Gene: FADS3

3995
CYB5RP|LLCDL3
fatty acid desaturase 3
protein-coding
11q12.2
Ensembl:ENSG00000221968 MIM:606150 Vega:OTTHUMG00000167500 UniprotKB:Q9Y5Q0
NC_000011.10
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
8.261e-1 (AD)  9.139e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
DXO0.898
CCDC1300.891
COG70.89
TRMT10.885
XAB20.884
STARD30.881
AKAP8L0.88
CRTC20.877
LEMD20.874
DVL20.873

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.676
OR4F29-0.631
MTRNR2L9-0.248
GSDMC-0.226
RERGL-0.224
MTRNR2L6-0.214
KLRC2-0.213
CETP-0.205
ADAMTS5-0.205
TDGF1-0.202

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0297902,2',3',4,4',5-hexachlorobiphenyl"2,2',3',4,4',5-hexachlorobiphenyl results in decreased expression of FADS3 mRNA"23829299
D000082AcetaminophenAcetaminophen results in increased expression of FADS3 mRNA21420995|2223033
D000082AcetaminophenAcetaminophen affects the expression of FADS3 mRNA17562736
D016604Aflatoxin B1Aflatoxin B1 affects the expression of FADS3 protein20106945
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of FADS3 mRNA21632981|2164198
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of FADS3 mRNA19770486
D000643Ammonium ChlorideAmmonium Chloride affects the expression of FADS3 mRNA16483693
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of FADS3 mRNA20106945|2163298
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of FADS3 mRNA19770486
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of FADS3 mRNA22228805
D004958EstradiolEstradiol results in increased expression of FADS3 mRNA20106945
C543008bis(4-hydroxyphenyl)sulfone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in increased expression of FADS3 mRNA28628672
C006780bisphenol Abisphenol A results in decreased expression of FADS3 mRNA22576693
C006780bisphenol Abisphenol A results in increased methylation of FADS3 gene22576693
C006780bisphenol Abisphenol A results in decreased expression of FADS3 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of FADS3 gene28505145
D002104CadmiumCadmium results in increased expression of FADS3 mRNA24376830
D019256Cadmium ChlorideCadmium Chloride affects the expression of FADS3 mRNA22110744
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of FADS3 mRNA27339419
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of and results in increased expression of FADS320938992
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of FADS3 gene20938992
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of FADS3 mRNA20938992
D002922CiguatoxinsCiguatoxins affects the expression of FADS3 mRNA18353800
D002994ClofibrateClofibrate results in increased expression of FADS3 protein6821269
C018021cobaltous chloridecobaltous chloride results in decreased expression of FADS3 mRNA19320972
D003300Copper[ATP7A gene mutant form results in increased abundance of Copper] which results in increased expression of FADS3 mRNA15467011
D019327Copper SulfateCopper Sulfate results in increased expression of FADS3 mRNA19549813
D016572CyclosporineCyclosporine results in increased expression of FADS3 mRNA20106945|2556210
D016572CyclosporineCyclosporine results in increased expression of FADS3 mRNA19770486
D003609DactinomycinDactinomycin results in increased expression of FADS3 mRNA21527772
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in increased expression of FADS3 mRNA28628672
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of FADS3 mRNA21266533
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in increased expression of FADS3 mRNA27392435
D002945CisplatinCisplatin results in increased expression of FADS3 mRNA27392435
D004041Dietary FatsDietary Fats results in decreased expression of FADS3 mRNA18042831
D004785Environmental PollutantsEnvironmental Pollutants results in decreased expression of FADS3 mRNA20064776
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of FADS3 mRNA22079256
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of FADS3 mRNA17942748
D005047EtoposideEtoposide results in increased expression of FADS3 mRNA21527772
C061365flusilazoleflusilazole results in increased expression of FADS3 mRNA22664269
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of and results in increased expression of FADS320938992
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of FADS3 gene20938992
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of FADS3 mRNA20938992
D005557FormaldehydeFormaldehyde results in increased expression of FADS3 mRNA27664576
C039281furanfuran results in increased expression of FADS3 mRNA25539665
D017313FenretinideFenretinide results in decreased expression of FADS3 mRNA28973697
D006861Hydrogen Peroxide[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of FADS3 protein18951874
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in increased expression of FADS3 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in increased expression of FADS3 mRNA28628672
C544151jinfukang[Cisplatin co-treated with jinfukang] results in increased expression of FADS3 mRNA27392435
C544151jinfukangjinfukang results in increased expression of FADS3 mRNA27392435
C410337K 7174K 7174 results in increased expression of FADS3 mRNA24086573
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of and results in increased expression of FADS320938992
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of FADS3 gene20938992
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of FADS3 mRNA20938992
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of FADS3 mRNA21527772
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of FADS3 mRNA"25554681
C017096n-butoxyethanoln-butoxyethanol results in increased expression of FADS3 mRNA19812364
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in increased expression of FADS3 mRNA25729387
D000073878Palm OilPalm Oil results in decreased expression of FADS3 mRNA18042831
C410127PCB 180PCB 180 results in increased expression of FADS3 mRNA23829299
C086401pentabromodiphenyl etherpentabromodiphenyl ether results in increased expression of FADS3 mRNA26705709
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in decreased expression of FADS3 mRNA18692542
D010656PhenylephrinePhenylephrine results in increased expression of FADS3 mRNA18158353
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of FADS3 mRNA19710929
C006253pirinixic acid[pirinixic acid co-treated with PPARA] results in decreased expression of FADS3 mRNA20813756
C006253pirinixic acidpirinixic acid results in decreased expression of FADS3 mRNA20813756|2381119
C006253pirinixic acidpirinixic acid results in decreased expression of FADS3 mRNA22484513
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of FADS3 mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of FADS3 mRNA22079256
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in decreased expression of FADS3 mRNA28903501
D011374ProgesteroneProgesterone results in increased expression of FADS3 mRNA21795739
D011441PropylthiouracilPropylthiouracil results in increased expression of FADS3 mRNA24780913
D011794QuercetinQuercetin results in increased expression of FADS3 mRNA21632981
D012643SeleniumSelenium results in increased expression of FADS3 mRNA19244175
C017947sodium arsenitesodium arsenite results in decreased expression of FADS3 mRNA22714537
D012999SomanSoman results in decreased expression of FADS3 mRNA19281266
C031655tauroursodeoxycholic acidtauroursodeoxycholic acid results in decreased expression of FADS3 mRNA15885361
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of FADS3 mRNA22574217
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of FADS3 mRNA21570461
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of FADS3 mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin promotes the reaction [AHR protein binds to FADS3 promoter]19654925
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of FADS3 mRNA28238261
D013749TetrachlorodibenzodioxinAHR protein alternative form affects the reaction [Tetrachlorodibenzodioxin results in decreased expression of FADS3 mRNA]21215274
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of FADS3 mRNA21215274
D019284ThapsigarginThapsigargin results in increased expression of FADS3 mRNA22378314
D013806Theophylline[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of FADS3 protein18951874
D013853ThioacetamideThioacetamide results in increased expression of FADS3 mRNA23411599
C009495titanium dioxidetitanium dioxide results in increased expression of FADS3 mRNA27760801
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of FADS3 mRNA28065790
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in increased expression of FADS3 mRNA25729387
D014212TretinoinTretinoin results in increased expression of FADS3 mRNA20488242|2266426
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of FADS3 mRNA"26179874
D014415TunicamycinTunicamycin results in increased expression of FADS3 mRNA22378314
D014580Ursodeoxycholic AcidUrsodeoxycholic Acid results in decreased expression of FADS3 mRNA15885361
D014635Valproic AcidValproic Acid affects the expression of FADS3 mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of FADS3 mRNA19101580|2317975
D014635Valproic AcidValproic Acid results in increased methylation of FADS3 gene29154799
C025643vinclozolinvinclozolin results in increased expression of FADS3 mRNA22570695
C088658zoledronic acidzoledronic acid results in increased expression of FADS3 mRNA20977926

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003674molecular_function-ND-  
GO:0016491oxidoreductase activity-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006636unsaturated fatty acid biosynthetic process-NAS10860662  
GO:0055114oxidation-reduction process-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005789endoplasmic reticulum membrane-IEA-  
GO:0016020membrane-NAS10860662  
GO:0016021integral component of membrane-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
21040914FADS gene polymorphisms in Koreans: association with omega6 polyunsaturated fatty acids in serum phospholipids, lipid peroxides, and coronary artery disease. (2011 Jan)Kwak JHAtherosclerosis