Gene: LIPE

3991
AOMS4|FPLD6|HSL|LHS
lipase E, hormone sensitive type
protein-coding
19q13.2
Ensembl:ENSG00000079435 MIM:151750 Vega:OTTHUMG00000182814 UniprotKB:Q05469
NG_034246.1
PubMed
0   ANCO-SNPs
ND
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
9.847e-1 (AD)  4.186e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
FA2H0.921
GPR620.921
SLC45A30.92
MAG0.909
ERBB30.902
TF0.898
DNAH170.897
GAL3ST10.893
KLK60.892
HAPLN20.891

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
NR2F2-0.354
WTIP-0.322
OR4F5-0.305
OR4F29-0.294
PCDH18-0.289
PAX2-0.288
NHS-0.281
MTRNR2L8-0.272
MTRNR2L9-0.269
MTRNR2L6-0.267

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of LIPE mRNA"21346803
C07699627-hydroxycholesterolLIPE protein promotes the reaction [27-hydroxycholesterol results in increased expression of STAR mRNA]23362264
C07699627-hydroxycholesterolLIPE protein promotes the reaction [27-hydroxycholesterol results in increased expression of STAR protein]23362264
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of LIPE mRNA"23196670
C1052604-tert-octylphenol[nonylphenol co-treated with 4-tert-octylphenol] results in decreased expression of LIPE mRNA28208108
D000242Cyclic AMPCyclic AMP results in increased activity of LIPE protein7155675
D000255Adenosine TriphosphateAdenosine Triphosphate results in increased activity of LIPE protein7155675
D000638AmiodaroneAmiodarone results in increased phosphorylation of LIPE protein28962527
D000638AmiodaroneINS inhibits the reaction [Amiodarone results in increased phosphorylation of LIPE protein]28962527
D000643Ammonium ChlorideAmmonium Chloride affects the expression of LIPE mRNA16483693
C547126AZM551248AZM551248 results in decreased expression of LIPE mRNA22323515
C095105bexarotenebexarotene results in decreased expression of LIPE mRNA16648578
C543008bis(4-hydroxyphenyl)sulfonebis(4-hydroxyphenyl)sulfone results in increased expression of LIPE mRNA27685785
C543008bis(4-hydroxyphenyl)sulfone[Dietary Fats co-treated with bis(4-hydroxyphenyl)sulfone] affects the expression of LIPE mRNA27241191
C006780bisphenol Abisphenol A results in increased expression of LIPE mRNA26944108
C006780bisphenol Abisphenol A results in decreased expression of LIPE mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of LIPE gene28505145
C006780bisphenol A[nonylphenol co-treated with bisphenol A] results in decreased expression of LIPE mRNA28208108
C032688boric acidboric acid inhibits the reaction [[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased expression of LIPE mRNA]28285642
D019256Cadmium Chloride[MT1 gene mutant form results in increased susceptibility to Cadmium Chloride] which results in decreased expression of LIPE mRNA23921151
D019256Cadmium Chloride[MT2 gene mutant form results in increased susceptibility to Cadmium Chloride] which results in decreased expression of LIPE mRNA23921151
D002392CatechinCatechin inhibits the reaction [Dietary Fats results in decreased expression of LIPE mRNA]23365609
D002395CatecholaminesCatecholamines affects the phosphorylation of and affects the activity of LIPE protein3420405
C534918CAY 10499CAY 10499 inhibits the reaction [Bucladesine results in increased activity of and results in increased phosphorylation of LIPE protein]23362264
C534918CAY 10499CAY 10499 results in decreased activity of LIPE protein23362264
C534918CAY 10499NR1H2 protein affects the reaction [CAY 10499 inhibits the reaction [Bucladesine results in increased phosphorylation of LIPE protein]]23362264
C534918CAY 10499NR1H3 protein affects the reaction [CAY 10499 inhibits the reaction [Bucladesine results in increased phosphorylation of LIPE protein]]23362264
C515629chiglitazarchiglitazar results in increased expression of LIPE mRNA23150725
D002713Chlorine[Ozone co-treated with Chlorine] results in increased expression of LIPE mRNA18636392
D002794Choline[Choline deficiency co-treated with Methionine deficiency] results in increased phosphorylation of LIPE protein25178843
D002794CholineMethionine inhibits the reaction [[Choline deficiency co-treated with Methionine deficiency] results in increased phosphorylation of LIPE protein]25178843
C074702chromium hexavalent ionchromium hexavalent ion affects the expression of LIPE mRNA28472532
D002994ClofibrateClofibrate results in increased expression of LIPE mRNA23811191
D002994ClofibrateClofibrate results in increased expression of LIPE mRNA11328961
C018021cobaltous chloridecobaltous chloride results in decreased expression of LIPE mRNA12032628|2291766
D005576ColforsinColforsin affects the localization of LIPE protein11160373
D003300CopperCopper deficiency results in increased expression of LIPE mRNA26033743
D003471CuprizoneCuprizone results in increased expression of LIPE mRNA26577399
D003676DeferoxamineDeferoxamine results in decreased expression of LIPE mRNA12032628
D003840Deoxycholic AcidDeoxycholic Acid results in decreased expression of LIPE mRNA23911798
D003907DexamethasoneDexamethasone results in increased expression of LIPE mRNA25047013
D003907Dexamethasoneboric acid inhibits the reaction [[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased expression of LIPE mRNA]28285642
D003907Dexamethasone[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased expression of LIPE mRNA28285642
D003907DexamethasoneDexamethasone results in increased phosphorylation of LIPE protein28292967
D003907Dexamethasone[licarin A affects the susceptibility to [INS protein co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone]] which results in increased expression of LIPE mRNA29288687
D003907Dexamethasone[licarin A affects the susceptibility to [INS protein co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone]] which results in increased expression of LIPE protein29288687
D003907Dexamethasone[licarin A affects the susceptibility to [INS protein co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone]] which results in increased expression of LIPE protein modified form29288687
D003907DexamethasoneN-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [[licarin A affects the susceptibility to [INS protein co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone]] which results in increased expression of LIPE protein]29288687
D003907DexamethasoneN-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [[licarin A affects the susceptibility to [INS protein co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone]] which results in increased expression of LIPE protein modified form]29288687
D003907DexamethasonePIK3R1 protein affects the reaction [Dexamethasone results in increased phosphorylation of LIPE protein]28292967
D003907Dexamethasone[PRKACA protein affects the susceptibility to [INS protein co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone]] which results in increased expression of LIPE protein modified form29288687
D003907DexamethasonePRKACA protein promotes the reaction [[licarin A affects the susceptibility to [INS protein co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone]] which results in increased expression of LIPE protein modified form]29288687
D003907Dexamethasonesodium pentaborate inhibits the reaction [[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased expression of LIPE mRNA]28285642
D003994Bucladesine[Bucladesine co-treated with LIPE protein] results in increased expression of ABCA1 protein23362264
D003994Bucladesine[Bucladesine co-treated with LIPE protein] results in increased expression of and results in increased phosphorylation of STAR protein23362264
D003994BucladesineBucladesine results in increased activity of LIPE protein23362264
D003994BucladesineBucladesine results in increased expression of and results in increased phosphorylation of LIPE protein23362264
D003994BucladesineBucladesine results in increased expression of LIPE mRNA23362264
D003994BucladesineCAY 10499 inhibits the reaction [Bucladesine results in increased activity of and results in increased phosphorylation of LIPE protein]23362264
D003994BucladesineLIPE protein affects the reaction [Bucladesine results in increased expression of and results in increased phosphorylation of STAR protein]23362264
D003994BucladesineLIPE protein affects the reaction [Bucladesine results in increased expression of PLIN1 mRNA]23362264
D003994BucladesineLIPE protein affects the reaction [Bucladesine results in increased expression of SCARB1 mRNA]23362264
D003994BucladesineLIPE protein affects the reaction [Bucladesine results in increased expression of STAR mRNA]23362264
D003994BucladesineN-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide affects the reaction [Bucladesine results in increased expression of and results in increased phosphorylation of LIPE protein]23362264
D003994BucladesineN-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Bucladesine results in increased expression of LIPE mRNA]23362264
D003994BucladesineNR1H2 protein affects the reaction [Bucladesine results in increased phosphorylation of LIPE protein]23362264
D003994BucladesineNR1H2 protein affects the reaction [CAY 10499 inhibits the reaction [Bucladesine results in increased phosphorylation of LIPE protein]]23362264
D003994BucladesineNR1H3 protein affects the reaction [Bucladesine results in increased phosphorylation of LIPE protein]23362264
D003994BucladesineNR1H3 protein affects the reaction [CAY 10499 inhibits the reaction [Bucladesine results in increased phosphorylation of LIPE protein]]23362264
D003994BucladesineBucladesine affects the localization of LIPE protein11160373
D003999Dichloroacetic AcidDichloroacetic Acid results in increased expression of LIPE mRNA28962523
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in increased expression of LIPE mRNA27392435
D002945CisplatinCisplatin results in increased expression of LIPE mRNA27392435
D004040Dietary CarbohydratesDietary Carbohydrates results in decreased expression of LIPE mRNA17490981
D004040Dietary Carbohydrates[Dietary Fats co-treated with Dietary Carbohydrates] affects the expression of LIPE protein22551950
D004040Dietary CarbohydratesDietary Carbohydrates results in increased expression of LIPE mRNA20110567
D004041Dietary Fats[Dietary Fats co-treated with Dietary Carbohydrates] affects the expression of LIPE protein22551950
D004041Dietary Fats[Dietary Fats co-treated with bis(4-hydroxyphenyl)sulfone] affects the expression of LIPE mRNA27241191
D004041Dietary FatsDietary Fats results in decreased expression of LIPE mRNA18042831|2013204
D004041Dietary FatsDietary Fats results in increased expression of LIPE mRNA20110567
D004041Dietary FatsPlant Extracts inhibits the reaction [Dietary Fats results in decreased expression of LIPE mRNA]20132043
D004041Dietary FatsQuercetin inhibits the reaction [Dietary Fats results in decreased expression of LIPE mRNA]24025686
D004041Dietary FatsCatechin inhibits the reaction [Dietary Fats results in decreased expression of LIPE mRNA]23365609
D004041Dietary FatsDietary Fats results in decreased expression of LIPE mRNA23365609
D004041Dietary FatsPlant Extracts inhibits the reaction [Dietary Fats results in decreased expression of LIPE mRNA]23365609
D004052DiethylnitrosamineDiethylnitrosamine results in increased expression of LIPE mRNA20360939
C550453dioxinodehydroeckoldioxinodehydroeckol results in decreased expression of LIPE mRNA20385110
C076126disodium (R,R)-5-(2-((2-(3-chlorophenyl)-2-hydroxyethyl)-amino)propyl)-1,3-benzodioxole-2,3-dicarboxylate"disodium (R,R)-5-(2-((2-(3-chlorophenyl)-2-hydroxyethyl)-amino)propyl)-1,3-benzodioxole-2,3-dicarboxylate results in increased expression of LIPE mRNA"20184727
D004837EpinephrineEpinephrine results in increased activity of LIPE protein7155675
D004837EpinephrineTheophylline inhibits the reaction [Epinephrine results in increased activity of LIPE protein]7155675
D004837EpinephrineEpinephrine results in increased expression of LIPE mRNA10777495
D004837EpinephrineEpinephrine affects the localization of LIPE protein11160373
D000431EthanolEthanol results in increased expression of LIPE mRNA22173916
D000431EthanolEthanol results in increased phosphorylation of LIPE protein28882574
D000431Ethanolgadolinium chloride inhibits the reaction [Ethanol results in increased phosphorylation of LIPE protein]28882574
D000431Ethanolrosiglitazone inhibits the reaction [Ethanol results in increased expression of LIPE mRNA]22173916
D000431EthanolEthanol results in increased phosphorylation of LIPE protein26115886
D000431EthanolScopoletin inhibits the reaction [Ethanol results in increased phosphorylation of LIPE protein]26115886
D000431EthanolSilymarin inhibits the reaction [Ethanol results in increased phosphorylation of LIPE protein]26115886
D005227Fatty AcidsLIPE protein affects the metabolism of Fatty Acids3420405
D005230Fatty Acids, Nonesterified"Fatty Acids, Nonesterified affects the activity of LIPE protein"14749208
D018120FinasterideFinasteride results in decreased expression of LIPE mRNA24136188
D005419FlavonoidsFlavonoids results in decreased expression of LIPE mRNA18035473
C038958gadolinium chloridegadolinium chloride inhibits the reaction [Ethanol results in increased phosphorylation of LIPE protein]28882574
D019833Genistein[Genistein co-treated with mono-(2-ethylhexyl)phthalate] results in increased expression of LIPE mRNA27181934
C046905glucosamine 6-O-sulfateglucosamine 6-O-sulfate results in decreased expression of LIPE mRNA19520133
C001293glucosamine 6-phosphateglucosamine 6-phosphate results in increased expression of LIPE mRNA19427183
C004312glycidolglycidol results in decreased expression of LIPE mRNA24915197
C479979GW0742GW0742 results in increased expression of LIPE protein20176998
C479979GW0742PPARD promotes the reaction [GW0742 results in increased expression of LIPE protein]20176998
D006728HormonesHormones affects the activity of LIPE protein3420405
D006728HormonesHormones affects the activity of LIPE protein3420405
D0150561-Methyl-3-isobutylxanthineboric acid inhibits the reaction [[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased expression of LIPE mRNA]28285642
D0150561-Methyl-3-isobutylxanthine[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased expression of LIPE mRNA28285642
D0150561-Methyl-3-isobutylxanthine[licarin A affects the susceptibility to [INS protein co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone]] which results in increased expression of LIPE mRNA29288687
D0150561-Methyl-3-isobutylxanthine[licarin A affects the susceptibility to [INS protein co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone]] which results in increased expression of LIPE protein29288687
D0150561-Methyl-3-isobutylxanthine[licarin A affects the susceptibility to [INS protein co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone]] which results in increased expression of LIPE protein modified form29288687
D0150561-Methyl-3-isobutylxanthineN-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [[licarin A affects the susceptibility to [INS protein co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone]] which results in increased expression of LIPE protein]29288687
D0150561-Methyl-3-isobutylxanthineN-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [[licarin A affects the susceptibility to [INS protein co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone]] which results in increased expression of LIPE protein modified form]29288687
D0150561-Methyl-3-isobutylxanthine[PRKACA protein affects the susceptibility to [INS protein co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone]] which results in increased expression of LIPE protein modified form29288687
D0150561-Methyl-3-isobutylxanthinePRKACA protein promotes the reaction [[licarin A affects the susceptibility to [INS protein co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone]] which results in increased expression of LIPE protein modified form]29288687
D0150561-Methyl-3-isobutylxanthinesodium pentaborate inhibits the reaction [[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased expression of LIPE mRNA]28285642
D007545IsoproterenolIsoproterenol results in increased phosphorylation of LIPE protein21042876
D007545IsoproterenolSirolimus promotes the reaction [Isoproterenol results in increased phosphorylation of LIPE protein]21042876
D007545IsoproterenolIsoproterenol affects the localization of LIPE protein10894095|1116037
D007545IsoproterenolIsoproterenol results in increased activity of LIPE protein10894095
D007545IsoproterenolPapaverine inhibits the reaction [Isoproterenol affects the localization of LIPE protein]10894095
D007545IsoproterenolPapaverine inhibits the reaction [Isoproterenol results in increased activity of LIPE protein]10894095
C544151jinfukang[Cisplatin co-treated with jinfukang] results in increased expression of LIPE mRNA27392435
C432503licarin A[licarin A affects the susceptibility to [INS protein co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone]] which results in increased expression of LIPE mRNA29288687
C432503licarin A[licarin A affects the susceptibility to [INS protein co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone]] which results in increased expression of LIPE protein29288687
C432503licarin A[licarin A affects the susceptibility to [INS protein co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone]] which results in increased expression of LIPE protein modified form29288687
C432503licarin AN-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [[licarin A affects the susceptibility to [INS protein co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone]] which results in increased expression of LIPE protein]29288687
C432503licarin AN-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [[licarin A affects the susceptibility to [INS protein co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone]] which results in increased expression of LIPE protein modified form]29288687
C432503licarin APRKACA protein promotes the reaction [[licarin A affects the susceptibility to [INS protein co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone]] which results in increased expression of LIPE protein modified form]29288687
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in decreased expression of LIPE mRNA"24972896
D008715Methionine[Choline deficiency co-treated with Methionine deficiency] results in increased phosphorylation of LIPE protein25178843
D008715MethionineMethionine deficiency results in increased phosphorylation of LIPE protein25178843
D008715MethionineMethionine inhibits the reaction [[Choline deficiency co-treated with Methionine deficiency] results in increased phosphorylation of LIPE protein]25178843
C016599mono-(2-ethylhexyl)phthalate[Genistein co-treated with mono-(2-ethylhexyl)phthalate] results in increased expression of LIPE mRNA27181934
C016599mono-(2-ethylhexyl)phthalatemono-(2-ethylhexyl)phthalate results in increased expression of LIPE mRNA25543134
C500085muraglitazarmuraglitazar results in increased expression of LIPE mRNA21515302
C063509N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamideN-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide affects the reaction [Bucladesine results in increased expression of and results in increased phosphorylation of LIPE protein]23362264
C063509N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamideN-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Bucladesine results in increased expression of LIPE mRNA]23362264
C063509N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamideN-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [[licarin A affects the susceptibility to [INS protein co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone]] which results in increased expression of LIPE protein]29288687
C063509N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamideN-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [[licarin A affects the susceptibility to [INS protein co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone]] which results in increased expression of LIPE protein modified form]29288687
C063509N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamideN-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Thioctic Acid results in increased phosphorylation of LIPE protein]22941773
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of LIPE mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of LIPE mRNA"25554681
D009525NiacinNiacin results in decreased activity of LIPE protein14749208
D009525NiacinNiacin results in decreased expression of LIPE mRNA19131065
D009532NickelNickel results in decreased expression of LIPE mRNA25583101
D009538NicotineNicotine results in decreased expression of LIPE mRNA29155039
C025256nonylphenol[nonylphenol co-treated with 4-tert-octylphenol] results in decreased expression of LIPE mRNA28208108
C025256nonylphenol[nonylphenol co-treated with bisphenol A] results in decreased expression of LIPE mRNA28208108
C108709oleoyl-estroneoleoyl-estrone results in decreased expression of LIPE mRNA17725831|1932603
D010100OxygenOxygen deficiency results in decreased expression of LIPE mRNA12032628
D010100OxygenOxygen deficiency results in increased expression of LIPE mRNA23539316
D010126OzoneOzone results in decreased expression of LIPE mRNA12763052
D010126Ozone[Ozone co-treated with Chlorine] results in increased expression of LIPE mRNA18636392
D000073878Palm OilPalm Oil results in decreased expression of LIPE mRNA18042831
D010208PapaverinePapaverine inhibits the reaction [Isoproterenol affects the localization of LIPE protein]10894095
D010208PapaverinePapaverine inhibits the reaction [Isoproterenol results in increased activity of LIPE protein]10894095
C023036perfluorooctanoic acidperfluorooctanoic acid results in increased expression of LIPE mRNA28511854
D010713PhosphatidylcholinesPhosphatidylcholines results in increased expression of LIPE mRNA23911798
D010713PhosphatidylcholinesPhosphatidylcholines results in decreased activity of LIPE protein2161247
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of LIPE mRNA19710929
C006253pirinixic acidpirinixic acid results in increased expression of LIPE mRNA17426115|1830175
C006253pirinixic acidpirinixic acid results in increased expression of LIPE mRNA19162173
D010936Plant ExtractsPlant Extracts inhibits the reaction [Dietary Fats results in decreased expression of LIPE mRNA]20132043
D010936Plant ExtractsPlant Extracts results in increased expression of LIPE protein20132043
D010936Plant ExtractsPlant Extracts results in increased phosphorylation of LIPE protein20132043
D010936Plant ExtractsPlant Extracts inhibits the reaction [Dietary Fats results in decreased expression of LIPE mRNA]23365609
D011441PropylthiouracilPropylthiouracil results in decreased expression of LIPE mRNA24780913
D011794QuercetinQuercetin inhibits the reaction [Dietary Fats results in decreased expression of LIPE mRNA]24025686
C059514resveratrolresveratrol results in increased expression of and results in increased phosphorylation of LIPE protein25140191
C059514resveratrolresveratrol results in increased expression of LIPE mRNA25140191
C059514resveratrolresveratrol results in decreased expression of LIPE mRNA21569266
C059514resveratrolresveratrol results in increased expression of LIPE mRNA24012391
C059514resveratrolresveratrol results in increased expression of LIPE protein23824959
C499731resveratrol-4'-O-glucuronideresveratrol-4'-O-glucuronide results in increased expression of LIPE mRNA22945685
C014794retinol palmitateLIPE protein results in increased hydrolysis of retinol palmitate16741517
C014794retinol palmitatePLIN3 protein inhibits the reaction [LIPE protein results in increased hydrolysis of retinol palmitate]16741517
C089032rimonabantrimonabant affects the expression of LIPE mRNA20110567
C089730rosiglitazonerosiglitazone results in increased expression of LIPE mRNA23150725
C089730rosiglitazonerosiglitazone affects the expression of LIPE mRNA22013433
C089730rosiglitazonerosiglitazone inhibits the reaction [Ethanol results in increased expression of LIPE mRNA]22173916
C089730rosiglitazonerosiglitazone results in increased expression of LIPE mRNA18643838
C089730rosiglitazonerosiglitazone results in increased expression of and results in increased activity of LIPE protein15887043
C089730rosiglitazonerosiglitazone results in increased expression of LIPE mRNA15887043|2151530
D012603ScopoletinScopoletin inhibits the reaction [Ethanol results in increased phosphorylation of LIPE protein]26115886
D012838SilymarinSilymarin inhibits the reaction [Ethanol results in increased phosphorylation of LIPE protein]26115886
D020123SirolimusSirolimus promotes the reaction [Isoproterenol results in increased phosphorylation of LIPE protein]21042876
C538809sodium pentaboratesodium pentaborate inhibits the reaction [[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased expression of LIPE mRNA]28285642
D018038Sodium SeleniteSodium Selenite results in increased phosphorylation of LIPE protein24140496
D053260SootSoot results in increased expression of LIPE mRNA26551751
D013311StreptozocinStreptozocin results in increased expression of LIPE mRNA16684804
D013311Streptozocinvanadyl sulfate inhibits the reaction [Streptozocin results in increased expression of LIPE mRNA]16684804
D013467SulindacSulindac results in decreased expression of LIPE mRNA24136188
D013629TamoxifenTamoxifen results in decreased expression of LIPE mRNA20937368|2512308
C084178telmisartanPPARD promotes the reaction [telmisartan results in increased expression of LIPE protein]20176998
C084178telmisartantelmisartan results in increased expression of LIPE protein20176998
D000068698TenofovirTenofovir affects the expression of LIPE mRNA20032539
C501413tesaglitazartesaglitazar results in increased expression of LIPE mRNA21515302
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of LIPE mRNA26290441|2823826
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of LIPE mRNA19490992
D013806TheophyllineTheophylline inhibits the reaction [Epinephrine results in increased activity of LIPE protein]7155675
D013806TheophyllineTheophylline results in increased activity of LIPE protein7155675
D013806TheophyllineTheophylline affects the localization of LIPE protein11160373
D008063Thioctic AcidN-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Thioctic Acid results in increased phosphorylation of LIPE protein]22941773
D008063Thioctic AcidThioctic Acid results in increased phosphorylation of LIPE protein22941773
C009495titanium dioxidetitanium dioxide results in increased expression of LIPE mRNA23557971
C423915TO-901317LIPE protein promotes the reaction [TO-901317 results in increased expression of STAR mRNA]23362264
C423915TO-901317LIPE protein promotes the reaction [TO-901317 results in increased expression of STAR protein]23362264
C423915TO-901317TO-901317 promotes the reaction [LIPE protein results in increased expression of SREBF1 mRNA]23362264
C057693troglitazonetroglitazone results in increased expression of LIPE mRNA12732648
C057693troglitazonetroglitazone results in increased expression of LIPE mRNA21515302
C057693troglitazone[troglitazone co-treated with TNF protein] results in increased expression of LIPE mRNA12732648
D014635Valproic AcidValproic Acid results in increased expression of LIPE mRNA24489787
C034028vanadyl sulfatevanadyl sulfate inhibits the reaction [Streptozocin results in increased expression of LIPE mRNA]16684804
C025643vinclozolinvinclozolin results in increased expression of LIPE mRNA22570695|2303416
D015215ZidovudineZidovudine affects the expression of LIPE mRNA20032539

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004806triglyceride lipase activity-IEA-  
GO:0005515protein binding-IPI17026959  
GO:0017171serine hydrolase activity-IEA-  
GO:0019901protein kinase binding-IEA-  
GO:0033878hormone-sensitive lipase activity-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006468protein phosphorylation-TAS3420405  
GO:0008203cholesterol metabolic process-IEA-  
GO:0016042lipid catabolic process-ISS-  
GO:0019433triglyceride catabolic process-IEA-  
GO:0042758long-chain fatty acid catabolic process-IEA-  
GO:0046340diacylglycerol catabolic process-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005811lipid droplet-ISS-  
GO:0005829cytosol-IDA-  
GO:0005901caveola-IEA-  
KEGG ID KEGG Term
hsa04910Insulin signaling pathway
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismIEA
R-HSA-163560Triglyceride catabolismIEA
R-HSA-556833Metabolism of lipidsIEA
R-HSA-8979227Triglyceride metabolismIEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
20887155Gene expression profiling of peripheral blood leukocytes identifies potential novel biomarkers of chronic obstructive pulmonary disease in current and former smokers. (2010 Dec)Edmiston JSBiomarkers
25541553Adiposity is associated with DNA methylation profile in adipose tissue. (2015 Aug)Agha GInt J Epidemiol