LGALS3BP mRNA19619570
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of LGALS3BP mRNA19619570
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of LGALS3BP mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of LGALS3BP mRNA21215274
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of LGALS3BP mRNA25613284
D013849ThimerosalThimerosal results in decreased expression of LGALS3BP mRNA27188386
D013853Thioacetamide[Diethylnitrosamine co-treated with Thioacetamide] results in increased expression of LGALS3BP mRNA28943392
C009495titanium dioxidetitanium dioxide results in increased expression of LGALS3BP mRNA23557971|2776080
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of LGALS3BP mRNA28065790
D014028Tobacco Smoke PollutionTobacco Smoke Pollution affects the expression of LGALS3BP mRNA20133372
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of LGALS3BP mRNA28111298
D014118Toxins, Biological"Toxins, Biological affects the expression of LGALS3BP mRNA"19682533
D014212Tretinoin[Tretinoin co-treated with arsenic trioxide] results in increased expression of LGALS3BP mRNA15894607
D014212TretinoinTretinoin results in increased expression of LGALS3BP mRNA15894607|1612912
D014415TunicamycinTunicamycin results in decreased expression of LGALS3BP mRNA22378314
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of LGALS3BP mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of LGALS3BP mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of LGALS3BP mRNA23179753|2438349
D014635Valproic AcidValproic Acid results in increased methylation of LGALS3BP gene29154799
D014635Valproic AcidValproic Acid affects the expression of LGALS3BP mRNA17292431
D014640VancomycinVancomycin results in decreased expression of LGALS3BP mRNA18930951
C025643vinclozolinvinclozolin affects the expression of LGALS3BP mRNA19015723
C025643vinclozolinvinclozolin results in increased expression of LGALS3BP mRNA22570695
C029297vinylidene chloridevinylidene chloride results in increased expression of LGALS3BP mRNA26682919
C111237vorinostatvorinostat results in decreased expression of LGALS3BP mRNA27188386

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005044scavenger receptor activity-IEA-  
GO:0005515protein binding-IPI29162697  
GO ID GO Term Qualifier Evidence PubMed
GO:0002576platelet degranulation-TAS-  
GO:0006898receptor-mediated endocytosis-IEA-  
GO:0006968cellular defense response-TAS8034587  
GO:0007155cell adhesion-IEA-  
GO:0007165signal transduction-TAS8390986  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-HDA27068509  
GO:0005576extracellular region-TAS-  
GO:0005615extracellular space-HDA16502470  
GO:0005615extracellular space-IBA21873635  
GO:0005615extracellular space-IDA25645918  
GO:0016020membrane-IEA-  
GO:0031012extracellular matrixCOLOCALIZES_WITHIBA21873635  
GO:0031089platelet dense granule lumen-TAS-  
GO:0062023collagen-containing extracellular matrix-HDA27559042  
GO:0062023collagen-containing extracellular matrixcolocalizes_withHDA20551380  
GO:0070062extracellular exosome-HDA19056867  19199708  21362503  23533145  
GO:0072562blood microparticle-HDA22516433  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-109582HemostasisTAS
R-HSA-114608Platelet degranulation TAS
R-HSA-76002Platelet activation, signaling and aggregationTAS
R-HSA-76005Response to elevated platelet cytosolic Ca2+TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
29762635An Epigenome-Wide Association Study (EWAS) of Obesity-Related Traits. (2018 May 14)Dhana KAm J Epidemiol