Gene: LIPC

3990
HDLCQ12|HL|HTGL|LIPH
lipase C, hepatic type
protein-coding
15q21.3
Ensembl:ENSG00000166035 MIM:151670 Vega:OTTHUMG00000132632 UniprotKB:P11150
NG_011465.1
PubMed
0   ANCO-SNPs
ND
22   
NA (AD)  NA (ND)   (Frontal_Cortex)
7.573e-2 (AD)  5.831e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
LTK0.605
EFCC10.572
IGFBP40.551
DACT10.539
SDK10.538
GPR830.533
SLCO2A10.53
NDNF0.527
CERKL0.527
SEMA3C0.522

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
FEZF2-0.254
BCAS1-0.245
C5orf64-0.238
LRAT-0.231
LPAR1-0.23
SOX3-0.227
MBP-0.226
CRYBB2-0.225
ARSJ-0.215
OR3A3-0.215

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0493251,2-dithiol-3-thione"1,2-dithiol-3-thione results in decreased expression of LIPC mRNA"19162173
C0892151-palmitoyl-2-lysophosphatidylcholine[LIPC gene mutant form co-treated with LIPG gene mutant form] results in decreased abundance of 1-palmitoyl-2-lysophosphatidylcholine24777581
C0839751-palmitoyl-2-oleoyl-sn-glycerolLIPC gene mutant form results in decreased abundance of 1-palmitoyl-2-oleoyl-sn-glycerol24777581
C5246161-stearoyl-2-docosahexaenoylglycerol[LIPC gene mutant form co-treated with LIPG gene mutant form] results in increased abundance of 1-stearoyl-2-docosahexaenoylglycerol24777581
C0973571-stearoyl-2-linoleoyl-sn-glycerolLIPC gene mutant form results in decreased abundance of 1-stearoyl-2-linoleoyl-sn-glycerol24777581
C0841991-stearoyl-2-oleoyl-sn-glycerol[LIPC gene mutant form co-treated with LIPG gene mutant form] results in decreased abundance of 1-stearoyl-2-oleoyl-sn-glycerol24777581
C0841991-stearoyl-2-oleoyl-sn-glycerolLIPC gene mutant form results in decreased abundance of 1-stearoyl-2-oleoyl-sn-glycerol24777581
C0291412,2,5,7,8-pentamethyl-1-hydroxychroman"2,2,5,7,8-pentamethyl-1-hydroxychroman results in decreased expression of LIPC mRNA"21920950
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of LIPC mRNA"19114083
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[Tetrachlorodibenzodioxin co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate co-treated with bisphenol A] results in decreased expression of LIPC mRNA"28433925
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of LIPC mRNA"21346803
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of LIPC mRNA"21346803
C5495433-hydroxy-4-prenyl-5-methoxystilbene-2-carboxylic acid3-hydroxy-4-prenyl-5-methoxystilbene-2-carboxylic acid analog results in increased expression of LIPC mRNA25716159
D000082AcetaminophenAcetaminophen results in decreased expression of LIPC mRNA29067470
D000082AcetaminophenAcetaminophen affects the expression of LIPC mRNA17562736
D000082AcetaminophenAcetaminophen results in decreased expression of LIPC mRNA17522070
D000171Acrolein"[Acrolein results in increased abundance of Cholesterol, VLDL] which results in decreased expression of and results in decreased activity of LIPC protein"20034506
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of LIPC gene27153756
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of LIPC mRNA19770486
D000638AmiodaroneAmiodarone affects the expression of LIPC mRNA19483382
D000643Ammonium ChlorideAmmonium Chloride affects the expression of LIPC mRNA16483693
D016718Arachidonic Acid[LIPC gene mutant form co-treated with LIPG gene mutant form] results in decreased abundance of Arachidonic Acid24777581
D016718Arachidonic AcidLIPC gene mutant form results in decreased abundance of Arachidonic Acid24777581
D001151ArsenicArsenic affects the methylation of LIPC gene25304211
D001262AtenololLIPC gene SNP affects the susceptibility to and affects the metabolism of Atenolol23536766
C447119bazedoxifenebazedoxifene results in increased expression of LIPC mRNA15961563
D001553BenzbromaroneBenzbromarone affects the expression of LIPC mRNA19483382
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of LIPC mRNA21632981|2623829
D004958EstradiolEstradiol results in increased expression of LIPC mRNA15961563
D004958EstradiolEstradiol results in decreased expression of LIPC mRNA19484750
D001629BezafibrateBezafibrate results in increased activity of LIPC protein3084275
C006780bisphenol Abisphenol A results in increased expression of LIPC mRNA29275510
C006780bisphenol A[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of LIPC mRNA28628672
C006780bisphenol A"[Tetrachlorodibenzodioxin co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate co-treated with bisphenol A] results in decreased expression of LIPC mRNA"28433925
C006780bisphenol Abisphenol A results in decreased expression of LIPC mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of LIPC gene28505145
C000611646bisphenol F[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of LIPC mRNA28628672
D0151248-Bromo Cyclic Adenosine Monophosphate8-Bromo Cyclic Adenosine Monophosphate results in increased expression of LIPC mRNA22079614
D002065BuspironeBuspirone results in decreased expression of LIPC mRNA24136188
C018475butyraldehydebutyraldehyde results in decreased expression of LIPC mRNA26079696
D019256Cadmium ChlorideCadmium Chloride affects the expression of LIPC mRNA22110744
D002251Carbon TetrachlorideCarbon Tetrachloride results in decreased expression of LIPC mRNA15056808
D002251Carbon TetrachlorideCarbon Tetrachloride results in decreased expression of LIPC mRNA17522070
C515629chiglitazarchiglitazar results in increased expression of LIPC mRNA23150725
D002713ChlorineChlorine results in decreased expression of LIPC mRNA18636392
D002713Chlorine[Ozone co-treated with Chlorine] results in increased expression of LIPC mRNA18636392
D002725ChloroformChloroform results in decreased expression of LIPC mRNA17522070
D008076Cholesterol, HDL"Dietary Fats affects the reaction [LIPC promoter SNP affects the abundance of Cholesterol, HDL]"12403660
D008076Cholesterol, HDL"LIPC gene polymorphism affects the abundance of Cholesterol, HDL"16030523
D008076Cholesterol, HDL"LIPC promoter SNP affects the abundance of Cholesterol, HDL"12403660
D015243Cholesterol, VLDL"[Acrolein results in increased abundance of Cholesterol, VLDL] which results in decreased expression of and results in decreased activity of LIPC protein"20034506
C029382cholesteryl arachidonate[LIPC gene mutant form co-treated with LIPG gene mutant form] results in increased abundance of cholesteryl arachidonate24777581
C021976cholesteryl linoleate[LIPC gene mutant form co-treated with LIPG gene mutant form] results in increased abundance of cholesteryl linoleate24777581
C095270cholesteryl linolenate[LIPC gene mutant form co-treated with LIPG gene mutant form] results in increased abundance of cholesteryl linolenate24777581
C032561cholesteryl myristate[LIPC gene mutant form co-treated with LIPG gene mutant form] results in increased abundance of cholesteryl myristate24777581
C014409cholesteryl oleate[LIPC gene mutant form co-treated with LIPG gene mutant form] results in increased abundance of cholesteryl oleate24777581
C026651cholesteryl palmitate[LIPC gene mutant form co-treated with LIPG gene mutant form] results in increased abundance of cholesteryl palmitate24777581
C032459choline plasmalogens[LIPC gene mutant form co-treated with LIPG gene mutant form] results in increased abundance of choline plasmalogens24777581
C039671ciglitazone[ciglitazone binds to PPARG protein alternative form] which results in increased expression of LIPC mRNA16197558
C039671ciglitazone[ciglitazone binds to PPARG protein] which results in increased expression of LIPC mRNA16197558
D002994ClofibrateClofibrate affects the expression of LIPC mRNA19483382
D002994ClofibrateClofibrate results in decreased expression of LIPC mRNA17522070
D019327Copper SulfateCopper Sulfate results in decreased expression of LIPC mRNA19549813
D003474CurcuminCurcumin affects the expression of LIPC mRNA27208389
D016572CyclosporineCyclosporine results in decreased expression of LIPC mRNA20106945|2556210
D016572CyclosporineCyclosporine results in increased expression of LIPC mRNA27989131
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of LIPC mRNA28628672
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of LIPC mRNA28628672
D003907DexamethasoneDexamethasone results in decreased expression of LIPC mRNA17522070
D004008DiclofenacDiclofenac results in decreased expression of LIPC mRNA26934552
D004040Dietary CarbohydratesDietary Carbohydrates results in decreased expression of LIPC mRNA20110567
D004041Dietary Fats"Dietary Fats affects the reaction [LIPC promoter SNP affects the abundance of Cholesterol, HDL]"12403660
D004041Dietary FatsDietary Fats results in decreased expression of LIPC mRNA20110567|2501614
D004051Diethylhexyl Phthalate"[Tetrachlorodibenzodioxin co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate co-treated with bisphenol A] results in decreased expression of LIPC mRNA"28433925
D004052DiethylnitrosamineDiethylnitrosamine results in decreased expression of LIPC mRNA24535843
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with Thioacetamide] results in decreased expression of LIPC mRNA28943392
D004052DiethylnitrosamineDiethylnitrosamine results in decreased expression of LIPC mRNA19638242
C013965diolein[LIPC gene mutant form co-treated with LIPG gene mutant form] results in decreased abundance of diolein24777581
C013965dioleinLIPC gene mutant form results in decreased abundance of diolein24777581
D004144DiosgeninDiosgenin results in increased activity of LIPC protein20149787
C005071dipalmitin[LIPC gene mutant form co-treated with LIPG gene mutant form] results in decreased abundance of dipalmitin24777581
C005071dipalmitinLIPC gene mutant form results in decreased abundance of dipalmitin24777581
D004281Docosahexaenoic Acids[LIPC gene mutant form co-treated with LIPG gene mutant form] results in decreased abundance of Docosahexaenoic Acids24777581
D004281Docosahexaenoic AcidsLIPC gene mutant form results in decreased abundance of Docosahexaenoic Acids24777581
D015118Eicosapentaenoic Acid[LIPC gene mutant form co-treated with LIPG gene mutant form] results in decreased abundance of Eicosapentaenoic Acid24777581
D015118Eicosapentaenoic AcidLIPC gene mutant form results in decreased abundance of Eicosapentaenoic Acid24777581
D004918Erythromycin EstolateErythromycin Estolate results in decreased expression of LIPC mRNA17522070
D000431Ethanol[Zinc deficiency co-treated with Ethanol] results in decreased expression of LIPC mRNA24155903
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of LIPC mRNA14976129
D005001EthionineEthionine affects the expression of LIPC mRNA19483382
D058607Fibric AcidsFibric Acids results in increased activity of LIPC protein9515185
C082360fipronilfipronil results in increased expression of LIPC mRNA23962444
D005485FlutamideFlutamide results in decreased expression of LIPC mRNA24136188
D005485FlutamideFlutamide results in increased expression of LIPC mRNA24793618
C065180fluvastatin[ABCA1 gene SNP co-treated with CETP gene SNP co-treated with LIPC gene SNP co-treated with LPL gene SNP] affects the susceptibility to fluvastatin19773416
C065180fluvastatin[APOB gene SNP co-treated with APOE gene SNP co-treated with HMGCR gene SNP co-treated with LDLR gene SNP co-treated with PCSK9 gene SNP co-treated with ABCA1 gene SNP co-treated with CETP gene SNP co-treated with LIPC gene SNP co-treated with LPL gene SNP] affects the susceptibility to fluvastatin19773416
D005632FructoseFructose results in increased expression of and results in increased activity of LIPC protein15504970
D005632FructoseFructose results in increased expression of LIPC mRNA15504970
D005632Fructoserosiglitazone inhibits the reaction [Fructose results in increased expression of and results in increased activity of LIPC protein]15504970
D005632Fructoserosiglitazone inhibits the reaction [Fructose results in increased expression of LIPC mRNA]15504970
C069837fullerene C60fullerene C60 results in decreased expression of LIPC mRNA19167457
C039281furanfuran results in decreased expression of LIPC mRNA25539665
C039281furanfuran results in increased methylation of LIPC gene22079235
D019833GenisteinGenistein results in decreased expression of LIPC mRNA21782745
D005897GlafenineGlafenine results in decreased expression of LIPC mRNA24136188
C425931GW 501516[GW 501516 binds to PPARD protein] which results in increased expression of LIPC mRNA16197558
C059714HDL cholesteryl esterLIPC protein results in increased uptake of HDL cholesteryl ester12611911
C059714HDL cholesteryl esterProteoglycans deficiency inhibits the reaction [LIPC protein results in increased uptake of HDL cholesteryl ester]12611911
C059714HDL cholesteryl esterSCARB1 protein promotes the reaction [LIPC protein results in increased uptake of HDL cholesteryl ester]12611911
C029424hydrazinehydrazine results in decreased expression of LIPC mRNA15370871
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of LIPC mRNA28628672
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of LIPC mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of LIPC mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of LIPC mRNA28628672
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of LIPC mRNA26752646
D008070LipopolysaccharidesLipopolysaccharides results in decreased expression of LIPC mRNA27339419
D008070Lipopolysaccharides[Tetrachlorodibenzodioxin co-treated with Lipopolysaccharides] results in decreased methylation of LIPC gene21212295
D008148LovastatinLovastatin affects the expression of LIPC mRNA27208389
D008727MethotrexateMethotrexate results in decreased expression of LIPC mRNA15120968
D009270NaloxoneNaloxone results in decreased expression of LIPC mRNA17522070
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of LIPC mRNA"25620056
D0150581-Naphthylisothiocyanate1-Naphthylisothiocyanate results in decreased expression of LIPC mRNA17522070
C051752nefazodonenefazodone results in decreased expression of LIPC mRNA24136188
C012655nimesulidenimesulide results in decreased expression of LIPC mRNA24136188
C097760N-palmitoylsphingosine[LIPC gene mutant form co-treated with LIPG gene mutant form] results in increased abundance of N-palmitoylsphingosine24777581
C033173N-stearoylsphingomyelin[LIPC gene mutant form co-treated with LIPG gene mutant form] results in increased abundance of N-stearoylsphingomyelin24777581
C464660obeticholic acidobeticholic acid results in decreased expression of LIPC mRNA27939613
D019787Linoleic Acid[LIPC gene mutant form co-treated with LIPG gene mutant form] results in decreased abundance of Linoleic Acid24777581
D019301Oleic Acid[LIPC gene mutant form co-treated with LIPG gene mutant form] results in decreased abundance of Oleic Acid24777581
D009853OmeprazoleOmeprazole affects the expression of LIPC mRNA19483382
D010126Ozone[Ozone co-treated with Chlorine] results in increased expression of LIPC mRNA18636392
D019308Palmitic Acid[LIPC gene mutant form co-treated with LIPG gene mutant form] results in decreased abundance of Palmitic Acid24777581
D019308Palmitic AcidLIPC gene mutant form results in decreased abundance of Palmitic Acid24777581
C033171palmitoylsphingomyelin[LIPC gene mutant form co-treated with LIPG gene mutant form] results in increased abundance of palmitoylsphingomyelin24777581
C471071perfluorohexanesulfonic acidperfluorohexanesulfonic acid results in decreased expression of LIPC mRNA21705711
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in decreased expression of LIPC mRNA21705711
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of LIPC mRNA19162173
D010578PetroleumPetroleum affects the expression of LIPC mRNA25208076
C031181phenanthrenephenanthrene results in decreased expression of LIPC mRNA19457238
D010634PhenobarbitalPhenobarbital affects the expression of LIPC mRNA19159669
D010634PhenobarbitalPhenobarbital results in decreased expression of LIPC mRNA12807726
D010634PhenobarbitalPhenobarbital results in decreased expression of LIPC mRNA16510358
D010713Phosphatidylcholines[LIPC gene mutant form co-treated with LIPG gene mutant form] results in increased abundance of Phosphatidylcholines24777581
D010713PhosphatidylcholinesLIPC gene mutant form results in increased abundance of Phosphatidylcholines24777581
C060836pioglitazonepioglitazone results in increased expression of LIPC mRNA20503262
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of LIPC mRNA19710929
C006253pirinixic acid[pirinixic acid co-treated with PPARA] results in decreased expression of LIPC mRNA20813756
C006253pirinixic acidpirinixic acid results in decreased expression of LIPC mRNA20813756
C006253pirinixic acidpirinixic acid affects the expression of LIPC mRNA19483382
D059808PolyphenolsPolyphenols results in decreased expression of LIPC mRNA16293270
C045950propiconazolepropiconazole results in decreased expression of LIPC mRNA21278054
D011441PropylthiouracilPropylthiouracil affects the expression of LIPC mRNA19483382
D011509ProteoglycansProteoglycans deficiency inhibits the reaction [LIPC protein results in increased uptake of HDL cholesteryl ester]12611911
D011794QuercetinQuercetin results in decreased expression of LIPC mRNA21632981
D011802QuinidineQuinidine results in decreased expression of LIPC mRNA17522070
C025474rebaudioside Arebaudioside A affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of LIPC mRNA]25554529
D015474IsotretinoinIsotretinoin results in increased expression of LIPC mRNA20436886
C089032rimonabantrimonabant results in increased expression of LIPC mRNA20110567
C089730rosiglitazonerosiglitazone results in increased expression of LIPC mRNA23150725
C089730rosiglitazonerosiglitazone inhibits the reaction [Fructose results in increased expression of and results in increased activity of LIPC protein]15504970
C089730rosiglitazonerosiglitazone inhibits the reaction [Fructose results in increased expression of LIPC mRNA]15504970
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of LIPC mRNA25895662
C016104sodium bichromatesodium bichromate results in decreased expression of LIPC mRNA25993096
C026564stearoyl alpha-lysolecithin[LIPC gene mutant form co-treated with LIPG gene mutant form] results in increased abundance of stearoyl alpha-lysolecithin24777581
C037149stearoylarachidonylglycerol[LIPC gene mutant form co-treated with LIPG gene mutant form] results in increased abundance of stearoylarachidonylglycerol24777581
C012042steviolsteviol affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of LIPC mRNA]25554529
C012043steviosidestevioside affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of LIPC mRNA]25554529
D013629TamoxifenTamoxifen results in decreased expression of LIPC protein3108557
C030141taurine-ursodeoxycholate conjugatetaurine-ursodeoxycholate conjugate promotes the reaction [LEP gene mutant form results in decreased expression of LIPC mRNA]21079772
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of LIPC mRNA19684285|2010694
D013749Tetrachlorodibenzodioxin"[Tetrachlorodibenzodioxin co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate co-treated with bisphenol A] results in decreased expression of LIPC mRNA"28433925
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Lipopolysaccharides] results in decreased methylation of LIPC gene21212295
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin promotes the reaction [AHR protein binds to LIPC gene]28213091
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin promotes the reaction [AHR protein binds to LIPC promoter]19654925
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of LIPC mRNA16960034|1968428
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of LIPC mRNA16960034|2121527
D013752TetracyclineTetracycline results in decreased expression of LIPC mRNA17522070
D013806TheophyllineTheophylline results in decreased expression of LIPC mRNA17522070
D013853Thioacetamide[Diethylnitrosamine co-treated with Thioacetamide] results in decreased expression of LIPC mRNA28943392
D013853ThioacetamideThioacetamide affects the expression of LIPC mRNA19483382
D014280Triglycerides[LIPC gene mutant form co-treated with LIPG gene mutant form] results in decreased abundance of Triglycerides24777581
D014280TriglyceridesLIPC gene mutant form results in decreased abundance of Triglycerides24777581
C015559trimellitic anhydridetrimellitic anhydride results in increased expression of LIPC mRNA19042947
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of LIPC mRNA"26179874
C406224valdecoxibvaldecoxib results in decreased expression of LIPC mRNA24136188
D014635Valproic AcidValproic Acid results in increased expression of LIPC mRNA29154799
D014874Water Pollutants, Chemical"Water Pollutants, Chemical affects the expression of LIPC mRNA"25208076
D015032ZincZinc deficiency affects the expression of LIPC mRNA24155903
D015032Zinc[Zinc deficiency co-treated with Ethanol] results in decreased expression of LIPC mRNA24155903

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004620phospholipase activity-TAS3244012  
GO:0004806triglyceride lipase activity-IDA182536  2839510  
GO:0004806triglyceride lipase activity-TAS-  
GO:0008201heparin binding-IEA-  
GO:0030169low-density lipoprotein particle binding-ISS-  
GO:0034185apolipoprotein binding-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006633fatty acid biosynthetic process-IDA182536  
GO:0008203cholesterol metabolic process-IEA-  
GO:0019433triglyceride catabolic process-IDA182536  2839510  8640403  
GO:0034372very-low-density lipoprotein particle remodeling-IDA8640403  
GO:0034373intermediate-density lipoprotein particle remodeling-TAS2839510  
GO:0034374low-density lipoprotein particle remodeling-IMP3244012  
GO:0034375high-density lipoprotein particle remodeling-IMP3244012  
GO:0034382chylomicron remnant clearance-TAS9685400  
GO:0034638phosphatidylcholine catabolic process-TAS2839510  
GO:0042632cholesterol homeostasis-IMP1883393  
GO:0043691reverse cholesterol transport-IC14531818  
GO:0051004regulation of lipoprotein lipase activity-TAS-  
GO:0070328triglyceride homeostasis-IMP1883393  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-TAS-  
GO:0005615extracellular space-IDA2839510  
GO:0005788endoplasmic reticulum lumen-TAS-  
GO:0034364high-density lipoprotein particle-IEA-  
KEGG ID KEGG Term
hsa00561Glycerolipid metabolism
hsa01100Metabolic pathways
Reactome ID Reactome Term Evidence
R-HSA-174824Plasma lipoprotein assembly, remodeling, and clearanceTAS
R-HSA-382551Transport of small moleculesTAS
R-HSA-8963889Assembly of active LPL and LIPC lipase complexesTAS
R-HSA-8963899Plasma lipoprotein remodelingTAS
R-HSA-8964026Chylomicron clearanceTAS
R-HSA-8964043Plasma lipoprotein clearanceTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
22247473Prospective assessment of genetic effects on progression to different stages of age-related macular degeneration using multistate Markov models. (2012 Mar)Yu YInvest Ophthalmol Vis Sci
29801032Association of Single-Nucleotide Polymorphisms in Age-Related Macular Degeneration With Pseudodrusen: Secondary Analysis of Data From the Comparison of AMD Treatments Trials. (2018 May 3)Lin LYJAMA Ophthalmol
21139980Associations of smoking, body mass index, dietary lutein, and the LIPC gene variant rs10468017 with advanced age-related macular degeneration. (2010 Nov 17)Seddon JMMol Vis
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