Gene: SHC4

399694
RaLP|SHCD
SHC adaptor protein 4
protein-coding
15q21.1
Ensembl:ENSG00000185634 MIM:617372 Vega:OTTHUMG00000131513 UniprotKB:Q6S5L8
NC_000015.10
SNP Mapped
1   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
6.893e-1 (AD)  3.058e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs8031813chr15:48961764 (GRCh38.p7)C>A / C>Talcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
COL4A50.901
C10orf900.896
TMEM980.884
ASPA0.88
HSPA20.877
ERBB30.877
DOCK50.877
ST180.871
AMER20.87
SLC44A10.863

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CUX2-0.429
CHRNA2-0.413
PRTN3-0.398
SDK1-0.394
PCDH8-0.387
HCN4-0.386
LTK-0.384
SHISA8-0.382
TP53I11-0.38
CALB2-0.378

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SHC4 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SHC4 mRNA"27188386
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of SHC4 gene27153756
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of SHC4 mRNA22100608
C547126AZM551248AZM551248 results in decreased expression of SHC4 mRNA22323515
C030935benz(a)anthracene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of SHC4 mRNA27858113
C006703benzo(b)fluoranthene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of SHC4 mRNA27858113
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of SHC4 mRNA20064835
D001564Benzo(a)pyrene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of SHC4 mRNA27858113
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of SHC4 mRNA21715664
D004958Estradiol[Estradiol co-treated with Progesterone] results in decreased expression of SHC4 mRNA20660070
C006780bisphenol Abisphenol A results in decreased methylation of SHC4 gene22576693
C006780bisphenol Abisphenol A results in increased expression of SHC4 mRNA22576693
C006780bisphenol Abisphenol A affects the expression of SHC4 mRNA25181051
C031180chrysene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of SHC4 mRNA27858113
D003033Coal TarCoal Tar results in decreased expression of SHC4 mRNA27858113
D003300Copper[Copper co-treated with Dietary Sucrose] results in increased expression of SHC4 mRNA26033743
D003300CopperCopper deficiency results in increased expression of SHC4 mRNA26033743
D003471CuprizoneCuprizone results in increased expression of SHC4 mRNA27523638
D019422Dietary Sucrose[Copper co-treated with Dietary Sucrose] results in increased expression of SHC4 mRNA26033743
D019422Dietary SucroseDietary Sucrose results in increased expression of SHC4 mRNA26033743
D004365Drugs, Chinese Herbal"Drugs, Chinese Herbal results in increased expression of SHC4 mRNA"23811387
D005557FormaldehydeFormaldehyde results in increased expression of SHC4 mRNA23649840
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of SHC4 mRNA24796395
D048628KetolidesKetolides analog results in decreased expression of SHC4 mRNA24967691
D008154LucanthoneLucanthone results in increased expression of SHC4 mRNA21148553
D008748MethylcholanthreneMethylcholanthrene results in increased expression of SHC4 mRNA20713471
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of SHC4 mRNA28001369
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of SHC4 mRNA23649840
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of SHC4 mRNA"20188158
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of SHC4 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of SHC4 mRNA"25554681
D009285NaphthoquinonesNaphthoquinones results in increased expression of SHC4 mRNA23811387
D009532NickelNickel results in decreased expression of SHC4 mRNA24768652|2558310
D011374Progesterone[Estradiol co-treated with Progesterone] results in decreased expression of SHC4 mRNA20660070
C005556propionaldehydepropionaldehyde results in increased expression of SHC4 mRNA26079696
C017947sodium arsenitesodium arsenite results in decreased expression of and affects the splicing of SHC4 mRNA25879800
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of SHC4 mRNA26377647
C012589trichostatin Atrichostatin A results in increased expression of SHC4 mRNA24935251
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SHC4 mRNA"27188386
D014635Valproic AcidValproic Acid results in decreased expression of SHC4 mRNA26272509
D014635Valproic AcidValproic Acid results in decreased methylation of SHC4 gene29154799
D014635Valproic AcidValproic Acid results in increased expression of SHC4 mRNA24935251
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of SHC4 gene25560391
C088658zoledronic acidzoledronic acid results in decreased expression of SHC4 mRNA24714768

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI24658140  24728074  
GO:0019901protein kinase binding-IBA21873635  
GO:0019904protein domain specific binding-IEA-  
GO:0030971receptor tyrosine kinase binding-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0006915apoptotic process-IEA-  
GO:0007169transmembrane receptor protein tyrosine kinase signaling pathway-IBA21873635  
GO:0008284positive regulation of cell proliferation-IEA-  
GO:0010468regulation of gene expression-IEA-  
GO:0035556intracellular signal transduction-IEA-  
GO:0048863stem cell differentiation-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005622intracellular-IEA-  
GO:0005886plasma membrane-IBA21873635  
GO:0030054cell junction-IEA-  
GO:0045211postsynaptic membrane-IEA-  
KEGG ID KEGG Term
hsa04012ErbB signaling pathway
hsa04062Chemokine signaling pathway
hsa04510Focal adhesion
hsa04650Natural killer cell mediated cytotoxicity
hsa04722Neurotrophin signaling pathway
hsa04910Insulin signaling pathway
hsa05100Bacterial invasion of epithelial cells
hsa05214Glioma
hsa05220Chronic myeloid leukemia
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal