Gene info: ID 3988

Gene: LIPA

GENE ID: 3988

Synonyms: CESD|LAL

Description: lipase A, lysosomal acid type

Gene type: protein-coding

Location: 10q23.31

dbXrefs: Ensembl:ENSG00000107798 MIM:613497 Vega:OTTHUMG00000018716 UniprotKB:P38571

RefSeq: NG_008194.1

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: ND

# Publications: 7

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 1.598e-1 (AD) 8.849e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
RNF13	0.872
SPTLC2	0.866
EDIL3	0.863
DIP2B	0.859
PSEN1	0.858
TMEM165	0.854
SLC12A2	0.854
LAMP2	0.854
ACSL1	0.854
PICALM	0.85

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
OR4F5	-0.482
OR4F29	-0.468
HES5	-0.261
WNT7B	-0.236
SLC29A4	-0.233
BRDT	-0.224
PPP1R3G	-0.22
PTGDR2	-0.212
WTIP	-0.211
SHISA8	-0.207

There is no DrugBank record for this gene !

ID	Drug Name	Action	PubMed
C049325	1,2-dithiol-3-thione	"1,2-dithiol-3-thione results in decreased expression of LIPA mRNA"	19162173
C111118	2',3,3',4',5-pentachloro-4-hydroxybiphenyl	"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of LIPA mRNA"	19114083
C014024	2,4,5,2',4',5'-hexachlorobiphenyl	"[Tetrachlorodibenzodioxin co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate co-treated with bisphenol A] results in decreased expression of LIPA mRNA"	28433925
C085911	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one affects the reaction [1-Methyl-4-phenylpyridinium affects the expression of LIPA mRNA]	12710931
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of LIPA mRNA"	27188386
C027576	4-hydroxy-2-nonenal	4-hydroxy-2-nonenal results in increased expression of LIPA mRNA	19191707
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of LIPA mRNA"	27188386
D000082	Acetaminophen	Acetaminophen results in increased expression of LIPA mRNA	22230336
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of LIPA mRNA	16483693
D000965	Antimony	Antimony results in decreased expression of LIPA mRNA	17547211
D000966	Antimony Potassium Tartrate	Antimony Potassium Tartrate results in decreased expression of LIPA mRNA	17547211
C030935	benz(a)anthracene	benz(a)anthracene results in decreased expression of LIPA mRNA	26377693
D004958	Estradiol	Estradiol affects the expression of LIPA mRNA	22574217
C006780	bisphenol A	bisphenol A results in increased expression of LIPA mRNA	29275510
C006780	bisphenol A	"[Tetrachlorodibenzodioxin co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate co-treated with bisphenol A] results in decreased expression of LIPA mRNA"	28433925
C006780	bisphenol A	bisphenol A affects the expression of LIPA mRNA	25181051
C006780	bisphenol A	bisphenol A results in increased methylation of LIPA gene	28505145
D020122	tert-Butylhydroperoxide	tert-Butylhydroperoxide results in decreased expression of LIPA mRNA	15336504
D019256	Cadmium Chloride	Cadmium Chloride results in increased expression of LIPA mRNA	26472689
D019256	Cadmium Chloride	Cadmium Chloride results in increased expression of LIPA mRNA	23741332
D002219	Carbamates	Carbamates analog results in increased carbamoylation of and results in decreased activity of LIPA protein	20557099
C100187	chloropicrin	chloropicrin results in decreased expression of LIPA mRNA	26352163
C031180	chrysene	chrysene results in decreased expression of LIPA mRNA	26377693
D003300	Copper	Copper results in decreased expression of LIPA mRNA	20875833
D019327	Copper Sulfate	Copper Sulfate results in decreased expression of LIPA mRNA	19549813
D016572	Cyclosporine	Cyclosporine results in decreased expression of LIPA mRNA	25562108
D003907	Dexamethasone	Dexamethasone results in increased expression of LIPA mRNA	25047013
D003907	Dexamethasone	[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in decreased expression of LIPA mRNA	16054899
D003993	Dibutyl Phthalate	Dibutyl Phthalate results in increased expression of LIPA mRNA	21266533
D002945	Cisplatin	[Cisplatin co-treated with jinfukang] results in increased expression of LIPA mRNA	27392435
D002945	Cisplatin	Cisplatin results in increased expression of LIPA mRNA	27594783
C000944	dicrotophos	dicrotophos results in decreased expression of LIPA mRNA	28302478
D004041	Dietary Fats	Dietary Fats results in decreased expression of LIPA mRNA	18042831
D004051	Diethylhexyl Phthalate	"[Tetrachlorodibenzodioxin co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate co-treated with bisphenol A] results in decreased expression of LIPA mRNA"	28433925
D004128	Dimethylnitrosamine	Dimethylnitrosamine results in decreased expression of LIPA mRNA	17547211
D004178	Diquat	Diquat affects the expression of LIPA mRNA	22814884
D000431	Ethanol	[Fish Oils co-treated with Ethanol] results in increased expression of LIPA mRNA	17347304
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in decreased expression of LIPA mRNA	16872691
D005047	Etoposide	LIPA protein affects the susceptibility to Etoposide	16217747
C540355	fenamidone	fenamidone results in increased expression of LIPA mRNA	27029645
D005395	Fish Oils	[Fish Oils co-treated with Ethanol] results in increased expression of LIPA mRNA	17347304
D005897	Glafenine	Glafenine results in decreased expression of LIPA mRNA	24136188
D015759	Ionomycin	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of LIPA mRNA	25613284
D015056	1-Methyl-3-isobutylxanthine	[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in decreased expression of LIPA mRNA	16054899
C544151	jinfukang	[Cisplatin co-treated with jinfukang] results in increased expression of LIPA mRNA	27392435
C008261	lead acetate	lead acetate results in increased expression of LIPA mRNA	21829687
D008070	Lipopolysaccharides	Lipopolysaccharides results in decreased expression of LIPA mRNA	25613284
C015329	lycopene	lycopene results in increased expression of LIPA mRNA	16886892
D008628	Mercury	Mercury results in decreased expression of LIPA mRNA	17547211
D018817	N-Methyl-3,4-methylenedioxyamphetamine	"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of LIPA mRNA"	26251327
D018817	N-Methyl-3,4-methylenedioxyamphetamine	"N-Methyl-3,4-methylenedioxyamphetamine results in increased methylation of LIPA promoter"	26251327
D015655	1-Methyl-4-phenylpyridinium	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one affects the reaction [1-Methyl-4-phenylpyridinium affects the expression of LIPA mRNA]	12710931
D015655	1-Methyl-4-phenylpyridinium	U 0126 affects the reaction [1-Methyl-4-phenylpyridinium affects the expression of LIPA mRNA]	12710931
D008942	Mitoxantrone	LIPA protein affects the susceptibility to Mitoxantrone	16217747
C583365	N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide	"N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide results in decreased expression of LIPA mRNA"	29244179
D037742	Nanotubes, Carbon	"Nanotubes, Carbon analog affects the expression of LIPA mRNA"	25554681
C017096	n-butoxyethanol	n-butoxyethanol results in decreased expression of LIPA mRNA	19812364
C051752	nefazodone	nefazodone results in increased expression of LIPA mRNA	24136188
D009532	Nickel	Nickel affects the expression of LIPA mRNA	14575637
D009532	Nickel	Nickel results in increased expression of LIPA mRNA	24768652\|2558310
D009532	Nickel	trichostatin A inhibits the reaction [Nickel affects the expression of LIPA mRNA]	14575637
C022838	nickel chloride	nickel chloride results in decreased expression of LIPA mRNA	17547211
C028007	nickel monoxide	nickel monoxide results in increased expression of LIPA mRNA	19167457
D010126	Ozone	Ozone results in decreased expression of LIPA mRNA	16183385
D000073878	Palm Oil	Palm Oil results in decreased expression of LIPA mRNA	18042831
D010261	Paraoxon	Paraoxon results in decreased activity of LIPA protein	25250848
D010416	Pentachlorophenol	Pentachlorophenol results in increased expression of LIPA mRNA	23892564
D010634	Phenobarbital	Phenobarbital results in decreased expression of LIPA mRNA	23091169
D010634	Phenobarbital	Phenobarbital results in increased expression of LIPA mRNA	19162173
C006253	pirinixic acid	[pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of LIPA mRNA	19710929
C006253	pirinixic acid	pirinixic acid results in increased expression of LIPA mRNA	17426115
D011374	Progesterone	Progesterone results in increased expression of LIPA mRNA	21770760
C015586	propiverine	propiverine binds to LIPA protein	29273565
C513428	pyrachlostrobin	pyrachlostrobin results in increased expression of LIPA mRNA	27029645
D011794	Quercetin	Quercetin results in decreased expression of LIPA mRNA	21632981
C089730	rosiglitazone	[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in decreased expression of LIPA mRNA	16054899
C020806	tetrabromobisphenol A	tetrabromobisphenol A results in decreased expression of LIPA mRNA	25172293
D013749	Tetrachlorodibenzodioxin	"[Tetrachlorodibenzodioxin co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate co-treated with bisphenol A] results in decreased expression of LIPA mRNA"	28433925
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of LIPA mRNA	28238261
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of LIPA mRNA	22298810
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of LIPA mRNA	16054898\|2121527
D013755	Tetradecanoylphorbol Acetate	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of LIPA mRNA	25613284
D013830	Thiadiazoles	Thiadiazoles analog results in increased carbamoylation of and results in decreased activity of LIPA protein	20557099
C009495	titanium dioxide	titanium dioxide results in decreased expression of LIPA mRNA	23557971
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution results in decreased expression of LIPA mRNA	28065790
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution results in increased expression of LIPA protein	27818348
C012589	trichostatin A	trichostatin A inhibits the reaction [Nickel affects the expression of LIPA mRNA]	14575637
C012589	trichostatin A	trichostatin A results in increased expression of LIPA mRNA	24935251
C016805	tris(1,3-dichloro-2-propyl)phosphate	"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of LIPA mRNA"	26179874
D014415	Tunicamycin	Tunicamycin results in increased expression of LIPA mRNA	22378314
C113580	U 0126	U 0126 affects the reaction [1-Methyl-4-phenylpyridinium affects the expression of LIPA mRNA]	12710931
C406224	valdecoxib	valdecoxib results in increased expression of LIPA mRNA	24136188
D014635	Valproic Acid	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of LIPA mRNA"	27188386
D014635	Valproic Acid	Valproic Acid affects the expression of LIPA mRNA	25979313
D014635	Valproic Acid	Valproic Acid results in increased expression of LIPA mRNA	19101580\|2317975
D014635	Valproic Acid	Valproic Acid results in increased expression of LIPA mRNA	24489787
D001335	Vehicle Emissions	Vehicle Emissions results in decreased methylation of LIPA gene	25560391
C025643	vinclozolin	vinclozolin results in increased expression of LIPA mRNA	23160963

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0004771	sterol esterase activity	-	IBA	21873635
GO:0004771	sterol esterase activity	-	IDA	1718995
GO:0004771	sterol esterase activity	-	TAS	-
GO:0016298	lipase activity	-	IBA	21873635
GO:0016298	lipase activity	-	IDA	1718995

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0000902	cell morphogenesis	-	IEA	-
GO:0001816	cytokine production	-	IEA	-
GO:0006954	inflammatory response	-	IEA	-
GO:0008283	cell proliferation	-	IEA	-
GO:0016042	lipid catabolic process	-	IEA	-
GO:0016125	sterol metabolic process	-	IBA	21873635
GO:0030324	lung development	-	IEA	-
GO:0034383	low-density lipoprotein particle clearance	-	TAS	-
GO:0044255	cellular lipid metabolic process	-	IBA	21873635
GO:0048771	tissue remodeling	-	IEA	-
GO:0048873	homeostasis of number of cells within a tissue	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0001650	fibrillar center	-	IDA	-
GO:0005764	lysosome	-	TAS	1718995
GO:0043202	lysosomal lumen	-	TAS	-
GO:0043231	intracellular membrane-bounded organelle	-	IBA	21873635
GO:0043231	intracellular membrane-bounded organelle	-	IDA	-

KEGG ID	KEGG Term
hsa00100	Steroid biosynthesis
hsa04142	Lysosome

Reactome ID	Reactome Term	Evidence
R-HSA-174824	Plasma lipoprotein assembly, remodeling, and clearance	TAS
R-HSA-382551	Transport of small molecules	TAS
R-HSA-8964038	LDL clearance	TAS
R-HSA-8964043	Plasma lipoprotein clearance	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
20872721	Prevalence of low-risk and high-risk types of human papillomavirus and other risk factors for HPV infection in Germany within different age groups in women up to 30 years of age: an epidemiological observational study. (2010 Nov)	Iftner T	J Med Virol
11574131	Using a new HPV detection system in epidemiological research: change of views on cervical dyskaryosis? (2001 Oct)	Reesink-Peters N	Eur J Obstet Gynecol Reprod Biol
29798305	[Clinical features and prognostic factors of squamous cell carcinoma of the base of tonguean analysis of 124 cases]. (2017 Dec 20)	Zhang YX	Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi
27413660	Physical activity pattern, cardiorespiratory fitness, and socioeconomic status in the SCAPIS pilot trial - A cross-sectional study. (2016 Dec)	Lindgren M	Prev Med Rep
27827461	Association and interaction of APOA5, BUD13, CETP, LIPA and health-related behavior with metabolic syndrome in a Taiwanese population. (2016 Nov 9)	Lin E	Sci Rep
25916534	[Clinical features and expressions of p16, p53 protein of human papillomavirus-related tonsillar carcinoma]. (2015 Feb)	Zhang Y	Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi
24818747	Detection of mutation-specific epidermal growth factor receptor (E746-A750del) and lack of detection of human papillomavirus in oral squamous cell carcinoma. (2014 Oct)	Grimm M	Int J Oral Maxillofac Surg