Gene: LIF

3976
CDF|DIA|HILDA|MLPLI
LIF, interleukin 6 family cytokine
protein-coding
22q12.2
Ensembl:ENSG00000128342 MIM:159540 Vega:OTTHUMG00000150910 UniprotKB:P15018
NG_008721.1
PubMed
0   ANCO-SNPs
CD|ND|AD
5   
NA (AD)  NA (ND)   (Frontal_Cortex)
5.001e-1 (AD)  1.103e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PLAUR0.833
ADAMTS90.818
IL15RA0.796
IL60.795
GPRC5A0.789
TNFRSF12A0.787
TEAD40.784
STC10.781
ITGB30.779
CCL20.777

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
EDN3-0.509
KCNQ4-0.49
SCRT1-0.486
MARCH4-0.476
NEUROD6-0.467
TMEM179-0.465
EXTL1-0.465
KCNA2-0.464
ST6GALNAC5-0.462
MYADML2-0.461

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0122771,2-diamino-4-nitrobenzene"1,2-diamino-4-nitrobenzene results in increased expression of LIF mRNA"26198647
C0493251,2-dithiol-3-thione"1,2-dithiol-3-thione results in increased expression of LIF mRNA"19162173
C5598531-(5-chloro-6-(trifluoromethoxy)-1H-benzoimidazol-2-yl)-1H-pyrazole-4-carboxylic acid1-(5-chloro-6-(trifluoromethoxy)-1H-benzoimidazol-2-yl)-1H-pyrazole-4-carboxylic acid inhibits the reaction [LIF protein affects the reaction ALPL mRNA]26723917
C5598531-(5-chloro-6-(trifluoromethoxy)-1H-benzoimidazol-2-yl)-1H-pyrazole-4-carboxylic acid1-(5-chloro-6-(trifluoromethoxy)-1H-benzoimidazol-2-yl)-1H-pyrazole-4-carboxylic acid inhibits the reaction [LIF protein affects the reaction FGF5 mRNA]26723917
C5598531-(5-chloro-6-(trifluoromethoxy)-1H-benzoimidazol-2-yl)-1H-pyrazole-4-carboxylic acid1-(5-chloro-6-(trifluoromethoxy)-1H-benzoimidazol-2-yl)-1H-pyrazole-4-carboxylic acid promotes the reaction [LIF protein affects the reaction POU5F1 mRNA]26723917
C09724015-deoxy-delta(12,14)-prostaglandin J2"15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [LIF protein results in increased expression of STAT3 protein]"19922793
C09724015-deoxy-delta(12,14)-prostaglandin J2"15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [LIF protein results in increased phosphorylation of STAT3 protein]"19922793
C09724015-deoxy-delta(12,14)-prostaglandin J2"2,2-bis(4-glycidyloxyphenyl)propane inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [LIF protein results in increased expression of STAT3 protein]]"19922793
C09724015-deoxy-delta(12,14)-prostaglandin J2"2,2-bis(4-glycidyloxyphenyl)propane inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [LIF protein results in increased phosphorylation of STAT3 protein]]"19922793
C09724015-deoxy-delta(12,14)-prostaglandin J2"T 0070907 inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [LIF protein results in increased expression of STAT3 protein]]"19922793
C09724015-deoxy-delta(12,14)-prostaglandin J2"T 0070907 inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [LIF protein results in increased phosphorylation of STAT3 protein]]"19922793
C0512461-methylanthracene[1-methylanthracene co-treated with fluoranthene] results in increased expression of LIF mRNA28329830
C0512461-methylanthraceneSB 203580 inhibits the reaction [[1-methylanthracene co-treated with fluoranthene] results in increased expression of LIF mRNA]28329830
C5544281-nitrosocyclohexyl acetate1-nitrosocyclohexyl acetate affects the reaction [JAK1 protein results in increased phosphorylation of LIF protein]22905257
C5544281-nitrosocyclohexyl acetate1-nitrosocyclohexyl acetate inhibits the reaction [LIF protein results in increased activity of CEBPD protein]22905257
C5544281-nitrosocyclohexyl acetate1-nitrosocyclohexyl acetate inhibits the reaction [LIF protein results in increased activity of ICAM1 protein]22905257
C5544281-nitrosocyclohexyl acetate1-nitrosocyclohexyl acetate inhibits the reaction [LIF protein results in increased activity of STAT3 protein]22905257
C5486512-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in increased expression of LIF mRNA19933214
C0939732-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [[bisphenol A affects the activity of ESR1 protein] promotes the reaction [LIF protein results in increased activity of STAT3 protein]]14975756
C0939732-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [[Endosulfan affects the activity of ESR1 protein] promotes the reaction [LIF protein results in increased activity of STAT3 protein]]14975756
C0939732-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [[Methoxychlor affects the activity of ESR1 protein] promotes the reaction [LIF protein results in increased activity of STAT3 protein]]14975756
C0192732,2-bis(4-glycidyloxyphenyl)propane"2,2-bis(4-glycidyloxyphenyl)propane inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [LIF protein results in increased expression of STAT3 protein]]"19922793
C0192732,2-bis(4-glycidyloxyphenyl)propane"2,2-bis(4-glycidyloxyphenyl)propane inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [LIF protein results in increased phosphorylation of STAT3 protein]]"19922793
C0192732,2-bis(4-glycidyloxyphenyl)propane"2,2-bis(4-glycidyloxyphenyl)propane inhibits the reaction [ciglitazone inhibits the reaction [LIF protein results in increased expression of STAT3 protein]]"19922793
C0192732,2-bis(4-glycidyloxyphenyl)propane"2,2-bis(4-glycidyloxyphenyl)propane inhibits the reaction [ciglitazone inhibits the reaction [LIF protein results in increased phosphorylation of STAT3 protein]]"19922793
C0109142,4-diaminotoluene"2,4-diaminotoluene results in increased expression of LIF mRNA"20713471
C0369902-amino-3,8-dimethylimidazo(4,5-f)quinoxaline"2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in decreased expression of LIF mRNA"20816883
C0292162-amino-3-methylimidazo(4,5-f)quinoline"2-amino-3-methylimidazo(4,5-f)quinoline results in increased expression of LIF mRNA"26198647
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in increased expression of LIF mRNA"28351761
C0179063-dinitrobenzene3-dinitrobenzene results in increased expression of LIF mRNA24140754
C0275764-hydroxy-2-nonenal4-hydroxy-2-nonenal results in decreased expression of LIF mRNA19191707
C0207389,10-dihydro-9,10-dihydroxybenzo(a)pyrene"9,10-dihydro-9,10-dihydroxybenzo(a)pyrene results in increased expression of LIF mRNA"26238291
D000082AcetaminophenAcetaminophen affects the expression of LIF mRNA17562736
D000082AcetaminophenAcetaminophen results in increased expression of LIF mRNA12705907|2605643
D000082AcetaminophenIL6 protein affects the reaction [Acetaminophen results in increased expression of LIF mRNA]12705907
D020106AcrylamideAcrylamide results in decreased expression of LIF mRNA28959563
D016604Aflatoxin B1Aflatoxin B1 affects the expression of LIF protein20106945
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of LIF mRNA21641981|2210060
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of LIF mRNA19770486
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of LIF mRNA23630614
D000638AmiodaroneAmiodarone results in increased expression of LIF mRNA19774075
D000643Ammonium ChlorideAmmonium Chloride affects the expression of LIF mRNA16483693
C059765amphotericin B, deoxycholate drug combination"amphotericin B, deoxycholate drug combination results in increased expression of LIF mRNA"22863853
D034341Aristolochic AcidsAristolochic Acids results in increased expression of LIF mRNA21834575
C006632arsenic trioxidearsenic trioxide results in increased expression of LIF mRNA20458559|2670570
D017638Asbestos, Crocidolite"Asbestos, Crocidolite affects the expression of LIF mRNA"25757056
D001241AspirinAspirin results in increased expression of LIF mRNA21035850
D001241AspirinAspirin results in increased expression of LIF protein21035850
D001379AzathioprineAzathioprine results in increased expression of LIF mRNA22623647|2619864
C547126AZM551248AZM551248 results in decreased expression of LIF mRNA22323515
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of LIF mRNA20106945|2163298
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of LIF mRNA19770486
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of LIF mRNA"20382639|2623829
D004958Estradiol[Estradiol co-treated with EGF protein] results in increased expression of LIF mRNA24758408
D004958Estradiol[Estradiol co-treated with LIF protein] results in increased phosphorylation of MAPK1 protein14975756
D004958Estradiol[Estradiol co-treated with LIF protein] results in increased phosphorylation of MAPK3 protein14975756
D004958Estradiol[Estradiol co-treated with Progesterone] results in decreased expression of LIF mRNA20660070
D004958EstradiolEstradiol inhibits the reaction [LIF protein results in increased activity of STAT3 protein]14975756
D004958EstradiolEstradiol results in increased expression of LIF mRNA21185374
D004958EstradiolESR1 protein promotes the reaction [[Estradiol co-treated with Progesterone] results in increased expression of LIF mRNA]25210133
D004958Estradiol[Estradiol co-treated with Progesterone] results in increased expression of LIF mRNA25210133
D004958Estradiol[Progesterone co-treated with Estradiol] affects the expression of LIF15639816
D004958Estradiol[Tetrachlorodibenzodioxin co-treated with Estradiol] results in decreased expression of LIF mRNA18691609
C483161beta-hydroxy simvastatin acidbeta-hydroxy simvastatin acid results in decreased expression of LIF mRNA18192240
D001663BilirubinBilirubin results in increased expression of LIF mRNA20196124
C543008bis(4-hydroxyphenyl)sulfonebis(4-hydroxyphenyl)sulfone results in decreased expression of LIF mRNA27685785
C006780bisphenol A2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [[bisphenol A affects the activity of ESR1 protein] promotes the reaction [LIF protein results in increased activity of STAT3 protein]]14975756
C006780bisphenol A[bisphenol A affects the activity of ESR1 protein] promotes the reaction [LIF protein results in increased activity of STAT3 protein]14975756
C006780bisphenol A[bisphenol A co-treated with LIF protein] results in increased phosphorylation of MAPK1 protein14975756
C006780bisphenol A[bisphenol A co-treated with LIF protein] results in increased phosphorylation of MAPK3 protein14975756
C006780bisphenol Abisphenol A promotes the reaction [LIF protein results in increased activity of STAT3 protein]14975756
C006780bisphenol Abisphenol A results in decreased expression of LIF mRNA27685785
C006780bisphenol ATamoxifen inhibits the reaction [[bisphenol A affects the activity of ESR1 protein] promotes the reaction [LIF protein results in increased activity of STAT3 protein]]14975756
C006780bisphenol Abisphenol A results in decreased expression of LIF mRNA27022677
C006780bisphenol Abisphenol A results in decreased expression of LIF mRNA25181051
D0151248-Bromo Cyclic Adenosine Monophosphate[Dexamethasone co-treated with 8-Bromo Cyclic Adenosine Monophosphate co-treated with 1-Methyl-3-isobutylxanthine] results in decreased expression of LIF mRNA16997883
D0151248-Bromo Cyclic Adenosine Monophosphate[NR5A1 protein co-treated with LIF protein co-treated with 8-Bromo Cyclic Adenosine Monophosphate co-treated with Tretinoin] results in increased abundance of Progesterone21610156
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in increased expression of LIF mRNA12414654|1533650
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in increased methylation of LIF gene27509014
D002104CadmiumCadmium results in increased expression of LIF mRNA22562489
D002118CalciumLIF protein results in increased abundance of Calcium11073891
C059041calyculin A[calyculin A co-treated with LIF protein] results in increased phosphorylation of STAT3 protein22142222
C059041calyculin Acalyculin A results in decreased expression of LIF mRNA22142222
D002330CarmustineLIF mRNA results in increased susceptibility to Carmustine16365179
D002699ChlorambucilChlorambucil results in increased expression of LIF mRNA26198647
C039671ciglitazone"2,2-bis(4-glycidyloxyphenyl)propane inhibits the reaction [ciglitazone inhibits the reaction [LIF protein results in increased expression of STAT3 protein]]"19922793
C039671ciglitazone"2,2-bis(4-glycidyloxyphenyl)propane inhibits the reaction [ciglitazone inhibits the reaction [LIF protein results in increased phosphorylation of STAT3 protein]]"19922793
C039671ciglitazoneciglitazone inhibits the reaction [LIF protein results in increased expression of STAT3 protein]19922793
C039671ciglitazoneciglitazone inhibits the reaction [LIF protein results in increased phosphorylation of STAT3 protein]19922793
C039671ciglitazoneT 0070907 inhibits the reaction [ciglitazone inhibits the reaction [LIF protein results in increased expression of STAT3 protein]]19922793
C039671ciglitazoneT 0070907 inhibits the reaction [ciglitazone inhibits the reaction [LIF protein results in increased phosphorylation of STAT3 protein]]19922793
D002996ClomipheneClomiphene results in increased expression of LIF mRNA21851939
D019327Copper SulfateCopper Sulfate results in increased expression of LIF mRNA19549813
D003372CoumaphosCoumaphos results in increased expression of LIF mRNA26198647
D016572CyclosporineCyclosporine results in decreased expression of LIF mRNA27989131
D016572CyclosporineCyclosporine results in increased expression of LIF mRNA20106945|2163298
D016572CyclosporineCyclosporine results in increased expression of LIF mRNA23958496
D016572CyclosporineCyclosporine inhibits the reaction [LIF protein results in increased activity of CAMK2A protein]11073891
D016572CyclosporineCyclosporine inhibits the reaction [LIF protein results in increased activity of CAMK4 protein]11073891
D016572CyclosporineCyclosporine inhibits the reaction [LIF protein results in increased expression of NPPB protein]11073891
D003634DDTDDT results in increased expression of LIF mRNA26198647
C014347decitabinedecitabine results in increased expression of LIF mRNA17785578
D003703DemecolcineDemecolcine results in increased expression of LIF mRNA23649840
D003907Dexamethasone[Dexamethasone co-treated with 8-Bromo Cyclic Adenosine Monophosphate co-treated with 1-Methyl-3-isobutylxanthine] results in decreased expression of LIF mRNA16997883
D003907Dexamethasone[Dexamethasone co-treated with Genistein] results in decreased expression of LIF mRNA25136773
D003907DexamethasoneDexamethasone results in decreased expression of LIF mRNA25047013|2513677
D003976DiazinonDiazinon results in increased expression of LIF mRNA26198647
D003999Dichloroacetic AcidDichloroacetic Acid results in increased expression of LIF mRNA28962523
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in decreased expression of LIF mRNA27392435
D002945CisplatinCisplatin results in decreased expression of LIF mRNA27392435
D002945CisplatinCisplatin results in increased expression of LIF mRNA21532991|2619864
D002945CisplatinCisplatin results in increased expression of LIF mRNA19833167
D002945CisplatinIL6 gene mutant form promotes the reaction [Cisplatin results in increased expression of LIF mRNA]19833167
D004041Dietary FatsDietary Fats results in increased expression of LIF mRNA21852083
D004041Dietary Fatsresveratrol inhibits the reaction [Dietary Fats results in increased expression of LIF mRNA]21852083
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in increased expression of LIF mRNA26198647
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in increased expression of LIF mRNA28286118
D004317DoxorubicinDoxorubicin results in increased expression of LIF mRNA28940058
D004391DustDust results in increased expression of LIF mRNA17805423
D004533Egtazic AcidEgtazic Acid inhibits the reaction [LIF protein results in increased phosphorylation of CAMK2A protein]11073891
D004726Endosulfan2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [[Endosulfan affects the activity of ESR1 protein] promotes the reaction [LIF protein results in increased activity of STAT3 protein]]14975756
D004726Endosulfan[Endosulfan affects the activity of ESR1 protein] promotes the reaction [LIF protein results in increased activity of STAT3 protein]14975756
D004726Endosulfan[Endosulfan affects the activity of ESR2 protein] promotes the reaction [LIF protein results in increased activity of STAT3 protein]14975756
D004726Endosulfan[Endosulfan co-treated with LIF protein] results in increased phosphorylation of MAPK1 protein14975756
D004726Endosulfan[Endosulfan co-treated with LIF protein] results in increased phosphorylation of MAPK3 protein14975756
D004726EndosulfanEndosulfan promotes the reaction [LIF protein results in increased activity of STAT3 protein]14975756
D004726EndosulfanTamoxifen inhibits the reaction [[Endosulfan affects the activity of ESR1 protein] promotes the reaction [LIF protein results in increased activity of STAT3 protein]]14975756
D004791Enzyme InhibitorsEnzyme Inhibitors promotes the reaction [LIF protein results in increased phosphorylation of and results in increased activity of STAT3 protein]22366233
D004791Enzyme InhibitorsEnzyme Inhibitors results in increased susceptibility to LIF protein22366233
C040833ethyl acrylateethyl acrylate results in increased expression of LIF mRNA26198647
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in increased expression of LIF mRNA23649840
D005038EthylnitrosoureaEthylnitrosourea results in increased expression of LIF mRNA26198647
C540355fenamidonefenamidone results in increased expression of LIF mRNA27029645
C007738fluoranthene[1-methylanthracene co-treated with fluoranthene] results in increased expression of LIF mRNA28329830
C007738fluorantheneSB 203580 inhibits the reaction [[1-methylanthracene co-treated with fluoranthene] results in increased expression of LIF mRNA]28329830
D005492Folic Acid[Folic Acid deficiency co-treated with Methotrexate] results in increased expression of LIF mRNA24657277
D005557FormaldehydeFormaldehyde results in increased expression of LIF mRNA23649840
D019833Genistein[Dexamethasone co-treated with Genistein] results in decreased expression of LIF mRNA25136773
D019833GenisteinGenistein results in decreased expression of LIF mRNA25136773
D005947GlucoseGlucose promotes the reaction [AGT protein results in increased expression of LIF mRNA]19225232
D005947GlucoseGlucose results in increased expression of LIF mRNA19225232
D005947Glucose[Valsartan co-treated with Simvastatin] inhibits the reaction [Glucose promotes the reaction [AGT protein results in increased expression of LIF mRNA]]19225232
D005947GlucoseValsartan inhibits the reaction [Glucose promotes the reaction [AGT protein results in increased expression of LIF mRNA]]19225232
D005947GlucoseGlucose results in increased expression of LIF mRNA17178593
D006046Gold[Gold co-treated with Silicon Dioxide] results in increased secretion of LIF protein22155353
D006046GoldGold results in increased secretion of LIF protein22155353
D006861Hydrogen PeroxideHydrogen Peroxide affects the expression of LIF mRNA23410634
D006861Hydrogen PeroxideHydrogen Peroxide results in increased expression of LIF mRNA12414654
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of LIF mRNA25613284
D0150561-Methyl-3-isobutylxanthine[Dexamethasone co-treated with 8-Bromo Cyclic Adenosine Monophosphate co-treated with 1-Methyl-3-isobutylxanthine] results in decreased expression of LIF mRNA16997883
D007529IsoflavonesIsoflavones affects the expression of LIF mRNA16365062
C544151jinfukang[Cisplatin co-treated with jinfukang] results in decreased expression of LIF mRNA27392435
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of LIF mRNA24796395|2596192
C561695(+)-JQ1 compound"(+)-JQ1 compound inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of LIF mRNA]"24799421
C119620kenpaullonekenpaullone results in increased expression of LIF mRNA17993264
C063302KN 62KN 62 inhibits the reaction [LIF protein results in increased activity of CAMK2A protein]11073891
C063302KN 62KN 62 inhibits the reaction [LIF protein results in increased activity of CAMK4 protein]11073891
C063302KN 62KN 62 inhibits the reaction [LIF protein results in increased expression of ACTA1 protein]11073891
C063302KN 62KN 62 inhibits the reaction [LIF protein results in increased expression of FOS protein]11073891
C063302KN 62KN 62 inhibits the reaction [LIF protein results in increased expression of NPPA protein]11073891
C063302KN 62KN 62 inhibits the reaction [LIF protein results in increased expression of NPPB protein]11073891
C045463leflunomideleflunomide results in increased expression of LIF mRNA28988120
C067431letrozoleletrozole results in increased expression of LIF mRNA21851939
C067431letrozoleletrozole results in increased expression of LIF protein21851939
D001556LindaneLindane results in increased expression of LIF mRNA26198647
C482199lipopolysaccharide, E coli O55-B5"LIF protein affects the reaction [Progesterone inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased abundance of Nitric Oxide]]"23409146
C482199lipopolysaccharide, E coli O55-B5"LIF protein inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased abundance of Nitric Oxide]"23409146
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in increased expression of LIF mRNA"11578593
C482199lipopolysaccharide, E coli O55-B5"pyrrolidine dithiocarbamic acid inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of LIF mRNA]"11578593
C440499lipopolysaccharide, Escherichia coli O111 B4"(+)-JQ1 compound inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of LIF mRNA]"24799421
C440499lipopolysaccharide, Escherichia coli O111 B4"lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of LIF mRNA"24799421
D008070LipopolysaccharidesLipopolysaccharides results in decreased expression of LIF mRNA12057914
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of and results in increased secretion of LIF protein26918785
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of LIF mRNA14678569
D008070Lipopolysaccharides"methyl 2-cyano-3,12-dioxoolean-1,9-dien-28-oate inhibits the reaction [Lipopolysaccharides results in increased expression of and results in increased secretion of LIF protein]"26918785
D058185Magnetite Nanoparticles[Succimer binds to Magnetite Nanoparticles] which results in increased expression of LIF mRNA21641980
D008727Methotrexate[Folic Acid deficiency co-treated with Methotrexate] results in increased expression of LIF mRNA24657277
D008727MethotrexateMethotrexate results in increased expression of LIF mRNA21678067|2465727
D008731Methoxychlor2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [[Methoxychlor affects the activity of ESR1 protein] promotes the reaction [LIF protein results in increased activity of STAT3 protein]]14975756
D008731Methoxychlor[Methoxychlor affects the activity of ESR1 protein] promotes the reaction [LIF protein results in increased activity of STAT3 protein]14975756
D008731Methoxychlor[Methoxychlor affects the activity of ESR2 protein] promotes the reaction [LIF protein results in increased activity of STAT3 protein]14975756
D008731Methoxychlor[Methoxychlor co-treated with LIF protein] results in increased phosphorylation of MAPK1 protein14975756
D008731Methoxychlor[Methoxychlor co-treated with LIF protein] results in increased phosphorylation of MAPK3 protein14975756
D008731MethoxychlorMethoxychlor promotes the reaction [LIF protein results in increased activity of STAT3 protein]14975756
D008731MethoxychlorTamoxifen inhibits the reaction [[Methoxychlor affects the activity of ESR1 protein] promotes the reaction [LIF protein results in increased activity of STAT3 protein]]14975756
D008731MethoxychlorMethoxychlor results in increased expression of LIF mRNA24806340
C445068methyl 2-cyano-3,12-dioxoolean-1,9-dien-28-oate"methyl 2-cyano-3,12-dioxoolean-1,9-dien-28-oate inhibits the reaction [Lipopolysaccharides results in increased expression of and results in increased secretion of LIF protein]"26918785
D008748MethylcholanthreneMethylcholanthrene promotes the reaction [AHR protein binds to LIF promoter]20348232
D008748MethylcholanthreneMethylcholanthrene results in increased expression of LIF mRNA20713471
D008753Methylenebis(chloroaniline)Methylenebis(chloroaniline) results in increased expression of LIF mRNA26198647
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of LIF mRNA23649840
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of LIF mRNA"23634900
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of LIF mRNA"25554681
C017096n-butoxyethanoln-butoxyethanol results in increased expression of LIF mRNA19812364
D009529NicardipineNicardipine inhibits the reaction [LIF protein results in increased activity of CAMK2A protein]11073891
D009529NicardipineNicardipine inhibits the reaction [LIF protein results in increased activity of CAMK4 protein]11073891
D009529NicardipineNicardipine inhibits the reaction [LIF protein results in increased phosphorylation of CAMK2A protein]11073891
C028007nickel monoxidenickel monoxide results in decreased expression of LIF mRNA19167457
C029938nickel sulfatenickel sulfate results in decreased expression of LIF mRNA22714537
D009569Nitric Oxide"LIF protein affects the reaction [Progesterone inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased abundance of Nitric Oxide]]"23409146
D009569Nitric Oxide"LIF protein inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased abundance of Nitric Oxide]"23409146
D010100OxygenOxygen deficiency inhibits the reaction [LIF protein affects the reaction ALPL mRNA]26723917
D010100OxygenOxygen deficiency promotes the reaction [LIF protein affects the reaction FGF5 mRNA]26723917
D010100OxygenOxygen deficiency promotes the reaction [LIF protein affects the reaction NANOG mRNA]26723917
D010100OxygenOxygen deficiency promotes the reaction [LIF protein affects the reaction ZFP42 mRNA]26723917
D010100OxygenLIF protein inhibits the reaction [[Oxygen deficiency co-treated with Oxygen] results in increased chemical synthesis of Reactive Oxygen Species]11524388
C021229oxyhyponitriteoxyhyponitrite inhibits the reaction [LIF protein results in increased activity of STAT3 protein]22905257
C021229oxyhyponitriteoxyhyponitrite inhibits the reaction [LIF protein results in increased activity of STAT3 protein]22905257
D010126Ozone[LEP gene mutant form results in increased susceptibility to Ozone] which results in increased expression of LIF protein27472835
D010126OzoneOzone results in decreased expression of LIF mRNA16330353
D052638Particulate MatterParticulate Matter results in increased expression of LIF mRNA17450221|2217879
C086401pentabromodiphenyl etherpentabromodiphenyl ether results in increased expression of LIF mRNA26705709
D010862PilocarpinePilocarpine results in increased expression of LIF mRNA10506506
D028321Plant PreparationsPlant Preparations affects the expression of LIF mRNA16046712
C060540polyhexamethyleneguanidinepolyhexamethyleneguanidine results in increased expression of LIF protein29175452
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of LIF mRNA22714537
D011374Progesterone[Estradiol co-treated with Progesterone] results in decreased expression of LIF mRNA20660070
D011374ProgesteroneESR1 protein promotes the reaction [[Estradiol co-treated with Progesterone] results in increased expression of LIF mRNA]25210133
D011374Progesterone[Estradiol co-treated with Progesterone] results in increased expression of LIF mRNA25210133
D011374Progesterone"LIF protein affects the reaction [Progesterone inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased abundance of Nitric Oxide]]"23409146
D011374ProgesteroneLIF protein affects the susceptibility to Progesterone23409146
D011374Progesterone[NR5A1 protein co-treated with LIF protein co-treated with 8-Bromo Cyclic Adenosine Monophosphate co-treated with Tretinoin] results in increased abundance of Progesterone21610156
D011374ProgesteroneProgesterone affects the expression of LIF23407384
D011374ProgesteroneProgesterone affects the expression of LIF mRNA17307916
D011374Progesterone[Progesterone co-treated with Estradiol] affects the expression of LIF15639816
D011374ProgesteroneProgesterone results in increased expression of LIF mRNA23409146
C033607puerarinpuerarin results in decreased expression of LIF mRNA22919047
C513428pyrachlostrobinpyrachlostrobin results in increased expression of LIF mRNA27029645
C020972pyrrolidine dithiocarbamic acid"pyrrolidine dithiocarbamic acid inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of LIF mRNA]"11578593
D011794QuercetinQuercetin results in increased expression of LIF mRNA21632981|2619864
D015125OxyquinolineOxyquinoline results in increased expression of LIF mRNA26198647
D017382Reactive Oxygen SpeciesLIF protein inhibits the reaction [[Oxygen deficiency co-treated with Oxygen] results in increased chemical synthesis of Reactive Oxygen Species]11524388
D017382Reactive Oxygen SpeciesLIF protein results in decreased chemical synthesis of Reactive Oxygen Species11524388
C031389resorcinolresorcinol results in increased expression of LIF mRNA26198647
C059514resveratrolresveratrol results in increased expression of and results in increased secretion of LIF protein18592012
C059514resveratrolresveratrol results in increased expression of LIF mRNA18592012
C059514resveratrolresveratrol inhibits the reaction [Dietary Fats results in increased expression of LIF mRNA]21852083
D019438RitonavirRitonavir results in decreased expression of LIF26626330
C093642SB 203580SB 203580 inhibits the reaction [[1-methylanthracene co-treated with fluoranthene] results in increased expression of LIF mRNA]28329830
D064586Selenic AcidSelenic Acid promotes the reaction [LIF protein results in increased expression of CCL2]22366233
D064586Selenic AcidSelenic Acid promotes the reaction [LIF protein results in increased phosphorylation of and results in increased activity of STAT3 protein]22366233
D064586Selenic AcidSelenic Acid results in increased susceptibility to LIF protein22366233
D017632Asbestos, Serpentine"Asbestos, Serpentine results in decreased expression of LIF mRNA"21148743
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of LIF mRNA25895662
D012822Silicon DioxideSilicon Dioxide results in increased expression of LIF mRNA22300531|2535159
D012822Silicon Dioxide[Gold co-treated with Silicon Dioxide] results in increased secretion of LIF protein22155353
D012822Silicon DioxideSilicon Dioxide results in increased expression of LIF mRNA19073995
D019821Simvastatin[Valsartan co-treated with Simvastatin] inhibits the reaction [Glucose promotes the reaction [AGT protein results in increased expression of LIF mRNA]]19225232
C017947sodium arsenitesodium arsenite results in decreased expression of LIF mRNA22714537
C017947sodium arsenitesodium arsenite results in increased expression of LIF mRNA12760830
D004113Succimer[Succimer binds to Magnetite Nanoparticles] which results in increased expression of LIF mRNA21641980
C458508T 0070907"T 0070907 inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [LIF protein results in increased expression of STAT3 protein]]"19922793
C458508T 0070907"T 0070907 inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [LIF protein results in increased phosphorylation of STAT3 protein]]"19922793
C458508T 0070907T 0070907 inhibits the reaction [ciglitazone inhibits the reaction [LIF protein results in increased expression of STAT3 protein]]19922793
C458508T 0070907T 0070907 inhibits the reaction [ciglitazone inhibits the reaction [LIF protein results in increased phosphorylation of STAT3 protein]]19922793
D016559TacrolimusTacrolimus results in increased expression of LIF mRNA23958496
D013629TamoxifenTamoxifen inhibits the reaction [[bisphenol A affects the activity of ESR1 protein] promotes the reaction [LIF protein results in increased activity of STAT3 protein]]14975756
D013629TamoxifenTamoxifen inhibits the reaction [[Endosulfan affects the activity of ESR1 protein] promotes the reaction [LIF protein results in increased activity of STAT3 protein]]14975756
D013629TamoxifenTamoxifen inhibits the reaction [[Methoxychlor affects the activity of ESR1 protein] promotes the reaction [LIF protein results in increased activity of STAT3 protein]]14975756
C047246temozolomideLIF mRNA results in increased susceptibility to temozolomide16365179
C020806tetrabromobisphenol Atetrabromobisphenol A results in increased expression of LIF mRNA25172293
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of LIF mRNA12377990|2010694
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of LIF mRNA21570461
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Estradiol] results in decreased expression of LIF mRNA18691609
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of LIF mRNA18691609|1993321
D013755Tetradecanoylphorbol AcetateTetradecanoylphorbol Acetate results in increased expression of LIF mRNA26198647
D013755Tetradecanoylphorbol Acetate[Zinc co-treated with Tetradecanoylphorbol Acetate] affects the expression of LIF mRNA16979875
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of LIF mRNA25613284
D019284ThapsigarginThapsigargin inhibits the reaction [LIF protein results in increased activity of CAMK4 protein]11073891
D013853ThioacetamideThioacetamide results in increased expression of LIF mRNA23411599
D014118Toxins, Biological"Toxins, Biological affects the expression of LIF mRNA"19682533
D014212TretinoinTretinoin results in increased expression of LIF mRNA16249480
D014212Tretinoin[NR5A1 protein co-treated with LIF protein co-treated with 8-Bromo Cyclic Adenosine Monophosphate co-treated with Tretinoin] results in increased abundance of Progesterone21610156
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of LIF mRNA"26179874
C013320tris(2-butoxyethyl) phosphatetris(2-butoxyethyl) phosphate affects the expression of LIF mRNA29024780
C057693troglitazonetroglitazone results in decreased susceptibility to LIF protein7956951
C057693troglitazonetroglitazone results in increased expression of LIF mRNA19140230
D014520UrethaneUrethane results in decreased expression of LIF mRNA28818685
D014635Valproic AcidValproic Acid results in decreased expression of LIF mRNA29154799
D014635Valproic AcidValproic Acid results in increased methylation of LIF gene29154799
D000068756Valsartan[Valsartan co-treated with Simvastatin] inhibits the reaction [Glucose promotes the reaction [AGT protein results in increased expression of LIF mRNA]]19225232
D000068756ValsartanValsartan inhibits the reaction [AGT protein results in increased expression of LIF mRNA]19225232
D000068756ValsartanValsartan inhibits the reaction [Glucose promotes the reaction [AGT protein results in increased expression of LIF mRNA]]19225232
D014638VanadatesVanadates promotes the reaction [LIF protein results in increased phosphorylation of and results in increased activity of STAT3 protein]22366233
D014638VanadatesVanadates results in increased susceptibility to LIF protein22366233
C034028vanadyl sulfatevanadyl sulfate results in increased expression of LIF mRNA16330358
D014700VerapamilVerapamil inhibits the reaction [LIF protein results in increased activity of CAMK2A protein]11073891
D014700VerapamilVerapamil inhibits the reaction [LIF protein results in increased activity of CAMK4 protein]11073891
D014700VerapamilVerapamil inhibits the reaction [LIF protein results in increased phosphorylation of CAMK2A protein]11073891
C025643vinclozolinvinclozolin results in increased methylation of LIF promoter22570695
D014750VincristineVincristine results in increased expression of LIF mRNA23649840
C029297vinylidene chloridevinylidene chloride results in increased expression of LIF mRNA26682919
D002762CholecalciferolCholecalciferol results in increased expression of LIF mRNA17170073
D024483Vitamin K 3Vitamin K 3 results in increased expression of LIF mRNA12414654|2341063
D015032Zinc[Zinc co-treated with Tetradecanoylphorbol Acetate] affects the expression of LIF mRNA16979875
D015032ZincZinc deficiency results in decreased expression of LIF mRNA18356318

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005102signaling receptor binding-IPI8999038  
GO:0005125cytokine activity-IBA21873635  
GO:0005125cytokine activity-IDA7957045  22783022  
GO:0005146leukemia inhibitory factor receptor binding-IBA21873635  
GO:0005146leukemia inhibitory factor receptor binding-IDA7957045  
GO:0005146leukemia inhibitory factor receptor binding-IPI8999038  
GO:0005515protein binding-IPI14527405  16051226  
GO:0008083growth factor activity-IBA21873635  
GO:0008083growth factor activity-IDA7957045  8999038  12643274  
GO ID GO Term Qualifier Evidence PubMed
GO:0001974blood vessel remodeling-IEA-  
GO:0006955immune response-IEA-  
GO:0007260tyrosine phosphorylation of STAT protein-IEA-  
GO:0007275multicellular organism development-TAS3143918  
GO:0007566embryo implantation-IEA-  
GO:0008284positive regulation of cell proliferation-IBA21873635  
GO:0008284positive regulation of cell proliferation-IDA7957045  8999038  
GO:0008285negative regulation of cell proliferation-IEA-  
GO:0010469regulation of signaling receptor activity-IEA-  
GO:0019221cytokine-mediated signaling pathway-TAS-  
GO:0019827stem cell population maintenance-IEA-  
GO:0033138positive regulation of peptidyl-serine phosphorylation-IDA7508917  
GO:0033141positive regulation of peptidyl-serine phosphorylation of STAT protein-IDA20624457  
GO:0042531positive regulation of tyrosine phosphorylation of STAT protein-IDA20624457  
GO:0043410positive regulation of MAPK cascade-IDA7508917  
GO:0045595regulation of cell differentiation-IBA21873635  
GO:0045651positive regulation of macrophage differentiation-IDA7957045  
GO:0045835negative regulation of meiotic nuclear division-IEA-  
GO:0045944positive regulation of transcription by RNA polymerase II-IDA7508917  20624457  22783022  
GO:0046697decidualization-IEA-  
GO:0046888negative regulation of hormone secretion-IDA7867561  
GO:0048286lung alveolus development-IEA-  
GO:0048644muscle organ morphogenesis-IEA-  
GO:0048666neuron development-IEA-  
GO:0048711positive regulation of astrocyte differentiation-IEA-  
GO:0048861leukemia inhibitory factor signaling pathway-IBA21873635  
GO:0048861leukemia inhibitory factor signaling pathway-IDA8999038  12643274  
GO:0048863stem cell differentiation-IEA-  
GO:0050731positive regulation of peptidyl-tyrosine phosphorylation-IDA7508917  
GO:0060426lung vasculature development-IEA-  
GO:0060463lung lobe morphogenesis-IEA-  
GO:0060707trophoblast giant cell differentiation-IEA-  
GO:0060708spongiotrophoblast differentiation-IEA-  
GO:0070373negative regulation of ERK1 and ERK2 cascade-IEA-  
GO:0072108positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis-IDA20624457  
GO:0072307regulation of metanephric nephron tubule epithelial cell differentiation-IDA20624457  
GO:1900182positive regulation of protein localization to nucleus-IDA22783022  
GO:1901676positive regulation of histone H3-K27 acetylation-IDA22783022  
GO:1903025regulation of RNA polymerase II regulatory region sequence-specific DNA binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-TAS-  
GO:0005615extracellular space-IBA21873635  
GO:0005615extracellular space-IC12643274  
GO:0005829cytosol-IDA-  
KEGG ID KEGG Term
hsa04060Cytokine-cytokine receptor interaction
hsa04630Jak-STAT signaling pathway
Reactome ID Reactome Term Evidence
R-HSA-1280215Cytokine Signaling in Immune systemTAS
R-HSA-168256Immune SystemTAS
R-HSA-449147Signaling by InterleukinsTAS
R-HSA-6783589Interleukin-6 family signalingTAS
R-HSA-6783783Interleukin-10 signalingTAS
R-HSA-6785807Interleukin-4 and 13 signalingTAS
R-HSA-6788467IL-6-type cytokine receptor ligand interactionsTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
26642056In Utero Cigarette Smoke Affects Allergic Airway Disease But Does Not Alter the Lung Methylome. (2015)Eyring KRPLoS One
24435975p53 signaling pathway polymorphisms associated to recurrent pregnancy loss. (2014 Mar)Fraga LRMol Biol Rep
7839126Trace element reference values in tissues from inhabitants of the European Union. VIII. Thallium in the Italian population. (1994 Dec 18)Sabbioni ESci Total Environ
20139427Effects of oral and vaginal administration of levonorgestrel emergency contraception on markers of endometrial receptivity. (2010 Apr)Meng CXHum Reprod
21846370Chronic alcohol ingestion exacerbates skeletal muscle myopathy in HIV-1 transgenic rats. (2011 Aug 16)Clary CRAIDS Res Ther