Gene: ABLIM1

3983
ABLIM|LIMAB1|LIMATIN|abLIM-1
actin binding LIM protein 1
protein-coding
10q25.3
Ensembl:ENSG00000099204 MIM:602330 Vega:OTTHUMG00000019088 UniprotKB:O14639
NG_029872.2
PubMed
0   ANCO-SNPs
AD
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
5.900e-1 (AD)  9.158e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
AHCYL20.89
EIF4EBP20.873
SPARCL10.87
NEBL0.866
MAP3K50.864
ZHX30.862
MTMR30.861
CPE0.856
PRKCA0.855
KDM3B0.854

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.729
OR4F29-0.711
CD8B-0.21
GNG8-0.207
NANOGNB-0.195
CCDC140-0.195
C9orf135-0.191
L1TD1-0.191
GHRH-0.19
GAB4-0.19

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0264861,2,5,6-dibenzanthracene"1,2,5,6-dibenzanthracene results in increased expression of ABLIM1 mRNA"26377693
C0297902,2',3',4,4',5-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of ABLIM1 mRNA"25510870
C0817662,4,4'-trichlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of ABLIM1 mRNA"25510870
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of ABLIM1 mRNA"25510870
C0098282,4,5,2',5'-pentachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of ABLIM1 mRNA"25510870
C0094072,5,2',5'-tetrachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of ABLIM1 mRNA"25510870
C0303702-methoxy-5-(2',3',4'-trimethoxyphenyl)tropone"2-methoxy-5-(2',3',4'-trimethoxyphenyl)tropone results in increased expression of ABLIM1 mRNA"20206263
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in decreased expression of ABLIM1 mRNA"18648102
D000082AcetaminophenAcetaminophen results in decreased expression of ABLIM1 mRNA21420995
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of ABLIM1 mRNA27153756
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of ABLIM1 gene27153756
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of ABLIM1 mRNA24449571
C006632arsenic trioxideABLIM1 protein results in decreased susceptibility to arsenic trioxide20707922
C006632arsenic trioxidearsenic trioxide results in increased expression of ABLIM1 mRNA20458559
D001280AtrazineAtrazine results in decreased expression of ABLIM1 mRNA25929836
C547126AZM551248AZM551248 results in decreased expression of ABLIM1 mRNA22323515
C030935benz(a)anthracene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of ABLIM1 mRNA27858113
D001554BenzeneBenzene results in increased expression of ABLIM1 mRNA20036648
C006703benzo(b)fluoranthene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of ABLIM1 mRNA27858113
C006703benzo(b)fluoranthenebenzo(b)fluoranthene results in increased expression of ABLIM1 mRNA26377693
C022921benzo(k)fluoranthenebenzo(k)fluoranthene results in decreased expression of ABLIM1 mRNA26377693
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased mutagenesis of ABLIM1 gene25435355
D001564Benzo(a)pyrene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of ABLIM1 mRNA27858113
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of ABLIM1 mRNA19770486
D004958EstradiolEstradiol affects the expression of ABLIM1 mRNA14699072
D004958Estradiol[Estradiol co-treated with Progesterone] results in decreased expression of ABLIM1 mRNA20660070
C044887beta-methylcholinebeta-methylcholine affects the expression of ABLIM1 mRNA21179406
C006780bisphenol Abisphenol A results in increased expression of ABLIM1 protein28273538
C006780bisphenol Abisphenol A results in increased expression of ABLIM1 mRNA27685785
C006780bisphenol Abisphenol A results in decreased expression of ABLIM1 mRNA26063408
C006780bisphenol Abisphenol A results in decreased expression of ABLIM1 mRNA25181051
C006780bisphenol Abisphenol A results in increased expression of ABLIM1 mRNA29097150
C013418bromfenacoumbromfenacoum results in decreased expression of ABLIM1 protein28903499
D0151248-Bromo Cyclic Adenosine Monophosphate8-Bromo Cyclic Adenosine Monophosphate results in decreased expression of ABLIM1 mRNA22079614
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in decreased expression of ABLIM1 mRNA15336504
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in decreased expression of ABLIM1 mRNA23650126
C031180chrysene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of ABLIM1 mRNA27858113
D016572CyclosporineCyclosporine results in decreased expression of ABLIM1 mRNA25562108|2798913
D016572CyclosporineCyclosporine results in decreased expression of ABLIM1 mRNA19770486
D002945CisplatinCisplatin results in decreased expression of ABLIM1 mRNA27594783
D004041Dietary FatsDietary Fats results in increased expression of ABLIM1 mRNA19030233
D004041Dietary Fats[Dietary Fats co-treated with resveratrol] results in increased expression of ABLIM1 mRNA21852083
D002117CalcitriolCalcitriol results in increased expression of ABLIM1 mRNA16002434
D0151279,10-Dimethyl-1,2-benzanthracene"9,10-Dimethyl-1,2-benzanthracene results in decreased expression of ABLIM1 mRNA"22485181
D004237DiuronDiuron results in decreased expression of ABLIM1 mRNA21551480
D004317DoxorubicinABLIM1 protein affects the susceptibility to Doxorubicin16217747
D004791Enzyme Inhibitors[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of ABLIM1 protein23301498
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in decreased expression of ABLIM1 mRNA23649840
D005947Glucose[INS protein co-treated with Glucose] results in decreased expression of ABLIM1 mRNA22634610
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of ABLIM1 mRNA25613284
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of ABLIM1 mRNA21889194|2343069
D007854LeadLead affects the expression of ABLIM1 mRNA28903495
D007854LeadLead affects the splicing of ABLIM1 mRNA28903495
D058185Magnetite Nanoparticles[Succimer co-treated with Magnetite Nanoparticles] results in decreased expression of ABLIM1 mRNA26378955
D008694MethamphetamineMethamphetamine results in increased expression of ABLIM1 mRNA26307267
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of ABLIM1 mRNA23649840
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of ABLIM1 mRNA"26251327
D015735MifepristoneMifepristone results in increased expression of ABLIM1 mRNA17584828
D016685MitomycinABLIM1 protein affects the susceptibility to Mitomycin16217747
C523799MRK 003ABLIM1 results in decreased susceptibility to MRK 00319903844
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of ABLIM1 mRNA"25554681|2562005
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of ABLIM1 mRNA"25554681|2562005
C028007nickel monoxidenickel monoxide results in increased expression of ABLIM1 mRNA19167457
C029938nickel sulfatenickel sulfate results in decreased expression of ABLIM1 mRNA22714537
C410127PCB 180"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of ABLIM1 mRNA"25510870
D010634PhenobarbitalPhenobarbital results in decreased expression of ABLIM1 mRNA23091169
D010672PhenytoinPhenytoin results in decreased expression of ABLIM1 mRNA15136057
C006253pirinixic acidpirinixic acid results in increased expression of ABLIM1 mRNA17426115|1830175
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of ABLIM1 mRNA22714537
D011192Potassium DichromatePotassium Dichromate results in decreased expression of ABLIM1 mRNA23608068
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in increased expression of ABLIM1 mRNA28903501
D011374Progesterone[Estradiol co-treated with Progesterone] results in decreased expression of ABLIM1 mRNA20660070
D011374ProgesteroneProgesterone results in increased expression of ABLIM1 mRNA20864642
C059514resveratrolresveratrol results in increased expression of ABLIM1 mRNA12569576
C059514resveratrol[Dietary Fats co-treated with resveratrol] results in increased expression of ABLIM1 mRNA21852083
D012402RotenoneRotenone results in decreased expression of ABLIM1 mRNA19013527
C078903seocalcitolseocalcitol results in increased expression of ABLIM1 mRNA12040012
D012834SilverSilver results in increased expression of ABLIM1 mRNA28959546
D012906SmokeSmoke results in decreased expression of ABLIM1 mRNA21095227
D012969Sodium FluorideSodium Fluoride results in decreased expression of ABLIM1 protein28918527
D004113Succimer[Succimer co-treated with Magnetite Nanoparticles] results in decreased expression of ABLIM1 mRNA26378955
D013629TamoxifenTamoxifen results in decreased expression of ABLIM1 mRNA25123088
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of ABLIM1 mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of ABLIM1 mRNA19770486|2597527
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of ABLIM1 mRNA25613284
D013853ThioacetamideThioacetamide results in increased expression of ABLIM1 mRNA23411599
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of ABLIM1 mRNA28065790
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased methylation of ABLIM1 gene26756918
D014212TretinoinTretinoin results in decreased expression of ABLIM1 mRNA16169686
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of ABLIM1 mRNA"26179874
C057693troglitazonetroglitazone results in decreased expression of ABLIM1 mRNA28973697
D014638VanadatesVanadates results in increased expression of ABLIM1 mRNA22714537
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of ABLIM1 gene25560391
D014747VinblastineABLIM1 protein affects the susceptibility to Vinblastine16217747

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003779actin binding-IEA-  
GO:0005515protein binding-IPI16189514  25416956  
GO:0046872metal ion binding-IEA-  
GO:0051015actin filament binding-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0007010cytoskeleton organization-IEA-  
GO:0007601visual perception-TAS9245787  
GO:0009887animal organ morphogenesis-TAS9245787  
GO:0030032lamellipodium assembly-IBA21873635  
GO:0030032lamellipodium assembly-IMP22684256  
GO:0060271cilium assembly-IBA21873635  
GO:0060271cilium assembly-IMP22684256  
GO ID GO Term Qualifier Evidence PubMed
GO:0001725stress fiber-IBA21873635  
GO:0001725stress fiber-IDA22684256  
GO:0005737cytoplasm-IEA-  
GO:0015629actin cytoskeleton-IBA21873635  
GO:0015629actin cytoskeleton-TAS9245787  
GO:0030027lamellipodium-IDA22684256  
KEGG ID KEGG Term
hsa04360Axon guidance
Reactome ID Reactome Term Evidence
R-HSA-1266738Developmental BiologyIEA
R-HSA-373752Netrin-1 signalingIEA
R-HSA-418885DCC mediated attractive signalingIEA
R-HSA-422475Axon guidanceIEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
21547531Polymorphisms in ABLIM1 are associated with personality traits and alcohol dependence. (2012 Feb)Wang KSJ Mol Neurosci