Gene: LGALS4

3960
GAL4|L36LBP
galectin 4
protein-coding
19q13.2
Ensembl:ENSG00000171747 MIM:602518 Vega:OTTHUMG00000182608 UniprotKB:P56470
NC_000019.10
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
4.433e-1 (AD)  7.319e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
GTF2IRD20.418
PYROXD20.404
LSMEM20.398
PPY0.398
XPNPEP30.397
MEF2B0.392
TRPV10.39
TBC1D20.382
CRTC30.382
CCDC810.38

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PLSCR5-0.224
ANKRD66-0.22
LINC00269-0.216
GPRIN2-0.21
TMPRSS7-0.208
SYTL5-0.205
IBSP-0.202
LECT2-0.198
KLHL1-0.197
GALNTL6-0.196

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in decreased expression of LGALS4 mRNA"28903501
C0319031-UFT protocolLGALS4 protein results in increased susceptibility to 1-UFT protocol16734730
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of LGALS4 mRNA"18648102
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of LGALS4 mRNA27153756
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of LGALS4 mRNA19770486
D000535Aluminum[APP protein modified form binds to Aluminum] which results in decreased expression of LGALS4 mRNA21298039
D000643Ammonium ChlorideAmmonium Chloride affects the expression of LGALS4 mRNA16483693
C547126AZM551248AZM551248 results in decreased expression of LGALS4 mRNA22323515
C030935benz(a)anthracenebenz(a)anthracene affects the expression of LGALS4 mRNA26377693
C006703benzo(b)fluoranthenebenzo(b)fluoranthene results in increased expression of LGALS4 mRNA26377693
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of LGALS4 mRNA22228805
D004958Estradiol[bisphenol A co-treated with Estradiol] results in increased expression of LGALS4 mRNA26496021
C006780bisphenol Abisphenol A results in decreased expression of LGALS4 mRNA26063408
C006780bisphenol A[bisphenol A co-treated with Estradiol] results in increased expression of LGALS4 mRNA26496021
C006780bisphenol Abisphenol A results in decreased expression of LGALS4 mRNA25181051
D002104CadmiumCadmium results in decreased expression of LGALS4 mRNA24376830
D019256Cadmium ChlorideCadmium Chloride affects the expression of LGALS4 mRNA22110744
D000069287CapecitabineLGALS4 protein results in increased susceptibility to Capecitabine16734730
D002922CiguatoxinsCiguatoxins affects the expression of LGALS4 mRNA18353800
D002994ClofibrateClofibrate results in increased expression of LGALS4 mRNA23811191
D016572CyclosporineCyclosporine results in decreased expression of LGALS4 mRNA20106945
D003976DiazinonDiazinon results in decreased methylation of LGALS4 gene22964155
D003999Dichloroacetic AcidDichloroacetic Acid results in increased expression of LGALS4 mRNA28962523
D004041Dietary FatsDietary Fats results in decreased expression of LGALS4 mRNA25016146
D004041Dietary FatsDietary Fats results in increased expression of LGALS4 mRNA18042831
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in increased expression of LGALS4 mRNA19850644
D004051Diethylhexyl PhthalatePPARA protein promotes the reaction [Diethylhexyl Phthalate results in increased expression of LGALS4 mRNA]19850644
D004237DiuronDiuron metabolite results in decreased expression of LGALS4 mRNA24172598
D004237DiuronDiuron results in increased expression of LGALS4 mRNA21551480
C025034doxifluridineLGALS4 protein results in increased susceptibility to doxifluridine16734730
C039281furanfuran results in increased expression of LGALS4 mRNA26194646|2738771
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of LGALS4 mRNA25613284
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in increased expression of LGALS4 mRNA"24972896
D008070LipopolysaccharidesLipopolysaccharides results in decreased expression of LGALS4 mRNA25613284
D008727MethotrexateMethotrexate affects the expression of LGALS4 mRNA18502557
D037742Nanotubes, Carbon"Nanotubes, Carbon affects the expression of LGALS4 mRNA"25620056
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of LGALS4 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of LGALS4 mRNA"25620056
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of LGALS4 mRNA"25554681
D017239PaclitaxelLGALS4 protein results in decreased susceptibility to Paclitaxel16734730
D000073878Palm OilPalm Oil results in increased expression of LGALS4 mRNA18042831
D010634PhenobarbitalPhenobarbital affects the expression of LGALS4 mRNA19159669
D010634PhenobarbitalPhenobarbital affects the expression of LGALS4 mRNA23091169
D010634PhenobarbitalPhenobarbital results in decreased expression of LGALS4 mRNA19270015
D010634PhenobarbitalPhenobarbital results in decreased expression of LGALS4 mRNA19162173
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of LGALS4 mRNA19710929
C006253pirinixic acidpirinixic acid results in increased expression of LGALS4 mRNA18301758|2381119
D017035PravastatinPravastatin results in decreased expression of LGALS4 mRNA27225895
D017035PravastatinPravastatin results in increased expression of LGALS4 mRNA27225895
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in decreased expression of LGALS4 mRNA19162173
C045950propiconazolepropiconazole results in decreased expression of LGALS4 mRNA21278054
C079198S 1 (combination)LGALS4 protein results in increased susceptibility to S 1 (combination)16734730
C541923sandostatinLARsandostatinLAR results in increased expression of LGALS4 mRNA17210224
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of LGALS4 mRNA25895662
C017947sodium arsenitesodium arsenite results in increased expression of LGALS4 mRNA17350061
D018038Sodium SeleniteSodium Selenite results in increased expression of LGALS4 mRNA18175754
C075117squalestatin 1squalestatin 1 affects the expression of LGALS4 mRNA27225895
C075117squalestatin 1squalestatin 1 results in increased expression of LGALS4 mRNA27225895
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of LGALS4 mRNA21570461
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with TIPARP gene mutant form] results in increased expression of LGALS4 mRNA25975270
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of LGALS4 mRNA22298810
D013750TetrachloroethyleneTetrachloroethylene results in increased expression of LGALS4 mRNA28973375
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of LGALS4 mRNA25613284
C009495titanium dioxidetitanium dioxide results in increased expression of LGALS4 mRNA23557971
D014241TrichloroethyleneTrichloroethylene results in increased expression of LGALS4 mRNA25549359
C012589trichostatin Atrichostatin A results in decreased expression of LGALS4 mRNA15901671
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of LGALS4 mRNA"26179874
D014635Valproic AcidValproic Acid results in decreased expression of LGALS4 mRNA29154799
D014635Valproic AcidValproic Acid affects the expression of LGALS4 mRNA17292431
D014635Valproic AcidValproic Acid results in decreased expression of LGALS4 mRNA15901671

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0016936galactoside binding-IEA-  
GO:0030246carbohydrate binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0007155cell adhesion-TAS9162064  
GO ID GO Term Qualifier Evidence PubMed
GO:0005615extracellular space-IEA-  
GO:0005829cytosol-TAS9162064  
GO:0005886plasma membrane-TAS9162064  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
22613842Genome-scale analysis of DNA methylation in lung adenocarcinoma and integration with mRNA expression. (2012 Jul)Selamat SAGenome Res