Gene info: ID 3973

Gene: LHCGR

GENE ID: 3973

Description: luteinizing hormone/choriogonadotropin receptor

Gene type: protein-coding

Location: 2p16.3

dbXrefs: Ensembl:ENSG00000138039 MIM:152790 Vega:OTTHUMG00000129257 UniprotKB:P22888

RefSeq: NG_008193.1

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: ND

# Publications: 1

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 1.657e-1 (AD) 6.560e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
MEDAG	0.665
SMR3A	0.653
NBPF7	0.629
CST9L	0.612
GJA10	0.592
C4orf17	0.591
SLC10A2	0.59
OR4C16	0.575
FIGLA	0.575
CYP7A1	0.527

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
BGLAP	-0.281
ASPDH	-0.277
HES6	-0.277
SLC27A5	-0.276
GJC2	-0.272
CLDND2	-0.27
C4orf48	-0.27
SLC25A48	-0.27
GGN	-0.268
ZNF771	-0.268

ID	Drug Name	Drug Type	CAS Num	Status	Role
DB00014	Goserelin	Small Molecule	65807-02-5	Approved	Target
DB00032	Menotropins	BiotechDrug	9002-68-0	Approved	Target
DB00044	Lutropin alfa	BiotechDrug	152923-57-4	Approved	Target
DB00050	Cetrorelix	Small Molecule	120287-85-6	Approved\|Investigational	Target
DB00097	Choriogonadotropin alfa	BiotechDrug	177073-44-8	Approved	Target
DB06719	Buserelin	BiotechDrug	57982-77-1	Approved\|Investigational	Target
DB09126	Chorionic Gonadotropin (Human)	BiotechDrug	9002-61-3	Approved	Target

ID	Drug Name	Action	PubMed
C558917	1-(4-chlorobenzoyl)-5-methoxy-1H-indole-3-acetic acid morpholineamide	[1-(4-chlorobenzoyl)-5-methoxy-1H-indole-3-acetic acid morpholineamide binds to and results in increased activity of CNR2 protein] which results in decreased expression of LHCGR mRNA	21109016
C558917	1-(4-chlorobenzoyl)-5-methoxy-1H-indole-3-acetic acid morpholineamide	[1-(4-chlorobenzoyl)-5-methoxy-1H-indole-3-acetic acid morpholineamide binds to and results in increased activity of CNR2 protein] which results in decreased expression of LHCGR protein	21109016
C511295	2,2',4,4'-tetrabromodiphenyl ether	"2,2',4,4'-tetrabromodiphenyl ether results in increased expression of LHCGR mRNA"	27291303
C093973	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [LHCGR protein results in increased phosphorylation of MAPK1 protein]	20610540
C093973	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [LHCGR protein results in increased phosphorylation of MAPK3 protein]	20610540
C404910	2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane	"2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane inhibits the reaction [FSHB protein results in increased expression of LHCGR mRNA]"	19414516
C085911	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [LHCGR protein results in increased phosphorylation of AKT1 protein]	20610540
C016392	3,3'-diindolylmethane	"3,3'-diindolylmethane results in increased expression of LHCGR mRNA"	27092574
C017906	3-dinitrobenzene	3-dinitrobenzene results in increased expression of LHCGR mRNA	21983209
C583074	4,4'-hexafluorisopropylidene diphenol	"4,4'-hexafluorisopropylidene diphenol results in decreased expression of LHCGR mRNA"	22504055
C116322	4-benzhydryloxy-1-(3-(1H-tetrazol-5-yl-)-propyl)piperidine	4-benzhydryloxy-1-(3-(1H-tetrazol-5-yl-)-propyl)piperidine inhibits the reaction [CGA protein results in increased expression of LHCGR mRNA]	21352547
C116322	4-benzhydryloxy-1-(3-(1H-tetrazol-5-yl-)-propyl)piperidine	4-benzhydryloxy-1-(3-(1H-tetrazol-5-yl-)-propyl)piperidine results in decreased expression of LHCGR mRNA	21352547
C105260	4-tert-octylphenol	4-tert-octylphenol results in increased expression of LHCGR mRNA	17011747
D020106	Acrylamide	Acrylamide results in decreased expression of LHCGR mRNA	28959563
D020106	Acrylamide	Acrylamide results in increased expression of LHCGR mRNA	22459607
D000242	Cyclic AMP	[CGB3 protein results in increased activity of LHCGR protein] which results in increased abundance of Cyclic AMP	19766106
D000242	Cyclic AMP	ESR1 protein promotes the reaction [[CGB3 protein results in increased activity of LHCGR protein] which results in increased abundance of Cyclic AMP]	19766106
D000242	Cyclic AMP	ESR2 protein promotes the reaction [[CGB3 protein results in increased activity of LHCGR protein] which results in increased abundance of Cyclic AMP]	19766106
D000242	Cyclic AMP	Estradiol inhibits the reaction [[CGB3 protein results in increased activity of LHCGR protein] which results in increased abundance of Cyclic AMP]	19766106
D000242	Cyclic AMP	[ESR2 gene mutant form results in decreased expression of LHCGR protein] inhibits the reaction [CGA protein results in increased abundance of Cyclic AMP]	20378682
D016604	Aflatoxin B1	Aflatoxin B1 results in decreased methylation of LHCGR gene	27153756
C011512	alpha-naphthoflavone	alpha-naphthoflavone inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of LHCGR protein]	20823264
D000638	Amiodarone	Amiodarone results in increased expression of LHCGR mRNA	19774075
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of LHCGR mRNA	16483693
D018501	Antirheumatic Agents	Antirheumatic Agents results in increased expression of LHCGR mRNA	24449571
C015001	arsenite	arsenite results in decreased expression of LHCGR mRNA	18191166
D001205	Ascorbic Acid	Ascorbic Acid inhibits the reaction [chromium hexavalent ion results in decreased expression of LHCGR mRNA]	18602937
D001280	Atrazine	[Atrazine co-treated with Bucladesine] results in increased expression of LHCGR mRNA	23200735
D001280	Atrazine	Atrazine inhibits the reaction [Chorionic Gonadotropin results in increased expression of LHCGR mRNA]	26923738
D001280	Atrazine	Atrazine inhibits the reaction [FSHB protein results in increased expression of LHCGR mRNA]	23583632
D001280	Atrazine	[Atrazine inhibits the reaction [FSHB protein results in increased expression of LHCGR mRNA]] inhibits the reaction [CGA protein results in increased expression of AREG mRNA]	23583632
D001280	Atrazine	[Atrazine inhibits the reaction [FSHB protein results in increased expression of LHCGR mRNA]] inhibits the reaction [CGA protein results in increased expression of EREG mRNA]	23583632
D001280	Atrazine	[Atrazine inhibits the reaction [FSHB protein results in increased expression of LHCGR mRNA]] inhibits the reaction [CGA protein results in increased expression of PGR mRNA]	23583632
D001280	Atrazine	Atrazine promotes the reaction [8-Bromo Cyclic Adenosine Monophosphate results in increased expression of LHCGR mRNA]	23583632
D001280	Atrazine	Atrazine results in decreased expression of LHCGR mRNA	19541795\|2228535
D001280	Atrazine	Atrazine results in increased expression of LHCGR mRNA	23200735
D001280	Atrazine	Quercetin inhibits the reaction [[Atrazine co-treated with Bucladesine] results in increased expression of LHCGR mRNA]	23200735
D001280	Atrazine	Quercetin inhibits the reaction [Atrazine results in increased expression of LHCGR mRNA]	23200735
D001280	Atrazine	U 0126 inhibits the reaction [Atrazine inhibits the reaction [FSHB protein results in increased expression of LHCGR mRNA]]	23583632
D001280	Atrazine	U 0126 inhibits the reaction [[Atrazine inhibits the reaction [FSHB protein results in increased expression of LHCGR mRNA]] inhibits the reaction [CGA protein results in increased expression of AREG mRNA]]	23583632
D001280	Atrazine	U 0126 inhibits the reaction [[Atrazine inhibits the reaction [FSHB protein results in increased expression of LHCGR mRNA]] inhibits the reaction [CGA protein results in increased expression of EREG mRNA]]	23583632
D001280	Atrazine	U 0126 inhibits the reaction [[Atrazine inhibits the reaction [FSHB protein results in increased expression of LHCGR mRNA]] inhibits the reaction [CGA protein results in increased expression of PGR mRNA]]	23583632
D019324	beta-Naphthoflavone	beta-Naphthoflavone inhibits the reaction [FSHB protein results in increased expression of LHCGR mRNA]	26923738
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased mutagenesis of LHCGR gene	25435355
D004958	Estradiol	Estradiol results in increased expression of LHCGR protein	23851042
D004958	Estradiol	Estradiol inhibits the reaction [[CGB3 protein results in increased activity of LHCGR protein] which results in increased abundance of Cyclic AMP]	19766106
C006780	bisphenol A	bisphenol A results in decreased expression of LHCGR mRNA	26911650\|2785533
C006780	bisphenol A	bisphenol A results in increased expression of LHCGR protein	23851042
C006780	bisphenol A	"bisphenol A inhibits the reaction [[Gonadotropins, Equine co-treated with Chorionic Gonadotropin] results in increased expression of LHCGR mRNA]"	28648634
C006780	bisphenol A	bisphenol A results in decreased expression of LHCGR mRNA	25434310
C006780	bisphenol A	bisphenol A results in decreased expression of LHCGR protein	25434310
C006780	bisphenol A	"bisphenol A promotes the reaction [Gonadotropins, Equine results in increased expression of LHCGR mRNA]"	28648634
C006780	bisphenol A	bisphenol A results in decreased expression of LHCGR mRNA	15901920\|2518105
C006780	bisphenol A	bisphenol A results in decreased expression of LHCGR protein	22302688
C000611646	bisphenol F	bisphenol F affects the expression of LHCGR mRNA	28741210
D015124	8-Bromo Cyclic Adenosine Monophosphate	8-Bromo Cyclic Adenosine Monophosphate results in decreased expression of LHCGR mRNA	22079614
D015124	8-Bromo Cyclic Adenosine Monophosphate	8-Bromo Cyclic Adenosine Monophosphate results in increased expression of LHCGR mRNA	23583632
D015124	8-Bromo Cyclic Adenosine Monophosphate	Atrazine promotes the reaction [8-Bromo Cyclic Adenosine Monophosphate results in increased expression of LHCGR mRNA]	23583632
C027561	butylbenzyl phthalate	butylbenzyl phthalate results in decreased expression of LHCGR mRNA	15728792
D002104	Cadmium	Cadmium results in decreased expression of LHCGR mRNA	17123754
D019256	Cadmium Chloride	Cadmium Chloride results in decreased expression of LHCGR mRNA	17123754
D019256	Cadmium Chloride	Cadmium Chloride results in decreased methylation of LHCGR promoter	22457795
C010059	carbamylhydrazine	carbamylhydrazine analog results in decreased expression of LHCGR mRNA	28834696
D020111	Chlorodiphenyl (54% Chlorine)	Chlorodiphenyl (54% Chlorine) results in decreased expression of LHCGR mRNA	29208485
D020111	Chlorodiphenyl (54% Chlorine)	Chlorodiphenyl (54% Chlorine) results in decreased expression of LHCGR protein	15808795\|2920848
C074702	chromium hexavalent ion	Ascorbic Acid inhibits the reaction [chromium hexavalent ion results in decreased expression of LHCGR mRNA]	18602937
C074702	chromium hexavalent ion	chromium hexavalent ion results in decreased expression of LHCGR mRNA	18602937
D003008	Cloprostenol	Cloprostenol results in decreased expression of LHCGR mRNA	15713365
D003008	Cloprostenol	Cloprostenol results in decreased expression of LHCGR protein	15713365
D005576	Colforsin	[Colforsin co-treated with deoxynivalenol] results in increased expression of LHCGR mRNA	26783879
D005576	Colforsin	[Colforsin co-treated with Zearalenone] results in increased expression of LHCGR mRNA	26783879
D003484	Cyanamide	Cyanamide inhibits the reaction [CGA protein results in increased expression of LHCGR mRNA]	22285649
C007262	deoxynivalenol	[Colforsin co-treated with deoxynivalenol] results in increased expression of LHCGR mRNA	26783879
D003993	Dibutyl Phthalate	Dibutyl Phthalate results in decreased expression of LHCGR mRNA	25434310
D003993	Dibutyl Phthalate	Dibutyl Phthalate results in decreased expression of LHCGR protein	25434310
D003993	Dibutyl Phthalate	Dibutyl Phthalate results in decreased expression of LHCGR mRNA	15620428\|1572879
D003994	Bucladesine	[Atrazine co-treated with Bucladesine] results in increased expression of LHCGR mRNA	23200735
D003994	Bucladesine	Bucladesine results in decreased expression of LHCGR mRNA	21693180
D003994	Bucladesine	Quercetin inhibits the reaction [[Atrazine co-treated with Bucladesine] results in increased expression of LHCGR mRNA]	23200735
C036042	dicyclohexyl phthalate	dicyclohexyl phthalate results in decreased expression of LHCGR mRNA	15620428
D004051	Diethylhexyl Phthalate	Diethylhexyl Phthalate results in decreased expression of LHCGR mRNA	27405655
D004051	Diethylhexyl Phthalate	Diethylhexyl Phthalate results in decreased expression of LHCGR protein	27405655
D004051	Diethylhexyl Phthalate	[Diethylhexyl Phthalate co-treated with ethylene dimethanesulfonate] results in decreased expression of LHCGR mRNA	23064086
D004051	Diethylhexyl Phthalate	Diethylhexyl Phthalate results in decreased expression of LHCGR mRNA	15728792\|2503135
D004054	Diethylstilbestrol	Diethylstilbestrol results in increased expression of LHCGR protein	23851042
D004054	Diethylstilbestrol	Diethylstilbestrol promotes the reaction [FSHB protein results in increased expression of LHCGR mRNA]	15878960
D004054	Diethylstilbestrol	Diethylstilbestrol results in decreased expression of LHCGR mRNA	17011747\|2261589
D004054	Diethylstilbestrol	Diethylstilbestrol results in increased expression of LHCGR mRNA	17011747
C089799	diheptyl phthalate	diheptyl phthalate results in decreased expression of LHCGR mRNA	22112501
C012125	diisononyl phthalate	diisononyl phthalate results in decreased expression of LHCGR mRNA	25445723
D015127	9,10-Dimethyl-1,2-benzanthracene	"9,10-Dimethyl-1,2-benzanthracene results in increased expression of LHCGR mRNA"	22485181
C034171	di-n-pentyl phthalate	di-n-pentyl phthalate results in decreased expression of LHCGR mRNA	15728792
D004221	Disulfiram	Disulfiram inhibits the reaction [[FSHB protein co-treated with LHB protein co-treated with Testosterone] results in increased expression of LHCGR mRNA]	22285649
D004221	Disulfiram	Tretinoin inhibits the reaction [Disulfiram inhibits the reaction [[FSHB protein co-treated with LHB protein co-treated with Testosterone] results in increased expression of LHCGR mRNA]]	22285649
C074283	estradiol 3-benzoate	estradiol 3-benzoate results in increased expression of LHCGR mRNA	15223135
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in increased expression of LHCGR protein	23851042
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in decreased expression of LHCGR mRNA	15834898
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in increased expression of LHCGR mRNA	24632129
C024565	ethylene dichloride	ethylene dichloride results in increased expression of LHCGR mRNA	28973639
C024565	ethylene dichloride	ethylene dichloride results in increased expression of LHCGR protein	28973639
C002994	ethylene dimethanesulfonate	[Diethylhexyl Phthalate co-treated with ethylene dimethanesulfonate] results in decreased expression of LHCGR mRNA	23064086
D005038	Ethylnitrosourea	Ethylnitrosourea results in increased mutagenesis of LHCGR gene	16495775
D015025	Zearalenone	[Colforsin co-treated with Zearalenone] results in increased expression of LHCGR mRNA	26783879
D005473	Fluoxetine	Fluoxetine results in decreased expression of LHCGR mRNA	19493577
D019833	Genistein	Genistein results in increased expression of LHCGR protein	23851042
D019833	Genistein	Genistein results in increased expression of LHCGR mRNA	22553218
D019833	Genistein	[Genistein co-treated with Methoxychlor] results in decreased expression of LHCGR mRNA	21782745
D019833	Genistein	Genistein results in decreased expression of LHCGR mRNA	15901920
D006064	Gonadotropins, Equine	"bisphenol A inhibits the reaction [[Gonadotropins, Equine co-treated with Chorionic Gonadotropin] results in increased expression of LHCGR mRNA]"	28648634
D006064	Gonadotropins, Equine	"[Gonadotropins, Equine co-treated with Chorionic Gonadotropin] results in increased expression of LHCGR mRNA"	28648634
D006064	Gonadotropins, Equine	"bisphenol A promotes the reaction [Gonadotropins, Equine results in increased expression of LHCGR mRNA]"	28648634
D006064	Gonadotropins, Equine	"Gonadotropins, Equine results in increased expression of LHCGR mRNA"	28648634
D006063	Chorionic Gonadotropin	"bisphenol A inhibits the reaction [[Gonadotropins, Equine co-treated with Chorionic Gonadotropin] results in increased expression of LHCGR mRNA]"	28648634
D006063	Chorionic Gonadotropin	"[Gonadotropins, Equine co-treated with Chorionic Gonadotropin] results in increased expression of LHCGR mRNA"	28648634
D006063	Chorionic Gonadotropin	Atrazine inhibits the reaction [Chorionic Gonadotropin results in increased expression of LHCGR mRNA]	26923738
D006063	Chorionic Gonadotropin	Chorionic Gonadotropin results in increased expression of LHCGR mRNA	26923738
C089796	hexabromocyclododecane	[hexabromocyclododecane co-treated with CGA protein] results in decreased expression of LHCGR mRNA	25447410
C089796	hexabromocyclododecane	hexabromocyclododecane inhibits the reaction [FSHB protein results in increased expression of LHCGR mRNA]	24071787
C089796	hexabromocyclododecane	hexabromocyclododecane results in decreased expression of LHCGR mRNA	25447410
C089796	hexabromocyclododecane	tyrphostin AG 1478 inhibits the reaction [hexabromocyclododecane inhibits the reaction [FSHB protein results in increased expression of LHCGR mRNA]]	24071787
C089796	hexabromocyclododecane	U 0126 inhibits the reaction [hexabromocyclododecane inhibits the reaction [FSHB protein results in increased expression of LHCGR mRNA]]	24071787
D016729	Leuprolide	[Leuprolide co-treated with Testosterone] results in decreased expression of LHCGR mRNA	16032706
D016729	Leuprolide	Leuprolide results in decreased expression of LHCGR mRNA	16032706
D001556	Lindane	Lindane results in decreased expression of LHCGR protein	11250058
D008070	Lipopolysaccharides	Lipopolysaccharides results in decreased expression of LHCGR	26729232
D008550	Melatonin	Melatonin results in increased expression of LHCGR mRNA	21647435
D008555	Melitten	LHCGR protein results in increased susceptibility to [Melitten binds to CGB3 protein]	19261682
C088155	methanandamide	[methanandamide binds to and results in increased activity of CNR1 protein] which results in decreased expression of LHCGR mRNA	21109016
C088155	methanandamide	[methanandamide binds to and results in increased activity of CNR1 protein] which results in decreased expression of LHCGR protein	21109016
D008731	Methoxychlor	[Genistein co-treated with Methoxychlor] results in decreased expression of LHCGR mRNA	21782745
D008731	Methoxychlor	Methoxychlor results in decreased expression of LHCGR mRNA	22285353
D008731	Methoxychlor	Methoxychlor results in decreased expression of LHCGR protein	18848953
D008731	Methoxychlor	Methoxychlor results in increased expression of LHCGR mRNA	27663972
D008741	Methyl Methanesulfonate	Methyl Methanesulfonate results in decreased expression of LHCGR mRNA	26011545
D008777	Methyltestosterone	Methyltestosterone results in decreased expression of LHCGR mRNA	29191790
D008898	Mimosine	Mimosine results in decreased expression of LHCGR mRNA	19293332
D008898	Mimosine	Mimosine results in decreased expression of LHCGR mRNA	19293332
D008898	Mimosine	Mimosine results in decreased expression of LHCGR mRNA	19293332
C016599	mono-(2-ethylhexyl)phthalate	mono-(2-ethylhexyl)phthalate results in decreased expression of LHCGR mRNA	22401849
C016599	mono-(2-ethylhexyl)phthalate	mono-(2-ethylhexyl)phthalate results in decreased expression of LHCGR mRNA	22401849
C016340	o,p'-DDT	"o,p'-DDT results in increased expression of LHCGR protein"	23851042
C510603	Org 41841	Org 41841 binds to and results in increased activity of LHCGR protein	12362369
C510603	Org 41841	Org 41841 binds to LHCGR protein	16789744\|1864139
D052638	Particulate Matter	Particulate Matter results in increased expression of LHCGR mRNA	18449530
D052638	Particulate Matter	Particulate Matter results in decreased expression of LHCGR mRNA	23257834
D010457	Peptidoglycan	Peptidoglycan results in decreased expression of LHCGR mRNA	24727680
C522391	perfluorododecanoic acid	perfluorododecanoic acid results in decreased expression of LHCGR mRNA	19429406
D010852	Picrotoxin	Picrotoxin results in increased expression of LHCGR mRNA	15170462
C045362	prochloraz	prochloraz results in increased expression of LHCGR mRNA	21158436
D011441	Propylthiouracil	Propylthiouracil results in increased expression of LHCGR mRNA	21158436
D015237	Dinoprost	Dinoprost results in decreased expression of LHCGR mRNA	11517196
D011794	Quercetin	Quercetin inhibits the reaction [[Atrazine co-treated with Bucladesine] results in increased expression of LHCGR mRNA]	23200735
D011794	Quercetin	Quercetin inhibits the reaction [Atrazine results in increased expression of LHCGR mRNA]	23200735
C059514	resveratrol	resveratrol results in increased expression of LHCGR mRNA	22357324
C059514	resveratrol	resveratrol results in increased expression of LHCGR protein	22357324
D012715	Sesame Oil	Sesame Oil results in increased expression of LHCGR mRNA	29191790
D012834	Silver	Silver analog results in decreased expression of LHCGR mRNA	22727896
D012835	Silver Nitrate	Silver Nitrate results in increased expression of LHCGR mRNA	22727896
D012969	Sodium Fluoride	Sodium Fluoride results in increased expression of LHCGR protein	24071475
D013739	Testosterone	[FSHB protein co-treated with Testosterone] results in increased expression of LHCGR mRNA	18535249
D013739	Testosterone	Disulfiram inhibits the reaction [[FSHB protein co-treated with LHB protein co-treated with Testosterone] results in increased expression of LHCGR mRNA]	22285649
D013739	Testosterone	[FSHB protein co-treated with LHB protein co-treated with Testosterone] results in increased expression of LHCGR mRNA	22285649
D013739	Testosterone	[Leuprolide co-treated with Testosterone] results in decreased expression of LHCGR mRNA	16032706
D013739	Testosterone	LHCGR affects the susceptibility to Testosterone	20164437
D013739	Testosterone	LHCGR protein results in increased abundance of Testosterone	15514086
D013739	Testosterone	Tretinoin inhibits the reaction [Disulfiram inhibits the reaction [[FSHB protein co-treated with LHB protein co-treated with Testosterone] results in increased expression of LHCGR mRNA]]	22285649
D013739	Testosterone	FSHB protein promotes the reaction [[PRKACA protein mutant form co-treated with Testosterone] results in increased expression of LHCGR mRNA]	18535249
D013739	Testosterone	[PRKACA protein mutant form co-treated with Testosterone] results in increased expression of LHCGR mRNA	18535249
C004648	testosterone enanthate	testosterone enanthate results in decreased expression of LHCGR mRNA	21427060\|2560346
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of LHCGR protein	23851042
D013749	Tetrachlorodibenzodioxin	alpha-naphthoflavone inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of LHCGR protein]	20823264
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of LHCGR protein	20823264
D013749	Tetrachlorodibenzodioxin	AHR protein promotes the reaction [Tetrachlorodibenzodioxin results in decreased expression of LHCGR mRNA]	15223135
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of LHCGR mRNA	21570461
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of LHCGR mRNA	15223135
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin inhibits the reaction [FSHB protein results in increased expression of LHCGR promoter]	12770741
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased degradation of LHCGR promoter	12770741
C009495	titanium dioxide	titanium dioxide results in decreased expression of LHCGR mRNA	23565150
C009495	titanium dioxide	titanium dioxide results in decreased expression of LHCGR protein	23565150
C479163	tofacitinib	tofacitinib inhibits the reaction [PRL protein results in increased expression of LHCGR mRNA]	27708194
D014212	Tretinoin	Tretinoin inhibits the reaction [Disulfiram inhibits the reaction [[FSHB protein co-treated with LHB protein co-treated with Testosterone] results in increased expression of LHCGR mRNA]]	22285649
C025541	tri-o-cresyl phosphate	[tri-o-cresyl phosphate co-treated with LHB protein] results in increased expression of LHCGR mRNA	26794138
C005445	triphenyl phosphate	triphenyl phosphate results in decreased expression of LHCGR mRNA	23603146
C005445	triphenyl phosphate	triphenyl phosphate results in increased expression of LHCGR mRNA	23603146\|2686534
C016805	tris(1,3-dichloro-2-propyl)phosphate	"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of LHCGR mRNA"	23603146
C016805	tris(1,3-dichloro-2-propyl)phosphate	"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of LHCGR mRNA"	23603146\|2563791
C057693	troglitazone	troglitazone inhibits the reaction [CGB3 protein results in increased expression of LHCGR mRNA]	16230788
C057693	troglitazone	troglitazone results in decreased expression of LHCGR mRNA	16230788
C101044	tyrphostin AG 1478	tyrphostin AG 1478 inhibits the reaction [hexabromocyclododecane inhibits the reaction [FSHB protein results in increased expression of LHCGR mRNA]]	24071787
C101044	tyrphostin AG 1478	tyrphostin AG 1478 promotes the reaction [FSHB protein results in increased expression of LHCGR mRNA]	24071787
C113580	U 0126	U 0126 inhibits the reaction [Atrazine inhibits the reaction [FSHB protein results in increased expression of LHCGR mRNA]]	23583632
C113580	U 0126	U 0126 inhibits the reaction [[Atrazine inhibits the reaction [FSHB protein results in increased expression of LHCGR mRNA]] inhibits the reaction [CGA protein results in increased expression of AREG mRNA]]	23583632
C113580	U 0126	U 0126 inhibits the reaction [[Atrazine inhibits the reaction [FSHB protein results in increased expression of LHCGR mRNA]] inhibits the reaction [CGA protein results in increased expression of EREG mRNA]]	23583632
C113580	U 0126	U 0126 inhibits the reaction [[Atrazine inhibits the reaction [FSHB protein results in increased expression of LHCGR mRNA]] inhibits the reaction [CGA protein results in increased expression of PGR mRNA]]	23583632
C113580	U 0126	U 0126 inhibits the reaction [hexabromocyclododecane inhibits the reaction [FSHB protein results in increased expression of LHCGR mRNA]]	24071787
C113580	U 0126	U 0126 promotes the reaction [FSHB protein results in increased expression of LHCGR mRNA]	24071787
D014501	Uranium	Uranium analog results in decreased expression of LHCGR mRNA	27544493
D014635	Valproic Acid	Valproic Acid results in decreased expression of LHCGR mRNA	23152920
D001335	Vehicle Emissions	Vehicle Emissions results in decreased methylation of LHCGR gene	25487561
D001335	Vehicle Emissions	Vehicle Emissions results in increased expression of LHCGR mRNA	18449530
D001335	Vehicle Emissions	Vehicle Emissions results in decreased expression of LHCGR mRNA	23257834
C025643	vinclozolin	vinclozolin results in increased expression of LHCGR mRNA	17517826
C025643	vinclozolin	vinclozolin results in decreased expression of LHCGR mRNA	22285353
D015039	Ziram	Ziram results in decreased expression of LHCGR mRNA	28973382
D015039	Ziram	Ziram results in decreased expression of LHCGR protein	28973382

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0004964	luteinizing hormone receptor activity	-	IBA	21873635
GO:0004964	luteinizing hormone receptor activity	-	IMP	11847099
GO:0008528	G-protein coupled peptide receptor activity	-	IBA	21873635
GO:0035472	choriogonadotropin hormone receptor activity	-	ISS	-
GO:0038106	choriogonadotropin hormone binding	-	ISS	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0007186	G-protein coupled receptor signaling pathway	-	TAS	-
GO:0007187	G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger	-	TAS	7719343
GO:0007189	adenylate cyclase-activating G-protein coupled receptor signaling pathway	-	IBA	21873635
GO:0007189	adenylate cyclase-activating G-protein coupled receptor signaling pathway	-	ISS	-
GO:0007190	activation of adenylate cyclase activity	-	IBA	21873635
GO:0007190	activation of adenylate cyclase activity	-	ISS	-
GO:0007200	phospholipase C-activating G-protein coupled receptor signaling pathway	-	IBA	21873635
GO:0007200	phospholipase C-activating G-protein coupled receptor signaling pathway	-	ISS	-
GO:0008584	male gonad development	-	TAS	7719343
GO:0009755	hormone-mediated signaling pathway	-	IBA	21873635
GO:0022602	ovulation cycle process	-	IBA	21873635
GO:0030539	male genitalia development	-	TAS	9626653
GO:0032962	positive regulation of inositol trisphosphate biosynthetic process	-	ISS	-
GO:0042700	luteinizing hormone signaling pathway	-	IBA	21873635
GO:0042700	luteinizing hormone signaling pathway	-	IMP	11847099
GO:0045762	positive regulation of adenylate cyclase activity	-	IMP	11847099
GO:0050890	cognition	-	IMP	23227193
GO:0071371	cellular response to gonadotropin stimulus	-	ISS	-
GO:0071373	cellular response to luteinizing hormone stimulus	-	IMP	11847099

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005768	endosome	-	TAS	10617611
GO:0005886	plasma membrane	-	IDA	11847099
GO:0005886	plasma membrane	-	TAS	-
GO:0005887	integral component of plasma membrane	-	IBA	21873635
GO:0005887	integral component of plasma membrane	-	ISS	-

KEGG ID	KEGG Term
hsa04020	Calcium signaling pathway
hsa04080	Neuroactive ligand-receptor interaction

Reactome ID	Reactome Term	Evidence
R-HSA-162582	Signal Transduction	TAS
R-HSA-372790	Signaling by GPCR	TAS
R-HSA-373076	Class A/1 (Rhodopsin-like receptors)	TAS
R-HSA-375281	Hormone ligand-binding receptors	TAS
R-HSA-388396	GPCR downstream signalling	TAS
R-HSA-418555	G alpha (s) signalling events	TAS
R-HSA-500792	GPCR ligand binding	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
19837924	Maternal smoking and developmental changes in luteinizing hormone (LH) and the LH receptor in the fetal testis. (2009 Dec)	Fowler PA	J Clin Endocrinol Metab