Gene: LIG3

3980
LIG2
DNA ligase 3
protein-coding
17q12
Ensembl:ENSG00000005156 MIM:600940 Vega:OTTHUMG00000128519 UniprotKB:P49916
NG_029221.1
PubMed
0   ANCO-SNPs
ND
4   
8.146e-1 (AD)  6.471e-1 (ND)   (Frontal_Cortex)
8.360e-1 (AD)  6.538e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PRKDC0.898
DHX80.897
CIAO10.894
SF3B30.889
TP53BP10.885
KPNA60.884
TMEM1310.883
NSUN40.883
SART30.882
RALGAPB0.881

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.526
OR4F29-0.469
MTRNR2L6-0.345
CTNNA3-0.326
KLRC2-0.316
MTRNR2L9-0.303
MTRNR2L10-0.294
P2RY14-0.285
CSAG1-0.279
HEY2-0.274

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00290BleomycinSmall Molecule11056-06-7Approved|InvestigationalTarget
ID Drug Name Action PubMed
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of LIG3 mRNA"21346803
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of LIG3 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of LIG3 mRNA"27188386
D000082AcetaminophenAcetaminophen results in decreased expression of LIG3 mRNA22230336
D000082AcetaminophenAcetaminophen affects the expression of LIG3 mRNA17562736
D000082Acetaminophen[Clofibrate co-treated with Acetaminophen] affects the expression of LIG3 mRNA17585979
D000082AcetaminophenPPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of LIG3 mRNA]17585979
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of LIG3 mRNA19770486
D001151ArsenicArsenic results in decreased expression of LIG3 mRNA21332098
D001151ArsenicArsenic results in decreased expression of LIG3 protein21332098
D001151ArsenicCurcumin inhibits the reaction [Arsenic results in decreased expression of LIG3 mRNA]21332098
D001151ArsenicCurcumin inhibits the reaction [Arsenic results in decreased expression of LIG3 protein]21332098
C006780bisphenol Abisphenol A results in decreased expression of LIG3 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of LIG3 gene28505145
C000611646bisphenol F[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of LIG3 mRNA28628672
D002994Clofibrate[Clofibrate co-treated with Acetaminophen] affects the expression of LIG3 mRNA17585979
D002994ClofibratePPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of LIG3 mRNA]17585979
D003474CurcuminCurcumin inhibits the reaction [Arsenic results in decreased expression of LIG3 mRNA]21332098
D003474CurcuminCurcumin inhibits the reaction [Arsenic results in decreased expression of LIG3 protein]21332098
D016572CyclosporineCyclosporine results in increased expression of LIG3 mRNA20106945|2556210
C010902decabromobiphenyl etherdecabromobiphenyl ether results in increased expression of LIG3 mRNA24317228
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of LIG3 mRNA28628672
C000944dicrotophosdicrotophos results in increased expression of LIG3 mRNA28302478
C118739entinostatentinostat results in decreased expression of LIG3 mRNA27188386
D004791Enzyme Inhibitors[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of LIG3 protein23301498
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of LIG3 mRNA22079256
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of LIG3 mRNA17942748
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in decreased expression of LIG3 mRNA23649840
D005557FormaldehydeFormaldehyde results in decreased expression of LIG3 mRNA23649840
C069837fullerene C60fullerene C60 results in decreased expression of LIG3 mRNA19167457
D019833GenisteinGenistein results in decreased expression of LIG3 mRNA15257099
D017313FenretinideFenretinide results in increased expression of LIG3 mRNA28973697
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of LIG3 mRNA28628672
D007501IronIron results in decreased activity of LIG3 protein20622253
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of LIG3 mRNA28628672
C544151jinfukangjinfukang results in increased expression of LIG3 mRNA27392435
D008746Methylazoxymethanol AcetateMethylazoxymethanol Acetate affects the expression of LIG3 mRNA28349193
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of LIG3 mRNA23649840
D008825MiconazoleMiconazole results in increased expression of LIG3 mRNA22262564
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of LIG3 mRNA"25620056
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in decreased expression of LIG3 protein26178269
C011272perfosfamideperfosfamide results in decreased expression of LIG3 mRNA11754170
D010795Phthalic AcidsPhthalic Acids results in increased expression of LIG3 mRNA21061450
C006253pirinixic acidpirinixic acid results in decreased expression of LIG3 mRNA18445702
C019536potassium bromatepotassium bromate results in decreased expression of LIG3 mRNA22539617
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of LIG3 mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of LIG3 mRNA22079256
C031280pyrazolepyrazole results in increased expression of LIG3 mRNA17945193
D012402RotenoneRotenone results in decreased expression of LIG3 mRNA19013527
D012834SilverSilver results in decreased expression of LIG3 mRNA27131904
C017947sodium arsenitesodium arsenite results in decreased expression of LIG3 mRNA20643705
C017947sodium arsenitesodium arsenite results in increased expression of LIG3 mRNA20643705
D012969Sodium FluorideSodium Fluoride results in increased expression of LIG3 mRNA27862939
D013662TeaTea results in increased expression of LIG3 mRNA22181980
D013662TeaTea results in increased expression of LIG3 protein22181980
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of LIG3 mRNA20106945|2163298
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of LIG3 mRNA21570461
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of LIG3 mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of LIG3 mRNA21215274
C012589trichostatin Atrichostatin A affects the expression of LIG3 mRNA28542535
C015559trimellitic anhydridetrimellitic anhydride results in increased expression of LIG3 mRNA19042947
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of LIG3 mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of LIG3 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of LIG3 mRNA23179753|2800136
D014635Valproic AcidValproic Acid results in decreased methylation of LIG3 gene29154799
D014638VanadatesVanadates results in decreased expression of LIG3 mRNA22714537

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003677DNA binding-IEA-  
GO:0003909DNA ligase activity-IDA9809069  
GO:0003909DNA ligase activity-TAS-  
GO:0003910DNA ligase (ATP) activity-IBA21873635  
GO:0005515protein binding-IPI15744309  17353931  24407287  25609649  26496610  
GO:0005524ATP binding-IEA-  
GO:0008270zinc ion binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000724double-strand break repair via homologous recombination-TAS-  
GO:0006273lagging strand elongation-IBA21873635  
GO:0006283transcription-coupled nucleotide-excision repair-TAS-  
GO:0006288base-excision repair, DNA ligation-IDA19589734  
GO:0006288base-excision repair, DNA ligation-TAS-  
GO:0006297nucleotide-excision repair, DNA gap filling-TAS-  
GO:0006302double-strand break repair-IDA19589734  
GO:0007049cell cycle-IEA-  
GO:0033151V(D)J recombinationNOTIDA9809069  
GO:0051103DNA ligation involved in DNA repair-IBA21873635  
GO:0051301cell division-IEA-  
GO:0071897DNA biosynthetic process-IEA-  
GO:0090298negative regulation of mitochondrial DNA replication-IMP21878356  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IBA21873635  
GO:0005654nucleoplasm-IDA-  
GO:0005654nucleoplasm-TAS-  
GO:0005737cytoplasm-IBA21873635  
GO:0005739mitochondrion-IBA21873635  
KEGG ID KEGG Term
hsa03410Base excision repair
Reactome ID Reactome Term Evidence
R-HSA-110381Resolution of AP sites via the single-nucleotide replacement pathwayTAS
R-HSA-5649702APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement PathwayTAS
R-HSA-5685939HDR through MMEJ (alt-NHEJ)TAS
R-HSA-5693532DNA Double-Strand Break RepairTAS
R-HSA-5693538Homology Directed RepairTAS
R-HSA-5696397Gap-filling DNA repair synthesis and ligation in GG-NERTAS
R-HSA-5696398Nucleotide Excision RepairTAS
R-HSA-5696399Global Genome Nucleotide Excision Repair (GG-NER)TAS
R-HSA-6781827Transcription-Coupled Nucleotide Excision Repair (TC-NER)TAS
R-HSA-6782210Gap-filling DNA repair synthesis and ligation in TC-NERTAS
R-HSA-73884Base Excision RepairTAS
R-HSA-73894DNA RepairTAS
R-HSA-73933Resolution of Abasic Sites (AP sites)TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
23951112Genetic variation in the base excision repair pathway, environmental risk factors, and colorectal adenoma risk. (2013)Corral RPLoS One
25252713Factors modifying the risk for developing acute skin toxicity after whole-breast intensity modulated radiotherapy. (2014 Sep 25)De Langhe SBMC Cancer
17203305Genetic variation in the base excision repair pathway and bladder cancer risk. (2007 Apr)Figueroa JDHum Genet
19147782DNA repair gene polymorphisms and risk of pancreatic cancer. (2009 Jan 15)Li DClin Cancer Res