Gene: LIMK1

3984
LIMK|LIMK-1
LIM domain kinase 1
protein-coding
7q11.23
Ensembl:ENSG00000106683 MIM:601329 Vega:OTTHUMG00000023448 UniprotKB:P53667
NG_008129.1
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
6.281e-2 (AD)  8.143e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ATXN7L30.96
RNF1570.953
IQSEC30.945
CDK160.94
PPFIA30.939
DIRAS10.938
CPLX20.934
PACSIN10.934
BRSK10.933
STX1B0.931

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.634
OR4F29-0.587
CLEC2B-0.453
CNN2-0.439
REST-0.439
SGMS2-0.432
RAI14-0.426
RBPMS-0.425
SH2D1A-0.423
WWTR1-0.421

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB08912DabrafenibSmall Molecule-Approved|InvestigationalTarget
ID Drug Name Action PubMed
C0284513,4,3',4'-tetrachlorobiphenyl"3,4,3',4'-tetrachlorobiphenyl affects the expression of LIMK1 mRNA"20638727
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in increased expression of LIMK1 mRNA"23196670
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in decreased expression of LIMK1 mRNA"18648102
D000082AcetaminophenAcetaminophen results in increased expression of LIMK1 mRNA29067470
D000082AcetaminophenAcetaminophen affects the expression of LIMK1 mRNA17562736
D000535Aluminum[APP protein modified form binds to Aluminum] which results in increased expression of LIMK1 mRNA21298039
D000643Ammonium ChlorideAmmonium Chloride affects the expression of LIMK1 mRNA16483693
D001554BenzeneBenzene results in increased expression of LIMK1 mRNA12928149
D001554BenzeneTRP53 protein affects the reaction [Benzene results in increased expression of LIMK1 mRNA]12928149
C022921benzo(k)fluoranthenebenzo(k)fluoranthene results in increased expression of LIMK1 mRNA26377693
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of LIMK1 mRNA21569818
C006780bisphenol Abisphenol A affects the expression of LIMK1 mRNA21786754
C006780bisphenol Abisphenol A results in increased expression of LIMK1 mRNA25181051
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in increased expression of LIMK1 mRNA15003993
D002713Chlorine[Ozone co-treated with Chlorine] affects the expression of LIMK1 mRNA18636392
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in decreased expression of LIMK1 protein17366564
D020111Chlorodiphenyl (54% Chlorine)INS1 protein inhibits the reaction [Chlorodiphenyl (54% Chlorine) results in decreased expression of LIMK1 protein]17366564
D002994ClofibrateClofibrate results in decreased expression of LIMK1 mRNA17585979
D019327Copper SulfateCopper Sulfate results in decreased expression of LIMK1 mRNA19549813
D016572CyclosporineCyclosporine results in increased expression of LIMK1 mRNA20106945
D002945CisplatinCisplatin results in decreased expression of LIMK1 mRNA19561079
C000944dicrotophosdicrotophos results in increased expression of LIMK1 mRNA28302478
C036042dicyclohexyl phthalatedicyclohexyl phthalate results in increased expression of LIMK1 mRNA26924002
C024629dimethyl phthalatedimethyl phthalate affects the expression of LIMK1 mRNA26924002
D004317DoxorubicinDoxorubicin results in increased oxidation of LIMK1 protein28818578
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of LIMK1 mRNA17555576
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of LIMK1 mRNA17942748
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of LIMK1 mRNA17942748
D018690Excitatory Amino Acid AgonistsExcitatory Amino Acid Agonists promotes the reaction [MIR134 mRNA results in decreased expression of LIMK1 protein]28404816
C069837fullerene C60fullerene C60 results in decreased expression of LIMK1 mRNA19167457
D019833GenisteinGenistein results in decreased expression of LIMK1 mRNA28938591
D019833GenisteinGenistein results in decreased expression of LIMK1 protein28938591
D005839GentamicinsGentamicins results in decreased expression of LIMK1 mRNA15350274
D006861Hydrogen Peroxide[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of LIMK1 protein18951874
C544151jinfukangjinfukang results in increased expression of LIMK1 mRNA27392435
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of LIMK1 mRNA23086925
D008070LipopolysaccharidesLipopolysaccharides results in decreased expression of LIMK1 mRNA12057914
C030957methylmercury IImethylmercury II results in increased expression of LIMK1 mRNA27241350
C030957methylmercury IIProbucol inhibits the reaction [methylmercury II results in increased expression of LIMK1 mRNA]27241350
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of LIMK1 mRNA"26251327
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium affects the expression of LIMK1 mRNA12710931
D0156551-Methyl-4-phenylpyridiniumU 0126 affects the reaction [1-Methyl-4-phenylpyridinium affects the expression of LIMK1 mRNA]12710931
C517284monomethyl phthalatemonomethyl phthalate affects the expression of LIMK1 mRNA26924002
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of LIMK1 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of LIMK1 mRNA"25554681
C009618O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate"O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate results in decreased expression of LIMK1 mRNA"21673326
C009618O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate"PON1 protein affects the reaction [O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate results in decreased expression of LIMK1 mRNA]"21673326
D010126Ozone[Ozone co-treated with Chlorine] affects the expression of LIMK1 mRNA18636392
D010269ParaquatParaquat results in increased expression of LIMK1 mRNA17077588|1819848
D010634PhenobarbitalNR1I3 protein affects the reaction [Phenobarbital results in increased expression of LIMK1 mRNA]19482888
D010634PhenobarbitalPhenobarbital results in increased expression of LIMK1 mRNA19482888
C006253pirinixic acidpirinixic acid results in increased expression of LIMK1 mRNA23811191
C006253pirinixic acidpirinixic acid results in increased expression of LIMK1 mRNA19162173
D011341ProbucolProbucol inhibits the reaction [methylmercury II results in increased expression of LIMK1 mRNA]27241350
C059514resveratrolresveratrol results in decreased expression of LIMK1 mRNA19397895
C059514resveratrolresveratrol results in decreased expression of LIMK1 protein19397895
C017947sodium arsenitesodium arsenite results in increased expression of LIMK1 mRNA20308225
C017947sodium arsenitesodium arsenite results in increased expression of LIMK1 mRNA28595984
D010042OuabainOuabain results in decreased expression of LIMK1 mRNA28795476
D013629TamoxifenTamoxifen affects the expression of LIMK1 mRNA17555576
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of LIMK1 mRNA12377990
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of LIMK1 mRNA21570461
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of LIMK1 mRNA17942748
D013806Theophylline[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of LIMK1 protein18951874
D013853ThioacetamideThioacetamide results in increased expression of LIMK1 mRNA23411599
D014241TrichloroethylenePPARA protein inhibits the reaction [Trichloroethylene results in decreased expression of LIMK1 mRNA]15363585
C113580U 0126U 0126 affects the reaction [1-Methyl-4-phenylpyridinium affects the expression of LIMK1 mRNA]12710931
D014635Valproic AcidValproic Acid results in increased methylation of LIMK1 gene29154799
C108830Y 27632Y 27632 results in decreased expression of LIMK1 protein modified form17138966

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004672protein kinase activity-NAS8537403  
GO:0004674protein serine/threonine kinase activity-IBA21873635  
GO:0004674protein serine/threonine kinase activity-TAS-  
GO:0005515protein binding-IPI8940095  10559936  10652353  15220930  15660133  16837009  
17500066  17512523  17853892  18028908  19424295  20133759  
21219645  
GO:0005524ATP binding-IEA-  
GO:0031072heat shock protein binding-IDA17512523  
GO:0046872metal ion binding-IEA-  
GO:0046982protein heterodimerization activity-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006468protein phosphorylation-IDA17512523  
GO:0006468protein phosphorylation-IMP23633677  
GO:0007165signal transduction-TAS10428028  10436159  
GO:0007266Rho protein signal transduction-TAS10436159  
GO:0007399nervous system development-TAS8689688  
GO:0030036actin cytoskeleton organization-TAS10428028  
GO:0032233positive regulation of actin filament bundle assembly-IDA17512523  
GO:0038096Fc-gamma receptor signaling pathway involved in phagocytosis-TAS-  
GO:0045773positive regulation of axon extension-ISS-  
GO:0051444negative regulation of ubiquitin-protein transferase activity-IDA17512523  
GO ID GO Term Qualifier Evidence PubMed
GO:0005737cytoplasm-IBA21873635  
GO:0005737cytoplasm-IDA17512523  
GO:0005829cytosol-IDA-  
GO:0005829cytosol-TAS-  
GO:0005925focal adhesion-IEA-  
GO:0016020membrane-IEA-  
GO:0016607nuclear speck-IDA-  
GO:0030027lamellipodium-ISS-  
GO:0043005neuron projection-IBA21873635  
GO:0043005neuron projection-ISS-  
KEGG ID KEGG Term
hsa04360Axon guidance
hsa04666Fc gamma R-mediated phagocytosis
hsa04810Regulation of actin cytoskeleton
Reactome ID Reactome Term Evidence
R-HSA-1266738Developmental BiologyTAS
R-HSA-1266738Developmental BiologyIEA
R-HSA-162582Signal TransductionTAS
R-HSA-162582Signal TransductionIEA
R-HSA-168249Innate Immune SystemTAS
R-HSA-168249Innate Immune SystemIEA
R-HSA-168256Immune SystemTAS
R-HSA-168256Immune SystemIEA
R-HSA-194315Signaling by Rho GTPasesTAS
R-HSA-194315Signaling by Rho GTPasesIEA
R-HSA-195258RHO GTPase EffectorsTAS
R-HSA-195258RHO GTPase EffectorsIEA
R-HSA-2029480Fcgamma receptor (FCGR) dependent phagocytosisTAS
R-HSA-2029480Fcgamma receptor (FCGR) dependent phagocytosisIEA
R-HSA-2029482Regulation of actin dynamics for phagocytic cup formationTAS
R-HSA-2029482Regulation of actin dynamics for phagocytic cup formationIEA
R-HSA-2682334EPH-Ephrin signalingIEA
R-HSA-373755Semaphorin interactionsTAS
R-HSA-373755Semaphorin interactionsIEA
R-HSA-3928662EPHB-mediated forward signalingIEA
R-HSA-399954Sema3A PAK dependent Axon repulsionTAS
R-HSA-399954Sema3A PAK dependent Axon repulsionIEA
R-HSA-400685Sema4D in semaphorin signalingIEA
R-HSA-416572Sema4D induced cell migration and growth-cone collapseIEA
R-HSA-422475Axon guidanceTAS
R-HSA-422475Axon guidanceIEA
R-HSA-5627117RHO GTPases Activate ROCKsIEA
R-HSA-5627123RHO GTPases activate PAKsTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
21228795Impact of LIMK1, MMP2 and TNF-alpha variations for intracranial aneurysm in Japanese population. (2011 Mar)Low SKJ Hum Genet