Gene: LIG1

3978
-
DNA ligase 1
protein-coding
19q13.33
Ensembl:ENSG00000105486 MIM:126391 Vega:OTTHUMG00000183187 UniprotKB:P18858
NG_007395.1
PubMed
0   ANCO-SNPs
ND
4   
NA (AD)  NA (ND)   (Frontal_Cortex)
4.418e-1 (AD)  2.080e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
MAU20.895
NUMA10.88
CSAD0.878
RBM50.873
ANKZF10.873
ANAPC20.868
HDAC60.866
DPH70.865
SRRM10.86
EZH10.854

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.487
OR4F29-0.452
MTRNR2L9-0.36
MTRNR2L6-0.36
MTRNR2L10-0.345
TRDN-0.317
TTLL10-0.31
OR4F16-0.308
KLRC2-0.298
TTLL10-AS1-0.293

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00290BleomycinSmall Molecule11056-06-7Approved|InvestigationalTarget
ID Drug Name Action PubMed
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of LIG1 mRNA"22698814|2890350
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of LIG1 mRNA"19114083
C0294972,3-bis(3'-hydroxybenzyl)butyrolactone"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of LIG1 mRNA"19167446
C0312782-chloroethyl ethyl sulfide2-chloroethyl ethyl sulfide results in increased phosphorylation of and results in increased activity of LIG1 protein16700562
C0312782-chloroethyl ethyl sulfide"N(6),N(6)-dimethyladenine inhibits the reaction [2-chloroethyl ethyl sulfide results in increased phosphorylation of LIG1 protein]"16700562
C0312782-chloroethyl ethyl sulfidewortmannin inhibits the reaction [2-chloroethyl ethyl sulfide results in increased phosphorylation of LIG1 protein]16700562
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in increased expression of LIG1 mRNA"23196670
C0067574-biphenylamine4-biphenylamine results in decreased expression of LIG1 mRNA24857880
D000082AcetaminophenAcetaminophen results in increased expression of LIG1 mRNA22230336
D000082AcetaminophenAcetaminophen results in decreased expression of LIG1 mRNA17942131
D000082AcetaminophenAcetaminophen results in increased expression of LIG1 mRNA12540782
D000082Acetaminophen"O(2)-vinyl-1-(pyrrolidin-1-yl)diazen-1-ium-1,2-diolate inhibits the reaction [Acetaminophen results in increased expression of LIG1 mRNA]"12540782
D016604Aflatoxin B1Aflatoxin B1 affects the expression of LIG1 protein20106945
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of LIG1 gene27153756
D000393Air PollutantsAir Pollutants results in increased expression of LIG1 protein28389379
D000643Ammonium ChlorideAmmonium Chloride affects the expression of LIG1 mRNA16483693
C059765amphotericin B, deoxycholate drug combination"amphotericin B, deoxycholate drug combination results in increased expression of LIG1 mRNA"22863853
D001151ArsenicArsenic affects the methylation of LIG1 gene25304211
C015001arsenitearsenite results in increased expression of LIG1 mRNA15996700
D001280AtrazineAtrazine results in increased expression of LIG1 mRNA25929836
D001564Benzo(a)pyreneAHR protein inhibits the reaction [Benzo(a)pyrene results in decreased expression of LIG1 mRNA]15034205
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of LIG1 mRNA15034205|1794213
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of LIG1 mRNA22228805
C006780bisphenol Abisphenol A results in decreased expression of LIG1 mRNA29275510
C006780bisphenol A[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of LIG1 mRNA28628672
C006780bisphenol Abisphenol A results in increased expression of LIG1 mRNA25181051
C005961bis(tri-n-butyltin)oxidebis(tri-n-butyltin)oxide results in decreased expression of LIG1 mRNA17942131
C546611brevetoxin 2brevetoxin 2 results in increased expression of LIG1 mRNA20498034
C016274bromoacetatebromoacetate results in decreased expression of LIG1 mRNA19753638
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in decreased expression of LIG1 mRNA15336504
D002104CadmiumCadmium results in decreased activity of LIG1 protein16677676
D019256Cadmium ChlorideCadmium Chloride results in increased expression of LIG1 mRNA15501611
D002220CarbamazepineCarbamazepine affects the expression of LIG1 mRNA25979313
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of LIG1 mRNA27339419
D002330CarmustineCarmustine results in decreased expression of LIG1 mRNA16005536
D002392Catechin[Catechin co-treated with Grape Seed Proanthocyanidins] results in decreased expression of LIG1 mRNA24763279
D002509CephaloridineCephaloridine results in increased expression of LIG1 mRNA18500788
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of LIG1 mRNA22872676
D003300Copper[NSC 689534 binds to Copper] which results in decreased expression of LIG1 mRNA20971185
D003300CopperCopper affects the expression of LIG1 mRNA23825565
D019327Copper SulfateCopper Sulfate results in decreased expression of LIG1 mRNA19549813
D003375Coumestrol"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of LIG1 mRNA"19167446
D003375Coumestrol[Coumestrol co-treated with resveratrol] results in increased expression of LIG1 mRNA19167446
D003375CoumestrolCoumestrol results in increased expression of LIG1 mRNA19167446
C408982CPG-oligonucleotideCPG-oligonucleotide results in decreased expression of LIG1 mRNA21878529
D003471CuprizoneCuprizone results in increased expression of LIG1 mRNA26577399
D016572CyclosporineCyclosporine results in decreased expression of LIG1 mRNA20106945|2163298
D016572CyclosporineCyclosporine results in decreased expression of LIG1 mRNA17942131
C007262deoxynivalenoldeoxynivalenol affects the phosphorylation of LIG1 protein23811945
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of LIG1 mRNA28628672
D003976DiazinonDiazinon results in increased methylation of LIG1 gene22964155
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of LIG1 mRNA21266533
D003999Dichloroacetic AcidDichloroacetic Acid results in increased expression of LIG1 mRNA28962523
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in increased expression of LIG1 mRNA27392435
D002945CisplatinCisplatin results in increased expression of LIG1 mRNA27392435|2759478
C000944dicrotophosdicrotophos results in increased expression of LIG1 mRNA28302478
D004026DieldrinDieldrin affects the expression of LIG1 mRNA23041725
D004052DiethylnitrosamineDiethylnitrosamine results in increased expression of LIG1 mRNA17854601
D004052DiethylnitrosamineRB1 protein inhibits the reaction [Diethylnitrosamine results in increased expression of LIG1 mRNA]17854601
D002117CalcitriolCalcitriol results in decreased expression of LIG1 mRNA21592394
D002117Calcitriol[Testosterone co-treated with Calcitriol] results in decreased expression of LIG1 mRNA21592394
D004317DoxorubicinDoxorubicin results in decreased expression of LIG1 mRNA27181935
D004317DoxorubicinFungal Polysaccharides inhibits the reaction [Doxorubicin results in decreased expression of LIG1 mRNA]27181935
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of LIG1 mRNA17555576
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of LIG1 mRNA17942748
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of LIG1 mRNA17942748
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in increased expression of LIG1 mRNA23649840
C024352fludarabine[LAQ824 co-treated with fludarabine] results in decreased expression of LIG1 mRNA18852132
D005472FluorouracilLIG1 protein affects the susceptibility to Fluorouracil15548681
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of LIG1 mRNA22872676
D062610Fungal PolysaccharidesFungal Polysaccharides inhibits the reaction [Doxorubicin results in decreased expression of LIG1 mRNA]27181935
C039281furanfuran results in increased expression of LIG1 mRNA20194422
C039281furanfuran results in increased expression of LIG1 mRNA22079235|2553966
C511402Grape Seed Proanthocyanidins[Catechin co-treated with Grape Seed Proanthocyanidins] results in decreased expression of LIG1 mRNA24763279
D017313FenretinideFenretinide results in increased expression of LIG1 mRNA28973697
C056493imiquimodimiquimod results in decreased expression of LIG1 mRNA21878529
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of LIG1 mRNA28628672
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of LIG1 mRNA25613284
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of LIG1 mRNA28628672
C544151jinfukang[Cisplatin co-treated with jinfukang] results in increased expression of LIG1 mRNA27392435
C544151jinfukangjinfukang results in increased expression of LIG1 mRNA27392435
C410337K 7174K 7174 results in decreased expression of LIG1 mRNA24086573
C477361LAQ824[LAQ824 co-treated with fludarabine] results in decreased expression of LIG1 mRNA18852132
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of LIG1 mRNA22872676
D008727MethotrexateMethotrexate results in decreased expression of LIG1 mRNA16005536
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of LIG1 mRNA23649840
D008769MethylnitronitrosoguanidineMethylnitronitrosoguanidine results in decreased expression of LIG1 mRNA12634122
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in decreased expression of LIG1 mRNA24810058
D008825MiconazoleMiconazole results in decreased expression of LIG1 mRNA22262564
D016685MitomycinMitomycin results in decreased expression of LIG1 mRNA12760830
D009151Mustard GasCASP3 protein affects the reaction [Mustard Gas results in increased phosphorylation of LIG1 protein]16906506
D009151Mustard GasMustard Gas results in increased activity of LIG1 protein11428624
D009151Mustard GasMustard Gas results in increased phosphorylation of LIG1 protein16906506|1984537
C001020N(6),N(6)-dimethyladenine"N(6),N(6)-dimethyladenine inhibits the reaction [2-chloroethyl ethyl sulfide results in increased phosphorylation of LIG1 protein]"16700562
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of LIG1 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of LIG1 mRNA"25554681
C029938nickel sulfatenickel sulfate results in increased expression of LIG1 mRNA16100012
C558013NSC 689534[NSC 689534 binds to Copper] which results in decreased expression of LIG1 mRNA20971185
C107010O(2)-vinyl-1-(pyrrolidin-1-yl)diazen-1-ium-1,2-diolate"O(2)-vinyl-1-(pyrrolidin-1-yl)diazen-1-ium-1,2-diolate inhibits the reaction [Acetaminophen results in increased expression of LIG1 mRNA]"12540782
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in decreased expression of LIG1 mRNA25729387
C030110oxaliplatinoxaliplatin results in decreased expression of LIG1 mRNA25729387
D010126Ozone[Ozone co-treated with NOTCH3 gene mutant form] results in increased expression of LIG1 mRNA25658374
D017239PaclitaxelPaclitaxel results in decreased expression of LIG1 mRNA15000894
D010416PentachlorophenolPentachlorophenol results in increased expression of LIG1 mRNA23892564
C058305phenethyl isothiocyanatephenethyl isothiocyanate results in decreased expression of LIG1 mRNA26678675
D010634PhenobarbitalPhenobarbital affects the expression of LIG1 mRNA19159669
D010634PhenobarbitalNR1I3 protein affects the reaction [Phenobarbital results in increased expression of LIG1 mRNA]19482888
D010634PhenobarbitalPhenobarbital results in increased expression of LIG1 mRNA19482888|2309116
C006253pirinixic acidpirinixic acid results in increased expression of LIG1 mRNA23811191
D011374ProgesteroneProgesterone results in increased expression of LIG1 mRNA23012394
D011374ProgesteroneProgesterone results in decreased expression of LIG1 mRNA16966611
D011374ProgesteroneProgesterone results in decreased expression of LIG1 mRNA20726854
C438462pyrrolo(2,1-c)(1,4)benzodiazepine"pyrrolo(2,1-c)(1,4)benzodiazepine analog binds to and results in decreased activity of LIG1 protein"26079053
C059514resveratrol[Coumestrol co-treated with resveratrol] results in increased expression of LIG1 mRNA19167446
C547185riccardin Driccardin D results in decreased expression of LIG1 mRNA24069304
C017947sodium arsenitesodium arsenite results in decreased expression of LIG1 mRNA12760830
C017947sodium arsenitesodium arsenite results in increased expression of LIG1 mRNA28595984
C017947sodium arsenitesodium arsenite results in decreased expression of LIG1 mRNA20643705
C017947sodium arsenitesodium arsenite results in increased expression of LIG1 mRNA20643705
C016104sodium bichromatesodium bichromate results in decreased expression of LIG1 mRNA22155349
C016104sodium bichromatesodium bichromate results in increased expression of LIG1 mRNA22155349
C016104sodium bichromatesodium bichromate results in increased expression of LIG1 mRNA22110744
D053260SootSoot results in increased expression of LIG1 mRNA26551751
C105686SU 5402SU 5402 affects the expression of LIG1 mRNA15298682
D000952Antigens, Polyomavirus Transforming"Antigens, Polyomavirus Transforming results in increased expression of LIG1 mRNA"26680231
D013629TamoxifenTamoxifen affects the expression of LIG1 mRNA17555576
D013739Testosterone[Testosterone co-treated with Calcitriol] results in decreased expression of LIG1 mRNA21592394
D013739TestosteroneTestosterone results in decreased expression of LIG1 mRNA21592394
D013749TetrachlorodibenzodioxinAHR protein inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of LIG1 mRNA]15034205
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of LIG1 mRNA21570461
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of LIG1 mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of LIG1 mRNA15034205
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of LIG1 mRNA25613284
C523062thio-dimethylarsinatethio-dimethylarsinate results in increased expression of LIG1 mRNA27320638
D013866ThioguanineThioguanine results in decreased expression of LIG1 mRNA16005536
C009495titanium dioxidetitanium dioxide affects the expression of LIG1 mRNA17656681
C009495titanium dioxidetitanium dioxide results in increased expression of LIG1 mRNA23557971
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in decreased expression of LIG1 mRNA25729387
D019772TopotecanTopotecan affects the expression of LIG1 mRNA25729387
D014212TretinoinTretinoin results in decreased expression of LIG1 mRNA16249480
C015559trimellitic anhydridetrimellitic anhydride results in increased expression of LIG1 mRNA19042947
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of LIG1 mRNA"26179874
C057693troglitazonetroglitazone results in decreased expression of LIG1 mRNA19140230
D014635Valproic AcidValproic Acid results in increased methylation of LIG1 gene29154799
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of LIG1 gene25560391
C029297vinylidene chloridevinylidene chloride results in increased expression of LIG1 mRNA26682919
C009687wortmanninwortmannin inhibits the reaction [2-chloroethyl ethyl sulfide results in increased phosphorylation of LIG1 protein]16700562

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003677DNA binding-IEA-  
GO:0003909DNA ligase activity-IDA9809069  
GO:0003909DNA ligase activity-IMP15871698  
GO:0003909DNA ligase activity-TAS-  
GO:0003910DNA ligase (ATP) activity-IBA21873635  
GO:0005524ATP binding-IEA-  
GO:0046872metal ion binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006266DNA ligation-TAS-  
GO:0006273lagging strand elongation-IBA21873635  
GO:0006281DNA repair-TAS8696349  
GO:0006283transcription-coupled nucleotide-excision repair-TAS-  
GO:0006284base-excision repair-IDA19589734  
GO:0006297nucleotide-excision repair, DNA gap filling-TAS-  
GO:0006298mismatch repair-TAS-  
GO:0009653anatomical structure morphogenesis-TAS8696349  
GO:0033151V(D)J recombinationNOTIDA9809069  
GO:0051103DNA ligation involved in DNA repair-IBA21873635  
GO:0051301cell division-IEA-  
GO:0071897DNA biosynthetic process-IEA-  
GO:1903461Okazaki fragment processing involved in mitotic DNA replication-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IBA21873635  
GO:0005634nucleus-TAS8696349  
GO:0005654nucleoplasm-IDA-  
GO:0005654nucleoplasm-TAS-  
GO:0005737cytoplasm-IBA21873635  
GO:0005739mitochondrion-IBA21873635  
GO:0043231intracellular membrane-bounded organelle-IDA-  
KEGG ID KEGG Term
hsa03030DNA replication
hsa03410Base excision repair
hsa03420Nucleotide excision repair
hsa03430Mismatch repair
Reactome ID Reactome Term Evidence
R-HSA-110362POLB-Dependent Long Patch Base Excision RepairTAS
R-HSA-110373Resolution of AP sites via the multiple-nucleotide patch replacement pathwayTAS
R-HSA-157579Telomere MaintenanceTAS
R-HSA-162587HIV Life CycleTAS
R-HSA-162594Early Phase of HIV Life CycleTAS
R-HSA-162906HIV InfectionTAS
R-HSA-1640170Cell CycleTAS
R-HSA-1643685DiseaseTAS
R-HSA-174414Processive synthesis on the C-strand of the telomereTAS
R-HSA-174417Telomere C-strand (Lagging Strand) SynthesisTAS
R-HSA-180786Extension of TelomeresTAS
R-HSA-5358508Mismatch RepairTAS
R-HSA-5358565Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)TAS
R-HSA-5358606Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)TAS
R-HSA-5651801PCNA-Dependent Long Patch Base Excision RepairTAS
R-HSA-5663205Infectious diseaseTAS
R-HSA-5696397Gap-filling DNA repair synthesis and ligation in GG-NERTAS
R-HSA-5696398Nucleotide Excision RepairTAS
R-HSA-5696399Global Genome Nucleotide Excision Repair (GG-NER)TAS
R-HSA-6781827Transcription-Coupled Nucleotide Excision Repair (TC-NER)TAS
R-HSA-6782210Gap-filling DNA repair synthesis and ligation in TC-NERTAS
R-HSA-69183Processive synthesis on the lagging strandTAS
R-HSA-69186Lagging Strand SynthesisTAS
R-HSA-69190DNA strand elongationTAS
R-HSA-69239Synthesis of DNATAS
R-HSA-69242S PhaseTAS
R-HSA-69278Cell Cycle, MitoticTAS
R-HSA-69306DNA ReplicationTAS
R-HSA-73884Base Excision RepairTAS
R-HSA-73886Chromosome MaintenanceTAS
R-HSA-73894DNA RepairTAS
R-HSA-73933Resolution of Abasic Sites (AP sites)TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
21976407Genetic variability in DNA repair and cell cycle control pathway genes and risk of smoking-related lung cancer. (2012 Oct)Buch SCMol Carcinog
18709642Nucleotide excision repair genes and risk of lung cancer among San Francisco Bay Area Latinos and African Americans. (2008 Nov 1)Chang JSInt J Cancer
12009232Polymorphism of DNA ligase I and risk of lung cancer--a case-control analysis. (2002 Jun)Shen HLung Cancer
17203305Genetic variation in the base excision repair pathway and bladder cancer risk. (2007 Apr)Figueroa JDHum Genet