Gene: FADS1

3992
D5D|FADS6|FADSD5|LLCDL1|TU12
fatty acid desaturase 1
protein-coding
11q12.2
Ensembl:ENSG00000149485 MIM:606148 Vega:OTTHUMG00000157155 UniprotKB:O60427
NC_000011.10
PubMed
0   ANCO-SNPs
ND
5   
7.047e-1 (AD)  4.818e-1 (ND)   (Frontal_Cortex)
7.178e-1 (AD)  8.160e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
DDR10.834
FADS20.833
MYO60.819
DHTKD10.816
AHCYL10.804
AGT0.8
HADHB0.796
PON20.792
TMEM1360.79
SLC18B10.787

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.488
OR4F29-0.471
KLHL38-0.327
MIP-0.304
EPPIN-0.293
CACNA1F-0.288
RTP1-0.278
OPRD1-0.275
FAM160A1-0.271
KCNH5-0.271

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00132Alpha-Linolenic AcidSmall Molecule463-40-1Approved|NutraceuticalTarget
DB00159IcosapentSmall Molecule10417-94-4Approved|NutraceuticalTarget
DB09328VayarinSmall MoleculeApproved|InvestigationalEnzyme
DB13168Omega-6 fatty acidsSmall MoleculeNutraceuticalEnzyme
ID Drug Name Action PubMed
C0184061-(3-trifluoromethylphenyl)piperazine1-(3-trifluoromethylphenyl)piperazine results in increased expression of FADS1 mRNA26821219
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of FADS1 mRNA"28903501
C4901661-(4-methoxyphenyl)piperazine1-(4-methoxyphenyl)piperazine results in increased expression of FADS1 mRNA26821219
C0780921-piperonylpiperazine1-piperonylpiperazine results in increased expression of FADS1 mRNA26821219
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of FADS1 mRNA"19114083
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of FADS1 mRNA"21346803
C00799725-hydroxycholesterol25-hydroxycholesterol inhibits the reaction [beta-hydroxy simvastatin acid results in increased expression of FADS1 mRNA]17655842
C00799725-hydroxycholesterol25-hydroxycholesterol results in decreased expression of FADS1 mRNA17655842
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of FADS1 mRNA"21346803
C0303702-methoxy-5-(2',3',4'-trimethoxyphenyl)tropone"2-methoxy-5-(2',3',4'-trimethoxyphenyl)tropone results in decreased expression of FADS1 mRNA"20206263
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of FADS1 mRNA"29216392
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in increased expression of FADS1 mRNA"23196670
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with methylmercuric chloride co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of FADS1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with methylmercuric chloride co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of FADS1 mRNA"27188386
D000082AcetaminophenAcetaminophen results in decreased expression of FADS1 mRNA29067470
D000082AcetaminophenAcetaminophen results in increased expression of FADS1 mRNA21420995|2223033
D000082AcetaminophenAcetaminophen affects the expression of FADS1 mRNA17562736
D000082AcetaminophenAcetaminophen results in decreased expression of FADS1 mRNA15084756|1752207
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of FADS1 mRNA27153756
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of FADS1 mRNA19770486
D017962alpha-Linolenic Acid[alpha-Linolenic Acid co-treated with Estradiol] results in increased expression of FADS1 mRNA19576517
D017962alpha-Linolenic Acid"[[alpha-Linolenic Acid co-treated with Estradiol] results in increased expression of FADS1 mRNA] which affects the abundance of Fatty Acids, Unsaturated"19576517
D017962alpha-Linolenic Acid[alpha-Linolenic Acid co-treated with Testosterone] results in decreased expression of FADS1 mRNA19576517
D017962alpha-Linolenic Acid"[[alpha-Linolenic Acid co-treated with Testosterone] results in decreased expression of FADS1 mRNA] which affects the abundance of Fatty Acids, Unsaturated"19576517
D017962alpha-Linolenic Acidfulvestrant inhibits the reaction [[alpha-Linolenic Acid co-treated with Estradiol] results in increased expression of FADS1 mRNA]19576517
D000638AmiodaroneAmiodarone results in increased expression of FADS1 mRNA19224547
D000643Ammonium ChlorideAmmonium Chloride affects the expression of FADS1 mRNA16483693
D001554BenzeneBenzene affects the expression of FADS1 mRNA15878777
D019324beta-Naphthoflavone[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of FADS1 mRNA18164116
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of FADS1 mRNA19770486
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of FADS1 mRNA"20018196
D004958Estradiol[alpha-Linolenic Acid co-treated with Estradiol] results in increased expression of FADS1 mRNA19576517
D004958Estradiol"[[alpha-Linolenic Acid co-treated with Estradiol] results in increased expression of FADS1 mRNA] which affects the abundance of Fatty Acids, Unsaturated"19576517
D004958EstradiolEstradiol results in increased expression of FADS1 mRNA20106945
D004958Estradiolfulvestrant inhibits the reaction [[alpha-Linolenic Acid co-treated with Estradiol] results in increased expression of FADS1 mRNA]19576517
C483161beta-hydroxy simvastatin acid25-hydroxycholesterol inhibits the reaction [beta-hydroxy simvastatin acid results in increased expression of FADS1 mRNA]17655842
C483161beta-hydroxy simvastatin acid[beta-hydroxy simvastatin acid co-treated with ciglitazone] results in increased expression of FADS1 mRNA17655842
C483161beta-hydroxy simvastatin acidbeta-hydroxy simvastatin acid promotes the reaction [Fenofibrate results in increased expression of FADS1 mRNA]17655842
C483161beta-hydroxy simvastatin acidbeta-hydroxy simvastatin acid results in increased expression of FADS1 mRNA17655842
C483161beta-hydroxy simvastatin acidFenofibrate promotes the reaction [beta-hydroxy simvastatin acid results in increased expression of FADS1 mRNA]17655842
D001629BezafibrateBezafibrate results in increased activity of FADS1 protein7606338|9032088
C006780bisphenol Abisphenol A results in increased expression of FADS1 mRNA25047013|2768578
C006780bisphenol Abisphenol A results in decreased expression of FADS1 mRNA25181051
D0151248-Bromo Cyclic Adenosine Monophosphate8-Bromo Cyclic Adenosine Monophosphate results in increased expression of FADS1 mRNA22079614
D002065BuspironeBuspirone results in decreased expression of FADS1 mRNA24136188
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of FADS1 mRNA19031917
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of FADS1 mRNA24982889
D000074262Canola OilCanola Oil affects the expression of FADS1 mRNA16177195
D002220CarbamazepineCarbamazepine affects the expression of FADS1 mRNA25979313
D002251Carbon TetrachlorideCarbon Tetrachloride results in decreased expression of FADS1 mRNA27339419
D002251Carbon TetrachlorideCarbon Tetrachloride results in decreased activity of FADS1 protein12679053
D002251Carbon TetrachlorideCarbon Tetrachloride results in decreased expression of FADS1 mRNA17522070|1922454
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in decreased expression of FADS1 mRNA23650126
D002725ChloroformChloroform results in decreased expression of FADS1 mRNA17522070
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of FADS1 gene20938992
C039671ciglitazone[beta-hydroxy simvastatin acid co-treated with ciglitazone] results in increased expression of FADS1 mRNA17655842
C039671ciglitazoneciglitazone results in increased expression of FADS1 mRNA17655842
D002994ClofibrateClofibrate results in increased activity of FADS1 protein7606338
D002994ClofibrateClofibrate results in increased expression of FADS1 mRNA12851107
C018021cobaltous chloridecobaltous chloride results in decreased expression of FADS1 mRNA19320972|1937684
D005576ColforsinColforsin results in increased expression of FADS1 mRNA16751804
D019327Copper SulfateCopper Sulfate results in decreased expression of FADS1 mRNA19549813
C030123coumarincoumarin results in decreased expression of FADS1 mRNA18480146
D003375Coumestrol[Coumestrol co-treated with resveratrol] results in increased expression of FADS1 mRNA19167446
D003375CoumestrolCoumestrol results in increased expression of FADS1 mRNA19167446
D003474CurcuminCurcumin affects the expression of FADS1 mRNA27208389
D003474CurcuminCurcumin results in decreased expression of FADS1 mRNA27208389
C057862cyanoginosin LRcyanoginosin LR results in decreased expression of FADS1 protein26984711
D016572CyclosporineCyclosporine affects the expression of FADS1 mRNA20106945
D016572CyclosporineCyclosporine results in decreased methylation of FADS1 promoter27989131
D016572CyclosporineCyclosporine results in decreased expression of FADS1 mRNA19224547
C014347decitabinedecitabine results in increased expression of FADS1 mRNA16367923|1790848
D003907DexamethasoneDexamethasone results in increased expression of FADS1 mRNA25047013
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in increased expression of FADS1 mRNA28628672
D003907DexamethasoneDexamethasone results in decreased expression of FADS1 mRNA17522070
C088674dibromoacetic aciddibromoacetic acid results in decreased expression of FADS1 mRNA21046364
D003993Dibutyl PhthalateDibutyl Phthalate affects the expression of FADS1 mRNA21745491
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of FADS1 mRNA17379624|2126653
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of FADS1 mRNA17379624
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in increased expression of FADS1 mRNA27392435
D002945CisplatinCisplatin results in increased expression of FADS1 mRNA27392435|2759478
D002945CisplatinFADS1 protein affects the susceptibility to Cisplatin16217747
D004008DiclofenacDiclofenac results in decreased expression of FADS1 mRNA26934552
D004041Dietary FatsDietary Fats results in decreased expression of FADS1 mRNA19030233
D019422Dietary SucroseDietary Sucrose results in increased expression of FADS1 mRNA15763435
D019422Dietary Sucrosetroglitazone inhibits the reaction [Dietary Sucrose results in increased expression of FADS1 mRNA]15763435
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of FADS1 mRNA18164116
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with Thioacetamide] results in decreased expression of FADS1 mRNA28943392
D002117CalcitriolCalcitriol results in increased expression of FADS1 mRNA21592394
D002117Calcitriol[Testosterone co-treated with Calcitriol] results in increased expression of FADS1 mRNA21592394
C015835dimethyl-4-toluidinedimethyl-4-toluidine results in increased expression of FADS1 mRNA27638505
D004918Erythromycin EstolateErythromycin Estolate results in decreased expression of FADS1 mRNA17522070
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of FADS1 mRNA17555576
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of FADS1 mRNA17942748
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of FADS1 mRNA17942748
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of FADS1 mRNA28196854
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of FADS1 mRNA16940010
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of FADS1 mRNA16940010
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of FADS1 mRNA16174780|1694001
D005228Fatty Acids, Essential"Fatty Acids, Essential deficiency results in increased expression of FADS1 mRNA"23333450
D005231Fatty Acids, Unsaturated"[[alpha-Linolenic Acid co-treated with Estradiol] results in increased expression of FADS1 mRNA] which affects the abundance of Fatty Acids, Unsaturated"19576517
D005231Fatty Acids, Unsaturated"[[alpha-Linolenic Acid co-treated with Testosterone] results in decreased expression of FADS1 mRNA] which affects the abundance of Fatty Acids, Unsaturated"19576517
D011345Fenofibratebeta-hydroxy simvastatin acid promotes the reaction [Fenofibrate results in increased expression of FADS1 mRNA]17655842
D011345FenofibrateFenofibrate promotes the reaction [beta-hydroxy simvastatin acid results in increased expression of FADS1 mRNA]17655842
D011345FenofibrateFenofibrate results in increased expression of FADS1 mRNA17655842
D005395Fish OilsFish Oils results in decreased expression of FADS1 mRNA15654130
D005411Flame RetardantsFlame Retardants results in decreased expression of FADS1 mRNA18534652
D005411Flame RetardantsFlame Retardants results in increased expression of FADS1 mRNA18534652
D005472FluorouracilFADS1 protein affects the susceptibility to Fluorouracil16217747
D005485FlutamideFlutamide results in decreased expression of FADS1 mRNA24136188
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of FADS1 gene20938992
D005557FormaldehydeFormaldehyde results in decreased expression of FADS1 mRNA23649840
C070081fulvestrantfulvestrant inhibits the reaction [[alpha-Linolenic Acid co-treated with Estradiol] results in increased expression of FADS1 mRNA]19576517
D015248GemfibrozilGemfibrozil results in increased activity of FADS1 protein7606338
D005839GentamicinsGentamicins results in increased expression of FADS1 mRNA22061828
D005897GlafenineGlafenine results in decreased expression of FADS1 mRNA24136188
C089796hexabromocyclododecanehexabromocyclododecane results in decreased expression of FADS1 mRNA18534652
C089796hexabromocyclododecanehexabromocyclododecane results in increased expression of FADS1 mRNA18534652
D017313FenretinideFenretinide results in increased expression of FADS1 mRNA28973697
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in increased expression of FADS1 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in increased expression of FADS1 mRNA28628672
C544151jinfukang[Cisplatin co-treated with jinfukang] results in increased expression of FADS1 mRNA27392435
C544151jinfukangjinfukang results in increased expression of FADS1 mRNA27392435
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of FADS1 mRNA21889194
D048628KetolidesKetolides analog results in increased expression of FADS1 mRNA24967691
D008095Lithocholic AcidLithocholic Acid results in decreased expression of FADS1 mRNA20359477
D008383MargarineFADS1 gene SNP affects the susceptibility to Margarine21793953
D008627Mercuric ChlorideMercuric Chloride results in decreased expression of FADS1 mRNA16507785
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of FADS1 gene20938992
D008727MethotrexateFADS1 protein affects the susceptibility to Methotrexate16217747
D008727MethotrexateMethotrexate results in increased expression of FADS1 mRNA17400583
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of FADS1 mRNA26272509
C004925methylmercuric chloride"[NOG protein co-treated with methylmercuric chloride co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of FADS1 mRNA"27188386
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in decreased expression of FADS1 mRNA16026605
D015741MetriboloneMetribolone results in increased expression of FADS1 mRNA16751804
C406082monomethylarsonous acidmonomethylarsonous acid results in decreased expression of FADS1 protein24625837
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of FADS1 mRNA"25620056
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of FADS1 mRNA"25620056
C461488N-benzylpiperazineN-benzylpiperazine results in increased expression of FADS1 mRNA26821219
C051752nefazodonenefazodone results in decreased expression of FADS1 mRNA24136188
C012655nimesulidenimesulide results in decreased expression of FADS1 mRNA24136188
C025589ochratoxin Aochratoxin A results in decreased expression of FADS1 mRNA19287073
D015525Fatty Acids, Omega-3"Fatty Acids, Omega-3 results in decreased expression of FADS1 mRNA"23333450
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in decreased expression of FADS1 mRNA25729387
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in increased expression of FADS1 mRNA18692542
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of FADS1 protein26879310
C023036perfluorooctanoic acidperfluorooctanoic acid results in increased expression of FADS1 mRNA25868421
D010795Phthalic AcidsPhthalic Acids results in decreased expression of FADS1 mRNA15728792|2106145
D010840PhytosterolsAPOE gene mutant form affects the reaction [Phytosterols results in increased expression of FADS1 mRNA]18155511
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of FADS1 mRNA19710929
C006253pirinixic acidpirinixic acid results in increased expression of FADS1 mRNA17950772|1830175
C006253pirinixic acidPPARA protein promotes the reaction [pirinixic acid results in increased expression of FADS1 mRNA]17950772
C006253pirinixic acidpirinixic acid results in increased expression of FADS1 mRNA15654130
D010936Plant ExtractsPlant Extracts results in increased expression of FADS1 mRNA23557933
D011374ProgesteroneProgesterone results in increased expression of FADS1 mRNA18070364
D011441PropylthiouracilPropylthiouracil results in decreased expression of FADS1 mRNA24780913
C059514resveratrol[Coumestrol co-treated with resveratrol] results in increased expression of FADS1 mRNA19167446
D015474IsotretinoinIsotretinoin results in decreased expression of FADS1 mRNA20436886
C089730rosiglitazonerosiglitazone results in increased expression of FADS1 mRNA21515302
C054125sesaminsesamin results in decreased activity of FADS1 protein14974737
C016104sodium bichromatesodium bichromate results in decreased expression of FADS1 mRNA25993096
D013311StreptozocinStreptozocin results in decreased expression of FADS1 mRNA25246140
D013629TamoxifenTamoxifen affects the expression of FADS1 mRNA17555576
D013629TamoxifenTamoxifen results in decreased expression of FADS1 mRNA25123088
C031655tauroursodeoxycholic acidtauroursodeoxycholic acid results in decreased expression of FADS1 mRNA15885361
D013739Testosterone[alpha-Linolenic Acid co-treated with Testosterone] results in decreased expression of FADS1 mRNA19576517
D013739Testosterone"[[alpha-Linolenic Acid co-treated with Testosterone] results in decreased expression of FADS1 mRNA] which affects the abundance of Fatty Acids, Unsaturated"19576517
D013739Testosterone[Testosterone co-treated with Calcitriol] results in increased expression of FADS1 mRNA21592394
D013739TestosteroneTestosterone results in increased expression of FADS1 mRNA21592394
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of FADS1 mRNA20106945|2163298
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of FADS1 mRNA21570461|2637764
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of FADS1 mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin promotes the reaction [AHR protein binds to FADS1 gene]28213091
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of FADS1 mRNA16960034|2821309
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of FADS1 mRNA16960034|2121527
D013752TetracyclineTetracycline results in decreased expression of FADS1 mRNA17522070
D013849ThimerosalThimerosal results in decreased expression of FADS1 mRNA27188386
D013853Thioacetamide[Diethylnitrosamine co-treated with Thioacetamide] results in decreased expression of FADS1 mRNA28943392
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of FADS1 mRNA28065790
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in decreased expression of FADS1 mRNA25729387
C057693troglitazonetroglitazone inhibits the reaction [Dietary Sucrose results in increased expression of FADS1 mRNA]15763435
D014520UrethaneUrethane results in decreased expression of FADS1 mRNA28818685
D014580Ursodeoxycholic AcidUrsodeoxycholic Acid results in decreased expression of FADS1 mRNA15885361
D014635Valproic AcidValproic Acid affects the expression of FADS1 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of FADS1 mRNA23179753|2718838
D014635Valproic AcidValproic Acid affects the expression of FADS1 mRNA17963808
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of FADS1 gene25560391
C025643vinclozolinvinclozolin results in increased expression of FADS1 mRNA22570695
D015032ZincZinc results in decreased expression of FADS1 mRNA15226459
D019287Zinc SulfateZinc Sulfate results in decreased expression of FADS1 mRNA15226459

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000248C-5 sterol desaturase activity-TAS10601301  
GO:0016491oxidoreductase activity-IDA10601301  
GO:0045485omega-6 fatty acid desaturase activity-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006355regulation of transcription, DNA-templated-NAS10601301  
GO:0006636unsaturated fatty acid biosynthetic process-IDA10601301  
GO:0006636unsaturated fatty acid biosynthetic process-IEA-  
GO:0007267cell-cell signaling-NAS10601301  
GO:0008654phospholipid biosynthetic process-TAS10601301  
GO:0009267cellular response to starvation-IDA10601301  
GO:0019216regulation of lipid metabolic process-TAS-  
GO:0036109alpha-linolenic acid metabolic process-TAS-  
GO:0043651linoleic acid metabolic process-TAS-  
GO:0045595regulation of cell differentiation-NAS10601301  
GO:0046456icosanoid biosynthetic process-TAS10601301  
GO:0055114oxidation-reduction process-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005739mitochondrion-IEA-  
GO:0005789endoplasmic reticulum membrane-TAS-  
GO:0016020membrane-HDA19946888  
GO:0016020membrane-NAS10601301  
GO:0016021integral component of membrane-NAS10601301  
GO:0043231intracellular membrane-bounded organelle-NAS10601301  
KEGG ID KEGG Term
hsa01040Biosynthesis of unsaturated fatty acids
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-1989781PPARA activates gene expressionTAS
R-HSA-2046104alpha-linolenic (omega3) and linoleic (omega6) acid metabolismTAS
R-HSA-2046105Linoleic acid (LA) metabolismTAS
R-HSA-2046106alpha-linolenic acid (ALA) metabolismTAS
R-HSA-400206Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)TAS
R-HSA-556833Metabolism of lipidsTAS
R-HSA-8978868Fatty acid metabolismTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
21040914FADS gene polymorphisms in Koreans: association with omega6 polyunsaturated fatty acids in serum phospholipids, lipid peroxides, and coronary artery disease. (2011 Jan)Kwak JHAtherosclerosis
20972250Genetic loci associated with lipid concentrations and cardiovascular risk factors in the Korean population. (2011 Jan)Park MHJ Med Genet
23303382Genome-wide association study of serum albumin:globulin ratio in Korean populations. (2013 Mar)Hong KWJ Hum Genet
29549917Associations among FADS1 rs174547, eicosapentaenoic acid/arachidonic acid ratio, and arterial stiffness in overweight subjects. (2018 Mar)Kim MProstaglandins Leukot Essent Fatty Acids
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