Gene: LIG4

3981
LIG4S
DNA ligase 4
protein-coding
13q33.3
Ensembl:ENSG00000174405 MIM:601837 Vega:OTTHUMG00000017328 UniprotKB:P49917
NG_007396.1
PubMed
0   ANCO-SNPs
ND
4   
NA (AD)  NA (ND)   (Frontal_Cortex)
9.052e-3 (AD)  1.127e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
DNAJB140.937
MTMR60.931
SLC25A460.93
PANK30.926
ACSL40.926
TRUB10.925
AP1AR0.924
PJA20.924
UCHL50.919
ADSS0.919

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.518
OR4F29-0.488
CSAG1-0.44
MTRNR2L10-0.437
MTRNR2L6-0.411
MTRNR2L9-0.386
EVC2-0.383
RHOD-0.372
MTRNR2L8-0.36
S100A12-0.357

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0326681-nitropyrene1-nitropyrene results in increased expression of LIG4 mRNA19041380
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of LIG4 mRNA"21346803
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of LIG4 mRNA"21346803
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of LIG4 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of LIG4 mRNA"27188386
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of LIG4 gene27153756
D000393Air PollutantsAir Pollutants results in increased expression of LIG4 protein28389379
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of LIG4 mRNA24449571
D001151ArsenicArsenic results in decreased expression of LIG4 mRNA21332098
D001151ArsenicArsenic results in decreased expression of LIG4 protein21332098
D001151ArsenicCurcumin inhibits the reaction [Arsenic results in decreased expression of LIG4 mRNA]21332098
D001151ArsenicCurcumin inhibits the reaction [Arsenic results in decreased expression of LIG4 protein]21332098
D017638Asbestos, Crocidolite"Asbestos, Crocidolite results in increased expression of LIG4 mRNA"18687144
C006703benzo(b)fluoranthenebenzo(b)fluoranthene results in increased expression of LIG4 mRNA26377693
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of LIG4 mRNA22228805
D004958Estradiol[bisphenol A co-treated with Estradiol] results in decreased expression of LIG4 mRNA26496021
C006780bisphenol A[bisphenol A co-treated with Estradiol] results in decreased expression of LIG4 mRNA26496021
D000069286BortezomibBortezomib results in increased expression of LIG4 mRNA20977926
D003010ClorgylineClorgyline results in increased expression of LIG4 mRNA19691856
D003375CoumestrolCoumestrol results in decreased expression of LIG4 mRNA19167446
D003474CurcuminCurcumin inhibits the reaction [Arsenic results in decreased expression of LIG4 mRNA]21332098
D003474CurcuminCurcumin inhibits the reaction [Arsenic results in decreased expression of LIG4 protein]21332098
D016572CyclosporineCyclosporine results in decreased expression of LIG4 mRNA25562108
C089595cylindrospermopsincylindrospermopsin results in increased expression of LIG4 mRNA23726867
D013759DronabinolDronabinol results in increased expression of LIG4 mRNA18454173
D004317DoxorubicinLIG4 protein affects the reaction [Doxorubicin results in increased activity of CASP3 protein]18508926
D004317DoxorubicinLIG4 protein affects the reaction [Doxorubicin results in increased activity of CASP8 protein]18508926
D004317DoxorubicinLIG4 protein affects the reaction [Doxorubicin results in increased activity of CASP9 protein]18508926
D0150732-Acetylaminofluorene2-Acetylaminofluorene results in decreased expression of LIG4 mRNA19167416
D004397FonofosFonofos results in increased methylation of LIG4 promoter22847954
D006046Gold[Polyethyleneimine binds to Gold] which affects the expression of LIG4 mRNA28433809
C544151jinfukangjinfukang results in decreased expression of LIG4 mRNA27392435
D007854LeadLIG4 gene polymorphism affects the susceptibility to Lead22466227
C008261lead acetatelead acetate results in decreased expression of LIG4 mRNA22641619
D018021Lithium ChlorideLithium Chloride results in increased expression of LIG4 mRNA19285016
D018021Lithium ChlorideLithium Chloride results in increased expression of LIG4 protein19285016
D058185Magnetite Nanoparticles[Succimer co-treated with Magnetite Nanoparticles] results in increased expression of LIG4 mRNA26378955
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of LIG4 mRNA28001369
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of LIG4 mRNA"25620056
C017096n-butoxyethanoln-butoxyethanol results in decreased expression of LIG4 mRNA19812364
C022838nickel chloridenickel chloride results in decreased expression of LIG4 mRNA28472268
D009538NicotineNicotine results in increased expression of LIG4 mRNA16949557
D010278ParathionParathion results in increased methylation of LIG4 promoter22847954
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in decreased expression of LIG4 mRNA27153767
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of LIG4 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of LIG4 mRNA26272509
D010936Plant ExtractsPlant Extracts results in increased expression of LIG4 mRNA23557933
D011094Polyethyleneimine[Polyethyleneimine binds to Gold] which affects the expression of LIG4 mRNA28433809
C045950propiconazolepropiconazole results in increased expression of LIG4 mRNA21278054
D011441PropylthiouracilPropylthiouracil results in decreased expression of LIG4 mRNA24780913
C547185riccardin Driccardin D results in increased expression of LIG4 mRNA24069304
D004113Succimer[Succimer co-treated with Magnetite Nanoparticles] results in increased expression of LIG4 mRNA26378955
D013662TeaTea results in increased expression of LIG4 mRNA22181980
D013662TeaTea results in increased expression of LIG4 protein22181980
C012568terbufosterbufos results in increased methylation of LIG4 promoter22847954
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with TIPARP gene mutant form] results in decreased expression of LIG4 mRNA25975270
D013853ThioacetamideThioacetamide results in increased expression of LIG4 mRNA23411599
C012589trichostatin Atrichostatin A results in increased expression of LIG4 mRNA24935251
D014520UrethaneUrethane results in decreased expression of LIG4 mRNA28818685
D014635Valproic AcidValproic Acid affects the expression of LIG4 mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of LIG4 mRNA19101580|2317975
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of LIG4 gene25560391
C025643vinclozolinvinclozolin results in increased expression of LIG4 mRNA23034163

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003677DNA binding-IDA8798671  
GO:0003909DNA ligase activity-IDA12517771  
GO:0003909DNA ligase activity-TAS-  
GO:0003910DNA ligase (ATP) activity-IDA8798671  22192310  
GO:0005515protein binding-IPI9242410  9259561  9809069  11702069  16439205  17389648  
17396150  21070942  22529269  22658747  23178593  23219551  
25416956  25910212  
GO:0005524ATP binding-IEA-  
GO:0008022protein C-terminus binding-IPI12589063  
GO:0016874ligase activity-IDA9242410  
GO:0046872metal ion binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000012single strand break repair-IDA8798671  
GO:0001701in utero embryonic development-ISS-  
GO:0002328pro-B cell differentiation-ISS-  
GO:0006266DNA ligation-IDA12517771  
GO:0006297nucleotide-excision repair, DNA gap filling-IBA21873635  
GO:0006297nucleotide-excision repair, DNA gap filling-IDA12517771  
GO:0006302double-strand break repair-IDA9242410  19589734  
GO:0006302double-strand break repair-ISS-  
GO:0006303double-strand break repair via nonhomologous end joining-IBA21873635  
GO:0006303double-strand break repair via nonhomologous end joining-IDA12517771  
GO:0006303double-strand break repair via nonhomologous end joining-IGI23275564  
GO:0006303double-strand break repair via nonhomologous end joining-IMP9809069  
GO:0006303double-strand break repair via nonhomologous end joining-ISS-  
GO:0006303double-strand break repair via nonhomologous end joining-TAS-  
GO:0007049cell cycle-IEA-  
GO:0007417central nervous system development-ISS-  
GO:0008283cell proliferation-ISS-  
GO:0010165response to X-ray-IMP9809069  
GO:0010332response to gamma radiation-ISS-  
GO:0033077T cell differentiation in thymus-ISS-  
GO:0033151V(D)J recombination-IDA9809069  
GO:0033152immunoglobulin V(D)J recombination-IBA21873635  
GO:0033153T cell receptor V(D)J recombination-ISS-  
GO:0035019somatic stem cell population maintenance-ISS-  
GO:0043524negative regulation of neuron apoptotic process-ISS-  
GO:0045190isotype switching-ISS-  
GO:0048146positive regulation of fibroblast proliferation-ISS-  
GO:0050769positive regulation of neurogenesis-ISS-  
GO:0051102DNA ligation involved in DNA recombination-ISS-  
GO:0051103DNA ligation involved in DNA repair-IDA12517771  
GO:0051103DNA ligation involved in DNA repair-ISS-  
GO:0051276chromosome organization-ISS-  
GO:0051301cell division-IEA-  
GO:0051402neuron apoptotic process-ISS-  
GO:0071285cellular response to lithium ion-IEA-  
GO:0071897DNA biosynthetic process-IEA-  
GO:0075713establishment of integrated proviral latency-TAS-  
GO:0097680double-strand break repair via classical nonhomologous end joining-IMP24837021  
GO:2001252positive regulation of chromosome organization-IMP23275564  
GO ID GO Term Qualifier Evidence PubMed
GO:0000784nuclear chromosome, telomeric region-IC23275564  
GO:0000793condensed chromosome-IDA12589063  
GO:0005634nucleus-IDA8798671  12589063  
GO:0005654nucleoplasm-IDA-  
GO:0005654nucleoplasm-TAS-  
GO:0005958DNA-dependent protein kinase-DNA ligase 4 complex-IBA21873635  
GO:0005958DNA-dependent protein kinase-DNA ligase 4 complex-IDA15194694  
GO:0005958DNA-dependent protein kinase-DNA ligase 4 complex-ISS-  
GO:0032807DNA ligase IV complex-IBA21873635  
GO:0032807DNA ligase IV complex-IMP9809069  
GO:0036464cytoplasmic ribonucleoprotein granule-IDA-  
GO:0070419nonhomologous end joining complex-IDA20383123  25941166  
KEGG ID KEGG Term
hsa03450Non-homologous end-joining
Reactome ID Reactome Term Evidence
R-HSA-162587HIV Life CycleTAS
R-HSA-162592Integration of provirusTAS
R-HSA-162594Early Phase of HIV Life CycleTAS
R-HSA-162906HIV InfectionTAS
R-HSA-1643685DiseaseTAS
R-HSA-1648432-LTR circle formationTAS
R-HSA-5663205Infectious diseaseTAS
R-HSA-5693532DNA Double-Strand Break RepairTAS
R-HSA-5693571Nonhomologous End-Joining (NHEJ)TAS
R-HSA-73894DNA RepairTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
19147782DNA repair gene polymorphisms and risk of pancreatic cancer. (2009 Jan 15)Li DClin Cancer Res
19408343Lung cancer susceptibility and prognosis associated with polymorphisms in the nonhomologous end-joining pathway genes: a multiple genotype-phenotype study. (2009 Jul 1)Tseng RCCancer
18768166Single-nucleotide polymorphisms in DNA double-strand break repair genes: association with head and neck cancer and interaction with tobacco use and alcohol consumption. (2008 Oct 30)Werbrouck JMutat Res
23663450Genetic polymorphisms of DNA double-strand break repair pathway genes and glioma susceptibility. (2013 May 10)Zhao PBMC Cancer