Gene: MYO18A

399687
MAJN|MYSPDZ|SP-R210|SPR210
myosin XVIIIA
protein-coding
17q11.2
Ensembl:ENSG00000196535 MIM:610067 Vega:OTTHUMG00000166360 UniprotKB:Q92614
NG_051989.1
SNP Mapped
1   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
6.842e-1 (AD)  9.406e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs7212295chr17:29104407 (GRCh38.p7)A>Galcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
BRD30.872
MCM3AP0.845
XPC0.834
DHX380.833
MAN2A20.831
EIF3A0.826
GIGYF20.825
NOP90.824
BACE10.807
TBC1D9B0.803

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F29-0.514
OR4F5-0.477
OR4F16-0.306
C17orf112-0.297
MTRNR2L6-0.284
MTRNR2L10-0.269
ODAM-0.268
UGT2B11-0.258
MOGAT2-0.248
RSPO1-0.246

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in decreased expression of MYO18A mRNA"18648102
D000082AcetaminophenAcetaminophen affects the expression of MYO18A mRNA17562736
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of MYO18A gene27153756
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of MYO18A mRNA19770486
D000616AminoglutethimideAminoglutethimide results in decreased expression of MYO18A protein26102013
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of MYO18A mRNA22228805
D004958EstradiolEstradiol results in increased expression of MYO18A mRNA23019147
C006780bisphenol Abisphenol A results in increased expression of MYO18A mRNA23019147
C006780bisphenol Abisphenol A results in decreased expression of MYO18A mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of MYO18A gene28505145
C018475butyraldehydebutyraldehyde results in decreased expression of MYO18A mRNA26079696
D019256Cadmium ChlorideCadmium Chloride results in increased expression of MYO18A mRNA25993096
D002251Carbon TetrachlorideCarbon Tetrachloride affects the expression of MYO18A mRNA17484886
D019327Copper SulfateCopper Sulfate results in decreased expression of MYO18A mRNA19549813
C014347decitabinedecitabine results in decreased expression of MYO18A mRNA19363521
C014347decitabineTP53 protein affects the reaction [decitabine results in decreased expression of MYO18A mRNA]19363521
D002945CisplatinCisplatin promotes the reaction [jinfukang results in increased expression of MYO18A mRNA]27392435
D002945Cisplatinjinfukang promotes the reaction [Cisplatin results in increased expression of MYO18A mRNA]27392435
C000944dicrotophosdicrotophos results in increased expression of MYO18A mRNA28302478
D004041Dietary FatsDietary Fats results in increased expression of MYO18A mRNA25016146
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of MYO18A mRNA17555576
D005485FlutamideFlutamide results in decreased expression of MYO18A mRNA24793618
D019833GenisteinGenistein results in increased expression of MYO18A mRNA23019147|2686566
D005897GlafenineGlafenine results in increased expression of MYO18A mRNA24136188
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of MYO18A mRNA25613284
C544151jinfukangCisplatin promotes the reaction [jinfukang results in increased expression of MYO18A mRNA]27392435
C544151jinfukangjinfukang promotes the reaction [Cisplatin results in increased expression of MYO18A mRNA]27392435
C544151jinfukangjinfukang results in increased expression of MYO18A mRNA27392435
D008694MethamphetamineMethamphetamine results in increased expression of MYO18A mRNA26307267
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of MYO18A mRNA"26251327
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of MYO18A mRNA"20188158
D008777MethyltestosteroneMethyltestosterone results in increased expression of MYO18A mRNA29191790
C583365N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide"N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide results in decreased expression of MYO18A mRNA"29244179
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of MYO18A mRNA"25620056
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of MYO18A mRNA"25620056
C046012pentanalpentanal results in decreased expression of MYO18A mRNA26079696
C059514resveratrolresveratrol results in decreased expression of MYO18A mRNA12569576
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of MYO18A mRNA25895662
D012969Sodium FluorideSodium Fluoride results in decreased expression of MYO18A mRNA27862939
D013629TamoxifenTamoxifen affects the expression of MYO18A mRNA17555576
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of MYO18A mRNA21570461
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of MYO18A mRNA25613284
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of MYO18A mRNA28065790
C057693troglitazonetroglitazone results in decreased expression of MYO18A mRNA28973697
D014635Valproic AcidValproic Acid results in increased methylation of MYO18A gene29154799
C025643vinclozolinvinclozolin results in increased expression of MYO18A mRNA22570695

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003677DNA binding-IEA-  
GO:0003723RNA binding-HDA22681889  
GO:0005515protein binding-IPI19837035  24485452  25965346  
GO:0005524ATP binding-IDA23990465  
GO:0008017microtubule binding-IEA-  
GO:0016887ATPase activityNOTIDA23990465  
GO:0043531ADP binding-IDA23990465  
GO:0051015actin filament binding-IDA23990465  
GO ID GO Term Qualifier Evidence PubMed
GO:0006259DNA metabolic process-IEA-  
GO:0007018microtubule-based movement-IEA-  
GO:0007030Golgi organization-IMP19837035  
GO:0016477cell migration-IMP18854160  
GO:0031032actomyosin structure organization-IMP18854160  
GO:0043030regulation of macrophage activation-IMP25965346  
GO:0043066negative regulation of apoptotic process-IMP24485452  
GO:0048194Golgi vesicle budding-IMP19837035  
GO:0050714positive regulation of protein secretion-IMP23345592  
GO:0090161Golgi ribbon formation-IMP19837035  
GO:0090164asymmetric Golgi ribbon formation-IMP19837035  
GO:1903028positive regulation of opsonization-IMP21123169  
GO ID GO Term Qualifier Evidence PubMed
GO:0000139Golgi membrane-IEA-  
GO:0005793endoplasmic reticulum-Golgi intermediate compartment-IEA-  
GO:0005802trans-Golgi network-IDA19837035  
GO:0009986cell surface-IEA-  
GO:0016020membrane-HDA19946888  
GO:0016459myosin complex-IEA-  
GO:0042641actomyosin-IDA18854160  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1226099Signaling by FGFR in diseaseTAS
R-HSA-1643685DiseaseTAS
R-HSA-1839117Signaling by cytosolic FGFR1 fusion mutantsTAS
R-HSA-1839124FGFR1 mutant receptor activationTAS
R-HSA-5655302Signaling by FGFR1 in diseaseTAS
R-HSA-5663202Diseases of signal transductionTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal